Scientists have successfully administered gene therapy orally, effectively curing lactose intolerance in rats. The study demonstrates the potential for an oral delivery system to treat other diseases, such as diabetes.
Scientists found that aspirin suppresses accumulation of genetic mutations causing hereditary colorectal cancer. Aspirin screens for cells with stable genetics, potentially preventing the disease. Researchers now plan a clinical trial to study higher doses of aspirin in preventing hereditary colon cancer.
DHEA supplements, believed to have anti-aging properties, may stimulate the production of IGF-1, increasing prostate cancer risk. Dr. Goldberg recommends monitoring serum DHEA, PSA, and IGF-1 levels for men taking DHEA supplements.
Researchers at Thomas Jefferson University used antisense therapy to prevent Burkitt's lymphoma development in laboratory mice, delaying tumor onset and decreasing its size. The strategy may also work in human patients who have relapsed after chemotherapy, with potential applications against various types of cancer.
Researchers at Thomas Jefferson University found that a naturally occurring substance in the cell membrane, GM1 ganglioside, improved symptoms in Parkinson's disease patients and slowed progression. The study showed significant differences in motor abilities between those who received the drug and those who did not.
Researchers at Jefferson University have identified a crucial mechanism of the tumor-suppressor protein Fhit, which plays a significant role in preventing cancer development. By understanding how Fhit works, scientists may be able to find ways to interfere with cancer growth and potentially develop new treatments.
Researchers at Jefferson Medical College have found a way to inhibit the hepatitis B virus by blocking its envelope creation, resulting in a dramatic drop in viral levels. The discovery may provide new leads for treating chronic HBV and HCV infections in humans.
Fetal cells may be linked to an immune system reaction in women with systemic sclerosis, a form of scleroderma. The study found that 46% of women with the condition had male DNA in their blood and skin biopsies.
Researchers found a significant association between clinic experience and survival of women with AIDS, with 71% of patients in high-experience clinics surviving 21 months after diagnosis. The study suggests that physicians who treat a certain illness more frequently may do it better, especially in HIV management.
Thomas Jefferson researchers discovered that lower levels of the tumor suppressor gene Rb2/p130 correlate with increased risk of returning disease and higher mortality in women with endometrial cancer. The study suggests a potential diagnostic test to guide treatment and improve patient outcomes.
A team of researchers at Thomas Jefferson University has developed a transgenic mouse to study the causes and effects of photoaging on human skin. The mouse line enables scientists to learn more about how ultraviolet light rays cause skin aging and wrinkling, and how this can be prevented through better sunscreen formulations.
Researchers at Thomas Jefferson University have created an autologous ovarian cancer vaccine that stimulates an immune response in patients, showing promise for treatment. The vaccine is custom-made for each patient and has been safe with no significant side effects, paving the way for further clinical trials.
Researchers at Thomas Jefferson University are conducting a gene therapy trial for glioblastoma, a form of brain cancer. The trial aims to delay disease progression and improve quality of life for patients, offering a potential cure for the deadliest type of brain tumor.
Researchers have identified a new molecular switch that triggers mismatch repair in cells, which can prevent colon cancer. The discovery provides a foundation to specifically target anticancer drugs to this gene.
Two studies support annual mammography starting age 40, reducing breast cancer deaths by 35-45% and outpacing radiation risks. The benefits of screening far outweigh the negligible risk of developing breast cancer from mammography.
Researchers at Thomas Jefferson University have developed a non-invasive gamma knife treatment that shows comparable results to surgery in alleviating Parkinson's disease symptoms. The treatment uses high doses of radiation to destroy targeted areas of the brain, potentially offering an alternative to traditional surgical options.
A new study by Thomas Jefferson University finds that traditional criteria for stroke-preventing surgery may overestimate men's risk and underestimate women's risk due to smaller carotid arteries. The 70% blockage threshold may need to be adjusted to account for these differences.
The technique correctly ruled out a diagnosis of cancer in 18 of 30 women whose suspicious mammograms were later shown to be benign. Additionally, none of the 14 cancers in the group were misdiagnosed by the 3D imaging method.
A new digital X-ray technology being studied at Thomas Jefferson University Hospital has the potential to replace film-based radiography, reducing healthcare costs and improving patient care. The technology offers enhanced image quality, lower radiation doses, and increased efficiency for radiologists.
Researchers create a novel form of botulinum toxin that survives the gastrointestinal system and can be used as an effective oral vaccine. This breakthrough has far-reaching implications for developing vaccines against diseases such as diphtheria, tetanus, and whooping cough.
A consensus group of breast cancer specialists has developed a classification system for DCIS, taking into account nuclear grade, necrosis, polarization, and architecture. The new system aims to improve patient treatment and discrimination between less aggressive and more aggressive cases.
Researchers found a strong correlation between low levels of the Rb-2/p130 protein and aggressive, metastasizing lung cancer. The study's findings may lead to a new lung cancer tumor-grading test to enable early diagnosis and tailor treatments.
Researchers found stents lower risk of death, heart attack, and repeat surgery compared to angioplasty for patients with obstructed vein grafts. The study's results suggest a new standard of care for hundreds of thousands of post-bypass patients.
Researchers at Thomas Jefferson University found that two missing cancer-suppressor genes play a crucial role in female development, leading to catastrophic cell death. The study suggests that the combination of missing genes is lethal to female mouse embryos, offering new insights into cancer mechanisms and potential therapeutic strat...
Researchers found a direct evidence of simian virus 40's potential mechanism in the development of mesothelioma, a rare cancer associated with asbestos exposure. The study suggests that SV40 targets key proteins preventing tumors from forming, rendering them ineffective.