Articles tagged with Biomedical Engineering
Stanford researchers have developed a novel 'scaffold-free' approach for treating damaged muscles, enabling the delivery of more healing cells to the traumatized area. The approach uses a custom molding technology to create dense muscle tissue in customizable geometric shapes and sizes, allowing for more effective muscle regeneration.
Researchers developed an expert consensus to standardize the use of ultrasound-derived fat fraction for assessing liver steatosis. The study found that UDFF showed strong correlations with histological steatosis grades and MRI-PDFF, demonstrating excellent reliability and robust diagnostic accuracy.
Dr. Aliesha O’Raw, Principal Investigator at TIBI and Co-Founder of OnVagus, has been selected for the 2026 ACS BrightEdge Entrepreneurs Program. The program provides mentorship, entrepreneur training, and early-stage investment support to advance cancer diagnostic and therapeutic solutions.
A novel drug delivery system developed by Osaka Metropolitan University improves Paclitaxel absorption by binding to the lipocalin-type prostaglandin D synthase enzyme, enabling selective delivery to cancer tissues. The system demonstrates significant tumor suppression effects even after administration cessation.
A new RNA therapy has been developed to enhance the heart's own ability to protect and repair itself after a heart attack. The therapy, which involves injecting particles into the arm, significantly reduced scarring and improved heart function in lab experiments, offering a potential breakthrough for heart patients.
A Chinese study reports a 100% technical and clinical success rate for robot-assisted brain angiography, with median procedure times 11 minutes shorter than manual angiography. No added radiation or complications were observed, showcasing the feasibility and safety of the YDHB-NS01 system
A new study identifies a previously unknown brainstem pathway controlling hand and arm movements, revealing a multi-stage pathway integrating signals from the cortex, brainstem, and spinal networks. This finding may lead to new therapies for stroke rehabilitation, providing additional targets for neuromodulation treatments.
Researchers have genetically engineered human stem cells that can evade immune rejection while carrying a built-in kill switch to prevent tumour formation. The engineered cells, known as FailSafe-AlloAccept, offer a potentially limitless supply of replacement cells and could serve as a universal cell source for diverse therapies.
Recent advances in photonic nanomaterials and healthcare devices have led to the development of wearable and implantable medical devices. These devices utilize light for precise manipulation of cells and tissues, offering new possibilities for early disease detection, light-based therapies, and personalized precision medicine.
The NRG-LU005 trial found that immunotherapy atezolizumab did not improve survival for patients with limited-stage small cell lung cancer when added to chemoradiation. Twice-daily radiation therapy, however, was associated with improved survival in this population.
Researchers at the Wyss Institute developed DoriVac, a DNA nanotechnology-enabled vaccine platform that induces broad immunity against infectious viruses, including SARS-CoV-2, HIV, and Ebola. The platform produces potent antigen-specific immune responses and is more stable and easier to manufacture than traditional vaccine platforms.
A conductive bioglue was developed to ensure firm adhesion and stable electrical signaling within the human body. It overcomes challenges in connecting damaged tissues or attaching bioelectronic devices, promoting muscle and nerve regeneration and stable implant stability.
A team of researchers from SASTRA Deemed University demonstrates a fiber-based method for compressing mid-infrared laser pulses into ultrashort, low-noise bursts efficiently. The system reduces input power from kilowatts to 80 watts, improving energy efficiency and thermal stability.
Researchers at Brown University have made significant progress in restoring two-way communication across a damaged spinal cord site. Electrical stimulation below the injury site partially restored muscle control in lower extremities, while stimulation above the injury enabled participants to understand their leg position in space. This...
A Mendelian randomization study found that PCSK9 inhibitors may reduce low back pain risk, while HMGCR and NPC1L1 inhibitors showed no association. The study validated known lipid-lowering effects on coronary heart disease risk, providing new insights into PCSK9 pleiotropy.
Researchers optimize interferometric diffusing wave spectroscopy technique to boost weak optical field returning from the brain, achieving over 20x signal to noise ratio. The novel approach provides higher brain sensitivity compared to DCS-inspired approaches and is approximately two orders of magnitude less expensive.
Researchers create living tissue at near-physiological cell density using a new bioprinting strategy called embedded 3D printing in a cell-dense suspension (EPICS). The method enables the precise fabrication of perfusable channels and dense cellular environments, mimicking real organs.
Researchers at Penn State have developed a new class of tunable biomaterials, known as granular aerogel scaffolds, to support tissue regeneration and vascularization in wound healing. The material offers improved cell infiltration and may help rapidly form new blood vessels and regenerate damaged tissue.
Researchers developed a new noninvasive brain stimulation technique by combining focused ultrasound with electrical stimulation, producing stronger, targeted brain responses. This approach, called transcranial electro-acoustic stimulation, clarifies conflicting results in the field and introduces a new approach to noninvasive brain sti...
NIK kinase's non-canonical NF-κB pathway is crucial for immune development and function, while its NF-κB-independent functions regulate cellular metabolism and mitochondrial health. Dysregulation of NIK is linked to various diseases, making it a promising therapeutic target.
The partnership aims to accelerate biomedical innovation through joint research programs, faculty collaboration, and expanded student training opportunities. Researchers will have access to shared laboratory infrastructure, reciprocal faculty affiliations, and joint grant proposals.
Researchers at Baylor College of Medicine discover tubulin's role in preventing toxic protein clumps in brain cells, potentially fighting Alzheimer's and Parkinson's diseases. Tubulin steers Tau and alpha synuclein proteins towards their healthy roles, reducing toxic aggregation.
Scientists create fluorescent nanoplastics that resemble real-world plastics in morphology, enabling real-time tracking and studying chronic exposure effects. The study reveals that smaller particles retain longer in the body, highlighting the need for further research on health risks due to microplastic ingestion.
Florida Atlantic University has received a $4.5 million grant from the US Air Force to establish a high-fidelity platform for autonomous decision-making and real-time sensor fusion research. The T-1A Jayhawk simulator will be used to study cognitive performance, situational awareness, stress and decision-making under pressure.
Researchers at Baylor College of Medicine have identified a potential therapeutic strategy for Rett syndrome by guiding brain cells to produce more functional MeCP2 protein. The approach, which involves deleting a specific ingredient from the gene that produces the protein, has shown promise in mice and cells derived from patients with...
Engineered tissue grafts can take on the liver's function and help patients with liver failure. The injected cells remain viable in the body for at least two months, generating enzymes and proteins like normal hepatocytes.
Seven UVA engineering faculty members received the university's highest research honors for their contributions to engineering and society. The awards recognize outstanding research that makes a difference to real people, with a focus on interdisciplinary collaboration and societal benefits.
A study found that WWTP upgrades improved river water quality by reducing total nitrogen concentrations. The upgrade triggered significant shifts in bacterial communities' composition and nitrogen-cycling functions, while viral communities adjusted their functional strategies.
Researchers developed CAR macrophages that crossed the blood-brain barrier, recognizing and destroying cancer cells and releasing signals to harm nearby tumors. The treatment showed significant reductions in brain tumor progression and increased survival in preclinical models.
Researchers at Arizona State University uncovered a scientific principle governing how nanoparticles interact with water in the body, leading to improved drug delivery. The study measured hydration energetics on biomolecule-coated magnetite nanoparticles, revealing altered interactions, immune recognition, and circulation potential.
Researchers at Simon Fraser University have developed a new, fully customizable 3D printed socket design that combines pressure mapping with AI software and a lighter infill. This innovation has shown improved comfort and reduced common complications for prosthetics wearers.
Scientists at Institute of Science Tokyo have discovered how LGP2 and MDA5 work together to recognize viral RNA. The study reveals that LGP2 binds to the ends of a dsRNA molecule, recruiting MDA5 molecules behind it and forming filament-like structures, ultimately triggering an innate immune response.
Researchers at the University of Basel have developed a new laser profile that enables deeper and faster cuts in hard tissues like bone. The top hat profile distributes energy more evenly, overcoming limitations of traditional laser systems and enabling joint implants and custom-made 3D-printed implants.
Five Lehigh University professors have been recognized for their innovative work, collectively holding over 2,000 U.S. patents. Their research focuses on diverse areas, including orthopaedic device technology, nanocrystalline alloys, and energy storage systems.
Researchers used machine learning techniques to compress a large model of the visual cortex, creating smaller versions that predict neural responses with high accuracy. The compact models revealed specific computational patterns in how neurons detect important features, offering insights into how visual information is processed.
Researchers identified multiple microRNAs linked to disease progression and built a model to distinguish high-risk patients with CKD. The M3V2 equation significantly outperformed conventional clinical markers in predicting both kidney decline and major cardiovascular events.
Researchers explore piezoelectric electrospun fibers that generate crucial electrical signals for tissue engineering and biomedical applications. These "smart" scaffolds have high flexibility, biomimetic structure, and tunable morphology, offering potential for enhanced tissue repair.
Researchers at Tokyo Metropolitan University have created a neutral molecule that can carry DNA into biological cells using a process called annealing. This breakthrough promises more effective therapies by reducing inflammation and improving delivery efficiency.
Emerging biochar-based nanomaterials show promise in tackling global challenges such as climate change and healthcare innovation. These materials may support cleaner energy systems, improved health technologies, and resilient infrastructure through their unique properties and applications.
Researchers have developed an artificial DNA base pair that relies on halogen bonds, enabling stable structures and recognizing naturally occurring enzymes. This breakthrough expands the genetic alphabet and could open up new possibilities in synthetic biology.
A new machine learning model interprets leg motion as expended energy, providing a more accurate measure of calories burned. The device has been shown to have double the accuracy of commercial smartwatches and activity trackers.
Xiwen Gong and Zhen Xu, both from the University of Michigan Engineering, received the award for developing optoelectronics and histotripsy, a cancer treatment using sound waves. The new treatment can spare patients from chemotherapy and radiation therapy.
Researchers at Harvard's John A. Paulson School of Engineering and Applied Sciences have developed a new fabrication method for printing robotic devices with long filaments featuring precisely placed hollow channels. This allows the device to bend and deform in predetermined ways, enabling the creation of soft robots with predictable s...
Developing a lifesaving device that can stop fatal blood loss in seconds, researchers at Texas A&M University have made significant breakthroughs. By using clay minerals and nano-silicate particles, the team has created injectable hemostatic bandages that reduce bleeding time by nearly 70%.
Researchers developed a vascularized liver tissueoid-on-a-chip that recapitulates key structural, functional, and immunological features of human liver tissue. The platform enabled the study of liver regeneration and immune-mediated allograft rejection in a physiologically relevant human system.
Researchers from Duke University found that uniform materials without complexity are the culprit behind deadly infections after heart surgery. Bioengineered grafts with decellularized tissue can greatly reduce complications. The study suggests designing new solutions similar to vascular tissue in interior complexity.
Researchers at Case Western Reserve University developed a strategy using ultrasound-activated nanobubbles to break down tumor barriers, making tumors softer and more penetrable to treatment-bearing molecules and immune cells. This breakthrough could fast-track therapy to clinical trials for solid tumors like prostate cancer.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
A study by University of Texas at Dallas bioengineers found that both cancerous and noncancerous colon tissue from young patients with colorectal cancer was mechanically stiffer than in older patients. This stiffness may promote the development of early-onset colorectal cancer, a condition rising over the past 30 years.
A new review highlights the cytokine storm's key role in lung injury and multi-organ dysfunction in acute respiratory distress syndrome (ARDS). The review emphasizes biological heterogeneity, subphenotypes, and the need for biomarker-guided patient stratification.
Researchers found that participants initially overestimated the awkwardness of their gait but improved as they practiced using the prosthetic device. Despite significant performance gains, participants remained inaccurate in assessing their own body movement, focusing on torso position rather than prosthetic behavior.
UCLA researchers have developed a novel gene-editing approach using lipid nanoparticles to deliver a full-length CFTR gene into human airway cells. The study shows promise for treating cystic fibrosis by correcting the underlying genetic mutation, which could lead to more effective and long-term therapies.
60Nd, a UC3M spin-off, develops NeoMag to study tumor behavior, traumatic brain injuries, and wound healing processes. The technology enables researchers to replicate physical disease behaviors and identify new therapeutic targets.
A yeast enzyme, Sc URA, has been found to sustain nucleotide synthesis independently of mitochondrial respiration in human cells. This discovery opens up new possibilities for treating mitochondrial diseases with no cure, and could provide a valuable experimental tool for understanding rare diseases and cancer.
The journal explores the convergence of computational biology, artificial intelligence, and healthcare innovation, with a focus on precision medicine and enhanced patient care. Submissions are accepted from researchers, clinicians, and technologists on topics such as AI in medicine, computational genomics, and drug discovery.
A new framework proposes a 'three-strata' model to classify gastrointestinal tract cancers, guiding more precise and effective strategies. The review advocates for chemotherapy-free approaches in highly immunogenic tumors and explores optimized combinations with chemotherapy for intermediate-sensitive tumors.
A recent study reveals that hydration and terminal chemistry of poly(ethylene) glycol (PEG) polymers influence immune recognition, providing insights into why some PEGylated drug coatings fail to evade the immune system. The findings pave the way for novel drug coatings with improved performance.
A study revealed a path of molecular events that can lead to Alzheimer's disease, including the formation of amyloid plaques and tau tangles. Researchers identified genes involved in immune and synaptic regulatory mechanisms as potential therapeutic targets.
Researchers discovered how bacteria Pseudomonas sp. SZ40 and Paenibacillus sp. SZ31 work together to produce a toxic substance against an amoeba predator. The study revealed the role of DL peptidases in converting lipopeptides into a substance that is harmful to the amoeba.
Researchers developed an AI-driven pipeline to create functional intracellular antibodies, overcoming major barriers in intrabody development. The approach successfully redesigned structures compatible within the cellular environment, enabling high target specificity and stability.