A study found a nearly two-fold increased risk of lung cancer among relatives of smokers, but no evidence of an increased risk among relatives of non-smokers. The researcher hopes to identify high-risk subgroups and develop tailored interventions or screening programs.
Women with circulating tumor cells in their blood have a median survival of less than 24 months, compared to over 24 months without them. The presence of cancer cells in the blood predicts prognosis more accurately than other factors, indicating a possible link between blood-circulating tumor cells and aggressive breast cancer.
Researchers found women with hypothyroidism are 57% less likely to develop aggressive, estrogen-sensitive breast cancer. The study suggests a possible biological role of thyroid hormone in breast cancer and offers novel preventive strategies.
Researchers found that celecoxib capsules stop the Sp1 transcription factor from activating genes associated with cancer growth. This led to reduced production of VEGF, a key angiogenic factor that feeds tumors. The study provides a novel molecular mechanism for celecoxib's antitumor activity and may lead to tailored treatment options.
Researchers at the University of Texas M. D. Anderson Cancer Center found that statin drugs can prevent breast cancer cells from growing by blocking proteins that inhibit cell cycle progression. The study suggests that potent anti-cancer drugs could be developed based on the unconverted form of statins.
Researchers found that a combination of endostatin and radiation therapy reduced new blood vessel growth in mice with squamous cell cancer. After radiation, endostatin blocked the growth of new blood vessels, leading to long-term survival and tumor control in 40% of mice.
Researchers discovered a link between genetic markers and prostate cancer spread in African-American men. The study found that the ratio of MMP to E-cadherin accurately predicted cancer metastasis.
A study by the University of Texas M. D. Anderson Cancer Center reveals a strong correlation between the loss of AP-2( transcription factor and the progression of different human gliomas. The findings suggest that this gene acts as a tumor suppressor, controlling various genes involved in cell proliferation and invasion.
Researchers found that a vitamin A derivative, 9-cis retinoic acid, increased RAR-_ gene expression and reduced precancerous lesions in former smokers. While promising, the treatment also showed side effects, and further studies are needed to determine its effectiveness.
A recent study found that high levels of cyclin E are closely associated with aggressive breast cancer, making it a powerful predictive marker. The presence of low molecular weight forms of cyclin E also showed strong prognostic value, indicating a higher risk of recurrence and spread.
UT MD Anderson Cancer Center receives $12 million SPORE grant to support head and neck cancer research, focusing on genetic susceptibility markers, angiogenic therapy, and other areas. The grant aims to accelerate progress in prevention, treatment, and early diagnosis of the disease.
Researchers conducted a Phase I clinical trial of endostatin, showing that it decreases blood flow to tumors and promotes the death of cancer cells. The study also found minor anti-tumor activity in two patients, but no long-term responses were seen.
A research team led by Dr. Rakesh Kumar has discovered a new form of a protein associated with aggressive forms of cancer, including breast cancer. MTA1s appears to intercept the key protein receptor responsible for communicating with estrogen inside cells.
Researchers found that ATG significantly improved the ability of patients to produce healthy blood cells, allowing them to stop blood transfusions. The treatment has also shown potential in preventing progression to leukemia and improving quality of life for patients with myelodysplastic syndromes.