Articles tagged with Biomedical Engineering
Researchers at Duke University developed a new approach to deliver GLP-1 medications orally that maintains efficacy without requiring fasting. The technique uses an elastin-like polypeptide-based delivery system that protects the peptide from stomach acid and releases it in the intestines, bypassing the stomach's destructive acids.
Researchers in Brazil's Cerrado biome found that reducing stream sampling from 11 to 6 transects maintained reliable classification of streams as least-disturbed, moderately disturbed, or severely disturbed. The study suggests a streamlined approach can reduce field time and processing costs while preserving ecological indicators.
The review outlines a comprehensive understanding of the chemokine and receptor network in the tumor microenvironment, introducing a novel 3D targeting framework to guide precision combination immunotherapies. The proposed
Recent advancements in animal models, organoid models, and bioengineered organoids have provided new tools for studying primary sclerosing cholangitis. These models replicate the effects of bile retention and inflammation, enabling studies of disease mechanisms, drug screening, and preclinical evaluation.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
Lanthanide nanoprobes have improved signal-to-noise ratio, enabling ultrasensitive detection of cancer biomarkers and visual identification of cancer cells. The nanoparticles maintain stable luminescence across a wide pH range and in simulated human body fluids, ensuring reliable performance.
A Spanish clinical trial demonstrates the potential of mesenchymal stem cells to reduce inflammation in Recessive Dystrophic Epidermolysis Bullosa (RDEB) patients, also known as 'butterfly skin'. The treatment showed improved symptoms like pruritus, sleep disturbances, and fatigue after receiving infusions.
The journal MedScience aims to integrate cutting-edge insights across medical sciences, focusing on emerging fields like cell therapy, AI-driven drug discovery, and precision medicine. This new platform serves as a dynamic hub for international academic exchange and translation of scientific breakthroughs into clinical practice.
The study found that visual occlusion triggers brain compensation characterized by enhanced functional connectivity between the right precentral and middle frontal gyri. Walking activates multiple sensorimotor pathways to support basic locomotion, and visual occlusion further strengthens this connection as a compensatory mechanism.
High-altitude exposure disrupts the gut ecosystem, leading to dysbiosis, impaired barrier function, and increased intestinal permeability. The gut microbiome influences host energy metabolism, immune responses, and acclimatization capacity, and alterations are linked to diseases such as metabolic disorders and colorectal cancer.
Researchers found that smoking substantially stiffens human lung parenchyma, making breathing progressively difficult. The study provides detailed mechanical data for human lungs, which may improve ventilator design and surgical planning tools.
Researchers at Mizzou's Molecular Imaging and Theranostics Center developed an automated approach to producing the prostate cancer treatment. The new method produces CTT1403 in just 38 minutes, compared to six hours with traditional methods, using a commercially available automated synthesis system.
Researchers discovered that disrupted PTH1R signaling drives abnormal cementum growth and tooth-bone fusion in adult mice, leading to severe dental complications. The study identified the loss of PTH1R signaling as a critical molecular safeguard against excessive cementum formation.
Researchers developed a new class of stretchy bioelectronics that can stick to biological tissue and relieve hypertension while causing less damage to surrounding tissue. The CaroFlex device uses gentle electrical frequencies to modulate the baroreceptor reflex, providing effective treatment for drug-resistant hypertension.
A new study published in the Chinese Neurosurgical Journal found that most basilar trunk artery aneurysms can be treated effectively using endovascular techniques, resulting in encouraging long-term recovery rates. However, larger aneurysms pose higher treatment risks and are associated with complications and poorer outcomes.
Researchers discovered that sea squirts package adhesive materials into nanocondensates, which deliver them to the destination and unpack for use. This mechanism is distinct from mussels' adhesion strategy, providing clues for developing bio-adhesives to assist in seaweed cultivation.
This section explores how recognizing sex as a biological variable and gender as a sociocultural construct can lead to more precise computational models and safer medical technologies. The aim is to foster an equitable and effective biomedical engineering field where technologies meet the needs of all populations.
The PrecisionView device enables clinicians to visualize both subcellular structures and underlying blood vessels across large tissue areas without invasive biopsies. It generates detailed maps of tissue areas spanning several square centimeters and displays results in real-time.
A new study by Technische Universität Berlin reveals that teaching Large Language Models to mimic human intuition and reasoning improves their ability to provide accurate medical care-seeking advice. The 'human reasoning blueprint' approach increased overall accuracy across all models, with significant gains in self-care advice.
Recent advances in medications, devices, and care pathways are redefining heart failure (HF) treatment. Emerging therapies beyond traditional EF silos have demonstrated broad efficacy across LVEF categories.
Researchers create shape-morphing filaments using rotational multimaterial 3D printing, enabling programmable artificial muscles that bend and twist on demand. The breakthrough could accelerate the development of complex technologies such as soft robotics, energy damping, and biomedical devices.
Researchers developed a novel ratiometric SERS platform using dual bioprobes for stable detection of circulating tumor cells (CTCs). The platform achieved a low limit of detection, minimal relative standard deviation, and high cell viability, offering a new strategy for sensitive CTC detection.
Researchers describe how oral nanomaterial formulations overcome conventional drug limitations in gastrointestinal disease treatment. Non-metallic nanomaterials, such as selenium nanoparticles, show better biocompatibility and tunable biodegradability.
Baylor College of Medicine researchers found that the brain can process sound and language without conscious awareness, even under general anesthesia. Neural signals predicted upcoming words in a sentence, mirroring predictive behavior in artificial intelligence.
Researchers have developed a new class of biodegradable, all-metal microrobots that can penetrate tissue and deliver medications without causing damage. These microrobots demonstrate both strength and safety in testing on mice, paving the way for potential applications in drug delivery and biopsy procedures.
Scientists have discovered a protective brain pathway that preserves dopamine-producing neurons and reduces degeneration in female models with Parkinson's disease. The study suggests that strengthening this pathway could help slow the progression of the disease, offering new potential for treatment.
A new study published in Eye and Vision finds that one drop of low-dose atropine can produce daylong effects in managing myopia. The researchers found that the drop showed clear changes in pupil size and focusing ability, but no short-term structural effects on the eye.
Researchers identify mechanical stability as a crucial factor in antibody effectiveness against SARS-CoV-2. The study found that conventional antibodies distribute mechanical load unevenly and that viral mutations influence both binding affinity and mechanical resistance.
Researchers at Nagoya University have developed a new method called SMART that accelerates enzyme evolution and reduces costs by accelerating the selection period from weeks to days. The system uses mRNA display, next-generation sequencing, and bioinformatics to identify superior enzyme variants.
Researchers developed a new method to identify cellular features supporting metastatic cancer growth, revealing an unexpected driver of immune suppression in bone metastasis. Estrogen receptor alpha-activated macrophages play a key role in immunosuppression and tumor progression.
Artificial platelets have been developed that remain stable and effective after a year at room temperature and two months at high temperatures. This technology could enable direct injection of synthetic platelets into bone marrow to treat life-threatening bleeding in remote areas or disaster zones.
Researchers aim to determine the connection between circulating lipoprotein (a) and calcific aortic valve disease, with a focus on biomechanics and early detection. They will also explore how mechanical forces influence disease progression and treatment.
The new consensus statement provides updated guidance on CIED lead management, including extraction and management of traditional devices and newer technologies. The recommendations aim to reduce clinical challenges and morbidity within a rapidly evolving technological landscape, ensuring better quality of life for patients.
Researchers developed an AI-powered methodology to identify and count target viruses more efficiently than previous techniques. The new approach uses electrochemical impedance spectroscopy and machine learning to separate signals from noise, enabling quick and accurate readings across a wide range of titers.
MIT researchers have developed an ultra-efficient microchip that can bring post-quantum cryptography techniques to wireless biomedical devices. The chip includes built-in protections against physical hacking attempts and is more than an order of magnitude more energy-efficient than prior designs.
Researchers have developed a universal toolkit for editing bacterial DNA in 15 diverse species, including human pathogens and fast-growing biotechnology organisms. The technology uses retrons, an immune system that produces DNA, to efficiently modify genes, with varying success rates across different species.
Researchers mapped how Sox9 guides cartilage formation in mouse embryonic limbs, finding that it dynamically targets different genes depending on developmental timing and cell type. The study provides a foundation for understanding skeletal development and may contribute to future research on bone and cartilage diseases.
Researchers develop a nature-inspired hybrid material that produces high-quality therapeutic proteins with nearly tenfold higher efficiency than traditional methods. The material's unique design enables it to adapt to different environments, alleviating hypoxic stress and activating cellular functions.
A research group developed an optimized signal transmission system for implantable medical devices, improving accuracy and strength of wireless signals. The approach uses ultra-wideband communication to coordinate multiple implants and reduce signal distortion, enabling more effective healthcare applications.
Researchers discovered a biomarker that can predict disease progression and mortality in patients with severe heart failure. Mid-regional pro-adrenomedullin (MR-proADM) levels are associated with greater disease severity, mortality, and heart failure events.
A recent review highlights how AI enables precision treatment, continuous monitoring and individualized prognostic modeling for heart failure patients. AI integrates large-scale structured electronic health records and multimodal imaging to characterize cardiac structure and function, enhancing diagnostic accuracy.
Researchers at Kyoto University found that chaotic component of heartbeat variability is sensitive to cognitive brain activity, providing a new indicator of brain-heart interaction. Chaos-based measures revealed clear and reproducible changes associated with task engagement, contrasting with conventional HRV indices.
The Alliance for Clinical Trials in Oncology has several active trials specifically designed to help people with head and neck cancers. Trials include testing high-dose prophylactic gabapentin to prevent opioid use during treatment, as well as immunotherapy with nivolumab and cabozantinib for mucosal melanoma and nasopharyngeal carcino...
A University of Texas at Arlington researcher is leading a study investigating cardio-sarcopenia, the combined loss of heart and muscle health in aging adults. The grant aims to uncover how heart dysfunction and muscle loss interact and detect biomarkers for earlier intervention.
Researchers at University of Michigan created a stem cell model that produces a yolk-sac-like structure in a human embryo, mimicking early pregnancy loss. The model uses mechanical signals to guide development and does not require genetic manipulation.
A study by the Alliance Foundation Trials shows that combining immunotherapy and chemotherapy before surgery can help more patients with locally advanced non-small cell lung cancer undergo complete cancer resection, improving their long-term health. The treatment also led to high rates of lymph node clearance and successful surgical re...
Researchers created a new polymer electrode that conforms to the skin, is comfortable, and can pick up ECG signals without gel or adhesives. The technology performed comparably to existing sensors in proof-of-concept testing, showcasing its potential for practical and cost-effective health monitoring applications.
A new biosensor detects active tuberculosis using a protein secreted by the bacterium, providing more accurate information from a clinical perspective. The device achieves high sensitivity and specificity, with promising potential for resource-poor countries.
A bidirectional brain-computer interface (BCI) allows individuals with spinal cord injuries to control a robotic exoskeleton using brain signals and receive artificial leg sensation. The system, developed by UC Irvine researchers, demonstrates high accuracy in step counting and sensory discrimination tasks.
Duracyte's technology uses an implantable device to produce therapeutic proteins continuously inside the human body, replacing injections and infusions with a single device. The device can sense biological signals, monitor tumor environments and adjust therapeutic output in real time.
Researchers at MIT have developed a way to measure multiple physical quantities with solid-state quantum sensors, exploiting entanglement to overcome signal mixing. This approach enables deeper understanding of the behavior of atoms and electrons in materials and living systems, such as cancer cells.
Researchers developed MitoCatch, a system that targets disease-affected cells with healthy mitochondria. The innovation enables efficient cell type-specific mitochondrial delivery, improving survival of damaged neurons in vitro and retinal ganglion cells in vivo.
High-resolution CT scans provide detailed images of mummified human remains, enabling accurate age determination and diagnosis of conditions such as osteoporosis. The analysis also sheds light on the mummification process and potential facial reconstructions of skulls.
Binghamton University has seen significant improvements in its graduate school rankings, with nearly three dozen programs earning national recognition. The university's Systems Science and Industrial Engineering program has been named the #31 Industrial and Systems Engineering graduate program in the US.
Researchers have combined ion pumps with click-to-release chemistry to enable precise electronic control of drug release for a broader range of therapeutics. This technology allows for targeted local therapy with lower doses, reducing side effects.
Oregon Health & Science University has received significant NIH funding to develop advanced microphysiologic models that mimic how cancers grow and respond to treatment within bone tissues. Two new awards focus on osteosarcoma and prostate cancer, aiming to improve understanding of disease spread and treatment responses.
The center offers state-of-the-art facilities for practical skills acquisition, digital technologies integration, and innovation in medical procedures. Future physicians will benefit from cadaver training, real-time imaging, and collaborative research opportunities.
Anand Ramamurthi, Lehigh's Peter C. Rossin Professor of Bioengineering and chair of the Department of Bioengineering, has been elected to the AIMBE College of Fellows for his groundbreaking work in regenerative technologies that can repair damaged tissues without surgery. His research aims to develop nonsurgical nanomedicines to treat ...
A study published in Chinese Medical Journal reveals how mitochondrial activity is regulated in heart muscle cells. Mitochondrial dysfunction disrupts energy production and affects cardiac outcomes, with various proteins managing mitochondrial biogenesis and mitophagy.
A comprehensive review highlights the role of extracellular vesicle-associated RNAs in developing and progressing IBD. EV-RNAs can serve as non-invasive biomarkers for early detection and targets for next-generation therapies, offering new hope for personalized precision treatment.