Researchers identified protective human monoclonal antibodies against West Nile virus and related orthoflaviviruses. These antibodies recognize specific sites on the virus envelope domain III, providing a promising lead for vaccine development and therapeutic interventions.
Researchers have uncovered a mechanism by which BRCA2-deficient tumors develop resistance to chemotherapy. The discovery sheds new light on the role of proteins BRCA2 and FIGNL1, revealing their unexpected function in maintaining DNA repair mechanisms.
Researchers have identified a new class of 'good autoantibodies' that neutralize chemokines, reducing inflammation and promoting a favorable disease course in patients with long Covid. The discovery is linked to a lower risk of prolonged symptoms and a milder illness.
Researchers at the Istituto di Ricerca in Biomedicina discovered coldspots within the coronavirus spike protein, which are remarkably conserved across variants. Antibodies targeting these coldspots showed promise in blocking virus infection and protecting against disease in preclinical models.