Researchers at TSRI uncover a natural mechanism that regulates angiogenesis, a process involved in cancer growth. A recombinant protein fragment, PEX, is developed to block angiogenesis and tumor growth in an experimental model, offering a potentially novel therapeutic approach.
Researchers create first commercially available catalytic antibody, which can catalyze aldol reactions with broad substrate range. This breakthrough addresses long-standing question of protein-catalyst efficiency.
A portable, hand-held biosensor has been developed to detect a wide range of medically important chemical compounds. The device, capable of detecting tiny concentrations of specific molecules, may represent a new type of practical and affordable device for various medical applications.
Researchers have solved the structure of the active site of the enzyme responsible for producing nitric oxide, a crucial signaling molecule involved in various physiological processes. The discovery provides insight into how NO production is controlled and may lead to the development of new drugs to modulate its activity.