Researchers have successfully implemented community-based projects to address cancer disparities among African-American and Hispanic communities, and Navajo Nation population. The initiatives improve data collection, provide insight into social factors, and lead to sustained health improvements.
Researchers identified two proteins, hnRNP-H1 and SAFB-2, as potential biomarkers for disease screening in African-American men. These proteins are involved in the growth of tumor cells and may play a role in hormone-related prostate cancer progression.
A recent study found racial discrepancies in breast cancer tumor gene profiles, suggesting inflammation plays a stronger role in development and progression in African-American women. African-American breast cancer patients tend to have a greater prevalence of an aggressive form of cancer less likely to respond to hormone therapy.
A study found that urban African-American women have difficulty meeting dietary goals that could help prevent cancer. The researchers linked high-risk dietary behaviors to younger age, depression, smoking, and birthplace in the District of Columbia.
African-American men face an observable disadvantage in prostate cancer survival due to genetic and behavioral differences. Research highlights the impact of cultural beliefs, such as fatalism and religiosity, on cancer detection and control, as well as the link between obesity and advanced-stage prostate cancer diagnosis.
Leslie Bernstein, a renowned researcher on hormone effects and physical activity on cancer risk, has been selected for the AACR-Prevent Cancer Foundation Award. Her work has vast implications on quality of life after cancer, challenging previous paradigms on breast cancer risk factors.
Researchers present findings on how poverty affects cancer prognosis, ethnicity influences medical care, and genetics impact survival rates among different groups of women. A study reveals African-American women face poorer disease-free survival rates due to racial-specific biology, prompting a reevaluation of screening guidelines. Mea...
Researchers found a protective effect of the TT version of the MTHFR gene against colorectal cancer in Asian populations, but not in others. The study suggests genetics may play a role in understanding health disparities in minority groups.
A genome-wide analysis of PPARg reveals new targets for drug development against obesity, diabetes, and cancer. The study provides clues into the transcriptional circuitry during adipogenesis and insulin sensitization.
Researchers developed a novel compound that blocks the breakdown of retinoic acid, derived from vitamin A, and found it to be an effective agent in treating animal models of human prostate cancer. The compound resulted in up to a 50 percent decrease in tumor volume and prevented further tumor growth.
Researchers have developed two molecular analogues of curcumin that demonstrate enhanced tumor suppressive properties against colorectal cancer. These new compounds have shown improved bioavailability and potency compared to natural curcumin.
Researchers found that inositol and IP6 protected human skin cells from UVB radiation damage and increased the potency of radiation therapy against cancer cells. The antioxidants may also offer protection against accidents or incidents involving nuclear material, such as dirty bombs.
A rare hereditary disorder, Li-Fraumeni syndrome, has been identified in an Asian female with early onset breast cancer. Genetic testing may help diagnose LFS in young women with a family history of the condition, which increases the risk of developing multiple primary tumors.
Researchers present emerging therapies targeting cancer cells, including a small molecule inhibitor of protein kinase D and an oncolytic herpes virus that selectively targets cancer cells without damaging nerves. These treatments offer promising methods for controlling disease and improving patient outcomes.
Researchers have discovered that combining targeted therapies can be more effective than single drugs, particularly when targeting multiple pathways such as the MAPK and PI3-kinase pathways. This approach may help overcome drug resistance and improve treatment outcomes for various types of cancer, including lung and breast cancer.
Researchers are discovering ways of combining new and existing drugs to fight cancer, broadening the targets of already-approved targeted therapeutics. A combination of CP-751871 and rapamycin has shown a highly effective therapy for xenografts derived from childhood sarcomas.
In a Phase I/II clinical trial, ECO-4601 demonstrated safety and efficacy in treating advanced solid tumors. The drug targets the RAS/MAPK signaling pathway and peripheral benzodiazepine receptor, offering a unique mechanism of action.
Researchers have developed new means of screening vast stores of data to find potential therapies for neuroblastoma and other cancers. By targeting cellular molecules along pathways crucial for sustaining cancer cell life, they identified 47 candidates with good potential against neuroblastoma.
GSK923295A, a first-in-class targeted therapy, demonstrates broad activity and potential for enhanced tolerability in preclinical studies. The experimental drug inhibits the mitotic kinesin CENP-E, leading to apoptosis and misaligned chromosomes in cancer cells.
Researchers present studies on novel insulin-like growth factor receptor enzyme inhibitors and approved drugs in new applications, showing promising results in solid tumors and metastatic renal cancer. Early evidence suggests antitumor activity and potential benefits for patients with advanced hepatocellular carcinoma and metastatic ki...
A study by ANZAC Research Institute suggests that a calcium deficiency can increase the likelihood of advanced breast cancer targeting bones. Dietary calcium intake could help prevent this spread and serve as an adjuvant treatment during therapy.
Researchers found a link between childbirth and reduced breast cancer risk, suggesting that fetal cells may play a role. The study discovered that women with male DNA in their bloodstream had a lower risk of developing breast cancer.
A new study used gene chip data to improve treatment outcomes for patients with advanced, incurable cancer. Four out of seven patients showed a better response than expected when their tumor's gene expression was analyzed and used to guide treatment.
Researchers found that certain cancer treatments can increase the expression of Nanog and BMI1 stem cell markers in cancer cells, allowing them to survive treatment and potentially leading to tumor growth. Understanding these pathways could lead to the development of new therapeutic targets.
Researchers developed an acoustic sensor that can detect small amounts of mesothelin, a biomarker associated with several cancers. The device uses electrodes and antibodies to identify changes in frequency caused by the presence of mesothelin.
A new blood test has been developed to detect lung cancer in its earliest stage, promising improved diagnosis and treatment options. The test targets the Human Aspartyl (Asparaginyl) ß-Hydroxylase protein, which is abnormally expressed on the surface of cancer cells.
Researchers have developed a new blood screening technique that can detect early-stage liver cancer and predict treatment outcomes. They detected an altered version of RASSF1A, a tumor-suppressing gene, in the blood of HCC patients and HBV-infected test subjects, with promising results.
Researchers have identified a panel of 15 genes that can serve as a biomarker for lung cancer, which may help identify individuals at high risk for the disease. The test, which analyzed gene activity in lung cells, showed a 96% accuracy rate in identifying lung cancer patients.
Researchers at Memorial Sloan-Kettering Cancer Center have developed a new therapy using re-engineered human T cells that can recognize and kill cancerous B cells. The treatment showed promising results in mice, eradicating cancer in 44% of those with human ALL tumors.
Researchers identified 17 genes linked to high-risk multiple myeloma, which can predict poor prognosis and guide therapy. The activity of these genes could help categorize patients' risk early, enabling personalized treatment plans.
Researchers will present novel findings on personalized medicine, including new biomarkers for early detection, advanced imaging technologies, and proteomics applications. Key advances include a blood test for liver cancer and a protein target for lung cancer diagnosis.
Researchers identified a region on chromosome 5p associated with dense breast tissue, a known risk factor for breast cancer. Women with dense breasts are three to five times more likely to develop breast cancer than those with less dense breasts.
Researchers found a blood protein, IGFBP-1, linked to obesity and exercise aversion may indicate increased pancreatic cancer risk. The study suggests lifestyle factors modifiable for improved prognosis.
Researchers found that green tea concentrate increased GST enzyme activity by up to 80% in people with low levels, suggesting a potential mechanism for its anti-cancer properties. The study suggests that green tea may help strengthen metabolic defense against toxins capable of causing cancer.
Researchers found no relationship between statin use and reduced testosterone levels in men, suggesting poor health is a greater factor. Statin use was associated with lower total testosterone levels, but this association vanished when considering age, body weight, and other factors.
Researchers found that smokeless tobacco users are exposed to higher amounts of tobacco-specific nitrosamines than cigarette smokers. The study highlights the dangers of smokeless tobacco and suggests that nicotine replacement therapy may be a safer alternative.
A phase II trial found that six of 17 patients with metastatic colorectal cancer showed significant tumor shrinkage after receiving the therapeutic vaccine TroVax. The study demonstrated the safety and immunogenicity of the vaccine, suggesting its potential as an immuno-therapy approach to enhance the immune response to tumors.
A new optical technology has been developed to detect early signs of pancreatic cancer, allowing for earlier diagnosis and potentially improving treatment outcomes. The technique uses a minimally invasive procedure that can identify cancerous tissue with high accuracy, even in patients with chronic pancreatitis or family history.
Researchers found that low doses of THC can facilitate infection of skin cells and promote cellular events leading to malignancy, raising concerns for those with lowered immune systems. The study emphasizes the need for caution when using marijuana medicinally or recreationally among vulnerable populations.
Researchers found that nimesulide, a COX-2 inhibitor, delayed the development of precancerous pancreatic lesions in mice by 90%, potentially offering a new approach to preventing pancreatic cancer in high-risk populations. The study suggests that inhibiting COX-2 may help slow or prevent the progression of pancreatic cancer.
Researchers found adult leukemia survivors are less active than the general population, with those who received cranial radiotherapy showing the lowest levels of physical activity. This decreased physical activity increases the risk of obesity, cardiovascular disease, and mortality in these patients.
A recent study published in Cancer Epidemiology, Biomarkers & Prevention found that obesity is a significant risk factor for developing multiple myeloma. The research, which analyzed data from over 100,000 participants, discovered that individuals with a higher Body Mass Index (BMI) were more likely to develop the disease.
A study found a significant association between the Western-style 'meat-sweet' diet and an increased risk of breast cancer among postmenopausal Chinese women, particularly those with estrogen receptor-positive tumors. The research suggests that low consumption of this dietary pattern may protect against breast cancer.
Researchers argue that traditional cancer vaccine trial endpoints may be misguided, focusing instead on patient survival and response to subsequent treatments. The study suggests that vaccines can prime the immune system, keeping tumors in check and enhancing the effectiveness of subsequent therapies.
Researchers have successfully engineered mesenchymal stem cells from human fat tissue into 'suicide genes' that seek out and destroy tumors. This gene therapy approach inhibits tumor growth by up to 68.5% in nude mice, showing promise as a novel cancer treatment strategy.
Patients treated with Tarceva who develop a moderate to severe rash experience longer survival without disease progression compared to those with mild rashes or none. The analysis found that more severe rashes were associated with improved clinical outcomes.
Researchers found gene variations in interleukin 1A and 1B to be a major risk factor for lung cancer, particularly among heavy smokers. These variants can lead to an overzealous inflammatory response, causing genetic damage and cancer.
Researchers from USC identified a technique for determining a tumor's 'immune signature,' which could lead to personalized medicine and improved diagnosis. The analysis revealed that a small subset of genes is integral in explaining immunological behavior, and may be useful for matching tumors with available therapies.
New research shows that cigarette smoke can cause changes in the DNA sequence of sperm cells, altering the genetic composition of offspring. The study found that male mice exposed to cigarette smoke had higher rates of genetic mutations than non-smoking mice, with the duration of exposure increasing the likelihood of damage.
Researchers found that consuming high amounts of vitamin B6, B12, and folate from food reduced the risk of pancreatic cancer by 59%, 73%, and 81% respectively. In contrast, multivitamin use was associated with a higher risk of developing the disease.