Articles tagged with Biomedical Engineering
Researchers at Arizona State University have developed a rapid and accurate diagnostic test called NasRED that can detect diseases like COVID-19 with high sensitivity. The test uses tiny gold nanoparticles to identify disease-related proteins in a sample of bodily fluid, providing lab-quality accuracy without expensive equipment.
Researchers have engineered CalBots, magnetic nanobots that can penetrate dentinal tubules and form durable seals, offering lasting relief from sensitivity. The study uses a new class of bioceramic cement to create a regenerative, active nanomaterial with potential implications for future healthcare.
A UCLA team has uncovered new details about the muscle controlling blinking, offering a pathway toward developing blink-assisting prostheses. The orbicularis oculi muscle contracts in complex patterns that vary by action and move the eyelid in more than just a simple up-and-down motion.
Researchers developed an organic molecule that simultaneously emits light suitable for displays and absorbs photons for deep-tissue bioimaging, overcoming a long-standing design challenge. The compound achieved high efficiency in both applications, paving the way for next-generation multifunctional materials.
Physicists from the IFJ PAN in Cracow have successfully produced homogeneous coatings of titanium oxide nanotubes on large metal surfaces, overcoming the obstacle of crystal grain boundaries. The method combines nanoparticle lithography and electrochemical anodization, enabling controlled material properties.
Researchers found that bystander CAR-negative CD8+ T cells expanded after CAR-T cell therapy and propagated with bispecific antibody treatment, leading to complete tumor remission. This study supports a new therapeutic effect of bystander T cells in combination with CAR-T and BsAb therapies.
Scientists have developed a breakthrough method to grow human kidney organoids from tissue stem cells, mirroring fetal kidney development over months. The organoids can be used for research and testing of new treatments for kidney diseases.
Scientists at UChicago Pritzker Molecular Engineering have developed polymer-based nanoparticles that self-assemble at room temperature in water, enabling stable delivery of proteins and RNA. These versatile particles can be used to carry various biologic drugs, including vaccines, with high efficiency and scalability.
Silvia Blemker, a renowned biomedical engineer, has been elected to lead the American Society of Biomechanics. She aims to bolster industry ties, expand funding for students and early-career researchers, and promote interdisciplinary collaboration.
Researchers have discovered a specialized mesenchymal-endothelial crosstalk that supports angiogenesis and osteogenesis, enabling periodontal bone regeneration. This communication network between mesenchymal stem cells and endothelial cells drives tissue repair and regeneration, holding promise for dental therapeutic strategies and bro...
Researchers discovered that magnetized surfaces significantly influence amyloid protein assembly, forming more fibrils and longer structures when aligned in one direction. The study suggests a new physical factor, Chiral-Induced Spin Selectivity (CISS), plays a direct role in protein self-assembly.
Researchers at Washington University in St. Louis have successfully induced a reversible torpor-like state in mice using focused ultrasound, offering a novel strategy for medical interventions. This technology aims to reduce energy demand and preserve organs for transplantation, promising to transform medicine.
A team of researchers is using NCSA resources to simulate the long-term progression of atrial fibrillation, a type of irregular heartbeat. By modeling the heart's electrical activity, they have uncovered a vicious cycle where adaptations to maintain calcium balance lead to continued arrhythmias and eventually a permanent condition.
Researchers found that combining lavender essential oil with its own hydrosol effectively preserves skin-care emulsions against bacteria and fungi. The simple pairing kept counts below European Pharmacopoeia limits, even at high temperatures.
The journal is seeking high-quality submissions that explore the potential of voice and speech analysis in diverse medical applications. Submissions focus on acoustic and voice analysis techniques, voice or vocal phenotyping, and vocal biomarkers in health and medicine.
A low-cost 'SimpleSilo' device mimics commercial silo bags without high cost, using inexpensive materials and easy-to-source supplies. The device demonstrated comparable performance to commercial silo bags and can be assembled by hospital staff in under an hour.
Researchers from the Institute of Physics of the Czech Academy of Sciences studied the biological effects of permanent magnetic fields and found that their distribution in space plays a critical role in healing. The study's detailed field maps offer practical guidance for optimizing magnet use in medicine and magnetobiology.
A new sleep algorithm developed by KAIST researchers helps users build healthy sleep habits by recommending the best bedtime based on their body's circadian rhythm. The algorithm is available on Samsung Galaxy smartwatches and aims to improve sleep quality and overall well-being.
Researchers at Chiba University have developed novel microfluidic devices that incorporate microcones to detect and characterize circulating tumor cells in blood. The devices demonstrated highly selective capture of human breast and lung cancer cells, with high efficiency even at high flow rates.
Researchers have demonstrated a novel vaccine delivery method using dental floss, which stimulates the production of antibodies in mucosal surfaces, such as the lining of the nose and lungs. This technique has shown superior antibody response compared to current oral vaccination methods.
Engineers at RMIT University have developed a new low-cost approach to creating 3D-printed titanium alloys, which are about a third cheaper than standard alloys. The new alloy has improved strength and performance compared to traditional 3D-printed titanium alloys.
A new silicone patch with star-shaped microneedles, called the ExoPatch, distinguishes melanoma from healthy skin in mice, capturing cancer biomarkers from exosomes. The test shows promise for early detection of the most aggressive form of skin cancer without a biopsy or blood draw.
Researchers designed a hydrogel system using milk-derived extracellular vesicles as both bioactive cargo and structural building blocks, enabling tissue engineering and regenerative medicine applications. The yogurt EVs promote healing and tissue regeneration without additional chemical additives.
Bonn researchers reduce cardiac arrhythmia after heart attacks by using gene therapy to overexpress connexin 43 in fibroblasts of cardiac scar tissue, leading to improved electrical connection between cells and reduced arrhythmias.
Researchers developed an AI platform to design proteins that arm immune cells to attack and kill cancer cells. The method reduces the process from years to just 4-6 weeks, offering a new approach to precision cancer treatment.
Researchers have developed a mechanical adhesive device that can attach to soft surfaces underwater, inspired by the hitchhiking sucker fish. The device uses pressure-based suction and has enhanced adhesion capabilities, making it suitable for delivering drugs in the GI tract or monitoring aquatic environments.
Researchers adapted optical coherence tomography (OCT) to visualize tiny structures in the human inner ear, correlating fluid levels with a patient's degree of hearing loss. The findings may help clinicians diagnose and treat hearing loss more quickly and effectively.
The article highlights the need for improved sepsis diagnosis, personalized treatment, and innovative trial designs. It advocates for a multifaceted approach integrating timely diagnosis, tailored therapy, and equitable implementation to tackle the global burden of sepsis.
Researchers developed a high-throughput phenotyping pipeline to analyze maize root development across genotypes, revealing extensive variability in root morphology and transcriptional profiles. Transcriptomic analysis identified thousands of differentially expressed genes related to hormone signaling, stress response, and cell wall org...
Researchers at MURR have optimized Terbium-161 for radiopharmaceutical use, enabling targeted destruction of cancer cells with high-energy electrons. The breakthrough could add extra therapeutic effectiveness to existing treatments without requiring new drug development.
A study published in Journal of the Mechanical Behavior of Biomedical Materials found that wrinkled skin is caused by its tendency to buckle under pressure due to age-related changes in its mechanical properties. As people age, their skin becomes more prone to wrinkles as it stretches and contracts in different directions.
Bioengineers at Harvard John A. Paulson School of Engineering and Applied Sciences have developed a computational model called BrainFlow that simulates cerebrospinal fluid flow in the presence of shunt implants, providing insight into optimal shunt design and placement for hydrocephalus patients.
The study explores the technological evolution of surgical robots and their current clinical applications. Surgical robots have addressed challenges in operating within small anatomical spaces, improving medical efficiency, but also increasing costs and complexity of operations.
Recent advances in biofabrication and biomedical electronics have led to the development of biohybrid-engineered tissue (BHET) platforms, turning passive constructs into intelligent systems. These platforms show promise in diverse applications, including brain organoids and cardiac tissues, blurring the line between biology and machine.
A KAIST research team has identified a new molecular mechanism in which alcohol-damaged liver cells increase reactive oxygen species, leading to cell death and inflammatory responses. They discovered that Kupffer cells act as a 'dual-function regulator' that can either promote or suppress inflammation through interactions with liver ce...
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
Researchers at Kyoto University have created a microphysiological system capable of simulating different regions of human lungs, including the airway and alveoli. This breakthrough enables accurate modeling of viral pathologies and holds promise for personalized treatment of respiratory diseases such as COVID-19.
Scientists have discovered that microglia play a crucial role in regulating blood flow to the brain, and targeting them may improve blood flow deficits. The study suggests that restoring microglia function could prevent or reverse memory-stealing diseases caused by lack of adequate blood flow.
Researchers aim to understand the role of blood vessels in traumatic brain injuries and their link to age-related cognitive impairment. They plan to use mice with a mutation in the UCH protein to explore how blocking this protein affects brain sugar processing and neurovascular function.
Researchers have developed a 3D bio-printed model of lung tissue that closely mimics natural complexity, enabling better testing of respiratory diseases and drug development. The model can be adapted to include additional cell types or patient-derived cells, making it a powerful tool for personalized medicine and disease modeling.
A new deep learning model enhances handheld 3D medical imaging by automatically tracking transducer motion without external sensors. The model produces more realistic 3D US images and can reconstruct blood vessel structures using ultrasound and photoacoustic data.
Researchers at RCSI University of Medicine and Health Sciences have developed a 3-D printed implant that delivers electrical stimulation to injured areas of the spinal cord, enhancing nerve cell growth. The study has shown promising results in lab experiments and may enable new medical devices for traumatic spinal cord injuries.
Researchers at Texas A&M University have developed a new type of adhesive that could improve the comfort and safety of wearable medical devices. The adhesive, made from polyelectrolyte-complex coatings, is water-based and has been shown to match the strength of commercial-grade adhesives while reducing skin irritation.
Researchers developed a new imaging approach combining two-photon microscopy and advanced algorithms to improve resolution and reduce noise. This allowed them to clearly see details smaller than 250 nanometers, enabling real-time observations of mitochondrial behavior in live animals.
Scientists at the Stowers Institute for Medical Research identified two distinct genes that regulate regeneration of sensory cells in zebrafish. The discovery may guide future studies on hearing loss and regenerative medicine in mammals, including humans.
The new agreement provides unlimited opportunities for open access publishing in JMIR's journals, eliminating article processing charges and streamlining the publication process. This partnership underscores TU/e's commitment to advancing open science and increasing research impact.
Researchers have engineered a monoclonal antibody that blocks allergic reactions against common pollen when applied inside the nose of mice, providing new hope for hay fever sufferers. The treatment, known as a 'molecular shield,' acts immediately and locally at the lining of the nose to prevent IgE antibodies from being activated.
Researchers at MIT developed an implantable device that can store glucagon to counteract hypoglycemia, a life-threatening condition for people with Type 1 diabetes. The device, about the size of a quarter, contains a small reservoir made of 3D-printed polymer and can be triggered remotely or automatically by a sensor.
Researchers have identified a hidden molecular mechanism involving two proteins that allows tumors to resist treatment. A new gelatin-based nanoparticle has been developed to shut down both proteins simultaneously, showing promising results in early studies with mice.
Researchers found that human stem cells can differentiate into bone cells simply by being squeezed through narrow spaces. This discovery could lead to the development of simpler and safer regenerative therapies by using physical signals instead of chemical cues. The study's findings have broader implications, including potential applic...
A new technology combines the coffee-ring effect with plasmonics and AI for rapid diagnostics, offering highly accurate results in under 12 minutes. The test can spot diseases like COVID-19, prostate cancer, and sepsis, making it a game-changer for point-of-care diagnostics.
GeniPhys has received FDA clearance for its self-assembling collagen scaffold, Collymer Self-Assembling Scaffold (SAS), which supports cellular infiltration and vascularization. The technology is indicated for various wound types and anchors a growing intellectual property portfolio with nearly 20 issued or pending patents.
A new computational method combines 4D flow MRI, CFD, and data assimilation to estimate blood flow in brain aneurysms with greater accuracy and efficiency. The approach focuses on the aneurysm region, reducing computational cost while improving flow estimation.
Chihtong Lee's research on retractor blade geometry explores how small design changes can improve patient recovery after spinal surgery. Her work, conducted in collaboration with Baylor College of Medicine, showed that blades with soft, biocompatible coatings significantly reduced tissue stress and postoperative complications.
Researchers from UCLA have developed innovative biomaterial strategies to mimic immunological synapses, enhancing T cell activation rates and long-term efficacy in CAR-T therapy. The approaches leverage flexible interfaces and mechanical properties to promote memory T cell formation and distribution.
A novel fluorescent probe, SLY, has been developed to precisely identify hepatocellular carcinoma tissue using sialylated glycans on the cell surface. The probe outperforms conventional methods by clearly distinguishing tumor margins within liver tissues.
Researchers have developed a fabric-based electrochemical biosensing system that enables autonomous sweat collection and molecular analysis across varied scenarios. The system uses a skin-interfaced stabilized hydrogel electrode to deliver a mild current that activates sweat glands, allowing for real-time health monitoring without rely...
The study proposes a modified ResUNet approach for automated liver segmentation from CT images, achieving high precision and accuracy. The model outperforms traditional methods, demonstrating stable performance in cross-dataset tests.
Researchers at the University of Surrey have identified genes that disrupt the survival of 'zombie' TB cells, which are resistant to antibiotics. By understanding these mechanisms, scientists can develop new drugs that target persisters and shorten treatment regimens.
A new study by University of Missouri researchers found that states granting full practice authority to APRNs significantly improves health outcomes and increases access to care. In contrast, restricted practice laws impose financial burdens on patients and limit APRN autonomy.