Researchers found that undetectable EBV DNA levels during treatment significantly reduced cancer recurrence risk, while detectable levels increased the risk of recurrence and metastasis. The study suggests using biomarker tests before and during treatment to guide clinical therapy.
Researchers found three subgroups of glioblastomas with varying degrees of methylation, leading to improved survival times in the subgroup with mixed levels. The study highlights the importance of methylation status in determining treatment outcomes and potential biomarkers for this disease.
A new breast cancer vaccine has been tested in mice and shown to completely eliminate HER2-positive tumors, even those resistant to current therapy. The vaccine uses activated immunity to target the HER2 receptor, potentially eliminating the need for existing therapies.
A new set of tools, 'Pathways to Clinical Goals,' aims to improve the translational research process, accelerating cancer therapy approval. The six pathways address various categories, including anti-cancer agents and lifestyle alterations, to clarify and streamline the research process.
Researchers have identified African-Americans as having a greater risk of developing lung cancer from chronic obstructive pulmonary disease (COPD), with a more than sixfold increased risk. Hay fever was also found to be protective among African-Americans, reducing the risk by 44%.
Researchers discovered a link between atomic bomb exposure and adult-onset papillary thyroid cancer, with a higher risk among younger people. The study found that radiation dose, age at the time of bombing, and elapsed time since exposure were independently associated with the development of the disease.
A combination of S-1 and irinotecan appears to offer a promising alternative to standard treatment for advanced non-small cell lung cancer, with similar response rates and progression-free survival. The experimental therapy resulted in less severe side effects compared to platinum-based chemotherapy regimens.
Researchers have discovered that methadone has surprising killing power against leukemia cells, including those resistant to chemotherapy and radiation. The agent activates the mitochondrial pathway, inducing apoptosis in cancer cells without harming non-leukemic blood cells.
Researchers found that standard flu vaccine boosted immune function in patients with recurrent or metastatic Ewing's sarcoma and alveolar rhabdomyosarcoma, leading to higher five-year overall survival rates. The study suggests immunotherapy could be beneficial for high-risk pediatric sarcomas.
A recent study found that immunosuppressive drugs like cyclosporine increase the expression of vascular endothelial growth factor (VEGF), which can signal tumor growth after organ transplantation. The researchers suggest that targeting VEGF with anti-VEGF therapies may reduce cancer risk in transplant patients.
The addition of hormone therapy following vaccine treatment improved overall survival in patients with castration-resistant prostate cancer. Vaccines can be safely and effectively combined with other therapies, including hormones.
Researchers identified resveratrol as a substance with anti-breast cancer properties by blocking estrogen DNA adducts. The study suggests that resveratrol may play a crucial role in preventing breast cancer.
The American Association for Cancer Research has awarded $1.8 million to three researchers to study genetic signatures, epigenetic staging, and individualized therapy for metastatic colon cancer. The grants aim to accelerate the discovery of new treatments and improve patient outcomes.
A panel of seven biomarkers can predict prostate cancer risk with high accuracy, offering a major step forward in patient care. Elevated levels of these biomarkers were associated with increased risk of relapse, and the combination of all seven variables accurately predicted risk 86.6 percent of the time.
A recent study suggests that dehydrated tomato products containing the organic carbohydrate FruHis may have strong anti-cancer properties. In an animal study, rats fed with a diet rich in FruHis and tomato paste showed longer survival from cancer compared to those without these ingredients.
New data suggests finasteride may be more effective than previously thought in preventing prostate cancer. The study analyzed over 18,000 men and found a significant reduction in aggressive tumors and an increased prevention of clinically significant disease.
A study published in Clinical Cancer Research found that genetic polymorphisms are associated with a lower risk of prostate cancer among Hispanic men. The research suggests that these genetic variations may help clinicians predict who is more likely to develop the disease, potentially reducing unnecessary screenings and treatments.
Researchers have found a biomarker that can distinguish between HG-PIN lesions destined to become cancerous and those that will remain benign. The PTOV1 gene marker is linked to prostate cancer development and can help determine which men with HG-PIN are at substantial risk of developing prostate cancer.
Researchers found a link between PTOV1 gene expression and prostate cancer development in HG-PIN lesions. The study suggests using the biomarker to determine which men with HG-PIN are at substantial risk of developing prostate cancer, potentially saving up to 40% of unnecessary biopsies.
Researchers found that prompt antibiotic treatment of H. pylori infections can reverse damage to the stomach lining and prevent gastric cancer. Treating mice with antibiotics at an early point of infection delayed the development of severe lesions that can lead to cancer.
Researchers found that lung cancer patients over 80 fare equally well after surgery as their younger counterparts, while elevated interleukin-12 levels are associated with poorer survival rates in melanoma patients. DNA methylation decreases with age, potentially contributing to cancer development.
Researchers have developed tests that diagnose, predict or monitor cancer risks without invasive tissue sampling. Oral epithelium can be used as a surrogate tissue to assess molecular damage to the lungs, allowing for convenient biomonitoring methods.
Researchers present data on new role for MRI in brain cancer and lapatinib's promise for stabilizing disease in patients with liver cancer. Functional diffusion mapping can provide earlier assessment of response for patients with glioma, a notoriously hard-to-treat cancer.
Researchers have found genetic differences in breast tumors between African-American and Caucasian women that may contribute to the more aggressive clinical features of breast cancer in African-American women. These differences were also seen in prostate cancer, suggesting a possible link to viral involvement and genetic factors.
Researchers have discovered novel methods for delivering drugs directly to cancer tumors, including the use of peptides and nanotechnology. These methods show promise in reducing malignant tumors in mice and increasing survival rates.
Recent discoveries suggest that stem cells can serve as potential therapeutic targets for many types of cancers. Researchers have identified specific markers, such as aldehyde dehydrogenase, to isolate cancer-initiating cells and track their response to treatment. These findings hold promise for the development of targeted therapies.
Researchers present promising results for new therapies targeting VEGF receptors and blood vessel formation in various types of cancer. These treatments have shown potential to shrink tumors and prolong survival for patients with glioblastoma and rectal cancer.
Researchers are using cellular strategies and new vaccines to direct the body's immune system against cancer. A phase I/II trial of a live Listeria cancer vaccine has shown that it is safe for humans and can reduce tumor size in some patients, with three women experiencing approximately 20 percent tumor reductions.
Researchers present data on the preventive effects of celecoxib and atorvastatin in colorectal, prostate and breast cancer. The study found that patients taking celecoxib had a significant reduction in adenomas, precursor to colon cancer, with low cardiovascular risk. A combination of atorvastatin and celecoxib also inhibited the growt...
Researchers found that combining low-dose DFMO with sulindac reduced recurrent colorectal adenoma risk by up to 95% without significant toxicity. The combination therapy also showed significant reductions in advanced adenoma recurrence rates, including a 92% reduction for larger adenomas.
Researchers found that sunitinib treatment slowed tumor growth and reduced the risk of metastasis in patients with advanced hepatocellular carcinoma. The median progression-free survival was four months, and the median overall survival was 10 months.
Researchers have identified two potential biomarkers that could help doctors monitor the effectiveness of treatment with sunitinib or bevacizumab for kidney and non-small cell lung cancer. A study found that circulating endothelial progenitor cells (ccEPCs) increase in patients who respond to therapy, while those who do not respond hav...
A study found that moderate drinking in women increases the risk of developing ER+/PR+ breast cancer, with higher risks observed for those who consumed more alcohol. Researchers also identified a link between specific genetic variations and increased breast cancer risk among postmenopausal drinkers.
The Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research supports early career scientists, while the International Collaboration award promotes global cooperation to accelerate progress against cancer. The awards aim to encourage innovative approaches to cancer prevention and treatment.
Patients with breast cancer who developed anemia during chemotherapy had a significantly higher risk of local recurrence compared to those without anemia. Anemia was defined as a serum hemoglobin level below 12 g/dL during chemotherapy, and occurred in 18.2% of patients receiving CMF chemotherapy.
Zur Hausen demonstrated the role of human papillomavirus in cervical cancer, providing key findings that led to the recognition of HPV as a primary cause. His research also linked HPV to other cancers, including laryngeal carcinoma and penile carcinoma.
Women with breast cancer who are obese experience more aggressive disease, including higher rates of inflammatory breast cancer and increased risk of recurrence. Obesity can lead to weight gain during treatment, further increasing the risk of recurrence.
The American Association for Cancer Research (AACR) provides financial support to 10 undergraduate students through the AACR-Thomas J. Bardos Science Education Awards for Undergraduate Students. The program allows students to present research, learn from educational sessions and symposia, and network with experts in the field.
The American Association for Cancer Research (AACR) is honoring world-class cancer researchers for their significant contributions to the fight against cancer. The AACR Awards Program recognizes outstanding achievements in basic cancer research, clinical care, therapeutics, and prevention.
A concentrated broccoli sprouts extract cut bladder tumor development in animal models, with isothyiocyanates delivering potent protective action. The study's results reinforce associations between cruciferous vegetable intake and reduced bladder cancer risk.
A new blood biomarker has been discovered that enables accurate prediction of prostate cancer metastasis. The biomarker, endoglin, measures plasma levels associated with an increased risk of cancer spread into regional lymph nodes. Adding this marker to current methods improves accuracy from 89.4% to 97.8%.
A new urine test detects prostate cancer more accurately than current methods, including PSA and PCA3 tests. The test identified 80% of patients with prostate cancer and was 61% effective in ruling out disease.
Researchers have developed a successful test vaccine that prevents the development of prostate cancer in 90% of young mice. The vaccine targets prostate stem cell antigen (PSCA), which is over-expressed in early-stage prostate cancers, and has been shown to mount an immune response against the protein.
The CTRC-AACR San Antonio Breast Cancer Symposium combines basic, translational, and clinical research to advance breast cancer research. The symposium aims to attract thought-leaders and high-quality papers in basic and translational breast cancer research.
Researchers found that eating veggies, gardening, and being physically active can reduce lung cancer risk in smokers and non-smokers. Additionally, a study suggests men are more prone to developing skin cancers due to differences in antioxidant levels and DNA repair capacity.
Research from the American Association for Cancer Research links weight gain and diabetes to increased risks of various cancers. Women with diabetes are 1.5 times more likely to develop colorectal cancer, while those with high C-peptide levels face a risk of death nearly three times higher than women with lower levels.
Research presents findings on plant-derived cancer medicines, highlighting the potential of black raspberry gel in preventing or slowing the growth of oral premalignant tumors. The study demonstrates that the gel slows or reduces lesion progression in about two-thirds of study participants, with no reported side effects.
Researchers explore ways to translate cancer prevention science into public health policy, highlighting the need for effective tobacco control measures. Boosting taxes, comprehensive advertising bans, smoke-free laws, and strengthening cigarette package warnings have been found to be effective in reducing tobacco consumption, but flawe...
Researchers found that diets rich in raw vegetables can prevent or slow the growth of some common cancers. Black raspberries may protect against esophageal cancer by reducing oxidative stress, while broccoli sprouts inhibit bladder cancer development through the delivery of cancer prevention agents.
Cancer Prevention Research is the world's first peer-reviewed scientific journal dedicated exclusively to cancer prevention. The journal will cover various disciplines, including molecular biology, medical oncology, and nutritional science, with an emphasis on linking preclinical and clinical research.