Articles tagged with Biomedical Engineering
Biomedical engineers at the University of Rochester have developed a novel technique using ultrasound waves to organize endothelial cells into patterns that promote the growth of new vessel networks. The team aims to treat ischemic injuries caused by damaged tissue in reconstructive and plastic surgeries.
Researchers developed a tri-culture heart-on-a-chip model of cardiomyocytes, fibroblasts, and endothelial cells to mimic in vivo cardiac behavior. The study successfully replicated endothelial cell morphology and functionality, as well as cardiac function with increased contractility.
A novel synthetic biology platform enables rapid and cost-effective transformation of protein binders into high-contrast nanosensors for various applications. The platform uses fluorogenic amino acids to increase fluorescence up to 100-fold, enabling the detection of specific proteins, peptides, and small molecules.
Researchers investigated peptide clumping behavior using molecular dynamics simulations and AI techniques. They discovered that aromatic amino acids enhance aggregation, while hydrophilic ones inhibit it, offering insights into peptide structure and function.
The University of Kentucky has been awarded a six-year, $18 million NSF grant to establish the NSF ESCAPE center for assessing pathogen emergence. The center will focus on environmental surveillance using social science, engineering, bioinformatics, and risk modeling to predict and prevent pandemics.
Researchers at Duke University have developed a computer model that simulates nerve responses to electrical stimulation, enabling the efficient design of more effective and targeted neuromodulation therapies. The new tool, called S-MF, runs thousands of times faster than current industry standards without sacrificing accuracy or detail.
Researchers led by Prof. Michael Brand successfully regenerated photoreceptors in zebrafish, demonstrating they regain their normal function and allowing the fish to recover complete vision. This breakthrough could potentially revolutionize treatment of diseases like retinitis pigmentosa or macular degeneration.
A recent case report presents a comprehensive diagnosis of Idiopathic Normal Pressure Hydrocephalus (iNPH) using advanced diagnostic techniques, including brain imaging, CSF tap tests, and infusion study. The study's results show significant improvements in patient outcomes and reduced clinical costs.
A new implant has been developed to encourage nerve cell repair after spinal cord injury. The implant uses electrical signals and a 3D-printed scaffold to bridge the gap and direct axons to grow back in the correct formation, promoting healing and recovery.
Researchers at the University of Utah developed Diadem, a noninvasive device that stimulates deep brain regions to disrupt faulty signals causing chronic pain. In a recent clinical trial, participants experienced significant pain relief after just one treatment session.
Researchers found that Prunin laurate, derived from citrus and coconut biomass, inhibits bacterial growth in periodontal pathogen Porphyromonas gingivalis. The compound is tasteless and hypoallergenic, making it a potential inexpensive antimicrobial solution for preventing oral inflammation.
A new textured heart valve implant has been shown to be less likely to cause clotting, improving health outcomes for patients who receive the implant. Certain conditions such as cancer and smoking elevate the risk of blood clots after heart surgery.
Researchers developed a new brain-computer interface that translates brain signals into speech with up to 97% accuracy, enabling a man with amyotrophic lateral sclerosis (ALS) to communicate with friends and family. The system was tested in real-time conversations with continuous updates, achieving high word accuracy rates.
Researchers have developed a suite of parameters that can be used to quantitatively measure different physical characteristics of the lung. The parameters were found to be highly sensitive and specific for diagnosing fibrosis and edema in an animal model, using only five necessary parameters.
Researchers developed an inexpensive, water-powered electric bandage that accelerates wound healing in chronic wounds. The bandage produces an electric field that promotes healing and reduces inflammation, with animals treated with the bandage showing a 30% faster rate of wound closure.
Researchers at Linköping University have created soft electrodes made of gold nanowires and silicone rubber, capable of stimulating nerve signals and capturing electrical signals. The material is expected to last for at least three years and has potential applications in medical devices.
Liheng Cai, a UVA engineering professor, has received a $1.9 million NIH grant to create advanced biomaterials that can be used to repair living tissues and build organ structures. His lab aims to develop polymers that mimic human biology and integrate healthy cells into the human body.
Researchers have reviewed advancements in wearable cuffless blood pressure monitoring, focusing on flexible electronics and machine learning. The integration of sensors, signal processing, and algorithms enables accurate blood pressure estimation, promising personalized medicine applications.
Scientists have developed a new way to 3D print materials that are strong enough to support human tissue and vary in shape and size. The breakthrough, known as CLEAR, helps pave the way toward a new generation of biomaterials for personalized implants and tissues.
A research group developed a long-acting artificial hepatocyte growth factor (HGF) mimetic molecule using cyclic peptides and protein engineering. The molecule improved liver fibrosis, lipid accumulation, and inflammation in a mouse model with non-alcoholic steatohepatitis (NASH), providing an option for NASH therapeutics.
Researchers at Johns Hopkins Medicine have developed a novel, non-invasive approach to measure intracranial pressure (ICP) in patients with traumatic brain injuries. The AI-powered method uses extracranial physiological waveforms to estimate ICP severity with high accuracy.
A team of researchers from Rice University has received a $2.5 million grant from the Lemelson Foundation for a graduate education program that aims to prepare students to be Kenya's next generation of inventors and entrepreneurs. The 'Impact Invention' master’s degree program focuses on project-based learning, collaboration, and entre...
Researchers from Chiba University developed a foldable pouch actuator that enables finger extension in soft rehabilitation gloves, overcoming the limitation of existing actuators. The FPA facilitates joint-specific movements and has potential applications in telerehabilitation and care facilities.
A new study from University of Florida researchers found that quick learners rely on the visual cortex in their brains when acquiring new motor skills. The study used brain-monitoring electrodes to analyze how people learn to walk at different speeds, revealing a clear difference between fast and slow learners.
Researchers have developed a new technique called burst sine wave electroporation (B-SWE) that can disrupt the blood-brain barrier around brain tumors without causing significant damage to healthy tissue. This method shows promise for treating aggressive brain cancers like glioblastoma, which currently have limited treatment options.
LMU researchers have developed strategies to repair mutated proteins that cause an inherited stroke disorder called CARASIL. The team used a combination of in-vitro and in-vivo methods to restore the function of the protease HTRA1, which plays a crucial role in maintaining equilibrium in the extracellular matrix.
Professors Philip LeDuc and Burak Ozdoganlar have developed a novel 3D ice printing technique that enables the creation of micro-scale structures with tailored geometries. Their method uses water as an ink substitute, allowing for the deposition of precise internal voids and channels.
Researchers developed a library of 27 polymers to improve RNA drug delivery, using design-of-experiment approach and statistical analysis. The study improves quality, efficiency, and precision of RNA drugs with optimized polymer nanoparticles.
A team of scientists at Harvard University developed a new RNA synthesis process that produces RNA with efficiencies comparable to current industry standards. The novel method can incorporate all common molecular modifications found in RNA drugs, expanding the RNA therapeutic design space.
A team of Penn State researchers has created a modular genetic circuit that turns cancer cells into a 'Trojan horse,' causing them to self-destruct and kill nearby drug-resistant cancer cells. The circuit outsmarts resistance and eliminates it before the cancer cells can evolve.
Physicists at Aalto University have developed a method to align bacterial cells using magnetic fields. By mixing bacteria into a liquid with millions of magnetic nanoparticles, the researchers can control the alignment of the rod-shaped bacteria in response to magnetic field strength. The findings offer insights into active matter phys...
Scientists studied Crassula muscosa and found its unique leaves pack tiny fins that manipulate the meniscus to direct liquid transport. An artificial mimic, CMIAs, mimics this effect, enabling real-time directional control of fluid flow in various technologies.
Researchers develop optogenetic system to precisely target cancer cells using light, inducing inflammatory cell death and triggering immune response. The approach aims to modulate the immune suppressive environment around cancer cells, helping T cells recognize and attack the disease.
Researchers from Chiba University develop sustainable method for producing biodegradable polymers using cuttlefish ink melanin. Decomposition products are converted into polymeric materials with potential applications in circular economies.
Research using a novel microscopic technique reveals that gold nanoparticles' lethality to cancer cells is more complex than previously thought. Smaller nanoparticles can regenerate and divide after initial stress, while larger star-shaped particles cause oxidative stress leading to programmed cell death.
Researchers at the Gwangju Institute of Science and Technology (GIST) have developed an innovative robotic rehabilitation system called SPINDLE to enhance the strength and dexterity of individuals with tremors. The study revealed significant benefits, including improved motor control, coordination, and neuroplasticity.
Researchers have developed a biodegradable scaffold to facilitate bladder tissue growth, reducing complications associated with traditional augmentation procedures. An implantable sensor also enhances patient monitoring, paving the way for improved bladder surgery outcomes.
Researchers develop a model of heart disease by tricking stem cells to behave like mature heart cells with a mutation that causes hypertrophic cardiomyopathy. The study reveals the connection between mechanical stress and electrical function in hearts, shedding light on why genetic mutations can cause arrhythmias.
Xiaohu Xia's research focuses on enhancing diagnostic efficacy of enzyme-linked immunosorbent assay (ELISA) testing using specially tailored nickel-platinum nanoparticles. His goal is to improve disease detection accuracy by more than 300 times, enabling early diagnosis of cancers like prostate and colorectal cancer.
Researchers have developed a method to deliver drugs to specific areas of the body using ultrasound waves, triggering drug release from stable nanocarriers. The approach is made both safe and efficient for the first time, paving the way for clinical trials.
Lopatkin's lab will investigate how bacterial metabolism contributes to antibiotic resistance using sophisticated tools and techniques. The research aims to identify drug-resistance mutations that arise in bacteria adapting to different antibiotics and metabolism-altering chemicals.
A new wearable patch, called the Wearable Aptalyzer, can continuously monitor levels of blood sugar, lactates, and other critical biomarkers without piercing the skin. This technology holds promise for improving care in remote settings and allowing early detection of diseases.
Researchers at Carnegie Mellon University have successfully integrated focused ultrasound stimulation into noninvasive BCIs, significantly boosting signal quality and enabling bidirectional brain-computer interfaces. The technology allows individuals to control a cursor or robotic arm using only their thoughts.
The 2024 Kavli Prize Laureates have made significant contributions to our understanding of exoplanet atmospheres, nanoscale materials for biomedical applications, and the localization of brain areas specialized for face recognition. Their work has broadened our knowledge of planetary life beyond Earth.
Researchers at Wyss Institute develop subcutaneous scaffolds to restimulate CAR-T cells, increasing therapeutic efficacy in mice with aggressive blood tumors. The biomaterials increase CAR-T cell numbers and steer differentiation into tumor-killing T cells.
Researchers at Kanazawa University have developed an electrochemical biosensor to detect ADAR1, a biomolecule associated with several diseases including neurological disorders and cancer. The device shows good sensitivity and selectivity, enabling rapid detection of ADAR1 concentrations in cells.
Researchers at Duke University created an ultrathin silk membrane that helps cells grow into functional tissues used for research, enabling the development of kidney disease models. The new membrane improves communication and growth between cells, mimicking natural human organ structures.
Researchers developed a human pancreatic cancer fibrotic barrier model to assess treatment strategies and test efficacy of therapeutic interventions. Inhibition of ROCK2 pathway resulted in reduced ECM remodeling and improved tissue permeability for drugs, highlighting its potential for enhancing drug delivery in PDAC.
Researchers develop vascularized organ-on-a-chip systems for personalized medicine, reducing animal testing and improving drug efficacy. These devices mimic human organs on a microscale, enabling precise manipulation of physical and chemical conditions.
Researchers developed an adhesive sensing device that seamlessly attaches to human skin to detect and monitor various health signals, such as glucose levels and heart rate. The device can be reprogrammed and recycled, making it a potential tool for managing diseases like diabetes.
A groundbreaking study reveals zwitterionic polymers can inhibit protein aggregation, a key mechanism behind various human diseases. The researchers found that hydrophobicity and molecular weight impact protein stabilization, offering new avenues for therapeutic strategies.
Researchers have developed a medicated foam that can deliver expensive gene therapies to cells, showing promise for treating cancers and autoimmune diseases. The foam outperformed liquid formulations in laboratory studies and showed no significant side effects when injected into mice.
Researchers develop an in vitro model to study tau aggregation, a process linked to neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The approach offers a short timeline for generating data and facilitates the study of potential therapeutic interventions.
The latest SLAS Technology issue highlights recent breakthroughs in skin cutaneous melanoma, glycan-bead coupling, and acoustic ejection mass spectrometry. Researchers adapt technological advancements for life sciences exploration and experimentation in biomedical research and development.
Researchers developed adhesive hydrogel coatings that eliminate fibrosis, a common issue with medical implants. The coatings bind devices to tissue and prevent the immune system from attacking them.
Researchers at Osaka Metropolitan University have discovered that plasma irradiation can accelerate tendon repair, showing faster regeneration and increased strength in lab rats. This breakthrough could lead to shorter treatment times and more reliable tendon healing for athletes and individuals with sports-related injuries.
A new study published in Nature Biomedical Engineering shows that targeted cancer treatment using antibody-displaying extracellular vesicles reduces tumour growth and improves survival in mice. The treatment has the potential to be used against other diseases and cancer types, offering a more effective and fewer side effects compared t...
Researchers designed a regenerative medicine therapy to speed up diabetic wound repair using tiny fat particles loaded with genetic instructions. The treatment targeted problem-causing cells and reduced swelling, promoting faster and more effective wound closure.
A Japanese research team used machine-learning-driven modular assembly systems to create a more efficient gene editing tool. The study demonstrated an improvement in genome editing efficiency by 5%, showcasing the effectiveness of engineering zinc-finger nucleases through structural modeling.
A new study shows that gene therapy delivered by nanocarriers can repair damaged discs and reduce signs of back pain in mice. The treatment, which uses naturally derived nanocarriers to deliver genetic material for a protein key to tissue development, restored structural integrity and function to degenerated discs.