Articles tagged with Biomedical Engineering
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers used mass spectrometry and transcriptomics to identify key targets of artemisinin, which may interfere with redox homeostasis, lipid metabolism, and protein synthesis. The study provides valuable insights into combating malaria and addressing emerging resistance.
A new electroenzymatic assembly transduction strategy-based biosensor has been developed for simultaneous detection of glucose, lactate, and cholesterol in clinical samples. The sensor exhibits high sensitivity and efficiency, with a detection time of under 30 seconds, and good agreement with laboratory results.
A new type of flexible neural electrode has been developed, which can accurately match the mechanical properties of brain tissue. The electrode was tested in epilepsy rat models, demonstrating accurate measurement of neural responses and stimulation of specific brain regions.
Researchers at Lund University developed a new 3D-simulation method to identify individuals at high risk of osteoporotic fractures. The method uses 2D X-ray images to produce 3D models of the thigh bone, enabling simulations of different scenarios and assessing risk more accurately.
Researchers identified distinct genomic characteristics that impact prognosis for patients with triple negative apocrine carcinoma. The study confirmed a five-year disease-free survival rate of 92.2% for these patients, significantly higher than those diagnosed with other types of TNBC.
The collaboration has garnered $5.68 million of grant support, with a five-year $2.13 million National Institutes of Health R01 grant and a five-year $2.89 million NIH R01 grant. Researchers are using computational biology to model a key Alzheimer's protein called TREM2 and its interactions with small chemical molecules.
A study using a placenta-on-a-chip model investigated the transport of pharmaceutical agents, such as naltrexone, to the fetus. The research revealed significantly higher expression levels of interleukin-6 and tumor necrosis factor-alpha in neural cells exposed to these agents.
Researchers at the University of Michigan developed a machine-learning algorithm that highlights issues in antibodies binding to non-target molecules. The model can be used on existing or new antibodies, reducing the number of manufacturing and testing iterations needed.
A recent study has successfully predicted potential drug outcomes and side effects by analyzing the discrepancy in gene perturbation effects between cells and humans. Researchers used machine learning to forecast drug approvals, improving reliability over conventional methods that only consider chemical properties.
Chung-Ang University researchers create an electrochemical DNA biosensor that detects HPV-16 and HPV-18 with high specificity, facilitating early diagnosis of cervical cancer. The sensor uses a graphitic nano-onion/MoS2 nanosheet composite to enhance conductivity.
A new Australian study found that implementing simple bone-strengthening strategies throughout the community can lead to a substantial decrease in hip fractures. The study analyzed data from over 3000 individuals aged 60+ and showed a 45% decline in hip fractures despite only a 3% increase in bone mineral density.
Researchers at University of Galway and MIT have developed an intelligent implantable device that can sense its environment, adapt to release drugs as required, and bypass scar tissue buildup. The device uses AI to tailor drug delivery to individual patients, reducing fibrotic encapsulation and ensuring consistent dosing.
Researchers discovered that titanium micro-spikes with rough surfaces can effectively kill drug-resistant fungus and Candida species through apoptosis. The findings suggest that these surface features may be a promising approach to combatting superbug resistance.
The Texas Heart Institute has received a five-year, $2 million grant from the National Institutes of Health to advance organ bioengineering. The project aims to develop transplantable bioartificial hearts to combat end-stage heart failure.
Researchers at the University of Sydney have developed a nanoscale optical technique to monitor protein aggregates forming in cells, which can lead to neurodegenerative diseases such as Alzheimer's and ALS. The study provides a new window into the transition of proteins from liquid to solid phase.
Imperial researchers have imaged Piezo1 channels in human cells and organs, revealing their role in regulating blood pressure, respiration, bladder control, and the immune system. This breakthrough could lead to a better understanding of their role in fundamental physiological processes and potentially new drug targets for diseases.
Imaging mass cytometry showcases odd numbers of proteins in kidneys of lupus patients, identifying novel markers for disease. The study found decreased and increased disease markers pointing to renal disease, with potential enlargement of glomeruli in some patients.
Researchers developed a platform that allows engineered biosensor bacteria to safely pass through the gastrointestinal tract in animal models. The platform enables real-time monitoring of gut health and can be used to diagnose and monitor various diseases, including inflammatory bowel disease. It has the potential to revolutionize pati...
A team of New Jersey researchers reviewed the evidence on robotic exoskeleton devices for individuals with acquired brain injury, laying out a systematic framework for future research. The review highlights the need for comprehensive approaches to evaluate these devices and their role in improving mobility in individuals with acquired ...
Researchers created a database linking utility patents and NIH funding to assess translational efficiency. The Translational Ratio metric provides insights into patenting efficiency and its impact on drug innovation and treatment development. Institutions with strong engineering operations tend to be more successful in producing patents.
Researchers successfully recreated lung cancer patient's internal environment using hydrogel and 3D bioprinting, preserving specific lung cancer subtype and genetic mutation characteristics. The study enables precise drug evaluation and personalized treatment options for lung cancer patients with underlying diseases.
Scientists have discovered that SARS-CoV-2 can infect cells using multiple entry points beyond ACE2, explaining its ability to jump between species. This finding highlights the need for continued monitoring of coronaviruses and their potential to cause future pandemics.
Researchers have developed a proof-of-concept technique to attach nanomaterials to living tissue and cells using nanoimprint lithography. The method enables biocompatible integration of smart devices with living tissue, opening up opportunities for biohybrid materials, bionic devices and biosensors.
Researchers aim to create machine learning tools that can analyze and quantify shape information from images, enabling more accurate diagnoses and improving patient care. A new family of deep neural networks, called DSNNs, will be developed to tackle AI's blind spot in image analysis.
A new study using MINDWATCH brain-monitoring technology reveals that listening to music and drinking coffee can measurably alter brain arousal, improving performance in working memory tasks. Perfume had a modest positive effect as well.
Researchers found that locusts have a clear preference for certain odors, such as grass and banana, while avoiding others like almond and citrus. They developed a model explaining how innate and learned preferences are generated in the locust's olfactory system.
Researchers at the University of Missouri have developed a new method using nanopores to advance discoveries in neuroscience and medical applications. The technique allows for real-time detection of dynamic aptamer-small molecule interactions, which can aid in understanding DNA and RNA diseases and drug discovery.
A new portable EEG headset has been validated and tested for at-home stroke rehabilitation. The low-cost device connects the brain to powered exoskeletons, promoting motor recovery outcomes.
A team of researchers developed a novel method that leverages temporal characteristics of blood pulse to estimate heart rates with improved accuracy, especially in scenes with ambient light fluctuations. The proposed method showed a 36.5% improvement in estimation accuracy compared to conventional methods.
Cyanobacteria can solidify inorganic materials like CO2, making them valuable for sustainable construction. Researchers developed an additive co-fabrication manufacturing process using bacterial strains and robotics.
Researchers at UC San Diego report new direct evidence of atrophy and fibrosis in pelvic floor muscles of women with symptoms of pelvic organ prolapse. They also showed that an acellular injectable skeletal muscle extracellular matrix hydrogel reduces the negative impact of simulated birth injury on rat pelvic floor muscles.
Researchers at Harvard developed a fiber-infused ink that allows 3D-printed heart muscle cells to align and contract like human heart cells, enabling the creation of functional heart ventricles. The innovation can be used to build life-like heart tissues with thicker muscle walls, paving the way for regenerative therapeutics.
Researchers from Sahmyook University found that phyllodulcin, a natural sweetener found in hydrangeas, can efficiently inhibit amyloid beta (Aβ) aggregation and dissociate its aggregates in an animal model study. The study suggests that phyllodulcin may be useful in delaying the onset and progression of Alzheimer's disease.
Researchers examined core elements shared between human intelligence and AGI, focusing on scale, multimodality, alignment, and reasoning. They found that brain-inspired AI systems can mimic human-like rapid learning capabilities through large language models.
Researchers have found that injuries on one part of an organism can trigger a whole-body response aiding wound healing and tissue regeneration. This coordination is crucial for successful regeneration in certain organisms such as planarians, zebrafish, and axolotls.
A new device, pioneered by Anqi Zhang, can record brain activity without harming neural tissue, using the passageways of blood vessels. This innovation overcomes previous limitations, enabling precise recording from individual neurons in living animals.
A novel biomaterials-based approach enhances adoptive T cell therapy with cancer vaccine technology, providing strong and long-lasting effects against solid tumors. In mice carrying melanomas, SIVET enables fast tumor shrinking and long-term protection.
Researchers at Duke University have developed a new approach to building point-of-care diagnostic devices that uses gravity to transport and mix liquid droplets. The device relies on commercially available surface coatings that can tweak the wettability and slipperiness of the channels, allowing for complex fluid paths to be designed.
Scientists have found that mixtures of polymers can form phase-separated droplets, similar to lava lamps, which interact with cell membranes in unexpected ways. These interactions affect the exterior structure of cells, creating a mosaic of droplets and signaling to the outside.
Researchers developed a soft, wireless implant that monitors the heart and delivers electrical stimuli to stop atrial fibrillation. The device dissolves harmlessly in the body after a clinically relevant period, reducing healthcare costs and improving patient outcomes.
A novel hydrogel has been developed to induce endometrial regeneration and elucidate its mechanism, offering new hope for patients struggling with infertility. The gel, made from uterus-derived decellularized extracellular matrix, successfully regenerated the endometrium in mice, creating a favorable environment for embryo implantation.
Researchers create a three-dimensional epithelial model that reproduces the human lip area, allowing for evaluation of cosmetic ingredients and products. The model's structure and differentiation mode are similar to those of actual human lip tissue.
The University of Pittsburgh researcher is working on a three-year project to harness the potential of liquid-solid interaction for biomedical engineering and suspension bridge construction. The study aims to precisely control microrobots through the bloodstream and prevent disasters like the Tacoma Narrows Bridge collapse.
A research team at CityU developed a multifunctional composite polymer coating with both radiative and non-radiative cooling capacity, enhancing heat dissipation in wearable electronics. The cooling interface achieved temperature drops of over 56°C, improving the performance of skin electronic devices.
A new study from Aarhus University has found that applying AI predictions of protein structures enhances the CRISPR technology, making the cuts in a patient's DNA more precise. This discovery may lead to better treatments for patients with genetic disorders and potentially develop cures for various genetic diseases.
Researchers at KIT have developed nanoparticles that can carry antibiotics directly to the lungs, increasing drug concentration and reducing resistance. The nanocarriers, containing Bedaquilin or BTZ-043, overcome biological barriers and show effectiveness in treating multidrug-resistant tuberculosis.
Scientists create optically controllable liposomes called LiDLs, which can selectively release contents inside cells upon exposure to acidic pH induced by green light. The researchers demonstrated that LiDLs efficiently deliver substances without causing side effects, showcasing exceptional extracellular stability.
Researchers at TUM developed a new approach to measure human brain activity using microelectrodes and awake brain surgery. They found individual neurons specialize in handling specific numbers, providing insights into cognitive functions and developing solutions for brain function disorders.
A University of Arizona professor has developed a 1-minute frailty testing platform to screen patients for frailty, enabling better care decisions. The platform measures motor, heart, and brain function using wearable sensors, providing an accurate diagnosis.
A new rapid viral plaque detection system enabled by holography and deep learning can help accelerate vaccine and drug development. The system reduces the detection time of traditional viral plaque assays by up to 48 hours, eliminating chemical staining and manual counting.
Researchers created a robot inspired by pangolins' ability to curl up into a ball, with a soft layer and hard metal components. The robot can emit heat when needed and transport particles like medicines, making it promising for minimally invasive medical procedures.
Researchers developed a new method for controlling lower limb exoskeletons using deep reinforcement learning, enabling more robust and natural walking control. The system has the potential to benefit users with spinal cord injuries, multiple sclerosis, stroke, and other neurological conditions.
Researchers developed tiny nano-sized pores that can detect specific proteins in complex biological fluids, such as blood. The breakthrough enables fast and accurate disease diagnosis, potentially leading to earlier interventions and improved treatment outcomes.
Researchers have developed a biodegradable ultrasound device that can open the blood-brain barrier, allowing chemotherapy to penetrate and kill brain cancer cells. The device is as powerful as traditional ceramic-based devices and has shown promising results in animal trials.
A handheld bioprinter has been developed to address limitations of previous designs, paving the way for applications in regenerative medicine, drug development, and custom orthotics. The device's modular design allows for control over printing mixture and properties, enabling repair and regeneration of defective tissues and organs.
Recent innovations in volumetric bioprinting by UMC Utrecht researchers enable faster and more clinically relevant printing of living tissues. By controlling chemical properties, the team creates smart materials that guide cell behavior and development, mimicking native biochemical environments.
Researchers at UMC Utrecht successfully merged two printing techniques to create functional tissues made from stem cells. Granular biogels enable high cell density, survival, and specialization, surpassing solid gels. This breakthrough boosts tissue functionality and opens up opportunities for regenerative medicine.
Researchers at City University of Hong Kong developed a novel, wearable, olfaction feedback system with wireless capabilities for virtual reality. The system releases various odours using miniaturized odour generators and has been tested with an average success rate of 93 percent.
A recent study from Michigan Medicine suggests relief may be possible for individuals with tinnitus, a condition characterized by ringing or hissing sounds. The innovative bi-sensory treatment device improved quality of life and reduced tinnitus loudness in nearly 70% of participants.
A new AI model, NeCLAS, can predict how nanoparticles bind to proteins, a crucial step in designing antibiotics and antivirals. This breakthrough could help combat antibiotic-resistant infections and develop new treatments for diseases.