Articles tagged with Biomedical Engineering
A comprehensive review highlights the role of extracellular vesicle-associated RNAs in developing and progressing IBD. EV-RNAs can serve as non-invasive biomarkers for early detection and targets for next-generation therapies, offering new hope for personalized precision treatment.
The clinical guideline emphasizes personalized care, recommending pre-exercise cardiovascular risk assessment and individualized exercise prescriptions. Adults with T2D are advised to engage in at least 150 minutes of moderate-intensity aerobic exercise per week, or a combination of aerobic and resistance training.
Researchers at Osaka Metropolitan University discovered that dragonfly visual protein detects red light similarly to mammals. This finding has potential applications in medical fields relying on red light-sensing, such as optogenetics.
Scientists at NTU Singapore found that glycerol-3-phosphate acyltransferase (GPAT) amplifies α-synuclein toxicity by altering fat metabolism in brain cells. Targeting GPAT activity may offer a new strategy for treating Parkinson's disease.
Researchers at Pohang University of Science & Technology discovered a way to prime skin cells for regeneration before injury, enabling rapid and effective healing. This approach, called mosaic partial reprogramming, reshapes surrounding cells and tissue microenvironment to accelerate wound healing.
Researchers at Terasaki Institute for Biomedical Innovation develop a smart contact lens that monitors intraocular pressure in real time and delivers treatment. The technology has shown promising results in preclinical models and aims to improve quality of life for patients with ocular diseases.
A study comparing two blood purification strategies for septic shock found that both CytoSorbⓇ and oXirisⓇ improved hemodynamic status by reducing lactate levels and vasopressor requirements. However, no significant differences were found in primary outcomes, suggesting comparable clinical benefits.
The Salk Institute will lead an ARPA-H-funded project to develop ultrasound-sensitive protein tools, wearable ultrasound delivery technology, and a translational path to the clinic for major unmet medical needs. The team aims to create a noninvasive therapy for conditions such as peripheral neuropathy.
A team of researchers has achieved a major milestone in developing a new treatment aimed at helping the body repair damaged joints at the source. The experimental treatments have shown promising results in animal models, restoring joint tissue to near-normal levels and significantly reducing pain markers for long periods.
Researchers at NYU Abu Dhabi have developed smart molecules that combine both imaging and therapeutic functions in a single system. The new molecules make tumors visible on MRI scans and help destroy cancer cells simultaneously, providing a safer alternative to gadolinium-based contrast agents.
The Texas A&M biomedical engineering department's scaffolded, inquiry-based biomimicry course has been shown to improve student engagement and imagination competency. Students learn to use nature as a model to solve engineering problems, resulting in breakthroughs in clinical impact and innovation.
A study by Princeton University researchers found that high-fat diets contribute to aggressive breast cancer growth, with tumors fed fatty acids forming hollow appendages. The team's 3D model showed that a ketogenic diet did not provide the expected benefits for this type of cancer.
The study found that cardiac manifestations, primarily electric conduction abnormalities, affect most DM1 patients, leading to life-threatening arrhythmias. However, the researchers discovered that turning off toxic RNA molecules can reverse some physical changes in the heart, but not all, particularly in male mice.
A Waseda University research team developed a nanotube membrane-based injector to directly and reliably manipulate the cytoplasmic composition of living cells. The system successfully transferred cytoplasmic contents, including mitochondria, into target cells with high efficiency and minimal damage.
Researchers developed an immune-capable 'cervix-on-a-Chip' model to study sexually transmitted infections (STIs), enabling a more accurate understanding of these conditions and the potential for better treatments. The model replicated key aspects of human biology, including the cervical microenvironment, microbiomes, and immune system.
A team of researchers at North Carolina State University has created an injectable microgel called B-knob triggered microgels (BK-TriGs) that can help reduce bleeding in infants during surgery. The microgel works by mimicking the mechanical properties of natural platelets, which helps to create fibrin networks and stanch bleeding.
A study reveals CHKA and EGFR cooperate to activate the MAPK pathway, driving glioma progression. CHKA knockdown suppresses tumor growth, while EGFR overexpression rescues this effect.
Researchers discovered that DNA polymerases can generate highly sophisticated DNA sequences from scratch, with some exceeding 85,000 bases. By controlling the reaction conditions and temperature, scientists can steer the composition of the sequences produced.
A new AI chatbot helps patients access retinal detachment advice through personalized, real-time, clinically grounded conversations. The system outperformed leading large language models and includes accessibility features for people with low vision or limited English proficiency.
Researchers created personalized digital twins of patients' hearts to improve cardiac ablation outcomes for life-threatening arrythmias. The approach resulted in faster and more accurate procedures, reducing recurrences of arrythmias and increasing success rates compared to traditional methods.
A team from UNIGE has created a molecular system that distinguishes and neutralises cancer cells with unprecedented precision, paving the way for autonomous, self-regulating drugs. The technology uses synthetic DNA strands to deliver potent drugs only where they are needed, reducing damage to healthy tissue.
The study reveals that chief cells transform into repair cells through three stages, involving self-digestion, gene expression changes, and cell proliferation. The researchers discovered that the enzyme STK38 plays a crucial role in regulating YAP1 activity during paligenosis.
The Robert A. Winn Excellence in Clinical Trials Award Program has partnered with AstraZeneca to support five medical students participating in the Winn Clinical Investigator Pathway Program (Winn CIPP). The program provides immersive training, mentorship, and hands-on experience to prepare students for careers in clinical research.
The PerQdisc procedure, a less-invasive treatment option, preserves the outer part of the disc, maintaining mobility and restoring functionality. Dr. Luis Tumialan's first patient experienced significant pain relief and was able to resume normal activities shortly after the procedure.
The new joint department combines expertise in medical devices, neuroengineering, imaging science, and more to advance biomedical research and translate discoveries into meaningful health advances. The partnership aims to accelerate the translation of discoveries into improvements in human health.
Dr. Yangzhi Zhu has been awarded a prestigious Career Development Award from the American Heart Association to support his research in translational biosensing and organ health assessment. The award aims to develop innovative sensing strategies for improving donor organ condition and supporting better clinical care.
Researchers at University of Michigan Engineering and Michigan Medicine used protein nanoparticles to genetically modify several types of human cells, including liver cancer and immune cells. The goal is to develop a safer method for delivering gene therapies without using modified viruses.
A study found that dentists have a higher prevalence of vision-related problems due to prolonged exposure to artificial lighting. Chronic dental lighting caused retinal damage, disruption of the blood-retinal barrier, and inflammation, ultimately impairing visual health.
A new brain-computer interface (BCI) has been developed that records brain activity from the lateral ventricle, a cerebrospinal fluid-filled cavity deep within the brain. The BCI showed signal bandwidth comparable to standard electrodes, but with superior long-term stability and a reduced immune response.
Researchers identify gut-derived cells as key initiators of autoimmune neuroinflammation in Multiple Sclerosis. The study reveals that intestinal epithelial cells upregulate antigen presentation pathways, leading to the expansion of pathogenic Th17 cells that migrate to the CNS.
Researchers at Baylor College of Medicine have discovered a new approach to cancer treatment by eliminating the gene SRC-3 in regulatory T cells. This eliminates the immunosuppressive action of SRC-3, enabling these cells to trigger an anti-cancer response that eradicates tumors without side effects.
A recent review highlights how immune cells synthesize and release neurotransmitters to modulate immune responses, blurring the boundaries between the nervous and immune systems.
Recent advancements in wireless power and data transfer (WPDT) systems for biomedical implants have led to significant improvements in power transfer efficiency, data communication capabilities, and biosafety. Innovative solutions such as reconfigurable power amplifiers, adaptive delay-compensated active rectifiers, and machine learnin...
PandaClaw automates complex real-time analyses, enabling researchers to discover novel targets and identify new indications through an intuitive natural language interface. The tool accelerates translational medical research by lowering the barrier for biologists to apply AI.
Researchers are developing a comprehensive diagnostic toolkit to detect lymphatic disorders earlier and as part of routine physical exams. The team, led by Dr. Zhenpeng Qin, is working on identifying biomarkers for lymphatic diseases through blood samples.
Researchers developed a novel composite material that combines biochar, carbon nanotubes, and iron carbide, significantly accelerating the breakdown of antibiotics in water. The system achieved up to 15 times higher removal rates compared to conventional materials, while requiring substantially less energy.
A recent study has uncovered a dynamic spleen-to-lung neutrophil axis that operates during antiviral defense, challenging traditional views of pulmonary neutrophil origin. The study found that splenic neutrophils migrate to the lung, replenishing local pools and participating in innate immune defense.
A study published in Nature Microbiology reveals that weaning from milk to solid food in early life reshapes the gut microbiome, training intestinal stem cells to respond better to microbes later in life. This process, known as epithelial immune memory, creates a lasting impression on gut health.
Researchers at Chalmers University of Technology successfully decoded leg movements directly from remaining nerves in people with above-knee amputations. This technology opens the way to future prostheses that feel and act like a natural part of the body, providing users with more control and sensory feedback.
Researchers have developed a low-cost fake drug detector that uses an infrared sensor to track pill dissolution rates. The device can identify legitimate medications from counterfeit ones with high accuracy, making it a valuable tool in the fight against global health threats.
Researchers at TU Graz developed a neuroadaptive VR system that adjusts the intensity of exposure to anxiety levels, optimizing effectiveness in treating arachnophobia. The system uses EEG data and heart rate analysis, providing reliable indicators of stress and anxiety.
The gut microbiota influences the central nervous system (CNS) through neural, immune, endocrine, and metabolic pathways. Dysregulation of this axis is linked to various neuropsychiatric and neurodegenerative disorders, including depression, schizophrenia, Alzheimer's disease, and Parkinson's disease.
Dr. Aliesha O’Raw, Principal Investigator at TIBI and Co-Founder of OnVagus, has been selected for the 2026 ACS BrightEdge Entrepreneurs Program. The program provides mentorship, entrepreneur training, and early-stage investment support to advance cancer diagnostic and therapeutic solutions.
Researchers discovered native fungal species in almond trees that can naturally suppress anthracnose disease, providing a sustainable alternative to chemical fungicides. The study identified Trichoderma viridescens and Neurospora intermedia as promising biofungicide candidates.
Researchers at MDI Bio Lab studied zebrafish, which can form new nephrons and connect them to existing tubules. The team found a coordinated cellular choreography that involves intersecting signaling systems, including the Wnt pathway, to guide the connection. This technique could one day guide human repair of damaged kidneys.
Stanford researchers have developed a novel 'scaffold-free' approach for treating damaged muscles, enabling the delivery of more healing cells to the traumatized area. The approach uses a custom molding technology to create dense muscle tissue in customizable geometric shapes and sizes, allowing for more effective muscle regeneration.
Researchers developed an expert consensus to standardize the use of ultrasound-derived fat fraction for assessing liver steatosis. The study found that UDFF showed strong correlations with histological steatosis grades and MRI-PDFF, demonstrating excellent reliability and robust diagnostic accuracy.
A novel drug delivery system developed by Osaka Metropolitan University improves Paclitaxel absorption by binding to the lipocalin-type prostaglandin D synthase enzyme, enabling selective delivery to cancer tissues. The system demonstrates significant tumor suppression effects even after administration cessation.
A new RNA therapy has been developed to enhance the heart's own ability to protect and repair itself after a heart attack. The therapy, which involves injecting particles into the arm, significantly reduced scarring and improved heart function in lab experiments, offering a potential breakthrough for heart patients.
A Chinese study reports a 100% technical and clinical success rate for robot-assisted brain angiography, with median procedure times 11 minutes shorter than manual angiography. No added radiation or complications were observed, showcasing the feasibility and safety of the YDHB-NS01 system
A new study identifies a previously unknown brainstem pathway controlling hand and arm movements, revealing a multi-stage pathway integrating signals from the cortex, brainstem, and spinal networks. This finding may lead to new therapies for stroke rehabilitation, providing additional targets for neuromodulation treatments.
Researchers have genetically engineered human stem cells that can evade immune rejection while carrying a built-in kill switch to prevent tumour formation. The engineered cells, known as FailSafe-AlloAccept, offer a potentially limitless supply of replacement cells and could serve as a universal cell source for diverse therapies.
Recent advances in photonic nanomaterials and healthcare devices have led to the development of wearable and implantable medical devices. These devices utilize light for precise manipulation of cells and tissues, offering new possibilities for early disease detection, light-based therapies, and personalized precision medicine.
The NRG-LU005 trial found that immunotherapy atezolizumab did not improve survival for patients with limited-stage small cell lung cancer when added to chemoradiation. Twice-daily radiation therapy, however, was associated with improved survival in this population.
Researchers at the Wyss Institute developed DoriVac, a DNA nanotechnology-enabled vaccine platform that induces broad immunity against infectious viruses, including SARS-CoV-2, HIV, and Ebola. The platform produces potent antigen-specific immune responses and is more stable and easier to manufacture than traditional vaccine platforms.
A conductive bioglue was developed to ensure firm adhesion and stable electrical signaling within the human body. It overcomes challenges in connecting damaged tissues or attaching bioelectronic devices, promoting muscle and nerve regeneration and stable implant stability.
A team of researchers from SASTRA Deemed University demonstrates a fiber-based method for compressing mid-infrared laser pulses into ultrashort, low-noise bursts efficiently. The system reduces input power from kilowatts to 80 watts, improving energy efficiency and thermal stability.
Researchers at Brown University have made significant progress in restoring two-way communication across a damaged spinal cord site. Electrical stimulation below the injury site partially restored muscle control in lower extremities, while stimulation above the injury enabled participants to understand their leg position in space. This...
A Mendelian randomization study found that PCSK9 inhibitors may reduce low back pain risk, while HMGCR and NPC1L1 inhibitors showed no association. The study validated known lipid-lowering effects on coronary heart disease risk, providing new insights into PCSK9 pleiotropy.
Researchers optimize interferometric diffusing wave spectroscopy technique to boost weak optical field returning from the brain, achieving over 20x signal to noise ratio. The novel approach provides higher brain sensitivity compared to DCS-inspired approaches and is approximately two orders of magnitude less expensive.