A clinical trial in Africa has discovered a single-dose treatment combining sulfadoxine, pyrimethamine, artesunate, and pyronaridine (SPAP) that is as effective as traditional multi-day treatments in curing uncomplicated malaria. The study addresses the growing threat of drug-resistant malaria parasites and improves treatment adherence.
A clinical trial found that ivermectin can be safely given to young children weighing as little as 5 kilograms, challenging existing manufacturer restrictions. The study's results could spur progress against diseases like intestinal worms, scabies, and river blindness.
Climate change is responsible for 19% of the current dengue burden, with a potential to spark an additional 40%-60% spike by 2050. A study found that moderating global warming would also moderate climate impacts on dengue infections.
The American Society of Tropical Medicine and Hygiene (ASTMH) has established a new research fellowship in malaria genomic epidemiology, honoring the late Professor Dominic Kwiatkowski. The fellowship aims to support early- to mid-career researchers from low- or middle-income countries in advancing malaria research.
A new study from Uganda documents partial resistance to artemisinin in 11 out of 100 African children with severe malaria, suggesting a growing concern for the efficacy of lifesaving malaria treatments. The study also reveals that 10 patients who were thought to have been cured suffered repeat malaria attacks within 28 days.
A new study reveals a distinct genetic fingerprint of Leishmania mexicana in non-traveler patients with cutaneous leishmaniasis, suggesting locally acquired cases are on the rise. The CDC warns that domestic sand flies may acquire a deadly form of visceral leishmaniasis via imported dogs.
A new assessment of monkeypox infections in the Democratic Republic of the Congo shows rising transmission rates, approaching the point where outbreaks are likely to be larger and more frequent. The study highlights the potential for sustained local outbreaks and increased risks of new outbreaks globally.
A new study has linked the invasive Anopheles stephensi mosquito to an unprecedented dry season wave of infections in Ethiopian city Dire Dawa, causing a 10-fold spike in malaria cases. The mosquito's ability to thrive in urban environments and resist insecticides poses a significant threat to Africa's efforts to eliminate malaria.
Researchers found high rates of SARS-COV-2 infections in Mali but low evidence of severe disease, hospitalization, or deaths. In contrast, COVID-19 patients with high levels of previous malaria infections showed lower risks of severe outcomes in Uganda.
Mass treatment with Ivermectin has halted the spread of river blindness in two Nigerian states, Plateau and Nasarawa, marking a major milestone in disease elimination efforts. Separate studies also show the potential for Ivermectin to reduce West Nile Virus transmission by mixing it into bird feed.