Articles tagged with Bioengineering
Researchers have developed a mineral coating that maintains mRNA activity for up to six months at room temperature. This breakthrough enables the storage of mRNA therapeutics like COVID-19 vaccines on medical shelves, bridging the gap between rich and poor communities.
A team of researchers developed a theoretical framework that can reproduce and predict the patterns associated with gastrulation in a chicken embryo. Small changes in cell parameters and behavior can have a dramatic impact on the resulting gastrulation patterns, which are seen in other species such as frogs, fish, and chameleons.
Scientists have solved a decades-long puzzle and unveiled ultra-hard materials that rival diamond in toughness. The breakthrough could lead to multifunctional materials for industrial applications such as protective coatings and high-endurance cutting tools.
Researchers developed a method to measure microvascular changes in the skin using AI and optoacoustic imaging technology, enabling non-invasive assessment of diabetes severity. The study identified 32 significant changes in blood vessels, which can be used to monitor disease progression.
The new robotic replica, called RRV, can mimic healthy and diseased states, allowing scientists to test cardiac devices and therapies. The model can also be used to study the effects of mechanical ventilation on the right ventricle and develop strategies to prevent right heart failure.
A team of engineers has developed a novel printing method called deep-penetrating acoustic volumetric printing (DVAP) that uses soundwaves to solidify biologically compatible structures in deep tissues. The technique involves a specialized ink that reacts to ultrasound waves, enabling the creation of intricate structures for biomedical...
Researchers at University at Buffalo have discovered a way to create strong and effective fuel cell catalysts that approach the performance of platinum. By adding hydrogen to the fabricating process, they were able to balance durability and efficiency, potentially making fuel cells more affordable and polluting-free.
Researchers at McGill University discovered a strong, quick-release connection between living and non-living tissues in marine mussels. The biointerface is mediated by serotonergic cilia-based adhesion, which can be controlled by neurotransmitters serotonin and dopamine.
Researchers at Wayne State University aim to extend the lifespan of infusion pumps and injection ports to minimize tissue damage and maintain site integrity. The project seeks to reduce inflammation and fibrosis caused by insulin phenolic preservatives, leading to improved diabetes management practices.
Researchers at MIT have developed an alternative method to study molecular signals in cells, allowing them to track up to seven different molecules simultaneously. The technique uses fluorescent proteins that flicker on and off at different rates, enabling the tracking of specific cellular functions over time.
Researchers discover chemical injection strengthens sandy soil through increased cohesion and internal friction angle, with no long-term strength loss. The treatment also enhances water-sealing capacity, mitigating flood risks and improving infrastructure durability.
Researchers have developed additively manufactured Ti-Ta-Cu alloys that exhibit improved biocompatibility and bacterial resistance, making them a promising alternative to traditional Ti6Al4V implants. The alloys were found to display remarkable synergistic effects in improving both in vivo biocompatibility and microbial resistance.
Researchers developed an integrated wearable sensor device using gold nanowires to measure multiple bio-signals simultaneously. The sensors demonstrated remarkable performance in detecting muscle tremors, heartbeat patterns, and body temperature changes.
Researchers used machine learning to guide high-throughput experimental screening of small molecules, finding ones that improve vaccine response and reduce inflammation. The team discovered a molecule that outperforms the best immunomodulators on the market, with potential applications in cancer treatment.
A recent study by Harvard researchers provides an engineering approach to understanding the failure of macrophages in cancer therapies. The team found that different phenotypes exhibit different penetration into tumors, with M0 macrophages showing improved transport efficiency.
Researchers are developing a bioengineered pancreas-like tissue using innovative biomaterials and engineered cells. The goal is to implant these cell-laden scaffolds into patients who need help managing their glucose levels.
Researchers at CSU and the University of St. Andrews created an effective antimicrobial material that slowly releases nitric oxide, killing bacteria and fungus over time.
Researchers have developed a system that enables accurate force measurement in soft material-based actuators, allowing for arbitrarily long periods of constant force. The new material combinations reduce energy consumption by up to thousandfold, enabling the creation of low-cost and high-performance solutions for assistive devices and ...
A recent study published in Scientific Reports identified the risk of virus exposure during face-to-face encounters as peaking within 5 seconds. The researchers used a mobile full-scale mannequin and particle-tracking velocimetry system to visualize and measure aerosol particles derived from exhaled air.
Researchers from Austria and France join forces to unravel the secrets of gene regulation during mammalian development using stem cell-derived 3D culture models. The project aims to understand how key molecular events influence gene transcription and regulation over hours and days.
Scientists from Central South University develop a novel approach to address bacterial infection in bone transplantation by enriching H2O2 and amplifying the Fenton reaction. The technique enhances biocompatibility and safety, promising reduced transplant failures and post-operative complications.
Researchers created a hydrogel mat with magnetic microparticles that mimic the forces of exercise. The team found that regularly exercising muscle cells resulted in longer, aligned fibers, and improved contraction capabilities.
Researchers have developed soft implantable fibers that can deliver light to major nerves through the body, allowing for precise illumination of nerve pain. The fibers are flexible and stretch with the body, enabling scientists to study peripheral nerve disorders in animal models without constraining movement.
U of I researchers have developed organic nanozymes that mimic the properties of natural enzymes, exhibiting peroxidase-like activities and detecting glyphosate with adequate accuracy. The OC nanozyme is quicker to produce, cost-effective, non-toxic, and environmentally friendly.
Researchers propose a hybrid control strategy combining model-based optimization and in-cell feedback control to solve the process-model mismatch issue. This approach enhances the regulation of metabolic toggle switches, leading to increased isopropanol yields and robust microbial material production.
A study by researchers at the University of California - Riverside found that certain aspects of video game play can stimulate dopamine release and potentially aid in treating Parkinson's disease symptoms. The research suggests a promising new approach for managing the condition.
Researchers created a new CRISPR-based gene therapy tool using locally sourced, human-derived proteins that can activate silent or insufficiently expressed genes. The DREAM tool mimics the natural ability of human cells to turn on specific genes in response to mechanical cues.
Researchers have developed DeepMB, a neural network that reconstructs high-quality optoacoustic images about 1,000 times faster than state-of-the-art algorithms. This enables clinicians to access optimal MSOT image quality in real-time, positively impacting clinical studies and patient care.
Researchers at the University of California - San Diego developed screen-printed, flexible sensors that can record brain activity and lactate levels in earbuds. The sensors allow for long-term health monitoring and detection of neuro-degenerative conditions.
A research team has discovered a novel approach to increase terpenoid production by fine-tuning isoprene pyrophosphate metabolism. The technique, which involves genetically encoded circuits, resulted in a remarkable increase in IPP synthesis and led to the production of high-value terpenoids.
Five lung stem cell variants dominate CF lungs, causing inflammation, fibrosis, and mucin secretion. CFTR modulators fail to suppress these inflammatory variants, suggesting they as key targets for new drugs.
Jennifer Kane is studying how microbes interact with Miscanthus roots to boost productivity and sustainability. The research aims to understand what conditions enable the plant to prosper, with potential implications for bioenergy production on marginal lands.
Researchers developed an artificial, multisensory integrated neuron that combines visual and tactile input for improved navigation and decision-making. The system mimics the human brain's ability to integrate multiple senses, enhancing sensor technology's efficiency and paving the way for eco-friendly AI uses.
A digital twin of the bladder has been developed to simulate normal and bladder outlet obstruction (BOO)-affected function. The model will help researchers better understand the connection between changes in BOO bladder wall structure and functionality, enabling them to develop new treatments and predict treatment success rates.
Researchers at EPFL engineered E. coli bacteria to exhibit enhanced extracellular electron transfer, producing electricity while metabolizing organic substrates. The bioengineered E. coli surpassed previous approaches, generating three times more electrical current in various environments, including wastewater from a brewery.
Using biochar in cement enhances mechanical properties and contributes to sustainability objectives, reducing the need for traditional cement content. This study provides an overview of biochar's suitability as a sustainable additive in cement, promoting environmentally beneficial outcomes.
Chung-Ang University researchers create an electrochemical DNA biosensor that detects HPV-16 and HPV-18 with high specificity, facilitating early diagnosis of cervical cancer. The sensor uses a graphitic nano-onion/MoS2 nanosheet composite to enhance conductivity.
A new artificial olfactory system, integrated on a single chip, detects food spoilage by identifying low levels of hydrogen sulfide and ammonia gases. The system tracks freshness scores in real-time during the spoilage process.
A study published in Nature Geoscience found that blowing snow produces fine sea salt aerosols, increasing particle concentration and cloud formation in the central Arctic. These aerosols contribute to Arctic warming by trapping surface long-wave radiation, boosting temperatures.
Researchers at University of Oxford have developed a miniaturized soft power source that can alter the activity of cultured human nerve cells, paving the way for miniature bio-integrated devices. The device uses internal ion gradients to generate energy, producing a current that persists for over 30 minutes.
Scientists have discovered that small fat-filled lipid droplets can indent and puncture a cell's nucleus, leading to elevated DNA damage. This finding has significant implications for various diseases, including cancer.
The Texas Heart Institute has received a five-year, $2 million grant from the National Institutes of Health to advance organ bioengineering. The project aims to develop transplantable bioartificial hearts to combat end-stage heart failure.
Researchers at Texas A&M University have developed an isochoric vitrification technique that preserves and revives live coral fragments without forming ice. This breakthrough enables the collection of coral samples throughout the year, supporting conservation efforts to protect reefs and their diverse ecosystems.
Researchers developed a water harvester device that harnesses atmospheric water vapor using metal-organic frameworks and ambient sunlight. The device successfully collected up to 285g of water per kilogram of MOF in extreme environments, showcasing its potential for universal applicability.
Researchers successfully recreated and mathematically validated two molecular languages at the origin of life, opening doors for nanotechnology development. They designed a programmable antibody sensor using multivalency, which detects antibodies over different concentration ranges.
Researchers successfully recreated lung cancer patient's internal environment using hydrogel and 3D bioprinting, preserving specific lung cancer subtype and genetic mutation characteristics. The study enables precise drug evaluation and personalized treatment options for lung cancer patients with underlying diseases.
Researchers at UBC Okanagan's Integrated Optics Laboratory develop imaging systems that apply terahertz radiation, enabling fast and accurate characterization of biological specimens. This technology holds promise for improving diagnostic imaging and detecting carcinogenesis.
A biomolecule has been engineered to selectively target and remove mucins from cancer cells, reducing tumor growth and increasing survival in lab-grown human cancer cells and mouse studies. This discovery could play a significant role in future therapies for cancer, as mucins are associated with many diseases.
A new recycling method reduces emissions by 60% and opens the door to reusing materials like plastic film, multilayer materials, and colored plastics. The technique recovers olefins from pyrolysis oil and uses them in a chemical process to convert into aldehydes and industrial alcohols.
Researchers at the University of Missouri have developed a new method using nanopores to advance discoveries in neuroscience and medical applications. The technique allows for real-time detection of dynamic aptamer-small molecule interactions, which can aid in understanding DNA and RNA diseases and drug discovery.
A miniature human heart model, approximately half a grain of rice in size, has been developed to transform drug testing and cardiovascular research. This self-paced, multi-chambered model provides real-time measurements of essential parameters, enabling unprecedented insights into heart function and diseases.
A team of researchers developed a novel method that leverages temporal characteristics of blood pulse to estimate heart rates with improved accuracy, especially in scenes with ambient light fluctuations. The proposed method showed a 36.5% improvement in estimation accuracy compared to conventional methods.
Researchers at UC San Diego report new direct evidence of atrophy and fibrosis in pelvic floor muscles of women with symptoms of pelvic organ prolapse. They also showed that an acellular injectable skeletal muscle extracellular matrix hydrogel reduces the negative impact of simulated birth injury on rat pelvic floor muscles.
A Pitt Professor believes oligodendrocytes, the nerve insulating cells, hold the solution to BCI's nagging problem. By understanding and preserving these cells, researchers aim to improve BCI's performance and expand its applications beyond paralysis.
A new study from the University of Chicago has laid out the internal structure of polyelectrolyte complexes, a special kind of molecular assembly that helps cells keep themselves organized. The researchers used a combination of simulations and neutron scattering to determine the precise structure of these molecules, which could lead to...
Researchers at Harvard developed a fiber-infused ink that allows 3D-printed heart muscle cells to align and contract like human heart cells, enabling the creation of functional heart ventricles. The innovation can be used to build life-like heart tissues with thicker muscle walls, paving the way for regenerative therapeutics.
Researchers analyzed photographs of honeybee and wasp nests containing over 22,000 cells. They found that both species used similar building techniques at the transition between small and large cells, including the construction of intermediate-sized hexagonal cells and pairs of pentagonal and heptagonal cells.
Researchers have developed a novel DNA-filtering system using α-hemolysin nanopores to reduce contamination in single-molecule DNA extraction. The technique, which uses phospholipids and the PCR clamp method, achieved a 99.98% reduction in DNA contamination.
Qimiao Si, a theoretical quantum physicist, and Jeffrey Tabor, a bioengineer and synthetic biologist, will pursue innovative projects in topological materials science and DNA synthesis. Their research aims to revolutionize fields like medicine, biotechnology, and energy.
A new study has created the largest single-cell atlas of the human kidney, mapping healthy and diseased cell states across over 90 patients. The atlas reveals that certain cell types in the kidney get stuck in a 'maladaptive repair state,' leading to disease progression and irreversible reduction of kidney functions.