A new UK research study found that creatine supplementation reduces brain damage in mice and rats with traumatic brain injury. Brain damage was reduced by 21%, 36% and 50% respectively when creatine was administered before or after the injury.
A recent study published in Thyroid journal found paclitaxel to have significant clinical activity against ATC, with 53% of patients showing improved survival time. The drug was infused continuously over 96 hours every three weeks for one to six treatments.
The UK Chandler Medical Center will conduct research on cervical, colorectal, and lung cancers in central Appalachia through prevention and early detection efforts. The center aims to reduce cancer incidence and mortality in Kentucky, Tennessee, Virginia, and West Virginia.
The UK College of Nursing faculty will conduct a three-year clinical trial to test the effects of a cognitive-behavioral group intervention on increasing self-esteem and reducing negative thoughts in low-income single mothers experiencing depressive symptoms. The study aims to improve mental health outcomes for this vulnerable population.
A study found that fiber supplements containing psyllium can lower harmful cholesterol by up to 5%, reducing the risk of heart attack by 10-15%. The treatment is considered a viable alternative to cholesterol-lowering medications, especially for those who have difficulty tolerating statins.
A study found that the plasmin system, which regulates blood clots, may also play a role in Alzheimer's disease. The researchers suggest that destroying amyloid-beta protein deposits with tPA could be a potential treatment for the disease. Further research is needed to confirm this model and explore its effectiveness.
Researchers at the University of Kentucky have discovered a new potential target for compounds that may treat or prevent Alzheimer's disease. The receptor RAGE interacts with amyloid fibrils, accelerating fibril formation and inducing cellular dysfunction.
The UK Markey Cancer Center will establish local coalitions and develop community outreach programs to address cancer barriers in Appalachian regions. The network aims to increase public awareness of clinical trials and promote participation among rural, medically underserved patients.
A UK study found that individuals who completed an intensive, very low calorie diet (VLCD) program maintained a significant weight loss of 23% or more for over five years. This is higher than the general rate of weight loss with modest programs, which averages 9%.
Researchers are refining technologies to identify active genes in the central nervous system, accelerating understanding of diseases like Alzheimer's, depression, and schizophrenia. Two teams use distinct approaches: one detects proteins or RNA in intact neurons, while the other identifies genes involved in daily rhythms.
Researchers at the UK College of Medicine are developing a technology to deliver drugs directly into brain tissue to treat Parkinson's disease. The team plans to use a modified Medtronic pump to deliver GDNF, a protein that has shown promise in protecting dopaminergic neurons in preclinical studies.
A UK study found that breast-feeding significantly boosts cognitive development in babies, with benefits seen as early as 6 months and sustained through 15 years of age. The study analyzed data from 20 published reports and found that breast milk provides essential nutrients required for rapid brain development.
Researchers at the University of Kentucky have discovered the molecular signals that lead to programmed cell death in spinal cord injuries. This breakthrough discovery may lead to the development of drugs to prevent or limit the consequences of spinal cord injury.
A UK researcher has partnered with R.J. Reynolds to develop nicotine-based drugs targeting Alzheimer's disease, Parkinson's disease, chronic pain, obesity, and depression. The partnership has resulted in several potential drug candidates being evaluated for clinical trials.
UK researchers found that stroke patients with left hemisphere damage are perceived more negatively due to language problems, while those with right hemisphere damage exhibit nonverbal communicative deficits. Educating caregivers about these effects can help ease communication problems.
The Young Women in Science program, supported by a $1.29 million grant, provides scientific education and mentoring to attract more young women to the field of drug abuse research. The program offers in-depth training and education for 52 participants over three years.
The University of Kentucky Markey Cancer Center will operate the Mid-South Cancer Information Service, providing up-to-date scientific information on cancer prevention and services. The five-year contract is worth $7.15 million.
A recent AAP recommendation suggests that young children with simple febrile seizures do not need anticonvulsant medication, instead aiming to prevent unnecessary testing and drug therapy.
Researchers are investigating the role of cyclic ADP-ribose (cADPR) in cell death pathways associated with oxidative stress, including heart attack, stroke, and cancer. The study aims to identify proteins that synthesize cADPR and develop new therapeutic agents to treat these diseases.
The conference focuses on lithium's applications in reducing suicidal acts in people with bipolar disorder, boosting the immune system, slowing down cancer cell growth, and interfering with viral infections. More than 300 experts will attend to discuss these topics and share latest research.
Researchers are enrolling physically active and sedentary individuals with spinal cord injuries to investigate the benefits of aerobic exercise on lipid profiles, glucose tolerance, independence, and quality of life. The study aims to develop a structured exercise program for SCI patients.
A study suggests that maternal stress and stress hormones may influence fetal brain development. Research found associations between maternal factors, such as medical and psychological stress, and fetal brain function.
Researchers from the University of Kentucky Medical Center have found no significant association between mercury levels in autopsied brains and dental amalgam status. The study, which compared over 200 brain samples, suggests that small amounts of mercury released from dental amalgams are not taken up by the brain.
A UK allied health professor has received a patent to test the effectiveness of combining lithium salts with existing anti-viral drug agents for AIDS patients. The proposed treatment aims to reduce toxic side effects and enhance the immune system, potentially reducing the amount of virus in the body.
A UK study found that decreasing food intake can help ward off age-related brain disorders such as Alzheimer's disease and Parkinson's disease. The research team led by Mark Mattson discovered that eating less made nerve cells in the brain more resistant to deterioration and death.
A recent study by UK researchers reveals how the Yersinia pestis bacterium uses its YopM toxin to target and destroy phagocytic cells, crippling the immune response. The findings provide new insights into bacterial causes of disease and cell biology, potentially leading to improved therapies for various diseases.
A UK research team has identified vulnerable atherosclerotic plaques in human aortic tissue using near-infrared spectroscopy. The technology aims to predict which plaques are harmless and which pose a risk of rupture, enabling targeted treatment to prevent heart attacks and strokes.
Researchers studied 1,200 female crack users, finding that exchangers were four times more likely to have been in substance abuse treatment and twice as likely to be homeless. The study aims to develop effective HIV prevention measures targeting women at risk of exchanging sex for drugs.
Elevated levels of corticipotropin-releasing hormone (CRH) may predict preterm delivery and shorter gestation lengths in pregnant women. The study found that higher CRH levels at 28-30 weeks gestation were associated with earlier deliveries and increased risk of preterm birth.
A University of Kentucky researcher has won a five-year extension on his MERIT award to study Leishmania donovani, a parasite that affects millions worldwide. The parasite, transmitted by sand flies, causes leishmaniasis, a disease often fatal and poorly treated.
The University of Kentucky has been awarded a $961,582 grant to establish interactive learning modules on the internet for writing grant proposals. The program will target historically underrepresented institutions and provide training and mentorship to help them develop their research capabilities.
Researchers aim to prevent leukemia relapse by educating the immune system using immunotherapy and genetically modified cells. The new technology could eliminate second rounds of chemotherapy, reducing toxicity and hospital stays.
Researchers found distinct patterns of gene expression linking cognitive control regions to stress control regions in laboratory animals. The study suggests that the brain controls stress responses through inhibition, rather than excitation, and may lead to the development of future stress intervention strategies.