Articles tagged with Biomedical Engineering
Researchers discover how an anticancer drug triggers an 'outside in' signal to get sucked into a cancer cell, providing insights into adhesion regulation and potential drug design targets. The study reveals a new mechanism for delivering drugs using P-cadherin protein.
Researchers developed surface-modified apatite coatings using pH control to enhance cell adhesion and improve the biocompatibility of implants. The study found that controlling the nanoscale surface layer of apatite nanoparticles leads to better binding affinity with biological tissues.
Researchers at MIT develop CuRVE technology, enabling uniform labeling of proteins across millions of individual cells in intact 3D tissues. This breakthrough allows for unprecedented insights into cellular functions and behaviors, overcoming limitations of existing labeling methods.
A new prototype developed by the University of the Basque Country assesses and rehabilitates balance problems in patients after a stroke or due to other conditions. The device makes reliable and repeatable measurements using sensors on a platform that stimulates the patient's balance.
Elizabeth Hillman, a pioneer in imaging method development, is leading the new Department of Imaging Sciences at St. Jude Children's Research Hospital. The department aims to develop innovative new imaging and measurement approaches that will enable groundbreaking scientific studies and improve patient care.
Researchers at University of Galway have made a breakthrough in bioprinting functional human heart tissue that can change shape, bringing research closer to generating fully functional organs. The technology has shown improved structural and functional maturity of bioprinted heart tissues.
PolyU's 16 projects funded by HMRF focus on healthcare innovation, covering areas like nursing care, health tech, and biomedical engineering. The research aims to address global healthcare challenges and improve overall well-being.
Researchers have discovered a complementary regulation system between DNA and RNA epigenetics, enabling more effective gene activation. This mechanism is crucial for cell development and specialization, and could lead to advances in cancer treatments through targeted therapies.
Researchers at UVA have developed computer models to target specific bacteria in specific parts of the body, reducing the chance of antibiotic resistance. This approach could lead to more effective treatments and reduce the need for broad-spectrum antibiotics.
A team led by University of Rochester professor Edmund Lalor aims to understand how the brain processes audiovisual information to improve speech comprehension for individuals with cochlear implants. They will use noninvasive electroencephalography (EEG) brainwave measurements to study how people respond to multisensory speech.
The American Physical Society's joint March Meeting and April Meeting will convene more than 14,000 physicists from around the world to present new research in various fields. The conference will be held in person in Anaheim, California and online everywhere March 16-21.
Scientists have identified the crucial role of weak molecular interactions in triggering autophagy, a process that breaks down unnecessary cell components. By artificially controlling these interactions, researchers aim to improve the degradation of aggregates in neurodegenerative diseases and enhance cancer treatments.
The study introduces Flexible-Spoke, Non-Pneumatic Tyres as a solution for manual wheelchair users. These tyres absorb impacts and vibrations, offering enhanced comfort and reduced weight compared to conventional options.
Researchers develop PSO-BP neural network to predict CO₂ hazard distance after pipeline rupture, reducing computational demands. The model is consistent with CO₂ concentration diffusion results.
Researchers developed a non-invasive way to assess fat composition around the heart using magnetic resonance imaging. This technique may help doctors identify patients at greatest risk for cardiac problems and predict treatment outcomes.
Researchers at Texas A&M University have uncovered a mechanism behind cancer progression: the stiffening of tumor cell's environment. This spreading causes increased cell proliferation and tumor growth.
Researchers have identified molecular changes that occur long before symptoms appear, shedding light on the development of Rett syndrome. These findings hold promise for developing safe gene therapies and monitoring biomarkers to track MECP2 gene function.
A study led by Henry J. Pownall and Khurram Nasir found a strong link between the amount of free cholesterol in HDL and its accumulation in macrophages, which can contribute to heart disease. The researchers aim to develop new diagnostics and treatments for managing heart disease using HDL-free cholesterol as a biomarker.
A University of Pittsburgh study uses life-cycle assessment to measure the environmental impact of ACL reconstruction and identify opportunities for reduction. The investigation highlights the significant carbon footprint of complex medical processes, emphasizing the need for sustainable innovations in healthcare.
Researchers at the University of Massachusetts Amherst designed a novel device that manipulates cell behavior by precisely modulating the pH of the cell's environment in real-time. The device was able to manipulate pH with a resolution of 0.1 pH units, far exceeding previous electrode-based attempts.
A QUT-led study found that surgeons are slow to adopt newly developed biomaterials or tissue-engineered solutions for treating bone defects. The researchers surveyed 337 surgeons and 99 scientists, revealing a significant gap between their optimism about future advancements and the slow adoption of these innovations in clinical practice.
Recent studies highlight conductive hydrogels as solutions in biosignal monitoring and electrical stimulation. Their tunable mechanical and electrical characteristics enable a wide range of applications, including wearable sensors, neural interfaces, and drug delivery systems.
Researchers created an advanced computational model to optimize maternal vaccine design and protect high-risk populations. The model helps reveal which antibodies can pass through effectively and when, enabling the development of safer, more effective vaccines.
Researchers developed a new approach to engineer tissue structures across multiple scales, from small cells to large organs. They used gallium as a molding material, allowing them to create complex vascular and interwoven networks that mimic natural biological systems.
Researchers at TUM have grown tumor organoids that reproduce the morphological complexity of pancreatic cancer cells in the laboratory. The team used machine learning to categorize the organoids into different phenotypes based on their appearance and behavior, which react differently to treatments.
Silvia Blemker, a University of Virginia biomedical engineer, has been elected Fellow of the National Academy of Inventors (NAI) for her work on muscle health. Her patented technology, Image-based Identification of Muscle Abnormalities, uses advanced imaging and analytics to provide detailed insights into muscle health.
A team of researchers at Penn State has pinpointed the exact moment of loss of consciousness due to anesthesia by mapping what happens in different brain regions during that moment. The study found that rapid activity in the medial prefrontal cortex, hippocampus, and thalamus triggers loss of consciousness.
The InteReg project aims to create interactive biomaterials that instruct cells to regenerate after brain or spinal cord injuries, potentially treating MS and other neurological disorders. The project, funded by the Carl Zeiss Foundation, brings together experts in biology, chemistry, medicine, and polymer research.
Researchers at Harvard University have developed a tissue-anchoring mechanism for medical devices, inspired by the circular hook-like attachment organ found in intestinal tapeworms. The device can be deployed in under 1 millisecond and anchors into soft tissue with minimal damage.
Researchers develop innovative hybrid control strategy to improve product yields in biosynthetic processes. The new approach combines model-based optimization with in-cell feedback control, outperforming traditional methods and promising reduced costs and environmental impact.
Researchers develop ultrasound-based method to control cell growth and orientation in cultured muscle cells. The technique uses ultrasonication to promote differentiation of myoblasts into myotubes, offering a promising alternative to current methods.
Researchers developed a microfluidic chip that can measure memory B cells' binding affinity to flu virus, helping track immunity. The device, Shear Activated Cell Sorting (SACS), can compare how well cells bind to original and new variants.
Researchers from Universitat Jaume I developed a non-invasive device for female urination in bedridden women, addressing comfort and sealing issues. The ERGOMIC device uses the Coanda effect to efficiently direct urine flow, making it simple, cheap, and reusable.
A team of researchers at Penn State developed a novel bioprinting technique that uses spheroids to create complex tissue, producing tissue 10-times faster and with high cell density. The technique enables the rapid fabrication of functional tissues and organs, opening new opportunities for regenerative medicine.
Researchers assess 20 years of clinical trials for cell therapy's safety and efficacy in treating heart failure, highlighting progress despite challenges. The field continues to evolve through lessons learned from past studies, with ongoing trials taking novel directions.
Dr Bøsch's work explores betalains' potential to impact blood pressure, diabetes, cardiovascular health, and gut microbiota. The award highlights the significance of her research in advancing functional food and feed applications with implications for human and animal health.
Researchers at UVA have developed a new polymer design that decouples stiffness and stretchability, allowing materials to be both strong and flexible. The 'foldable bottlebrush polymer networks' can store extra length within their structure, enabling them to elongate up to 40 times more than standard polymers without weakening.
Researchers at the University of Illinois have created a DNA-made nanorobot called NanoGripper that can pick up COVID-19 viruses for rapid detection and block viral particles from entering cells. The device also has potential applications in cancer treatment and preventive medicine.
The Emory University Hospital team successfully implanted the BrioVAD System, a novel magnetically levitated pump designed for patient ease and long-term health. This marks the first-time use of the device in the US, as part of the INNOVATE clinical trial.
Researchers created an animal model with a targeted mtDNA mutation to advance understanding of mitochondrial genetic disorders. The study found significant changes in brain structure and function, as well as metabolic abnormalities, linking mitochondrial dysfunction to cognitive-metabolic impairments.
Researchers have developed a new method for designing large artificial proteins with high accuracy, utilizing AI-based software Alphafold2. The approach combines accurate structure prediction with optimization techniques, allowing for the creation of proteins with tailored properties, such as precise binding and stability.
Christian Wolfrum will serve as NTU's chief academic officer, overseeing educational and research excellence, while strengthening talent development. He brings experience in translating research into real-world applications, having co-founded biotechnology firm Glycemicon AG.
A team of researchers at the University of California San Diego has developed a clinically validated, wearable ultrasound patch for continuous and noninvasive blood pressure monitoring. The device offers precise, real-time readings of blood pressure deep within the body, providing detailed trends in blood pressure fluctuations.
GNOMX Corp. has been awarded a contract by the US Department of Health and Human Services to develop an immune dysregulation host-based assay to predict sepsis patient readmission risk. The assay aims to reduce hospital expenses and improve patient outcomes.
The joint Ph.D. program will combine engineering immersion, commercialization training, and clinical shadowing to produce medical innovators capable of addressing unmet clinical needs. Students will be trained in translational thinking, engineering design principles, and entrepreneurship to develop technologies for precision diagnostic...
Researchers at UVA discovered the heart reacts to viral infections in one of three ways, with specific gene patterns indicating healing or damage. This finding may lead to better treatments for people at risk of heart failure and other chronic conditions linked to viral infections.
A new CNIC study identifies a surprising mechanism through which tissue viscoelasticity counteracts the sensing of rigidity. Cells respond to ECM viscoelasticity regulating response times and outweighing high-rigidity sensing.
Researchers developed a new AI-powered diagnostic system, FastGlioma, which reveals invisible cancerous tissue in brain tumor surgery. The technique may delay or prevent recurrence of high-grade tumors and improve patient survival.
Team Bath Heart, a team of students from the University of Bath, has won the second world Heart Hackathon title with their innovative artificial heart device. The team's prototype, which uses wireless charging and 3D printing, was praised for its novelty, progress, and presentation.
The study reveals that the hadal snailfish has unique metabolic adjustments to store energy, optimize energy utilization, and maintain membrane fluidity. The fish increases lipid reserves, elevates CoQ and ATPase levels, and adjusts fatty acid ratios to withstand food scarcity and high pressure.
Researchers have developed a new CRISPR-Cas method to decipher the function of genetic variants that contribute to cancer. The approach creates tens of thousands of cells with different gene variants, allowing scientists to identify which variants make cancer cells resistant to standard drugs.
Researchers at the University of British Columbia have developed a groundbreaking coating that mimics natural blood vessels to reduce clotting and bleeding risks. The coating's unique properties prevent clot formation without disrupting normal blood functions, offering a promising alternative to high-risk blood thinners.
Adipo Therapeutics' lead product ADPO-002NP shows promising results in increasing energy expenditure and improving insulin resistance by browning white adipose tissue. The company is now raising $8 million to move the treatment to first-in-human Phase I clinical trials.
Researchers led by Judith Su will develop a portable FLOWER sensing device for detecting zeptomolar concentrations of chemical warfare agents. The device has shown record-breaking sensitivity and could preserve the lives of active-duty service members.
A team of researchers, including Binghamton University's Ahyeon Koh, is working on an innovative project to treat inflammatory bowel diseases like Crohn's and ulcerative colitis. The goal is to create a 'cell factory' in the body that can produce pharmaceuticals to alleviate symptoms.
Researchers developed a new AI model, BiomedGPT, to support various biomedical tasks. The model achieved 16 state-of-the-art results in 9 biomedical tasks and demonstrated robust predictive abilities.
Researchers developed a wearable ultrasound device that tracks muscle function without invasive procedures, offering high-resolution imaging and wireless monitoring capabilities. The technology has potential applications in respiratory health and human-machine interfaces.
Researchers have developed a new batteryless and wireless sensor that can detect impending biliary stent obstructions without waiting for clinical symptoms, blood tests or imaging tests. The sensor is 8 millimeters long and has a signal-to-noise ratio of a million to one during testing.
The US Department of Defense has awarded $514,000 to study the efficacy of gene editors in treating Duchenne Muscular Dystrophy. Researchers will explore non-viral options for delivering gene therapy through 'self-delivering' gene editors, aiming to improve safety and efficacy.
Researchers at the University of Rochester developed a new liquid biopsy method called CAD-LB, which uses ultrathin membranes to easily identify EVs for rapid diagnosis. The method holds promise for diagnosing cancer quickly and affordably, as well as assessing therapy progress.