Articles tagged with Biomedical Engineering
A team of Penn State researchers has created a modular genetic circuit that turns cancer cells into a 'Trojan horse,' causing them to self-destruct and kill nearby drug-resistant cancer cells. The circuit outsmarts resistance and eliminates it before the cancer cells can evolve.
Physicists at Aalto University have developed a method to align bacterial cells using magnetic fields. By mixing bacteria into a liquid with millions of magnetic nanoparticles, the researchers can control the alignment of the rod-shaped bacteria in response to magnetic field strength. The findings offer insights into active matter phys...
Scientists studied Crassula muscosa and found its unique leaves pack tiny fins that manipulate the meniscus to direct liquid transport. An artificial mimic, CMIAs, mimics this effect, enabling real-time directional control of fluid flow in various technologies.
Researchers develop optogenetic system to precisely target cancer cells using light, inducing inflammatory cell death and triggering immune response. The approach aims to modulate the immune suppressive environment around cancer cells, helping T cells recognize and attack the disease.
Researchers from Chiba University develop sustainable method for producing biodegradable polymers using cuttlefish ink melanin. Decomposition products are converted into polymeric materials with potential applications in circular economies.
Research using a novel microscopic technique reveals that gold nanoparticles' lethality to cancer cells is more complex than previously thought. Smaller nanoparticles can regenerate and divide after initial stress, while larger star-shaped particles cause oxidative stress leading to programmed cell death.
Researchers at the Gwangju Institute of Science and Technology (GIST) have developed an innovative robotic rehabilitation system called SPINDLE to enhance the strength and dexterity of individuals with tremors. The study revealed significant benefits, including improved motor control, coordination, and neuroplasticity.
Researchers have developed a biodegradable scaffold to facilitate bladder tissue growth, reducing complications associated with traditional augmentation procedures. An implantable sensor also enhances patient monitoring, paving the way for improved bladder surgery outcomes.
Researchers develop a model of heart disease by tricking stem cells to behave like mature heart cells with a mutation that causes hypertrophic cardiomyopathy. The study reveals the connection between mechanical stress and electrical function in hearts, shedding light on why genetic mutations can cause arrhythmias.
Xiaohu Xia's research focuses on enhancing diagnostic efficacy of enzyme-linked immunosorbent assay (ELISA) testing using specially tailored nickel-platinum nanoparticles. His goal is to improve disease detection accuracy by more than 300 times, enabling early diagnosis of cancers like prostate and colorectal cancer.
Researchers have developed a method to deliver drugs to specific areas of the body using ultrasound waves, triggering drug release from stable nanocarriers. The approach is made both safe and efficient for the first time, paving the way for clinical trials.
Lopatkin's lab will investigate how bacterial metabolism contributes to antibiotic resistance using sophisticated tools and techniques. The research aims to identify drug-resistance mutations that arise in bacteria adapting to different antibiotics and metabolism-altering chemicals.
A new wearable patch, called the Wearable Aptalyzer, can continuously monitor levels of blood sugar, lactates, and other critical biomarkers without piercing the skin. This technology holds promise for improving care in remote settings and allowing early detection of diseases.
Researchers at Carnegie Mellon University have successfully integrated focused ultrasound stimulation into noninvasive BCIs, significantly boosting signal quality and enabling bidirectional brain-computer interfaces. The technology allows individuals to control a cursor or robotic arm using only their thoughts.
The 2024 Kavli Prize Laureates have made significant contributions to our understanding of exoplanet atmospheres, nanoscale materials for biomedical applications, and the localization of brain areas specialized for face recognition. Their work has broadened our knowledge of planetary life beyond Earth.
Researchers at Wyss Institute develop subcutaneous scaffolds to restimulate CAR-T cells, increasing therapeutic efficacy in mice with aggressive blood tumors. The biomaterials increase CAR-T cell numbers and steer differentiation into tumor-killing T cells.
Researchers at Kanazawa University have developed an electrochemical biosensor to detect ADAR1, a biomolecule associated with several diseases including neurological disorders and cancer. The device shows good sensitivity and selectivity, enabling rapid detection of ADAR1 concentrations in cells.
Researchers at Duke University created an ultrathin silk membrane that helps cells grow into functional tissues used for research, enabling the development of kidney disease models. The new membrane improves communication and growth between cells, mimicking natural human organ structures.
Researchers developed a human pancreatic cancer fibrotic barrier model to assess treatment strategies and test efficacy of therapeutic interventions. Inhibition of ROCK2 pathway resulted in reduced ECM remodeling and improved tissue permeability for drugs, highlighting its potential for enhancing drug delivery in PDAC.
Researchers develop vascularized organ-on-a-chip systems for personalized medicine, reducing animal testing and improving drug efficacy. These devices mimic human organs on a microscale, enabling precise manipulation of physical and chemical conditions.
A groundbreaking study reveals zwitterionic polymers can inhibit protein aggregation, a key mechanism behind various human diseases. The researchers found that hydrophobicity and molecular weight impact protein stabilization, offering new avenues for therapeutic strategies.
Researchers developed an adhesive sensing device that seamlessly attaches to human skin to detect and monitor various health signals, such as glucose levels and heart rate. The device can be reprogrammed and recycled, making it a potential tool for managing diseases like diabetes.
Researchers have developed a medicated foam that can deliver expensive gene therapies to cells, showing promise for treating cancers and autoimmune diseases. The foam outperformed liquid formulations in laboratory studies and showed no significant side effects when injected into mice.
The latest SLAS Technology issue highlights recent breakthroughs in skin cutaneous melanoma, glycan-bead coupling, and acoustic ejection mass spectrometry. Researchers adapt technological advancements for life sciences exploration and experimentation in biomedical research and development.
Researchers develop an in vitro model to study tau aggregation, a process linked to neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The approach offers a short timeline for generating data and facilitates the study of potential therapeutic interventions.
Researchers developed adhesive hydrogel coatings that eliminate fibrosis, a common issue with medical implants. The coatings bind devices to tissue and prevent the immune system from attacking them.
Researchers at Osaka Metropolitan University have discovered that plasma irradiation can accelerate tendon repair, showing faster regeneration and increased strength in lab rats. This breakthrough could lead to shorter treatment times and more reliable tendon healing for athletes and individuals with sports-related injuries.
A new study published in Nature Biomedical Engineering shows that targeted cancer treatment using antibody-displaying extracellular vesicles reduces tumour growth and improves survival in mice. The treatment has the potential to be used against other diseases and cancer types, offering a more effective and fewer side effects compared t...
Researchers designed a regenerative medicine therapy to speed up diabetic wound repair using tiny fat particles loaded with genetic instructions. The treatment targeted problem-causing cells and reduced swelling, promoting faster and more effective wound closure.
A new study shows that gene therapy delivered by nanocarriers can repair damaged discs and reduce signs of back pain in mice. The treatment, which uses naturally derived nanocarriers to deliver genetic material for a protein key to tissue development, restored structural integrity and function to degenerated discs.
A Japanese research team used machine-learning-driven modular assembly systems to create a more efficient gene editing tool. The study demonstrated an improvement in genome editing efficiency by 5%, showcasing the effectiveness of engineering zinc-finger nucleases through structural modeling.
Researchers at Princeton University and North Carolina State University have combined ancient paperfolding and modern materials science to create a soft robot that can bend and twist through mazes with ease. The new design allows the flexible robot to crawl forward and reverse, pick up cargo and assemble into longer formations.
The Multifunctional Ablative Gastrointestinal Imaging Capsule (MAGIC) combines OCT technology with an endoscope camera and ablation laser for superior esophageal imaging. It provides unmatched accuracy in detecting early lesions, enabling potential ablative treatment of esophageal abnormalities.
Researchers from Wyss Institute and Harvard University developed a biomaterial vaccine that enhances and sustains lymph node expansion, leading to more effective anti-tumor responses. The vaccine formulation, based on microscale mesoporous silica rods, reprograms antigen-presenting cells to orchestrate complex immune responses.
A team of researchers has developed a hemostasis sponge that swiftly staunchs kidney bleeding and facilitates wound recovery. The material uses kidney-derived decellularized extracellular matrix to recreate the kidney's microenvironment, boasting high biocompatibility.
Scientists at DTU and Lund University have found new enzymes that can remove both the A and B blood antigens and their blocking sugars, enabling the production of universal donor blood. This breakthrough has the potential to reduce logistics and costs associated with storing four different blood types.
A flexible microdisplay device can track and display neural activity in the brain, allowing neurosurgeons to visualize critical cortical boundaries and guide surgical interventions. The device reduces the need for a buffer zone, enabling more precise removal of harmful tissue.
Scientists have developed mini-colon tissues that can simulate the complex process of tumorigenesis outside the body with high fidelity. These miniature organs mimic the physical structure and cellular diversity of colon tissue, allowing researchers to study colorectal cancer development and test potential therapies.
Researchers increased EMG signal dimensions virtually to capture richer information about user intentions, improving gesture recognition accuracy. This approach leverages implicit coordination between muscles during movement, enhancing the control effect of prosthetic hands.
Researchers developed a new treatment method using plasma irradiation to speed up bone healing. The study found that displaced fractures exhibited stronger unions than nonirradiated ones, with strength increased by 3.5 times.
Researchers detected multifractality in electrical brain signals of patients with early-stage multiple sclerosis, suggesting complex communication between neurons. The study also found that healthy individuals have more regular fractal components, indicating a potential compensatory mechanism in the brain's neural networks.
Synthetic platelets made of hydrogel nanoparticles mimic the size and shape of human platelets, promoting clotting and healing. The innovative device has shown promising results in animal models and is being developed for clinical use to treat various medical conditions.
Researchers create universal method for creating wearable electronics with increased sweat permeability, enabling reliable long-term monitoring of biosignals. The device allows for continuous and stable monitoring of vital signs without signal disruption from perspiration.
Caterpillars of the Carolina sphinx moth have an extraordinary ability to instantly change their hemolymph's material properties, turning it into a viscoelastic fluid that helps stop bleeding. This discovery has potential applications for developing new drugs for humans to create fast-working thickeners of human blood.
A team of scientists from CU Boulder, Anschutz Medical Campus and CSU is developing non-invasive therapies for osteoarthritis, including a healing shot and annual infusion. They hope to begin trials in human patients within 3.5 years.
Physicists have developed FreeDTS, a modeling software that enables the study of biological membranes at the mesoscale. This tool will enhance our understanding of cell behavior and open routes for diagnostics of infections and diseases. The software's precision will guide experiments with accuracy, potentially leading to diagnoses bas...
Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins. The study identified over 600 new effector proteins that could be used therapeutically, including those that can efficiently degrade or stabilize target proteins.
Researchers at Duke University have developed a novel imaging platform to visualize the growth of the placenta throughout pregnancy. The approach provides detailed images of blood flow and oxygen metabolism, shedding light on how lifestyle factors and health complications affect placental development.
Artificial intelligence has been developed to spot COVID-19 features in lung ultrasound images, combining computer-generated images with real scans to identify signs of disease. The tool holds potential for developing wearables that track illnesses like congestive heart failure and monitor fluid buildup in patients' lungs.
A multi-institutional team is creating innovative technologies to reduce complications associated with left ventricular assist devices (LVADs), including infection, thrombosis, stroke, and bleeding. The new LVAD will deliver a physiological response to changes in the recipient's activity levels using a 'smart' Maglev drive technology.
Researchers at Rensselaer Polytechnic Institute have developed a patented process to produce heparin in the lab, offering a consistent and safe supply of the essential medicine. The discovery has the potential to revolutionize the production of heparin, reducing reliance on animal-derived sources and addressing global supply chain issues.
A new multitasking substance has been identified to prevent and treat both flu and COVID-19 infections concurrently. The long-acting recombinant cytokine protein rhIL-7-hyFc demonstrated therapeutic and preventive effects against various respiratory diseases, including COVID-19, influenza virus, and respiratory syncytial virus.
Researchers at the University of Rochester are developing a multimodal, non-invasive method to study the brain's physiology and reduce neurological issues associated with ECMO therapy. The technique uses electroencephalography, diffuse correlation spectroscopy, and evoked potentials to monitor blood flow and neural activity in the brain.
Researchers aim to address LVAD shortcomings, reducing blood damage and clotting risk through innovative designs and coatings. A novel flexible stented blood inlet and slippery hydrophilic coatings will be used to prevent flow stasis and clot formation.
Researchers have developed an injectable hydrogel that mitigates damage to the right ventricle of the heart in children with hypoplastic left heart syndrome. The treatment, made from cardiac extracellular matrix, improves heart function and slows tissue scarring, potentially increasing patient survival time.
Researchers at Duke University found that cooperative growth in bacterial colonies can lead to the emergence of 'cheating' bacteria that exploit others. The study demonstrates how environmental pressures can shape the evolution of microbial communities.
Researchers at UNSW Sydney have developed a new technology offering test strips for rapid, on-the-spot disease detection. The test strips are accurate and cost-effective, making them suitable for various applications including public health, environmental diagnostics, and cancer cell detection.
A new study highlights the contributions of 50 top scientists from elite universities to transforming medicine through cutting-edge biomedical engineering advances. Five primary medical challenges are identified, including precision engineering for personalized care and tissue engineering for human health.
Researchers developed protein-based microcapsules to enhance aptamer sensors, enabling direct detection of target molecules in biological samples. The system demonstrates robust protection against harmful proteins and simultaneous real-time sensing of multiple targets.
A study by the University of Tsukuba found that keratin microsphere gel enhanced cell proliferation and gene expression related to hair growth. The gel's stimulatory impact on papilla cells was validated through genetic analysis, demonstrating its potential as a safe and effective hair growth agent.