A study found that a phosphate-binding drug did not reduce cardiovascular measures in patients with early chronic kidney disease, suggesting dietary restriction may be the best way to mitigate phosphate's negative effects on the heart. Higher blood phosphate levels increase the risk of dying from heart-related causes.
A study found that racial disparities in end-of-life care among US adults with kidney failure are substantial and vary by region. Black patients are less likely to discontinue dialysis and be referred to hospice compared to white patients, especially in high-end life spending regions.
People with apple-shaped bodies are more likely to develop kidney disease due to lower kidney function, lower kidney blood flow, and higher blood pressure within the kidneys. Treatments that reduce kidney blood pressure may be beneficial for these individuals.
Research suggests that individuals with an apple-shaped body distribution may experience lower kidney function and higher blood pressure within the kidneys, increasing their risk of developing kidney disease. Treatments that reduce kidney blood pressure could be beneficial for these individuals.
A study found significant racial disparities in end-of-life care among US adults with kidney failure, with black patients less likely to be referred to hospice and discontinue dialysis compared to white patients. The differences were most pronounced in regions with the highest levels of end-of-life spending.
A study found that growth hormone therapy can help reverse growth problems in children with kidney failure by increasing bone turnover. However, treatment may not benefit overall bone health and may interrupt the relationship between bone turnover and parathyroid hormone markers.
Individuals who are overweight starting in early adulthood are twice as likely to have chronic kidney disease at age 60 to 64 years. Larger waist-to-hip ratios during middle age are also linked with chronic kidney disease at the same age. Avoiding excess weight gain could prevent many cases of chronic kidney disease, with over one-thir...
A study found that low vitamin D levels at three months post-transplantation were associated with lower kidney function and increased scarring at one year. Vitamin D deficiency is common in patients with kidney failure. Maintaining normal vitamin D levels may prevent renal function deterioration after transplantation.
A study of 1.2 million dialysis patients found Hispanics lived the longest, followed by Blacks, with Whites having the shortest survival time. The disparity may be due to differences in health status before kidney failure.
A study found that individuals with chronic kidney disease who adhered to a healthy lifestyle had a greater likelihood of surviving over a 13-year period. Nonsmoking was associated with the greatest survival benefits.
A recent study found that suboptimal kidney response to the hormone FGF-23 may increase risks for kidney disease patients, particularly those with lower urinary phosphorus levels. The study suggests that resistance to FGF-23's hormonal actions in the kidney may identify novel aspects of kidney dysfunction.
A study found that patients with greater knowledge and motivation about transplantation are more likely to receive a living donor transplant. This suggests that improving patient education may help reduce disparities in transplantation outcomes.
A study of over 404,000 dialysis patients found significant racial and geographic disparities in kidney care. Black patients received less pre-end-stage renal disease (ESRD) care than their white counterparts, particularly in rural and large-metro counties.
A recent study found that African Americans with kidney disease who experience large fluctuations in blood pressure are nearly three times more likely to die prematurely. Monitoring and addressing these day-to-day changes may improve health outcomes.
A global study found that children on dialysis with poor response to anemia medications are linked to inflammation, fluid retention, and hyperparathyroidism. High doses of anemia medications also increase the risk of premature death. The study provided valuable insights into anemia control in pediatric patients.
Pediatric kidney transplant recipients with antibodies are more likely to experience kidney injury and rejection. Steroids do not prevent this antibody-mediated injury, but monitoring recipients for antibodies and customizing immunosuppressive treatments can help.
A study found that lung ultrasound can detect asymptomatic lung congestion in dialysis patients, who are at high risk of premature death and cardiac events. Treating this condition may improve cardiovascular health and prevent deaths.
A study found that certain gene mutations increase the risk of developing aHUS and affect patient prognosis after diagnosis. Screening for these mutations may help diagnose and treat affected individuals.
Studies show dialysis patients using catheters face higher risks of death, infections, and cardiovascular events compared to those with arteriovenous fistulas or grafts. Higher quality studies are needed to determine the true safety of different types of vascular access.
A technique that removes additional toxins during dialysis decreased kidney failure patients' risk of dying from any cause by 30% over three years, with lower risks of heart-related causes and infections. The study's findings suggest OL-HDF may indeed prolong kidney failure patients' lives compared to conventional hemodialysis.
A study found that frequent dialysis can cause complications related to repeated access to the blood, including repair procedures and hospitalizations. The risk of these events was 76% higher with daily hemodialysis compared to conventional hemodialysis.
Adding fruits and vegetables to the diet has been shown to reduce metabolic acidosis and kidney injury in late-stage chronic kidney disease patients. One-year plasma total carbon dioxide levels increased in both groups, indicating a lessening of metabolic acidosis.
A recent study published in the Clinical Journal of the American Society of Nephrology found that African Americans and individuals without private insurance are less likely to receive a kidney transplant before needing dialysis. The study examined data from over 11,000 adult first-time deceased donor kidney transplant recipients in th...
A study finds that breast milk contains very low levels of tacrolimus, and babies can clear the drug at the same rate whether breast-fed or bottle-fed. Women taking tacrolimus who wish to breast-feed after counseling should not be discouraged from doing so.
A study found that among individuals with diabetes, those with both diabetes and kidney disease have a mortality rate of 31.1%, compared to 11.5% for those with diabetes but without kidney disease. Preventing and treating kidney disease in diabetics may be crucial to reducing mortality risk.
Residence in areas with higher average household income was linked with improved survival for both Black and White kidney failure patients. However, in White patients, income inequality was associated with mortality, while in Black patients exclusively, residence in highly segregated areas was associated with increased mortality.
A large, randomized trial found that angiotensin II blockade did not lessen tissue scarring or prevent kidney failure in kidney transplant recipients. The treatment was safe and well-tolerated but showed no benefit in slowing disease progression.
Retaining certain compounds normally excreted by the kidneys can cause insulin resistance in kidney disease patients. Treating mice with a prebiotic reduces these compound levels, preventing insulin resistance and related lipid abnormalities.
A new study found that six months of steroid treatment didn't reduce relapse rates or side effects in children with nephrotic syndrome, challenging previous assumptions about optimal treatment strategies. The research highlights the need for new treatment strategies to prevent frequent relapses in this disease.
Blocking the endothelin receptor reduces cardiovascular risk factors in patients with chronic kidney disease independent of blood pressure. The findings suggest that blocking the receptor may provide heart-related benefits to these patients, who have a higher risk of developing heart problems due to their condition.
A study found that disordered mineral metabolism worsens with progressive chronic kidney disease and is linked to a higher risk of kidney failure among African Americans. Measuring mineral metabolites may be a useful way to determine CKD patient prognosis, while targeting these metabolites could help slow disease progression.
The most severe form of acute kidney injury has seen a significant increase in incidence rates, with deaths associated with the condition also rising. The study highlights the need for further research into the causes behind this trend and potential interventions to reduce its impact.
African Americans experience faster progression of chronic kidney disease in later stages compared to other races. Screening for microalbuminuria is cost-effective for African Americans with diabetes or hypertension, improving care and reducing kidney failure risk.
A study found that open heart surgery is safer than angioplasty for dialysis patients with blocked arteries surrounding the heart, with five-year survival rates over 90% without kidney disease but dismal in kidney failure patients. Heart disease is a leading cause of death in kidney failure patients, affecting 30-60%.
A new study reveals that even low levels of preformed donor-specific antibodies can nearly double the risk of antibody-mediated rejection and increase kidney failure by 76%. This finding could help clinicians provide better donor-recipient matches and tailor immunosuppressive therapy.
Recent studies suggest that hypertension and diabetes are more prevalent in black versus white donors, but the risk attributable to donation remains unknown. Individuals with prediabetes can safely donate kidneys without increasing their risk of developing diabetes or kidney failure.
Researchers found that adding fruits and vegetables can reduce metabolic acidosis and preserve kidney function in CKD patients. Poor dietary habits and poverty are also linked to an increased risk of kidney disease, highlighting the need for targeted interventions to address disparities in care.
Researchers have successfully created functional 'organoids' that can carry out kidney functions when implanted into rats. The breakthrough could lead to more options for individuals with kidney failure and better tools for understanding and treating complex kidney diseases.
Researchers have identified a new therapeutic target for diabetic nephropathy, the leading cause of kidney failure, by activating liver x receptor (LXR) to inhibit osteopontin expression. Activation of LXR with a drug named T0901317 improves kidney health and function in diabetic mice.
A study reveals that kidney failure patients have less of the sugar coating on their blood vessels, leading to high levels of its constituents in the blood. This damage may contribute to their increased risk of heart problems.
A single gene variant in donors has been linked to a 69% increased risk for long-term failure of transplanted kidneys. The variant affects the expression of the protein that pumps drugs out of cells, which can be toxic to the kidneys.
Home hemodialysis could enable patients to increase their dialysis frequency, potentially providing a survival benefit. Increased physician and patient education can eliminate barriers to its adoption.
A study found that nearly half of Canadians view financial incentives for deceased kidney donation as acceptable. Lower-income individuals were not more likely to donate for financial gain, according to the researchers. The study suggests that financial incentives may increase donations from both living and deceased donors.
The American Society of Nephrology has identified five recommendations for reducing unnecessary medical interventions, including avoiding routine cancer screening and administering erythropoiesis stimulating agents in chronic kidney disease patients. By implementing these guidelines, healthcare costs can be lowered and patient care imp...
Researchers have identified a simple blood test that accurately detects autoimmune kidney disease and predicts patient outcomes. The test measures antiPLA2R autoantibodies, which are associated with disease severity and remission rates.
A new test can measure an individual's propensity for calcification in their blood, identifying those at increased risk of vascular calcification and potential heart disease. The test may also provide a basis for treatment monitoring in patients who receive calcification inhibitors.
A new study found that patients with common kidney disease IgA nephropathy who have normal kidney function and only minor urinary abnormalities at diagnosis experience remission without special treatments. No patients developed kidney failure over a 20-year follow-up, indicating an excellent prognosis.
A study found that even in the normal range, urinary protein excretion increases diabetics' heart risks. Patients may benefit from cardioprotective medications to mitigate this risk.
A recent study found that waiting to treat cytomegalovirus infections in transplant recipients until they reach a certain threshold is more beneficial than prophylactically treating all recipients. This approach led to less kidney scaring and better long-term organ survival among patients.
A study estimates that approximately 1 in 93 men and 1 in 133 women of middle age may develop kidney failure in their lifetime. People with reduced kidney function face a higher risk, with men facing a 7.51% chance and women a 3.21%.