Researchers at SRI International have developed a novel injectable formulation for malaria treatment that provides months of protection against the disease. The formulation has shown to maintain high concentrations of the anti-malarial drug ELQ-331 in the bloodstream, overcoming issues with resistance and patient compliance.
Research by Fiona Baker of SRI's Human Sleep Lab highlights the deep connections between adolescent sleep and overall health. Studies have shown that poor sleep patterns can affect brain development, weight gain, cognitive decline, and socioemotional difficulties in adolescents.
Researchers at SRI International have identified genes that enable insects to produce terpenes, a key component of their chemical communication. This breakthrough provides a roadmap for understanding how these chemicals are used and could lead to new ways to protect crops and prevent insect-borne diseases.
Neuroscientists at SRI International have found that a form of baclofen works better at treating narcolepsy than the best drug currently available when tested in mice. The research team also presents a mouse model of narcolepsy that mimics the human disorder, allowing for more precise control of hypocretin/orexin neuron loss and potent...
Researchers have discovered a biomarker that can track Huntington's disease progression using electrical activity in brain waves. The study found abnormalities in specific frequency bands prior to the onset of symptoms, suggesting a potential early indicator of the disease.
SRI International researchers are developing a topical microbicide gel to prevent HIV and HSV-2 infections in women. The novel product will utilize a patented bioadhesive polymeric platform for sustained drug delivery, aiming to limit the risk of drug resistance.
Researchers are developing a new oral multiple sclerosis drug that targets the molecule miR-326, which stimulates the production of immune system mediators. The drug aims to inhibit miR-326 and block the production of Th17 cells, potentially offering a more convenient treatment option for patients.
A genetic marker, rs2036527, associated with smoking quantity has been found in African Americans, predicting the number of cigarettes smoked per day. This discovery may help guide public health decisions related to smoking and lung cancer risk.
Researchers from SRI International and the University of Michigan have taken the first-ever measurement of naturally occurring auroral turbulence recorded using a nanosatellite radar receiver. The RAX CubeSat measured turbulence over Fairbanks, Alaska in response to a geomagnetic storm triggered by the largest solar flare in five years.
The report summarizes past research on cost and outcomes associated with online learning in higher education and offers strategies for K-12 settings. It recommends broadening access to quality online resources to increase opportunities for students in remote locations or low-enrollment schools.
Researchers found a new potential target, alpha3beta4 nicotinic acetylcholine receptor, which plays a role in addictive properties of cocaine, morphine, and nicotine. AT-1001, a highly selective compound, disrupts addiction processes and reduces nicotine withdrawal symptoms.
Researchers validate preclinical effectiveness of TB drug target DNA gyrase B, killing bacteria in both replicating and dormant states. This could lead to a shorter treatment length, improving patient compliance and reducing drug resistance.
Dr. Kilduff recognized for his role in discovering the neuropeptide hypocretin and developing therapeutics for sleep disorders such as narcolepsy and insomnia. He has published over 200 research papers and received funding from government agencies and private foundations.
SRI researchers conducted experiments to determine the risks associated with accidental hydrogen releases and subsequent combustion in a structure built to simulate a one-car garage. The study highlights important insights that will help consumers use hydrogen safely on a daily basis.
SRI International was chosen to lead three research and development centers in the NCI's Chemical Biology Consortium program. The goal of the program is to discover and develop new cancer therapeutics against novel molecular and genetic targets.
Scientists are using the novel AMISR system to investigate interaction between upper atmospheric phenomena and lower atmospheric storms. The system provides a unique perspective for studying climate change and other processes linked to energy transfer from the sun to Earth's atmosphere.
SRI International will screen a library of well-characterized drugs against the 2009 H1N1 influenza A virus. The project aims to identify new treatments with better efficacy and potency than current antiviral drugs. SRI's expertise in drug screening and development will help expedite the development of new therapies.
SRI International has received a $100,000 Grand Challenges Explorations grant to develop new antibiotics against antibiotic-resistant tuberculosis. The project aims to identify small organic molecule metabolites essential for bacterial growth and survival.
Dr. Caroline Wagner discusses how self-organizing networks have transformed scientific research, enabling global collaboration among researchers with complementary skills and expertise. Her work emphasizes the importance of adaptability and flexibility in institutions and knowledge systems.
SRI International will operate a 150-foot parabolic reflector antenna to test UHF communication signals from the Mars Global Surveyor spacecraft. The team will analyze received signals in real-time and send simulated signals to check the UHF link for future Mars missions.