Researchers found that IFN-a priming promotes lipid uptake and foam cell formation in lupus patients, increasing the risk of premature plaque build-up. This activation of the IFN signaling pathway may be linked to the increased cardiovascular risk in SLE patients.
The partnership will bring new benefits to members, including an online-only relaunch of the Wildlife Society Bulletin. Wiley-Blackwell's diverse publication portfolio and global reach make them a natural fit for publishing The Journal of Wildlife Management and Wildlife Monographs.
In a phase II trial, fostamatinib disodium, an oral spleen tyrosine kinase inhibitor, failed to demonstrate efficacy in patients with rheumatoid arthritis who had not responded to biologic agents. However, the drug was found to be safe and showed promise in subgroups of patients with elevated C-reactive protein levels.
Research reveals how Staphylococcus aureus bacteria adapt to evade the immune system and antibiotic treatments by forming small colony variants. These 'dormant forms' can persist within host cells for weeks, leading to relapsing infections.
Researchers recommend six key points for alternative-to-dismissal strategies to protect patient safety and encourage treatment. ATD programmes provide non-judgemental support and treatment that enables nurses to seek help and improve their chances of staying in the profession.
A recent study found that low socioeconomic status is associated with higher rates of depressive symptoms in RA patients. Researchers analyzed data from 466 patients and found significant disparities in mental health outcomes between those with high and low SES.
A new study reveals that female striped plateau lizards' colorful patches during reproduction season boost yolk antioxidants in their eggs, resulting in healthier offspring. The research suggests that females with more vibrant coloration may be more attractive to males and produce higher-quality offspring.
A study published in the Journal of Management Studies found that dominant CEOs can drive companies to extremes of performance. However, a strong board of directors can mitigate this effect and improve company performance. Companies with powerful boards tend to have better outcomes than those without them.
Two Agave species have yielded significantly more than other biofuel crops in independent studies, making them a promising alternative for global energy needs. The crop's potential to thrive in semi-arid regions without significant land demands offers a sustainable and environmentally-friendly production method.
A new study suggests that Asian tiger reserves can support over 10,000 wild tigers if managed as large-scale landscapes with connected core breeding sites. This strategy is crucial to doubling the tiger population by 2022, but it requires a global effort and proper design of infrastructure projects.
Two studies found that ITPA variants protect against treatment-related anemia in HCV patients, enabling safer use of antiviral therapy and reducing the need for erythropoietin treatment. The variants also help select patients who may tolerate higher doses of ribavirin, increasing the likelihood of viral clearance.
A study published in Hepatology found that HIV-infected patients with liver cancer have a higher risk of dropping off the transplantation wait list compared to HIV-negative patients. Despite this, overall survival and recurrence-free survival rates are not significantly affected following liver transplantation.
The 20th Century Reanalysis Project has created a comprehensive reanalysis of global weather events from 1871 to the present day. The dataset provides key historical comparisons for our own changing climate, allowing researchers to understand the impact of extreme weather and climate events over time.
A study by Elisabetta Rapiti found that women taking tamoxifen had 87% fewer lung cancer deaths than the general population. The research supports a hormonal influence on lung cancer and estrogen's role in patients' prognosis.
A new study explores the impact of sun dimming on atmospheric teleconnections, which are crucial for predicting weather regimes. The research suggests that a dimmed sun could alter the link between tropical temperatures and extra-tropical circulation, potentially affecting prevailing weather patterns.
Researchers successfully create human liver tissue using tissue engineering, showing promise for liver cell transplantation. The new model uses resorbable scaffolds made from surgical sutures and can be used to overcome the organ shortage in patients with acute liver failure.
A new study reveals that 12% of American male weightlifters aged 18-40 use illicit HGH, often associated with AAS and street drug abuse. The long-term risks of high-dose HGH use are little studied but may include cardiac, endocrine, and respiratory effects.
Wiley's Online Books program has evolved over the past decade, providing customers with a wide range of access and purchase options. With over 10,000 online books available, the platform offers unparalleled convenience for researchers, academics, and professionals worldwide.
A systematic review found that antioxidant supplements may benefit couples trying to conceive naturally, particularly when the male partner takes antioxidants. The review of 34 trials involving over 2,800 couples suggests a higher likelihood of pregnancy or live birth when antioxidants are used.
A new Cochrane Systematic Review questions the benefits of statins in people with no previous history of heart disease. Statin use should be prescribed with caution in those at low risk of cardiovascular disease, as the absolute numbers of people who benefit are lower.
The drug tranexamic acid (TXA) has been shown to reduce the risk of death in trauma patients with severe bleeding by 10%, potentially saving over 70,000 lives each year. TXA reduces clot breakdown and has few side effects, making it a promising treatment option for civilian and military settings.
Research confirms adult ADHD significantly increases risk of developing degenerative dementia with Lewy bodies (DLB), a common cause of dementia in older adults. The study, published in the European Journal of Neurology, found 48% of patients with DLB had previously suffered from adult ADHD.
A study found that women with false-positive mammograms reported significant anxiety and reduced quality of life, particularly if they were prone to anxiety. The effects lasted at least a year, with more diagnostic procedures required for a final diagnosis.
The American Geriatrics Society and British Geriatric Society's updated guidelines for preventing falls in older adults emphasize the importance of exercise, such as tai chi or physical therapy, to reduce fall risk. The guidelines also recommend environmental adaptations, medication reduction, and cataract surgery where necessary.
A recent study suggests that baby-led weaning, where babies feed themselves solid foods, is a feasible approach for most infants. However, it could pose nutritional risks for those who develop at a slower pace. The research recommends combining self-feeding with traditional spoon feeding to ensure balanced nutrition.
A new study in BioEssays reveals that the H1N1 pandemic challenged the conventional ideal of antigenic shift, where a virus emerges from an existing subtype. The research suggests that pandemics can result from a shift within lineages of existing subtypes, not just the introduction of a new strain.
A study by Colorado University's Sleep and Chronobiology Laboratory found that missing a night of sleep burns approximately 135 calories. Eight hours of sleep, on the other hand, saved the same amount of energy. The findings demonstrate a direct correlation between the sleep-wake cycle and energy expenditure.
The growth of winter tourism in European mountain ranges is threatening the population of indigenous bird species, including the Capercaillie. A recent study found that Capercaillie droppings showed a marked increase in stress hormone levels closer to locations with winter recreation activity.
Recent research suggests that P. acnes within the body may be the cause of infections, contradicting previous assumptions about contamination from skin. This oversight could lead to incorrect diagnoses and complications if treated with the wrong bug.
A new study found that regional differences in colorectal cancer testing rates among non-white groups are a major contributor to racial and ethnic disparities in screening rates. The research suggests that targeting these regional variations is key to improving overall screening rates.
A Spanish study found alarmingly high cardiovascular risk factors in a random selection of 2,270 adults, with low education levels linked to increased risk. The researchers also discovered strong links between smoking, obesity, abdominal obesity, and high cholesterol levels.
Ecologists developed a series of new methods to monitor stag beetle numbers using ginger lures and tiny microphones detecting larvae sounds. These methods offer promise for conserving this rare species by providing an accurate picture of its abundance.
A study published in Liver Transplantation found that over half of liver transplant patients develop metabolic syndrome, a condition associated with obesity, hypertension, and diabetes. This increases their risk for cardiovascular disease and mortality, but not necessarily mortality itself.
Scientists in Japan have discovered a compound in tomatoes that enhances fatty acid oxidation and regulates hepatic lipid metabolism. The extract, 9-oxo-octadecadienoic acid, has anti-dyslipidemic effects and can help prevent vascular diseases.
Women undergoing gastric band surgery reported significant improvements in urinary function and quality of life, while men experienced worsening erectile function. The study highlights the need for further research into the effects of weight loss surgery on urinary and sexual function.
A new study by Professor Ruth Striegel-Moore and team found that Native American (NA) women are more likely to report behavioral symptoms of eating disorders than men. Research also revealed a parallel between NA women and ethnically white women when considering binge eating, purging and eating disorder diagnoses.
A study found that maternal depression affects the health-related quality of life of children with epilepsy, but this impact is modulated by family resources and functioning. The accumulation of supportive resources for both mothers and children with epilepsy can lead to improved outcomes over time.
A recent study published in the Journal of Advanced Nursing found that nearly a third of tablet fragments deviated from recommended dosages by 15% or more after being split. The practice is considered highly inaccurate and potentially dangerous, especially for tablets with narrow margins between therapeutic and toxic doses.
Current clinical practice deviates from medical evidence-based recommendations for osteoarthritis management. Researchers suggest that weight loss programs and exercise are essential but often overlooked by clinicians. The study aims to improve the quality of OA healthcare by promoting a patient-centered approach.
Current smokers with early rheumatoid arthritis showed reduced response to treatment with methotrexate and tumor necrosis factor inhibitors. The study found that smoking history did not impact the effectiveness of these therapies.
Researchers found distinguishing characteristics of the ANA-HEp-2 test in healthy individuals and patients with autoimmune disease, reducing erroneous diagnoses. The study confirmed that the ANA-HEp-2 pattern is critical for diagnosing autoimmune disorders.
A study by German researchers discovered a link between the PNPLA3 gene and liver cirrhosis in Caucasian alcoholics, revealing that those carrying a specific genetic variant may be at a higher risk of developing the condition. The study found that up to 50% of these high-risk individuals may progress to cirrhosis.
Researchers found radiofrequency ablation to be a safe and effective therapy for managing hepatocellular carcinoma in cirrhotic patients. The procedure resulted in high complete response rates, with 98.5% of patients achieving disease-free status.
A study of 383 children found that those who dislike fruit and vegetables are 13 times more likely to develop functional constipation. The study also highlights the importance of adequate fluid intake and recommends changes to school policies and parent education.
Researchers found that ovarian cancer screening can only slightly reduce mortality rates, highlighting the need for prevention and better treatments. For high-risk women, targeted screening may offer more hope in reducing deaths from ovarian cancer.
A team of Bioengineers in the US has modified a bacterial strain to improve its ability to produce ethanol. The research reveals that adapting and metabolic engineering can be combined for strain improvement, increasing ethanol production.
A new Cochrane review confirms vitamin A supplementation programmes in developing countries effectively reduce measles and diarrhoea incidence, saving thousands of lives. Researchers recommend continued use but emphasize the need for long-term solutions like fortification and dietary diversification.
A recent study found that not all movie-watching experiences are enjoyable, with some films inducing emotional discomfort due to graphic content or disturbing themes. The presence of family members or unknown individuals can also impact viewer satisfaction.
Patients receiving mechanical ventilation may benefit from listening to music, which can relax them and reduce anxiety, heart rate, and breathing rate. The review of eight trials involving 213 patients found that music listening may be a promising stress management tool for critically ill patients.
A new Cochrane Systematic Review finds sublingual immunotherapy significantly reduces symptoms of allergic rhinitis and medication requirements. The treatment has very few serious adverse effects and is effective in children, offering a convenient alternative to injection immunotherapy.