Articles tagged with Biomedical Engineering
Researchers at Simon Fraser University have developed a new, fully customizable 3D printed socket design that combines pressure mapping with AI software and a lighter infill. This innovation has shown improved comfort and reduced common complications for prosthetics wearers.
A study found that WWTP upgrades improved river water quality by reducing total nitrogen concentrations. The upgrade triggered significant shifts in bacterial communities' composition and nitrogen-cycling functions, while viral communities adjusted their functional strategies.
Scientists at Institute of Science Tokyo have discovered how LGP2 and MDA5 work together to recognize viral RNA. The study reveals that LGP2 binds to the ends of a dsRNA molecule, recruiting MDA5 molecules behind it and forming filament-like structures, ultimately triggering an innate immune response.
Researchers at the University of Basel have developed a new laser profile that enables deeper and faster cuts in hard tissues like bone. The top hat profile distributes energy more evenly, overcoming limitations of traditional laser systems and enabling joint implants and custom-made 3D-printed implants.
Five Lehigh University professors have been recognized for their innovative work, collectively holding over 2,000 U.S. patents. Their research focuses on diverse areas, including orthopaedic device technology, nanocrystalline alloys, and energy storage systems.
Researchers used machine learning techniques to compress a large model of the visual cortex, creating smaller versions that predict neural responses with high accuracy. The compact models revealed specific computational patterns in how neurons detect important features, offering insights into how visual information is processed.
Researchers identified multiple microRNAs linked to disease progression and built a model to distinguish high-risk patients with CKD. The M3V2 equation significantly outperformed conventional clinical markers in predicting both kidney decline and major cardiovascular events.
Researchers explore piezoelectric electrospun fibers that generate crucial electrical signals for tissue engineering and biomedical applications. These "smart" scaffolds have high flexibility, biomimetic structure, and tunable morphology, offering potential for enhanced tissue repair.
Researchers at Tokyo Metropolitan University have created a neutral molecule that can carry DNA into biological cells using a process called annealing. This breakthrough promises more effective therapies by reducing inflammation and improving delivery efficiency.
A new machine learning model interprets leg motion as expended energy, providing a more accurate measure of calories burned. The device has been shown to have double the accuracy of commercial smartwatches and activity trackers.
Xiwen Gong and Zhen Xu, both from the University of Michigan Engineering, received the award for developing optoelectronics and histotripsy, a cancer treatment using sound waves. The new treatment can spare patients from chemotherapy and radiation therapy.
Researchers at Harvard's John A. Paulson School of Engineering and Applied Sciences have developed a new fabrication method for printing robotic devices with long filaments featuring precisely placed hollow channels. This allows the device to bend and deform in predetermined ways, enabling the creation of soft robots with predictable s...
Emerging biochar-based nanomaterials show promise in tackling global challenges such as climate change and healthcare innovation. These materials may support cleaner energy systems, improved health technologies, and resilient infrastructure through their unique properties and applications.
Researchers have developed an artificial DNA base pair that relies on halogen bonds, enabling stable structures and recognizing naturally occurring enzymes. This breakthrough expands the genetic alphabet and could open up new possibilities in synthetic biology.
Researchers developed a vascularized liver tissueoid-on-a-chip that recapitulates key structural, functional, and immunological features of human liver tissue. The platform enabled the study of liver regeneration and immune-mediated allograft rejection in a physiologically relevant human system.
Researchers from Duke University found that uniform materials without complexity are the culprit behind deadly infections after heart surgery. Bioengineered grafts with decellularized tissue can greatly reduce complications. The study suggests designing new solutions similar to vascular tissue in interior complexity.
Researchers at Case Western Reserve University developed a strategy using ultrasound-activated nanobubbles to break down tumor barriers, making tumors softer and more penetrable to treatment-bearing molecules and immune cells. This breakthrough could fast-track therapy to clinical trials for solid tumors like prostate cancer.
Developing a lifesaving device that can stop fatal blood loss in seconds, researchers at Texas A&M University have made significant breakthroughs. By using clay minerals and nano-silicate particles, the team has created injectable hemostatic bandages that reduce bleeding time by nearly 70%.
UCLA researchers have developed a novel gene-editing approach using lipid nanoparticles to deliver a full-length CFTR gene into human airway cells. The study shows promise for treating cystic fibrosis by correcting the underlying genetic mutation, which could lead to more effective and long-term therapies.
60Nd, a UC3M spin-off, develops NeoMag to study tumor behavior, traumatic brain injuries, and wound healing processes. The technology enables researchers to replicate physical disease behaviors and identify new therapeutic targets.
A yeast enzyme, Sc URA, has been found to sustain nucleotide synthesis independently of mitochondrial respiration in human cells. This discovery opens up new possibilities for treating mitochondrial diseases with no cure, and could provide a valuable experimental tool for understanding rare diseases and cancer.
The journal explores the convergence of computational biology, artificial intelligence, and healthcare innovation, with a focus on precision medicine and enhanced patient care. Submissions are accepted from researchers, clinicians, and technologists on topics such as AI in medicine, computational genomics, and drug discovery.
A new framework proposes a 'three-strata' model to classify gastrointestinal tract cancers, guiding more precise and effective strategies. The review advocates for chemotherapy-free approaches in highly immunogenic tumors and explores optimized combinations with chemotherapy for intermediate-sensitive tumors.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
A study by University of Texas at Dallas bioengineers found that both cancerous and noncancerous colon tissue from young patients with colorectal cancer was mechanically stiffer than in older patients. This stiffness may promote the development of early-onset colorectal cancer, a condition rising over the past 30 years.
A new review highlights the cytokine storm's key role in lung injury and multi-organ dysfunction in acute respiratory distress syndrome (ARDS). The review emphasizes biological heterogeneity, subphenotypes, and the need for biomarker-guided patient stratification.
Researchers found that participants initially overestimated the awkwardness of their gait but improved as they practiced using the prosthetic device. Despite significant performance gains, participants remained inaccurate in assessing their own body movement, focusing on torso position rather than prosthetic behavior.
A study revealed a path of molecular events that can lead to Alzheimer's disease, including the formation of amyloid plaques and tau tangles. Researchers identified genes involved in immune and synaptic regulatory mechanisms as potential therapeutic targets.
Researchers developed an AI-driven pipeline to create functional intracellular antibodies, overcoming major barriers in intrabody development. The approach successfully redesigned structures compatible within the cellular environment, enabling high target specificity and stability.
A team from the Universitat Politècnica de València and Corify Care has developed the first whole-heart mapping technology that provides real-time views of cardiac arrhythmias. This innovation enables physicians to make faster decisions, target ablations more effectively, and potentially reduce procedure time.
Microtubule researchers reveal how tubulin isotypes regulate luminal accessibility through reversible protofilament separation. The findings provide insights into mechano-transduction and could lead to novel biomaterials development.
Researchers discovered how bacteria Pseudomonas sp. SZ40 and Paenibacillus sp. SZ31 work together to produce a toxic substance against an amoeba predator. The study revealed the role of DL peptidases in converting lipopeptides into a substance that is harmful to the amoeba.
Researchers at the University of Arkansas developed an AI diagnostic tool to detect masked hypertension, a condition where people have high blood pressure but normal readings during exams. The tool uses machine learning and health indicators to predict masked hypertension with accuracy, potentially saving lives and improving patient care.
Researchers at NTU Singapore develop a new orally taken, gut-based compound that reduces dietary fat absorption in the intestines. The technology supports weight loss while minimizing effects on other organs and reducing stress on the liver when dietary fat intake is high.
The University of Missouri has launched its first human clinical trial using Eye90 microspheres, a radiopharmaceutical breakthrough device manufactured on campus. The study aims to assess the safety and effectiveness of Eye90 in treating unresectable liver tumors, including hepatocellular carcinoma and metastatic colorectal cancer.
Scientists have identified the FOXO1-KLHL6 axis as a novel therapeutic target to enhance T cell-mediated immune response against tumors. The research found that persistent T cell receptor signaling suppresses the transcription factor FOXO1, leading to the downregulation of the E3 ubiquitin ligase KLHL6 and promoting T cell exhaustion.
Researchers used advanced imaging to uncover early molecular changes in bone associated with osteoarthritis. The study found that subchondral bone beneath damaged cartilage showed strong upregulation of specific collagen fragments, suggesting that disease-related bone changes begin earlier than previously recognized.
Scientists have developed a novel computational framework for real-time, personalized heart rate variability monitoring. The framework provides robust, adaptive alerts and improves the accuracy of HRV analysis by excluding artifact-prone periods.
Halle Zhang joins Insilico Medicine to lead global clinical development strategy for the company's oncology portfolio. She brings over 20 years of experience in oncology clinical development and a track record of advancing therapies through registrational trials.
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
Researchers at Kyushu University discovered that cancer cells use a previously unrecognized physical mechanism called CODE to create water pressure that aids in their migration. This finding opens new avenues for therapies targeting amoeboid movement, a key strategy used by most advanced cancer cells.
Researchers developed a light-sensitive oligonucleotide probe that selectively detects 5-formylcytosine, an epigenetically important intermediate. The probe demonstrates stable cross-linking with 5fC across various conditions, enabling its detection in target DNA and complex biological samples.
Researchers developed smart 4D-printed vascular stents that expand naturally at body temperature, eliminating the need for external heating. The stents balance mechanical flexibility and radial strength, demonstrating long-term biomechanical compliance.
The review explores how next-generation sequencing can enhance early disease detection in newborns by analyzing DNA from dried blood spots. This genomic approach expands the benefits of NGS by identifying conditions not detectable through traditional biochemical testing.
Scientists have successfully grown human norovirus in the lab for up to 15 consecutive passages, enabling comprehensive studies of viral structure, antiviral drug screening, and vaccine development. The breakthrough uses a drug called TAK 779 to overcome host restrictions, allowing researchers to produce stable virus stocks.
Researchers at Flinders University developed a high-performance coating made from peppermint essential oil that protects against infection, inflammation, and oxidative stress. The coating demonstrates strong antibacterial action against key pathogens, including E. coli and Pseudomonas aeruginosa.
The ESMT Berlin DEEP Institute and Creative Destruction Lab will be launched in Doha to support technology transfer and innovation. The initiative aims to connect the innovation ecosystems of Germany and Qatar, fostering entrepreneurial growth and driving economic growth.
Researchers at Adelaide University have uncovered a crucial new mechanism controlling heart development by regulating key growth signals. Neural crest cells fine-tune Wnt signalling to ensure proper heart formation, and disruptions lead to serious congenital heart defects.
Researchers have developed an open-source pressure myography tool, HemoLens, which reduces the cost of vascular research to $750 from $40,000. The tool uses affordable manufacturing processes and customizable components, making it easier for researchers to study vascular function.
Researchers found that carrying one mutant copy of ATP13A2 and GBA1 drives a slow, progressive neurodegeneration in flies, leading to movement problems, neuron loss, and disruption in neural communication. Accumulation of glucosylceramide in glial cells is linked to the disease process.
A new platform developed by VIB and UGent researchers allows for more accurate prediction of antibody drug effects in humans. The platform uses a next-generation mouse model that closely reflects human immune biology, enabling better decisions early in drug development.
The University of Ottawa has launched the Ottawa Medical Artificial Intelligence Research Institute (OMARI), a center for research, education, and innovation in medical Artificial Intelligence. Led by Dr. Khaled El Emam, OMARI aims to facilitate cross-cutting collaborations and sharpen the university's competitive edge in AI-driven hea...
A review decodes the comprehensive role of GDF15 in prostate cancer metabolism, chemoresistance, and clinical applications, highlighting its involvement in cachexia, bone metastasis, and drug resistance. The study also explores the synergistic power of combining GDF15 with established markers for improved diagnosis and prognosis.
The FIU-Florida Heart Research Foundation Center for Innovation in Cardiovascular Health brings together experts in various fields to uncover the fundamental drivers of cardiovascular disease. The center will focus on AI-powered diagnostics, regenerative tissue technologies, and workforce development.
A team at Chalmers University of Technology has discovered biomarkers for Parkinson's disease in the blood, which could lead to early diagnosis via blood tests within five years. The study found distinct gene activities linked to DNA damage repair and stress response in patients in the early phase of the disease.
A UBCO research team has developed a lightweight, wearable brace that reduces involuntary hand tremors in people with Parkinson’s disease. The passive vibration-absorbing mechanism offers an accessible alternative to existing treatments.
The B-STING silica nanocomposite acts as a nanofactory of reactive oxygen species, activating itself in response to changes in the chemical environment. This material can be used to create biocidal coatings that are safe, durable, and resistant to dirt, with potential applications in medicine and other industries.
A study reveals that alternative splicing (AS) and genetic variation contribute to feed efficiency differences in fish. AS variants were linked to superior feed utilization, providing new molecular targets for breeding more efficient strains.
The article discusses the integration of heart imaging and proteomics to identify potential drug targets for cardiovascular diseases. The expert panel consensus guidelines establish a foundation for clinical practice, education, and future research in microbiota medicine.