Researchers at Harvard's Wyss Institute used sophisticated computer modeling and biotechnology to target ROS production in E. coli, rendering the bacteria more susceptible to existing antibiotics. The study provides a promising approach to boost the global antibiotic arsenal against deadly superbugs like tuberculosis.
The Wyss Institute team developed a new method to build 3D nanostructures using DNA 'bricks', expanding the repertoire of nanobiotechnology applications in medicine and beyond. The technique enables the creation of complex shapes with sophisticated surface features and intricate interior cavities.
Researchers at Harvard's Wyss Institute engineer a new kind of DNA barcode that can come in an almost limitless array of styles, allowing for vastly more vital information to be gathered from cell samples. The method harnesses the natural ability of DNA to self-assemble, enabling low-cost and robust cellular imaging.
The Wyss Institute is developing an automated instrument that integrates 10 human organs-on-chips to study complex human physiology outside the body. This will accelerate assessment of drug safety and efficacy, informing regulatory decision-making.
The Harvard Wyss Institute is developing a smart suit that improves physical endurance for soldiers by providing efficient actuation and joint support. The wearable system, made from soft, stretchable assistive devices, detects fatigue and boosts balance through low-level mechanical vibrations.
Researchers developed a biomimetic strategy delivering clot-busting nanotherapeutics directly to obstructed blood vessels, dissolving blood clots while minimizing bleeding side effects. The approach has significant implications for treating major causes of death such as heart attack and stroke.
Researchers at the Wyss Institute have developed a method for building complex nanostructures out of short synthetic strands of DNA. This technology, called single-stranded tiles, can assemble themselves into precisely designed shapes and may enable the creation of new nanoscale devices for targeted drug delivery.
Researchers at Harvard's Wyss Institute have developed a microfluidic device that can capture and culture rare circulating tumor cells from blood, providing insights into patient-specific drug sensitivity and cancer progression. The technology has the potential to become a valuable tool for cancer diagnosis and personalized treatment.
Researchers at Harvard's Wyss Institute have created a living human gut-on-a-chip that mimics the structure, physiology, and mechanics of the human intestine. The device supports the growth of living microbes and could help understand intestinal disorders such as Crohn's disease.
Scientists have developed a method to imbue yeast with magnetic properties, enabling potential applications in medical, industrial, and research settings. The technology could be used to target and isolate specific cells, guiding them toward certain manufacturing processes or interacting with non-living machinery.
Researchers at Harvard's Wyss Institute have developed a DNA nanorobot that can seek out specific cell targets and deliver molecular instructions to cause cancer cells to self-destruct. The technology uses modular components to mimic the body's immune system and has the potential to treat various diseases.
Researchers have developed 'smart' injectable nanotherapeutics that can selectively deliver drugs to the cells of the pancreas, increasing therapeutic efficacy by 200-fold and reducing toxic side effects. This technology has the potential to revolutionize treatment for Type I diabetes.
Wyss Institute founding director Donald Ingber received the 2011 Holst Medal for pioneering work on cellular mechanisms that control tissue and organ development. He also presented a lecture on his recent innovations, including bioinspired materials and Organ-on-Chip microsystems technologies.
Researchers at the Wyss Institute have developed a new material called Shrilk that replicates the exceptional strength and versatility of insect cuticle. With its unique mechanical and chemical properties, Shrilk could be used to replace plastics in consumer products, suture wounds, and serve as scaffolding for tissue regeneration.
Researchers found that bacteria with highly resistant isolates sacrifice their own fitness to produce indole, helping vulnerable members survive antibiotics. This complex behavior was previously unknown and has significant implications for understanding bacterial strains and antibiotic resistance.
Researchers at Harvard's Wyss Institute have engineered photosynthetic bacteria to produce simple sugars and lactic acid, offering a sustainable alternative for producing commodity chemicals. This innovation could lead to reduced carbon dioxide emissions and greater availability of biodegradable plastics.
Bioengineers at the Wyss Institute have developed a new technology to regenerate heart and other tissues by replicating natural design principles. The resulting protein nanofabrics can be customized to generate specific properties, making them ideal for tissue engineering scaffolds and high-performance textiles.
Researchers at Harvard's Wyss Institute have developed a method to grow cells in three dimensions using paper stacks, mimicking real tissues. This technique allows for uniform oxygen and nutrient delivery, making it easier to study cancer and other diseases.