Articles tagged with Biomedical Engineering
Researchers will examine protein stability mechanisms in Thermus thermophilus to advance treatments for diseases such as Alzheimer's, ALS, and cancer. The team will explore the structure of Rieske proteins and their role in energy production to understand how to restore stability.
Scientists at Northwestern University have developed the fastest test yet for diagnosing hepatitis C virus, delivering results in just 15 minutes – up to 75% faster than current rapid tests. The highly accurate diagnostic could revolutionize HCV care by improving diagnosis and accelerating treatment uptake.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
A newly developed wearable sensor uses polarized light to improve photoplethysmography (PPG) signal accuracy across different skin tones. The device splits light into two channels, detecting co-polarized and cross-polarized signals to filter out superficial scattering and capture stronger signals from deeper tissue.
A new framework demonstrates that urban watersheds release most ammonium through baseflow linked to leaking sewer systems, while agricultural regions shift seasonally between groundwater-dominated nitrate transport and storm-driven dissolved organic nitrogen pulses. Effective nitrogen management requires recognizing where pollution ori...
Researchers developed a manure-integrated nitrogen management strategy that rebalances soil microbes to reduce N₂O emissions while maintaining high crop yields. The approach improved soil quality and enriched key N₂O-reducing microbes, leading to lower greenhouse gas emissions.
Researchers at SwRI and Trinity University are working on a new prodrug to mitigate ischemia/reperfusion injury (IRI), which causes permanent cellular and tissue damage. The team aims to protect against IRI by targeting protein misfolding during cellular stress.
Researchers at Case Western Reserve University improved electrode performance in brain-computer interfaces by delivering anti-inflammatory drugs directly to the site of implantation using platelet-inspired nanoparticles. The breakthrough has potential applications for treating various diseases involving inflammation and vascular injury.
Researchers are formulating and evaluating an intranasal oxytocin delivery system to treat post-traumatic stress disorder (PTSD). The project aims to enhance the efficacy and palatability of existing treatments, expanding on prior research that explored using oxytocin to treat alcoholism.
A new machine learning model developed at the University of Michigan uses data from wearable sensors to predict how physical therapists would assess balance training performance. The model was trained with sensor data combined with analysis from physical therapists and predicted patients' balance ratings with nearly 90% accuracy.
A new advance in EEG imaging technology has improved mapping for epilepsy surgery, providing an accurate and non-invasive method. Pathological HFOs were found to be the most accurate biomarker for identifying epileptogenic brain regions, allowing for precise localization of seizure onset.
A new generation of brain-computer interface offers high-throughput information link to and from the brain, transforming treatment possibilities for neurological conditions like epilepsy and ALS. The single silicon chip implant is orders of magnitude faster and smaller than today's state-of-the-art devices.
Researchers at Penn State are developing a small, durable ventricular assist device (VAD) specifically designed for young children with heart failure. The PSU Child VAD aims to provide long-term support while waiting for a heart transplant, improving quality of life and outcomes.
Researchers at Science Tokyo have developed a tunable deterministic lateral displacement (DLD) cell-sorting platform using poly(N-isopropylacrylamide) hydrogel arrays. The device sorts cancer cells of defined sizes from blood samples with high-resolution size-based sorting, offering a promising tool for biomedical applications.
Researchers at NYU Tandon have developed a new algorithm that dramatically speeds up the reconstruction of microwave images, allowing for real-time diagnostic capabilities. This breakthrough could enable portable tools for stroke detection and breast cancer screening in low-resource settings.
The new PLAMseq technique enables simultaneous analysis of chromatin-associated proteins and their location in the genome, opening up new avenues for researching human diseases. This breakthrough could lead to a better understanding of epigenetic mechanisms underlying diseases such as cancer and neurological disorders.
A new organ-on-a-chip platform recapitulates age-dependent immune responses, allowing for more accurate testing of cancer vaccines in older adults. The platform reveals functional differences in immune responses between young and old lymphocytes, which are not detectable with traditional 2D cultures.
Researchers have created magnetic microcatheters for precise delivery of drugs and cells in reproductive medicine. The catheters can navigate complex anatomical pathways without damaging tissue due to their controlled movement.
A new study warns that delayed climate mitigation could lead to a sharp decline in the social cost of carbon, eroding global motivation for renewable energy adoption. The research reveals that if action is delayed until after 2050, damages may near 30% of GDP and the likelihood of limiting warming to 2°C falls below 10%.
A new study evaluates the ecological use of reclaimed water, identifying key dimensions of indicators for pollution level, purification process, sensory quality, and nature proximity. The authors propose a holistic framework to address these impacts and develop differentiated safety standards for toxins, nutrients, and pathogens.
A study published in Energy & Environment Nexus highlights the benefits of biochar in semi-continuous anaerobic digestion systems treating food waste. Biochar enhances hydrogen and methane production, stabilizes pH, and promotes microbial resilience, making it a practical and cost-effective additive for improving TPAD performance.
Researchers at Rice University have developed a way to make serum markers more sensitive by editing them inside the bloodstream, enabling clearer observation of gene-expression changes in the brain. This approach could lead to more precise diagnostic capabilities using simple blood tests.
Researchers develop direct regeneration approach to restore high-nickel lithium-ion battery cathodes, extending lifespan and improving energy density. The new method uses a LiOH-LiNiO3-lithium salicylate eutectic salt system to repair structural integrity and compensate for lithium loss.
A new study found that combining scientific inquiry with practical invention enhances both efforts, leading to more novel and influential work. Researchers who publish and patent simultaneously produce results that are more highly cited and impactful than those who only focus on one activity.
Scientists at Institute of Science Tokyo have developed an artificial metalloenzyme-based platform that enables dynamic control of artificial membranes, mimicking the behavior of natural biological membranes. The researchers successfully induced phase-separated domain disappearance and membrane division in artificial membranes using a ...
The UBC robotic platform helps scientists understand how the brain keeps us standing by mimicking delays in sensory feedback. By tweaking forces and adding short delays, the robot reveals that our sense of space and time work from the same playbook.
Researchers developed a non-invasive spinal stimulation system that bypasses the lesion site and strengthens preserved spinal circuits. This approach enables paraplegic patients to regain bilateral stepping control and improve step length and cadence.
An international team led by Lehigh University researcher Hannah Dailey is building predictive models to understand and eventually prevent bone healing complications. The team aims to incorporate biological differences into the model, using a library of imaging data from Switzerland's AO Research Institute Davos.
A team of researchers from Texas A&M University has developed a new method to give damaged cells new mitochondria, restoring energy output and cell health. The technique uses nanoflowers to boost stem cells, which then transfer their surplus mitochondria to injured neighbors.
Researchers at Baylor College of Medicine discovered a natural mechanism that clears amyloid plaques from the brains of mouse models with Alzheimer's disease, preserving cognitive function. Increasing Sox9 production triggered astrocytes' ability to remove toxic plaques, suggesting a potential astrocyte-based therapeutic approach.
A new algorithm developed by researchers at North Carolina State University can optimize the movement of robotic prosthetic devices and help users exhibit a more natural walking pattern. The algorithm improves hip range of motion and reduces lower back pain for all five study participants.
A simplified intelligent modelling platform online (SIMPO) has been developed to enable everyone to use professional-grade wastewater treatment modelling. SIMPO automates complex tasks, provides a practical tool for designing and optimizing processes, and offers an intuitive interface for students.
Researchers at Tulane University discovered a new nerve cell signaling mechanism that can turn on pain signaling after injury, potentially leading to safer treatments. The discovery of enzyme vertebrate lonesome kinase (VLK) offers a new way to influence cell behavior and could simplify drug development.
Researchers identified six major genetic groups, including the small-leafed sinensis and five broadleaf assamica populations from India, Indochina, and Yunnan. The study provides a genetic roadmap for global tea conservation and breeding, defining clear population boundaries and uncovering underused germplasm.
The National Institutes of Health has awarded a $2.5 million Phase II Small Business Innovation Research (SBIR) grant to Case Western Reserve University to develop medical technology that can track specific cells in the body, including cancer cells. This technology aims to enhance the ability to locate therapeutic cells or diseased cells.
Researchers at Virginia Tech's Fralin Biomedical Research Institute are studying how fluid flow contributes to the spread of glioblastoma tumors. They will use focused ultrasound and advanced MRI techniques to build a map of fluid flow in the whole brain and test the effectiveness of drug delivery.
A new study has discovered that cancer cells use different strategies to move through tight tissue gaps, with fibrosarcoma cells being more flexible and deformable. This flexibility allows them to squeeze through narrow gaps more efficiently, but does not affect the direction of their movement.
The 2025 Tata Transformation Prize recognizes Padubidri V. Shivaprasad's epigenetic engineering for climate-resilient rice, Balasubramanian Gopal's sustainable bio-manufacturing platform using E. coli bacteria, and Ambarish Ghosh's cancer-targeting magnetic nanorobots.
Researchers created a miniaturized replica of carotid arteries using 3D printing, mimicking the geometry and fluid dynamics of human blood vessels. The model revealed that platelet movement is crucial in blood clot formation, and high stress on blood vessels triggers significant platelet activity.
Engineers from the University of Rochester's Department of Biomedical Engineering are studying how cells interact mechanically with the extracellular matrix to build tissues and organs. The study aims to shed light on developmental diseases, such as cancer and failed wound healing, which involve distorted principles during development.
A new heart monitoring system featuring dry 3D-printed electrodes and AI software can diagnose up to 10 types of arrhythmias, reducing testing time and medical waste. The system's reusable design improves patient comfort and compliance during long-term monitoring.
Researchers have successfully engineered functional brain-like tissue without animal-derived materials, opening doors to more controlled and humane neurological drug testing. The new material functions as a scaffold for donor brain cells and can be used to model traumatic brain injuries or neurological diseases like Alzheimer's.
Researchers have developed an innovative antibody-based enzyme switch called 'Switchbody', which is activated upon antigen binding. The switch's mechanism relies on a 'trap-and-release' process, offering new opportunities in diagnostics and therapeutics.
A new biomimetic mRNA delivery platform improves PTEN expression levels in patients with colorectal cancer. The system boosts precision immunotherapy by targeting tumors and evading the immune system.
Researchers at UGA engineered a live bacterium to deliver Levodopa steadily from the gut to the brain, alleviating motor deficits in models of Parkinson's disease. This breakthrough could lead to fewer pills, steadier symptom control, and better quality of life for patients.
Matricelf is manufacturing the world's first engineered nerve tissues for paraplegics, aiming to enable patients to walk again. The company partnered with Tel Aviv Sourasky Medical Center (Ichilov) to produce the implants in cleanrooms, meeting regulatory requirements.
Researchers have summarized recent breakthroughs in theranostic nanomaterials, engineered nanoparticles that can both diagnose and treat TBI. These materials can deliver drugs precisely where damage occurs while monitoring biological changes inside the brain.
Researchers developed a 'humanized' model of aortic valve calcification, enabling testing of potential treatments. The breakthrough could lead to new therapies to stop or reverse calcium buildup, improving outcomes for people with heart disease.
Researchers have developed a new surgical instrument called the CAP-LIFT cannula that completely transforms arthroscopic procedures in the hip region. The device solves existing problems with limited space and allows for easier maneuverability of tools, reducing complications and recovery time.
A new study by Carnegie Mellon University's Wood Neuro Research Group uses advanced brain imaging and a digital visualization tool to better understand how pain is processed in the brain for people with sickle cell disease. The team found that patients had reduced connectivity across key brain networks linked to pain perception, partic...
Researchers at TUM have developed a method to transform stem cells into bone cells using nanorobots that exert external pressure on specific points in the cell wall. This process can be completed within three weeks and has the potential to produce cartilage and heart cells as well.
Scientists from Delft University of Technology have developed living materials that can detect disease biomarkers, catalyze environmental pollutant breakdown, and function as self-healing composites. The materials are made by embedding bacterial spores in a protective barrier and can be programmed to perform specific tasks.
The partnership designates JMIR Bioinformatics and Biotechnology as the official journal of MCBIOS, ensuring high-visibility publication of cutting-edge bioinformatics research. The agreement also provides benefits such as a discount on article processing fees and virtual education and training for MCBIOS members.
Researchers developed a novel exoskeleton CASIA-EXO with subject-adaptive control, enabling efficient motor relearning and enhancing neural plasticity. The system uses intention-based trajectory planning and performance-based intervention adaptation to individualize training trajectories and intervention levels.
A swarm of miniature magnetic soft robots, inspired by fish schools, can coordinate their movements to deliver targeted drug therapy to diseased tissue. The robots can navigate through narrow passages and adapt their shape to conform to the lesion's boundaries for optimal drug delivery coverage.
Researchers aim to identify new neurobiological factors for potential intervention in AUD, including a connection between endogenous retroviruses (ERVs) and neuroinflammation. The study seeks to investigate ERV expression and genotypes in AUD pathophysiology using innovative bioinformatics tools.
Researchers uncover tandem allosteric effect enabling efficient deacetylation of proteins by Sir2, a key enzyme for biological processes. This finding reveals new target for modulating Sir2, potentially leading to novel cancer treatments and therapeutic applications.
Recent research in pathological foundation models has demonstrated robust representation learning capabilities and generalization performance. These models enable multi-task transfer with minimal data, significantly enhancing clinical utility and generalizability.
The researchers developed a chromatic filtration strategy to narrow the emission spectrum of mechanoluminescent materials, resulting in high spectral resolution and reduced noise. The new technology has significant potential for applications such as wearable sensors and healthcare motion monitoring.
A recent study published in Chinese Medical Journal reveals that dihydroartemisinin upregulates CHAC1 through H3K9 acetylation modification, inducing ferroptosis in hepatic stellate cells and suppressing liver fibrosis progression. This discovery identifies molecular targets for developing new anti-fibrotic drugs.