Articles tagged with Biomedical Engineering
Bonn researchers reduce cardiac arrhythmia after heart attacks by using gene therapy to overexpress connexin 43 in fibroblasts of cardiac scar tissue, leading to improved electrical connection between cells and reduced arrhythmias.
Researchers developed an AI platform to design proteins that arm immune cells to attack and kill cancer cells. The method reduces the process from years to just 4-6 weeks, offering a new approach to precision cancer treatment.
Researchers have developed a mechanical adhesive device that can attach to soft surfaces underwater, inspired by the hitchhiking sucker fish. The device uses pressure-based suction and has enhanced adhesion capabilities, making it suitable for delivering drugs in the GI tract or monitoring aquatic environments.
Researchers adapted optical coherence tomography (OCT) to visualize tiny structures in the human inner ear, correlating fluid levels with a patient's degree of hearing loss. The findings may help clinicians diagnose and treat hearing loss more quickly and effectively.
The article highlights the need for improved sepsis diagnosis, personalized treatment, and innovative trial designs. It advocates for a multifaceted approach integrating timely diagnosis, tailored therapy, and equitable implementation to tackle the global burden of sepsis.
Researchers developed a high-throughput phenotyping pipeline to analyze maize root development across genotypes, revealing extensive variability in root morphology and transcriptional profiles. Transcriptomic analysis identified thousands of differentially expressed genes related to hormone signaling, stress response, and cell wall org...
Researchers at MURR have optimized Terbium-161 for radiopharmaceutical use, enabling targeted destruction of cancer cells with high-energy electrons. The breakthrough could add extra therapeutic effectiveness to existing treatments without requiring new drug development.
A study published in Journal of the Mechanical Behavior of Biomedical Materials found that wrinkled skin is caused by its tendency to buckle under pressure due to age-related changes in its mechanical properties. As people age, their skin becomes more prone to wrinkles as it stretches and contracts in different directions.
Bioengineers at Harvard John A. Paulson School of Engineering and Applied Sciences have developed a computational model called BrainFlow that simulates cerebrospinal fluid flow in the presence of shunt implants, providing insight into optimal shunt design and placement for hydrocephalus patients.
The study explores the technological evolution of surgical robots and their current clinical applications. Surgical robots have addressed challenges in operating within small anatomical spaces, improving medical efficiency, but also increasing costs and complexity of operations.
A KAIST research team has identified a new molecular mechanism in which alcohol-damaged liver cells increase reactive oxygen species, leading to cell death and inflammatory responses. They discovered that Kupffer cells act as a 'dual-function regulator' that can either promote or suppress inflammation through interactions with liver ce...
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
Recent advances in biofabrication and biomedical electronics have led to the development of biohybrid-engineered tissue (BHET) platforms, turning passive constructs into intelligent systems. These platforms show promise in diverse applications, including brain organoids and cardiac tissues, blurring the line between biology and machine.
Scientists have discovered that microglia play a crucial role in regulating blood flow to the brain, and targeting them may improve blood flow deficits. The study suggests that restoring microglia function could prevent or reverse memory-stealing diseases caused by lack of adequate blood flow.
Researchers aim to understand the role of blood vessels in traumatic brain injuries and their link to age-related cognitive impairment. They plan to use mice with a mutation in the UCH protein to explore how blocking this protein affects brain sugar processing and neurovascular function.
Researchers at Kyoto University have created a microphysiological system capable of simulating different regions of human lungs, including the airway and alveoli. This breakthrough enables accurate modeling of viral pathologies and holds promise for personalized treatment of respiratory diseases such as COVID-19.
A new deep learning model enhances handheld 3D medical imaging by automatically tracking transducer motion without external sensors. The model produces more realistic 3D US images and can reconstruct blood vessel structures using ultrasound and photoacoustic data.
Researchers at RCSI University of Medicine and Health Sciences have developed a 3-D printed implant that delivers electrical stimulation to injured areas of the spinal cord, enhancing nerve cell growth. The study has shown promising results in lab experiments and may enable new medical devices for traumatic spinal cord injuries.
Researchers at Texas A&M University have developed a new type of adhesive that could improve the comfort and safety of wearable medical devices. The adhesive, made from polyelectrolyte-complex coatings, is water-based and has been shown to match the strength of commercial-grade adhesives while reducing skin irritation.
Researchers have developed a 3D bio-printed model of lung tissue that closely mimics natural complexity, enabling better testing of respiratory diseases and drug development. The model can be adapted to include additional cell types or patient-derived cells, making it a powerful tool for personalized medicine and disease modeling.
Scientists at the Stowers Institute for Medical Research identified two distinct genes that regulate regeneration of sensory cells in zebrafish. The discovery may guide future studies on hearing loss and regenerative medicine in mammals, including humans.
Researchers developed a new imaging approach combining two-photon microscopy and advanced algorithms to improve resolution and reduce noise. This allowed them to clearly see details smaller than 250 nanometers, enabling real-time observations of mitochondrial behavior in live animals.
Researchers have engineered a monoclonal antibody that blocks allergic reactions against common pollen when applied inside the nose of mice, providing new hope for hay fever sufferers. The treatment, known as a 'molecular shield,' acts immediately and locally at the lining of the nose to prevent IgE antibodies from being activated.
The new agreement provides unlimited opportunities for open access publishing in JMIR's journals, eliminating article processing charges and streamlining the publication process. This partnership underscores TU/e's commitment to advancing open science and increasing research impact.
Researchers at MIT developed an implantable device that can store glucagon to counteract hypoglycemia, a life-threatening condition for people with Type 1 diabetes. The device, about the size of a quarter, contains a small reservoir made of 3D-printed polymer and can be triggered remotely or automatically by a sensor.
Researchers have identified a hidden molecular mechanism involving two proteins that allows tumors to resist treatment. A new gelatin-based nanoparticle has been developed to shut down both proteins simultaneously, showing promising results in early studies with mice.
Researchers found that human stem cells can differentiate into bone cells simply by being squeezed through narrow spaces. This discovery could lead to the development of simpler and safer regenerative therapies by using physical signals instead of chemical cues. The study's findings have broader implications, including potential applic...
A new technology combines the coffee-ring effect with plasmonics and AI for rapid diagnostics, offering highly accurate results in under 12 minutes. The test can spot diseases like COVID-19, prostate cancer, and sepsis, making it a game-changer for point-of-care diagnostics.
GeniPhys has received FDA clearance for its self-assembling collagen scaffold, Collymer Self-Assembling Scaffold (SAS), which supports cellular infiltration and vascularization. The technology is indicated for various wound types and anchors a growing intellectual property portfolio with nearly 20 issued or pending patents.
A new computational method combines 4D flow MRI, CFD, and data assimilation to estimate blood flow in brain aneurysms with greater accuracy and efficiency. The approach focuses on the aneurysm region, reducing computational cost while improving flow estimation.
Chihtong Lee's research on retractor blade geometry explores how small design changes can improve patient recovery after spinal surgery. Her work, conducted in collaboration with Baylor College of Medicine, showed that blades with soft, biocompatible coatings significantly reduced tissue stress and postoperative complications.
Researchers from UCLA have developed innovative biomaterial strategies to mimic immunological synapses, enhancing T cell activation rates and long-term efficacy in CAR-T therapy. The approaches leverage flexible interfaces and mechanical properties to promote memory T cell formation and distribution.
A novel fluorescent probe, SLY, has been developed to precisely identify hepatocellular carcinoma tissue using sialylated glycans on the cell surface. The probe outperforms conventional methods by clearly distinguishing tumor margins within liver tissues.
Researchers have developed a fabric-based electrochemical biosensing system that enables autonomous sweat collection and molecular analysis across varied scenarios. The system uses a skin-interfaced stabilized hydrogel electrode to deliver a mild current that activates sweat glands, allowing for real-time health monitoring without rely...
The study proposes a modified ResUNet approach for automated liver segmentation from CT images, achieving high precision and accuracy. The model outperforms traditional methods, demonstrating stable performance in cross-dataset tests.
Researchers at the University of Surrey have identified genes that disrupt the survival of 'zombie' TB cells, which are resistant to antibiotics. By understanding these mechanisms, scientists can develop new drugs that target persisters and shorten treatment regimens.
A new study by University of Missouri researchers found that states granting full practice authority to APRNs significantly improves health outcomes and increases access to care. In contrast, restricted practice laws impose financial burdens on patients and limit APRN autonomy.
Researchers have developed a technique to grow stem cells into single sheets, increasing the secretion of signaling proteins that help repair tissue and regulate the immune system. This new approach could improve stem cell-based treatments for conditions such as heart disease, liver damage, and autoimmune illnesses.
Researchers developed an in-silico meta-analysis tool to determine optimal laser irradiation conditions for treating nevus of Ota. The study found that picosecond laser treatment demonstrated higher efficacy and equivalent safety compared to nanosecond laser treatment.
Researchers at the Wyss Institute have identified vorinostat as a promising treatment for Rett Syndrome using an AI-driven drug discovery process and innovative disease modeling. The findings demonstrate disease-modifying abilities across multiple tissues, offering hope for a potentially curative treatment.
Scientists have developed a miniature device that mimics human bone marrow and immune environment, enabling predictive testing of cancer immunotherapy success in patients. The device recreates three regions of bone marrow where leukemia develops and retains the complex immune environment of the tissue.
Researchers have successfully controlled a dexterous robotic hand using noninvasive EEG-based Brain-Computer Interfaces (BCIs) for individual finger movements. The study demonstrates real-time brain decoding and motor imagery control, paving the way for potential applications beyond basic communication to intricate motor control.
Researchers developed patient-specific Cancer Chips to model esophageal tumor microenvironments, enabling accurate prediction of chemotherapy responses. The approach can rapidly stratify patients into responders and non-responders, paving the way for personalized medicine.
The new centre will investigate neural dynamics, developing novel interventions and devices to improve symptom relief and quality of life for people with brain disorders. It aims to harness neural dynamics for people with conditions like Parkinson’s disease or epilepsy.
Researchers found increased activity in two brain areas when participants reported cognitive fatigue: the right insula and dorsal lateral prefrontal cortex. These areas work together to regulate mental effort, suggesting that external incentives can prompt increased cognitive effort.
UVA Health received two anonymous $25 million estate gifts to support the Paul and Diane Manning Institute of Biotechnology. The institute will develop new treatments for hard-to-treat diseases with a state-of-the-art biomedical research facility expected to drive economic growth in Central Virginia.
A study reveals that ultra-small nanoparticles can induce abnormal protein conformation and have the potential to cause pathological conditions like Alzheimer's disease. The researchers used spectroscopy-based experiments to analyze the interactions between bovine serum albumin and silica nanoparticles.
Researchers from Binghamton University confirm the long-held 'urban myth' that saltwater dries out skin, increasing tissue stiffness and stress. A simple solution to alleviate tightness is taking a shower after coming out of the ocean.
Scientists from Institute of Science Tokyo create photo-switchable binding of DNA nanostructures that generate two distinct directional motions. The research paves the way for innovative fluid-based diagnostic chips and molecular computers.
Researchers at UC Irvine have successfully tested a new replacement heart valve designed for toddlers and young children with congenital cardiac defects. The Iris Valve can be implanted via a minimally invasive catheter, allowing treatment to begin earlier in very young patients.
Scientists have created a novel method to distinguish between healthy and senescent cells using electric fields, marking a fresh start in ageing research. The frequency-modulated dielectrophoresis (FM-DEP) technique is label-free, rapid, and easy to apply, allowing for the characterization of cell type by measuring the cutoff frequency.
Researchers found that intercellular flow plays a major role in tissue response to deformation, affecting organs' adaptability to conditions like aging and cancer. The study's findings could inform the design of artificial tissues and organs.
A Waseda University research team developed a method to measure thermal insulation of bedding systems, considering individual body parts. The study found that relying solely on whole-body insulation is not enough and revealed the importance of optimizing sleep environments for better quality.
A new national guideline provides unified strategies for managing RSV infections in children under five, emphasizing rapid antigen detection, oxygen therapy, and pharmacological treatments. The guideline also supports the use of monoclonal antibodies and recommends non-pharmaceutical interventions to prevent pediatric RSV infections.
JMIR Publications' portfolio of journals now includes 21 titles with a Journal Impact Factor. Several journals saw significant increases in impact factor, including JMIR Medical Education, which debuted with a score of 12.5, securing the top-ranked journal spot in its category.
Researchers at the University of Malaga have identified factors involved in the propagation of toxic protein aggregates, which accumulate in patients' brains. These brain accumulations are formed as a consequence of abnormal folding of soluble proteins and can lead to the spread of disease to different brain regions.
The Fraunhofer Institute's miniaturized quantum magnetometer provides precise measurements of magnetic fields with minimal interference. This technology enables new possibilities in biochemical measurements, microelectronics, and navigation systems, including GNSS-safe navigation without GPS.
A team of scientists from Colorado State University and the University of São Paulo have developed a seismological solution to improve the resolution of ultrasound images for lung monitoring. This breakthrough could lead to improved critical care for patients, including continuous lung monitoring at the bedside. The technique uses seis...
Professor Garry Duffy joins RCSI with a unique combination of institutional knowledge and fresh leadership perspective, focusing on integrating excellence in health sciences education with innovative patient-centred research. He aims to build on the university's heritage by enhancing anatomical education and pioneering research in rege...
A proof-of-concept study shows that chimeric antigen receptors (CARs) can distinguish between tau tangles and various forms of toxic amyloid plaques, two key contributors to Alzheimer's disease pathology. The technology has the potential to deliver therapeutic drugs directly to affected areas of the brain with reduced side effects.