Articles tagged with Biomedical Engineering
The partnership creates a stable, high-impact venue for MCBIOS members to publish their research, particularly the output from the Society's annual conference. The designation of JMIR Bioinformatics and Biotechnology as the official journal provides maximum visibility for cutting-edge work in bioinformatics and computational biology.
Researchers at the University of Missouri are exploring the use of extracellular vesicles to target lung cancer. By manipulating these tiny messenger particles, scientists can deliver specific instructions to kill cancer cells while sparing healthy ones.
A team of Pitt engineers has created self-powered spinal implant technology capable of transmitting real-time data from inside the body. The innovation utilizes new human-developed composites known as metamaterials to harvest energy and transmit signals wirelessly.
Researchers developed a generative AI model, BIGE, to generate optimal motions for athletes to avoid injuries and aid in rehabilitation. The model can produce realistic videos of motions that athletes can mimic during training or execute while injured.
Researchers developed a nanoparticle system combining lenalidomide and melarsoprol to activate the cGAS-STING pathway, promoting immunotherapy for HCC. The combination therapy significantly reduced tumor growth and improved survival in mouse models.
Research on per- and polyfluoroalkyl substances (PFASs) in drinking water has evolved through three distinct phases, with a focus on monitoring and treatment challenges. The study reveals growth in research, with cumulative publications expected to reach 7,689 by 2030.
The Stowers Institute has appointed its first AI Fellow, Sumner Magruder, to harness the potential of artificial intelligence in biological research. He will collaborate with researchers to design new algorithms and unlock insights from large datasets.
Researchers used boron isotope fingerprinting to track the release of boron from two glass compositions. The findings show that the formation of a protective altered layer controls long-term contaminant release, with magnesium-driven secondary mineral precipitation enhancing dissolution rates.
Researchers at FAU Engineering have developed foot-mounted wearable sensors and a 3D depth camera that accurately measure how people walk, even in busy clinical environments. The study findings reveal that these technologies match the accuracy of traditional tools but are more scalable, remote, and cost-effective.
A team of researchers has proposed a novel ultrathin flexible sensor inserted endovascularly to detect Type-I endoleaks with maximum rupture risk. The sensor is robust enough to withstand dynamic processes and exhibits long-term stability and functionality.
A team of researchers developed a battery-free wearable patch that measures bioimpedance to detect skin lesions, distinguishing between healthy and abnormal skin. The patch's effectiveness was tested on 10 volunteers, showing significant differences between healthy and suspicious moles.
Boston University researcher Brian Cleary has been awarded a five-year, $2.25 million NIH grant to investigate how gene expression changes over time in single cells. His project aims to develop new computational-experimental approaches to track RNA velocity vector fields and deepen understanding of cell physiology.
Researchers at Cincinnati Children's propose a unified approach to understand blood cell formation, identifying rare cell populations and gene regulatory networks. This breakthrough advances targeted therapies and stem cell engineering.
Researchers developed a non-destructive tool for evaluating loblolly pine disease resistance, achieving 81.5% training accuracy and 68.7% testing accuracy with NIR spectroscopy. The study demonstrates the potential of vibrational spectroscopy to transform forestry phenotyping and precision forestry.
A Moroccan ICU study shows that the plethysmographic perfusion index can help identify fluid responsiveness in critically ill patients with acute circulatory failure non-invasively. Two-thirds of patients were fluid responders, and PPI correctly identified responders with 70% sensitivity and 82% specificity.
Researchers from USC Neurorestoration Center and Caltech created a simple, noninvasive device using laser technology to measure brain blood flow. The tool has already been tested with humans in small proof of concept studies demonstrating its utility for assessing stroke risk and detecting brain injury.
Researchers have identified 57 unique proteins in urine that can indicate active damage to the kidneys, enabling non-invasive monitoring of lupus nephritis. This breakthrough could transform diagnosis and treatment for millions worldwide affected by systemic lupus erythematosus.
University of Missouri researchers are helping farmers prevent disease outbreaks by teaching biosecurity practices, such as hand sanitizing and wearing farm-dedicated shoes. They also provide guidance on safe composting methods to dispose of dead livestock, reducing the risk of disease spread.
Researchers discover that gray hair may be a result of a natural defense mechanism against cancer, where damaged stem cells undergo senescence-coupled differentiation, leading to graying. In contrast, bypassed stem cells can expand clonally and lead to tumor development.
A new study by Texas A&M University Health Science Center reveals how TFE3 oncofusions hijack RNA to build liquid-like hubs that promote cancer growth. The researchers also created a molecular switch to dissolve these hubs, cutting off tumor growth at its source.
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
Rebecca Richards-Kortum has been elected to the National Academy of Medicine for her major contributions to global health. She created low-cost, lifesaving technologies for underserved communities, transforming health systems worldwide through her innovations in cervical cancer diagnostics and neonatal care technologies.
A new study from the University of Kansas found that football practices can be up to 40% more physically demanding than games, with defensive backs running farther distances. The research used GPS technology to measure training loads and provide insights for coaches and trainers to design optimal practice schedules.
Scientists found a promising candidate, pleiotrophin, which is essential for brain development and function; restoring it may improve brain circuits in individuals with Down syndrome and other neurological diseases. The study's findings suggest using modified viruses to deliver the protein directly into cells could lead to new treatments.
Researchers used miniature human nose models to study how different bacteria interact with the lining of the nose. The study found that all three bacteria colonized the model without causing significant damage, triggering immune responses and reducing inflammation.
Researchers at Binghamton University created a new technique for engineering vascular systems using nanotubes, which improved blood distribution and supplied cells with nutrition and oxygen. The technology has potential applications in treating tumors or neurodegenerative diseases.
A large-scale study has identified hundreds of new viruses living inside bacteria in the human gut, which could be used to reshape the gut microbiome. The discovery provides a new approach to studying the gut microbiome and its influence on various diseases.
A TTUHSC researcher has been awarded a $198,822 CPRIT grant to investigate Integrin Subunit Alpha-V as a therapeutic target in ALT-dependent osteosarcomas. The goal is to develop a new drug to treat this difficult-to-treat cancer type.
A new study by University of Barcelona researchers describes a strategy to enhance neuronal regeneration and neuroplasticity using brain-derived neurotrophic factor (BDNF) combined with stem cell-based cell therapies. This approach has the potential to treat neurodegenerative diseases or brain injuries.
Researchers at Cincinnati Children's and Roche developed a patient-specific, immune-competent liver model to predict which drugs cause immune reactions. The miniaturized liver system built from stem cells and a patient's own immune cells reproduces hallmark signs of immune-mediated liver toxicity.
Researchers developed a more accurate cough-detection model using wearable health monitors' audio and movement data. The new model can distinguish between coughs and nonverbal sounds, improving the accuracy of respiratory disease tracking.
Researchers used advanced 3D canopy reconstruction to study forest adaptation to climate extremes. Thinning improves canopy light availability, boosting carbon uptake even under drought, while reduced rainfall suppresses photosynthetic performance.
The study demonstrates that combining LiDAR, multispectral, and thermal infrared imaging with ensemble learning significantly enhances prediction accuracy for aboveground biomass estimation. This scalable framework supports precision agriculture, phenotyping, and environmental monitoring.
Researchers at UC Davis discovered how desmosomes, which stick cells together, respond to mechanical stress. They found that the intermediate filaments transmit forces to a desmosome protein, causing it to open up and expose a site for signal transmission.
University of Michigan researchers propose a technique called Dynamic Sensor Selection to identify disease biomarkers. The approach, which applies control theory and observability principles to biological systems, has been shown to pinpoint biomarkers at each time point and reduce data complexity.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
Researchers found that a high-fat, low-carb ketogenic diet can improve brain health and stop or slow cognitive decline in individuals with the APOE4 gene. This study suggests that precision nutrition tailored to an individual's genotype, gut microbiome, gender, and age may be more effective than a one-size-fits-all approach.
Researchers at Flinders University developed a dual-function biomaterial that combats persistent infections and promotes bone regeneration. The new implant material, embedded with silver-gallium liquid metal nanoparticles, offers sustained antimicrobial protection while actively supporting bone healing.
Researchers use microchips with human tissue to study brain damage caused by sepsis and neurodegenerative diseases, finding that the blood-brain barrier breaks down under stress. The technology also reveals how pericytes support the barrier and may lead to new treatments for preserving or introducing these cells.
Researchers developed a new control algorithm that enables powered knee prostheses to mimic natural human motion, reducing tripping risks and strain on users' bodies. The study showed significant improvements in activities of daily living, such as sitting, standing, walking, and climbing stairs.
A large-scale study uncovered a strong connection between osteoporosis and rotator cuff tears, finding that individuals with osteoporosis are 1.56 times more likely to suffer an RCT. The study also identified common genetic variants influencing both conditions, suggesting a possible biological explanation for the link.
Researchers at UBC have successfully transplanted an enzyme-converted kidney into a brain-dead recipient, showing promise for universal donor organs in transplantation. The breakthrough uses special enzymes to remove blood-type antigens, making it possible to use mismatched organs from deceased donors.
Engineers at the University of Utah create a synthetic antifreeze protein inspired by polar fish, demonstrating its effectiveness in inhibiting ice crystal formation without toxicity. The innovation has potential applications in extending shelf life of frozen foods and improving storage of biologics.
Researchers at UCSB have created an algae-based gel as a platform for studying mammary epithelial cells, which can transform into cancer cells. The gel supports the development of normal mammary gland tissue and can be modified to direct cell growth, offering new insights into how cancer develops.
Researchers at The Hebrew University of Jerusalem have developed a binder-free method for 3D printing silica glass using light to trigger a chemical reaction. This breakthrough enables custom, high-performance glass components that were previously impossible to manufacture.
A new test delivers results in under an hour without specialized lab equipment, enabling 'screen-and-treat' strategies to save countless lives. The portable, battery-operated device is projected to cost less than $8 each, making it ideal for low-resource settings.
A study published by TTUHSC researchers found that the blood-brain barrier remains intact in a commonly used mouse model of Alzheimer's disease, suggesting that drug delivery strategies may need to be redesigned. The discovery challenges long-standing assumptions about the impact of Alzheimer's on the brain's protective shield.
Researchers at Carnegie Mellon University's Ren lab have developed AggreBots, microscale living robots made from human lung cells that can be controlled to deliver therapeutic or mechanical interventions. The biobots use cilia, nanoscopic hair-like propellers, for movement and can be programmed to perform specific tasks.
Researchers developed a technology combining AI analysis with optogenetics to diagnose Parkinson's disease in mice. The AI-predicted Parkinson's disease score exhibited significant differences from controls, proving sensitive in assessing severity.
Scientists introduce a new way to control when drugs are active or inactive in the body, potentially developing safer medicines. The technology was applied to create improved molecular sensors, including a rapid coronavirus sensor that responds about 70 times faster than previous protein-based tests.
The research team developed multifunctional nanocomposites that demonstrate excellent tumor-targeting capability through the EPR effect. Irradiation with near-infrared laser light achieved multidimensional therapeutic effects, including complete elimination of transplanted mouse cancers within 5 days.
The Emory BioFoundry Institute is investing in TopoDx, a MedTech startup developing rapid antimicrobial susceptibility testing. This technology addresses the growing threat of antibiotic resistance and aims to improve patient outcomes. With EBFI's support, TopoDx plans to accelerate towards FDA clearance and commercial deployment.
A new study finds that over 50% of small-molecule drug patents this century are connected to NIH-backed research that would likely be cut under a 40% budget reduction. This highlights the significant impact of federally funded research on the development of life-changing medicines.
Professor Lim Chwee Teck, Director of NUS iHealthtech, has been elected an International Fellow of the Royal Academy of Engineering for his pioneering research in biomedical engineering and wearable technologies. His work on disease diagnosis and therapy has translated into impactful healthcare solutions through start-ups.
Duke University researchers discovered that inhibiting an enzyme involved in iron regulation makes cancer cells vulnerable to cell death. By targeting STK17B kinase, they reactivated ferroptosis and increased the effectiveness of conventional therapies against multiple myeloma.
A new 3D imaging technique combines intensity diffraction tomography with adaptive optics to track subcellular structures over extended periods. This approach achieves high spatiotemporal resolution and molecular specificity, enabling the study of cellular dynamics.
Researchers at CU Boulder have developed a new method for creating human rabies vaccines that are stable at high temperatures and can be stored in a dry powder form. This innovation addresses the storage challenges faced by developing countries, where traditional vaccines often require refrigeration or specialized cold storage equipment.
Researchers at RMIT University have created a 3D-printed diamond–titanium device that can harvest energy from flowing liquid and receive wireless power, paving the way for smarter, safer implants. The innovation combines semiconductive diamonds with metallic titanium to create a structure that is both lightweight and electrically active.
Researchers have created a new class of lipid nanoparticles (LNPs) with complex internal arrangements, expanding their potential for carrying small-molecule drugs, proteins, metal ions, and mRNA. The breakthrough offers flexibility in designing delivery systems for different therapeutic molecules.
A research team developed a pipeline using pre-trained large language models to unify radiology and pathology reports, achieving high accuracy in tumor presence and stability. The system also predicted survival outcomes without additional training, distinguishing high-risk from low-risk groups.