Articles tagged with Biomedical Engineering
A new imaging technology at UH helps scientists study exosomes, tiny particles released by human cells that may be targets for diseases. The technology uses advanced lighting at the nanoscale to analyze exosomes one at a time, measuring features to pinpoint good drug targets.
Researchers have discovered that advanced brain interfacing technology used for both touch and vision prostheses is almost identical, despite being developed separately. This breakthrough could lead to faster restoration of lost senses, including sight and motor function, with a unified technology that benefits both patient groups.
Researchers developed a multi-functional biomaterial that eradicates residual cancer cells, prevents bacterial colonization, and regenerates missing bone tissue. Gallium oxide selectively targets bone cancer cells overexpressing transferrin receptors, causing cell death, while preventing infection in surgical sites.
New research reveals that asthma attacks cause overproduction of extracellular proteins and growth of blood vessels in the airways. Over time, these changes lead to constriction of breathing passages, resulting in long-term respiratory issues.
Scientists discovered a protein secreted by deep-sea extremophile Pyrodictium abyssi that self-assembles into a highly stable biofilm. This discovery opens new avenues for biomedical research and could lead to breakthroughs in wound dressing, medical device coatings, and tissue engineering.
Hanyang University researchers developed AI-guided microneedle patches that actively change shape at physiological temperature to help close wounds while delivering regenerative therapy and antibacterial protection. The platform accelerates wound closure and improves tissue regeneration compared with conventional approaches.
Researchers developed a pH-triggered nanocomposite that synchronizes the release of therapeutic agents, combating bacterial biofilms and oxidative stress. The platform accelerates healing and promotes tissue repair in infected wounds.
Researchers at CNIC developed a technique to analyze proteins in individual cardiomyocytes, uncovering new clues about cardiac regeneration. The study found that the transcription factor Myc alters protein expression differently in each cell, generating regenerative potential in a subpopulation of cardiomyocytes.
A new wearable monitoring system called OMEGA aims to replace outdated fetal heart rate monitoring technology with a unified real-time assessment of fetal oxygen delivery and adaptive capacity. The system could potentially reduce C-section rates and improve maternal and fetal health outcomes, saving millions in healthcare costs.
Researchers developed a method combining AI and mathematical models to accelerate MRI scans for breast cancer imaging, achieving improved tumor visibility and high diagnostic sensitivity. The ELITE method has the potential to improve not only MRI scans but also other imaging platforms.
Researchers identify cholesterol ester buildup as biomarker predicting progestin therapy response in young women with endometrioid endometrial carcinoma. Combination treatment with progestin and a statin doubles six-month remission rate and helps patients become mothers.
Researchers have developed a polymer-based microring resonator array with over 40 elements, demonstrating broadband acoustic detection and fine spatial resolution. The system achieved strong correspondence with biological structures, including blood vessel regions, in imaging mouse prostate tissue.
A new lab-on-a-chip platform, CellTrap, visualizes individual cell contacts to better understand the effectiveness of immunotherapies. The platform shows that early activation signals in immune cells indicate a cell-damaging effect later in cell-cell interactions.
Researchers found that over-the-counter probiotics contain only 36 unique species of bacteria, with most common species being forms of Lactobacillus. The analysis suggests a lack of consistency in the combination of species used to support gut health and vaginal health claims.
Researchers at KAIST have developed a highly stretchable piezoelectric fiber sensor that operates stably even under repeated deformation. The sensor can be stretched up to 668%, generating consistent electrical signals under various movements, and is expected to enable long-term monitoring of biosignals in wearable medical devices.
A new study integrates robotic exoskeletons with therapist-patient interaction to create a more personalized and effective approach to stroke rehabilitation. The therapy, called TEPI, has been shown to improve joint range of motion, step length, and muscle activation compared to conventional therapy.
Researchers at Harvard's SEAS have developed a highly sensitive calorimeter that can detect metabolic heat signals on the order of 100 picowatts in living cells. The device tracks the growth of small populations of bacteria in real-time, including monitoring how bacterial growth changes in response to different antibiotics.
Researchers at Institute of Science Tokyo have developed a novel culture system to produce stable, scalable, and low-cost clinical-grade intestinal organoids from patient biopsy samples. The innovative approach uses clinical-grade collagen and synthetic peptides to enhance growth and improve scalability.
Researchers from ETH Zurich have developed a system that uses light to selectively destroy glucocorticoid receptors on tumour cells, making them vulnerable to attack. This approach could lead to more targeted and effective cancer treatments with fewer side effects.
Researchers developed a new approach to monitor HIV in communities by analyzing viral genomes in wastewater. The method strongly coincided with diagnosed HIV cases, suggesting that wastewater signals can track HIV burden.
A team of MIT engineers has created a tiny ingestible sensor that can measure temperature from within the body, offering continuous monitoring for patients who are sick or at risk of hypothermia. The device is small enough to be easily ingested and can provide accurate temperature readings with an accuracy of 0.01 degrees Celsius.
A $4 million NIH grant will help UC Davis researchers develop and test bioengineered grafts infused with ligands to treat neurogenic bladders in children. The grafts, designed to grow their own blood supply, have the potential to reduce complications after standard bladder augmentation surgery.
A new study published in Advanced Science shows that a programmable device can close complex wounds quickly, improving wound healing. The device uses customizable force to adapt to different wound shapes, promoting blood flow, nutrient delivery, and reduced scarring.
A study by Baylor College of Medicine researchers identifies a set of dysfunctional genes and specific cell types that are vulnerable early on to genetic changes in Rett syndrome. The research reveals that even healthy cells can be influenced by their environment, contributing to widespread brain dysfunction in the disease.
The review highlights advances in multi-scale bioelectrical interactions, analyzing challenges such as interface impedance and material-tissue compatibility. It emphasizes a shift towards application-driven design, integrating biological needs with material selection and device engineering.
Researchers find that limiting methionine in the diet destabilizes DNA organization and leads to cancer cell death and increased animal survival. The study proposes a new connection between diet, gene regulation, and cancer growth, opening possibilities for treating aggressive brain tumors.
Scientists developed a bioelectronic material called SIRES that maintains conductivity despite stretching up to 300%. The device can be attached to internal organs and provide stable performance even during movement. A new platform for implantable sensors also sticks to wet tissues while delivering therapeutic interventions.
A Texas A&M University biomedical engineering capstone team developed a pediatric jaw brace to help five-year-old David Hardy breathe at night. The device, called The JawDropper, successfully improved his breathing and was awarded a first-place prize among all biomedical teams.
Researchers create siRNA delivery system based on IVSA technology, which targets EGFR-positive tumors with high efficacy and low toxicity. The system enables precise targeting and overcomes drug resistance challenges.
A POSTECH research team developed a haptic device that can operate inside MRI scanners, enabling the measurement of brain activity during VR experiences. The study found that adding tactile feedback increased brain activation in areas responsible for motor control, attention, and cognitive processing.
A recent study published in Development reveals that the UTY gene on the human Y chromosome still contributes to transcriptional regulation during early development. Despite its low expression and reduced enzymatic activity, UTY co-occupies active regulatory elements with its X chromosome homolog UTX.
Researchers propose reconsidering how histone deacetylase inhibitors work in cancer treatment, identifying genuine molecular targets as a key step to improve treatment. The study suggests that HDAC inhibitors may interfere with other proteins, suppressing cancer growth.
Researchers summarize recent developments in terahertz biophotonics, highlighting its potential for overcoming technical limitations in fields like skin cancer diagnosis, wound assessment, and drug discovery. The study provides a roadmap for future research to improve the field's practical applications.
The university's patented technology assists surgeons in detecting and visualizing significant arterial bleeding using augmented reality overlays, enabling precise control and quick action. This innovation aims to improve patient outcomes, save lives, and reduce hospital stays, infection rates, and treatment costs.
Scientists at Linköping University have developed artificial heart muscle cells using organic electronics, opening up new possibilities for prosthetics, heart implants, and sensors. The technology aims to harness the principles of effective electrical signaling in biological cardiac muscle cells.
The RBA hydrogels can stretch to more than three times their original length while remaining mechanically stable. They were used as strain sensors to detect subtle facial movements and distinguish between walking, jogging, and running in real time.
A new framework, VIBEMed, uses multi-agent collaboration to break complex clinical decisions into specialist roles and employs a three-level self-evolution mechanism to improve performance over time. This approach demonstrates superior performance in complex medical reasoning and treatment planning tasks.
Researchers at MIT have created a pacemaker that uses ultrasound technology to stimulate the heart, offering a potential surgery-free alternative to traditional cardiac implants. The device is designed as a small sticker that sends ultrasound pulses through the chest to regulate heart contractions and correct arrhythmias.
A novel biomaterial containing jackfruit latex, pomegranate peel extract, and simvastatin shows promising efficacy in treating periodontitis. The material has adhesive properties, allowing for targeted release of therapeutic compounds, and has been shown to promote regeneration of periodontal tissues.
A new monitoring system, NeuroSense, tracks cerebrospinal fluid at the bedside for faster intervention in intensive care units. The system detects biomarkers of infection and flow rate, enabling early warning of complications and better treatment decisions.
Researchers developed a novel fluorescent nanosensor to detect IPA, an emerging biomarker linked to gut health and disease. The sensor offers rapid detection within minutes, distinguishing IPA from closely related metabolites, enabling accurate measurement even in complex biological environments.
Current evidence suggests P2Y2 signaling is associated with multiple cancer-related processes, including cell proliferation, migration, and EMT. The receptor has also been linked to intracellular signaling pathways such as EGFR, PI3K–AKT, and MAPK.
A University of Utah team developed a smartwatch prototype that tracks blood pressure and flow using electrical properties of blood flow for continuous, cuff-free readings. The technology harnesses physics and machine learning to provide accurate and interpretable results.
Researchers found that traumatic occlusion combined with periodontitis leads to significant bone loss due to upregulated inflammatory pathways. The study suggests that excessive bite force does not directly cause damage but exacerbates existing dysregulation, making clinical applications of occlusal adjustment in treatment more relevant.
Researchers have developed custom 4D-printed implants that expand slowly and steadily, reducing the need for repeated injections and surgeries. The devices were tested in rabbits and showed promising results, including improved skin adaptation, reduced complications, and increased precision in reconstructive surgery.
A University of Michigan research team is exploring the development of knee exoskeletons to reduce joint contact forces and relieve osteoarthritis pain. Preliminary testing suggests that these orthotic brace-based exos and drone-style motors could provide significant relief.
Researchers at Institute of Science Tokyo genetically engineer cyanobacteria to produce sulfated polysaccharides, a sustainable route for manufacturing biomaterials. The study demonstrates the feasibility of engineering complex biosynthetic pathways in photosynthetic organisms.
Researchers developed a nanofiber drug delivery system that uses electrospun fiber membranes to deliver multiple drugs in concert, demonstrating improved efficacy against glioblastoma. The system enables localized long-term delivery of drugs directly at the tumor site after surgery.
Researchers from Zhejiang University present a comprehensive overview of stem cell-based strategies for treating traumatic brain injury. The study explores the therapeutic effects of stem cells, exosomes, and biomaterial scaffolds in promoting brain repair and functional recovery.
Researchers discovered acteoside alleviates hepatic ischemia-reperfusion injury through two mechanisms: inhibiting IRF1 nuclear translocation and promoting CMPK2 degradation. Acteoside reduces liver injury, serum ALT/AST, inflammatory infiltration, oxidative stress, and mtDNA release.
Researchers explore contrast-enhanced ultrasonography as a safer alternative to invasive hepatic venous pressure gradient for assessing portal hypertension. CEUS uses microbubble-based ultrasound contrast agents to track blood flow through the liver and surrounding vessels.
Researchers found that different types of tea create kombuchas with distinct chemical profiles, flavors, and aromas. Green and oolong teas produced kombuchas with high antioxidant activity, while black and pu-erh teas resulted in earthier flavors.
Researchers at Cincinnati Children's Hospital Medical Center have developed a new method to produce large, functional human gut organoids with nerve cells, growing them twice as fast as previous methods. These organoids can now be used for patching damage or restoring diminished functions of the small intestine, stomach, or colon.
Researchers identify conceptual weaknesses in established methods, suggesting targeted nerve and muscle activations for non-invasive electrostimulation. The study advocates for reconsidering high-frequency pulse usage to exhaust full potential for restoring motor function after paralysis.
Aging across the female reproductive tract is characterized by declining estrogen, cellular senescence, and chronic inflammation. Multi-omics datasets provide a powerful framework to measure biological age and reveal tissue-specific vulnerabilities.
H2AK119Ub is a versatile histone mark that organizes the genome into functional domains, orchestrates gene silencing, and maintains cell identities during development. Disruption of its signaling network is recognized as a driver of human diseases, particularly cancer.
A new study by the University of Southampton has found that reusable catheters are just as safe for patients as single-use ones and do not increase the risk of urinary tract infections. The study followed hundreds of patients for a year and discovered that those who tested reusable catheters used 35 per cent fewer antibiotics.
Paligenosis is a three-stage process involving autophagy, stemness gene induction, and proliferation. It ensures efficient regeneration in tissues like the stomach and pancreas, but its dysregulated activation can drive metaplasia and cancer. The review discusses biomarker prospects for distinguishing adaptive repair from malignant drift.
YTHDF2 plays critical roles in regulating HSC fate, immune cell development, and tumor-immune interactions. It also modulates the tumor microenvironment to promote tumor progression.
Researchers synthesized preclinical and clinical evidence of mRNA cancer vaccines across various cancers, including melanoma, non-small cell lung cancer, and acute myeloid leukemia. Key findings include improved recurrence-free survival in patients treated with mRNA-4157 plus pembrolizumab for melanoma.