Researchers at the University of Illinois have found that the ABCA1 protein plays a crucial role in directing how myeloid immune cells, particularly macrophages, behave. When ABCA1 is expressed, these cells become better at fighting cancer and supporting T cell function.
Researchers identified a cholesterol metabolite called hydroxycholesterol that suppresses the immune system's ability to attack cancer, leading to increased metastasis. The team discovered a line of communication used by immune cells and cancer cells that stimulates breast cancer progression.
Researchers found that baseline Anti-Mullerian Hormone (AMH) levels between 2.1-2.8 ng/ml correspond to 35-42% of live birth rates in women with cancer using fertility preservation. The study aims to improve prediction and standardization for fertility treatments.
A new technique allows researchers to track the distribution of chemotherapy drugs within cancer cells, enabling more accurate determination of treatment effectiveness. This breakthrough could pave the way for personalized cancer therapies.
A new blood-based liquid biopsy model, LiBIO score, predicts immunotherapy response with high accuracy. The model identifies an early post-treatment time point as optimal for assessing treatment response and can help identify patients who are more likely to benefit from immunotherapy.
A new mRNA cancer vaccine platform has been developed using a hydrogel-based approach that actively recruits immune cells. This improves efficiency and leads to stronger antitumor immune responses in preclinical models. The research is still in its early stages, but it holds promise for future cancer treatments.