Articles tagged with Biomedical Engineering
A new study found that urban rivers in Beijing harbor the highest burden of antibiotic resistance genes, while receiving waters show stronger mobilization signals, indicating a high risk of resistance exchange. The study highlights the need for risk-oriented water management in megacities.
Researchers developed a bio-based Fe-MOF nanoreactor that combines natural-ligand chemistry with multimetallic redox catalysis, biomimetic targeting and MRI visibility. The nanoplatform produced a strong ROS response, increased apoptosis, and tumor inhibition in breast cancer cells and mice.
Researchers identified referral gaps, diagnostic waits, and service pressures that can delay action after early autism concerns emerge. The study suggests practical changes to improve coordination and timely support for families, including repeat surveillance, closed-loop referral tracking, and needs-based support.
Engineered microbe-based micro/nanorobots can revolutionize clinical intervention for luminal cancers by navigating and adapting to hostile luminal cavities. The review categorizes this living robotic paradigm into four synergistic capabilities, including active navigation, environmental sensing, and continuous biosynthesis.
Researchers developed a portable AI-assisted microfluidic platform to detect sub-resistant bacteria, combining machine learning with the ancient 'six-four water diversion' principle. The platform provides a more refined view of bacterial drug response and can identify sub-resistant populations that conventional tests may overlook.
A new parametric design framework transforms flat paper sheets into self-folding helical sensors that measure biosignals. The approach combines sustainable materials with a simple software-guided design process, enabling rapid production of customized wearable electronics.
mRNA-LNPs are shifting the paradigm of drug delivery, enabling vaccines, personalized cancer vaccines, and in vivo gene editing. CAR-engineered cells can be directly generated in vivo, offering a streamlined alternative to ex vivo CAR-T manufacturing.
A new review in Medicine Plus traces the development of deep brain stimulation, mapping mechanisms and clinical targets across 16 disorders. It highlights future personalized strategies and calls for validated biomarkers and standardized reporting.
A modular nano-adaptor approach tunes T-cell activation to control CD3 activation and prevent toxicity, increasing therapeutic effectiveness in solid tumors. The platform has identified promising lead designs for multispecific nanoantibody configurations.
Researchers develop biodegradable nanobone material that activates body's own healing properties to regrow bone, reducing need for invasive procedures. The material generates 80% more new bone than a material control and activates a key bone-repair growth factor with 10 times the level achieved using conventional methods.
Researchers at the University of Missouri-Columbia have discovered a protein, TG2, that contributes to arterial stiffening and inflammation linked to high blood pressure. By blocking TG2 activity, they found that inflammation can be reduced, potentially leading to more precise treatments for cardiovascular disease.
Eric Perreault, a renowned research executive and academic leader, will lead the Morgridge Institute for Research, a biomedical research organization affiliated with the University of Wisconsin-Madison. The institute focuses on improving human health through cross-disciplinary research and collaborations.
Dunpeng Cai is leading the search for a treatment for aortic valve calcification, a disease that affects millions of older adults worldwide and causes the heart's aortic valve to harden and narrow over time. His team plans to test a drug compound to slow or prevent the disease by blocking a protein called DOCK2.
Researchers developed protein-coated CuS nanoparticles with excellent colloidal stability, pH-responsive behavior, and effective near-infrared-induced killing of breast cancer cells. The protein coating improved biocompatibility and reduced dark toxicity.
A study published in Advanced Materials Interfaces reveals that proteins with exposed arginine residues selectively accumulate on protein-resistant coatings, compromising biocompatibility of medical devices. Researchers developed a new design guideline for predicting and controlling protein corona formation at the molecular level.
A mathematical model developed by researchers from Hasanuddin University suggests that combining vaccination, treatment, quarantine, and educational campaigns could curb Mpox transmission. The model showed that a full-control strategy produced the greatest reduction in infections, with a 97.85% decrease in the total number of infected ...
Researchers from HKUST develop 'one-pot' testing platform TEMPO for rapid, single-step nucleic acid testing, reaching attomolar sensitivity comparable to laboratory methods. The platform has potential applications in infectious disease surveillance and genetic screening.
Researchers developed a microneedle patch that can detect early signs of kidney injury, stabilizing biomolecules in high-heat settings. The patch, coated with a metal-organic framework, preserves NGAL antibodies, a clinically validated biomarker for kidney damage.
Researchers at Penn State have developed a new approach to diagnose sepsis-causing bacteria in blood infections, which can rapidly identify the specific pathogens and ideal antibiotics. This new approach, called STREAM, enables faster diagnosis and treatment, potentially reducing antibiotic resistance and improving patient outcomes.
The RENI-1 study found durable and clinically meaningful outcomes for niraparib maintenance therapy in ovarian cancer patients, with median PFS reaching 36.5 months. Long-term niraparib use was feasible, particularly in patients with BRCA1/2 mutations, and did not adversely affect quality of life.
A tiny optical imaging probe designed for optical coherence tomography (OCT) imaging inside blood vessels in the brain has been developed. The probe can acquire full 360-degree images by using a tiny piezoelectric actuator to rotate an optical lens, eliminating rotational distortion.
A research team created an ultrathin artificial lung that reproduces the movement of alveoli, air sacs inside the lung, and demonstrates the response to influenza virus. The lung operated stably through 240,000 breaths and showed promise for studying lung disease and drug responses.
A study published in Virologica Sinica identifies three candidate antiviral compounds that interfere with different stages of the chikungunya virus life cycle. The compounds, MDL-12330A, bazedoxifene acetate, and anidulafungin, show distinct antiviral profiles, suggesting that CHIKV infection can be inhibited through different mechanisms.
Researchers developed a spatially programmable microfluidic chip for temperature-controlled separation of particles of multiple sizes in a single device. The device successfully separated multiple particle populations and isolated viable cancer cells, white blood cells, and red blood cells from diluted whole blood.
A new study investigates the effects of a multimodal intervention combining individualized neuromodulation with functional training on supraspinal functional characteristics and sensorimotor function in individuals with chronic ankle instability. The intervention, which includes transcranial direct current stimulation and functional co...
A new smartphone app called Mobilio uses AI, machine learning, and personalized audio cues to provide turn-by-turn directions, path guidance, and obstacle avoidance for people with blindness or low vision. The app completed outdoor navigation tasks 13% faster and reduced obstacle contact by 41% compared to Google Maps and a white cane.
A joint team from NJU and PKU achieves single-shot high-fidelity lensless dynamic imaging by merging physical modeling with neural representation. This approach enables the recovery of clear and high-resolution images of moving samples, paving the way for flexible and practical lensless imaging applications.
Robotic gastrectomy reduces complications, blood loss, and hospital stay compared to laparoscopic surgery for gastric cancer patients, with benefits seen in both distal and total gastrectomy procedures. Longer procedures may be offset by improved visualization and enhanced dexterity.
USC researchers have developed custom, 3D-printed MRI sensors that provide clearer images of small organs in infants and children. The sensors, which can be customized to individual patients, are made in under 10 minutes and cost around $30.
Approximately 1 in 9 individuals in China will develop a digestive system cancer in their lifetime, with a staggering 1 in 12 succumbing to these diseases. The study reveals a profound 'risk transition' with colorectal cancer presenting the highest lifetime incidence risk.
A new flu vaccine, made using baker's yeast, has shown strong immune responses in mice, protecting against three different strains of flu, including those that mutate slowly. The vaccine targets the M2 protein, which is less likely to mutate and could provide broader protection against future flu strains.
Researchers develop technology to capture 3D molecular snapshots of hair follicles and reconstruct time to visualize organ formation. By analyzing hair follicle development, scientists may gain insights into congenital conditions and develop new treatments for hair loss.
A large-scale study in China found the prevalence of PCOS among pregnant women increased from 0.79 to 19.0 per 10,000 between 2012 and 2021, with significantly higher risks of adverse maternal and neonatal outcomes. Women with PCOS had increased risks of diabetes, hypertension, preeclampsia, and cesarean delivery, as well as fetal risk...
Researchers found that NF1 loss in ER+ breast cancer cells promotes bone metastasis by inducing osteoclast formation and immunosuppression, leading to a self-reinforcing cycle of cancer growth and bone damage.
A team from Osaka Metropolitan University created a coconut oil-based fuel that can be added to jet fuel without lowering performance. The fuel blend showed comparable thermal efficiency and reduced hydrocarbon emissions, making it a promising alternative.
A new technology developed by TAU's Sagol Center for Regenerative Medicine is approaching its first implantation in a person with paralysis following spinal cord injury. The implant, produced from the patient's own cells and tissues, aims to restore ability to stand, walk, and regain independence.
A new analysis found that only 3 out of 1,357 AI medical devices authorized by the US FDA were tested on patient outcomes, while most were only evaluated on substantial equivalence to existing devices. The study suggests that existing policies for AI device authorization should be redesigned to prioritize clinical effectiveness.
Researchers at Hiroshima University found that changing the carbon source for bacterial fermentation produces high-value biomaterials with promising biomedical and industrial applications. The study shows that sugarcane molasses produces EPSs with superior antioxidant and antibacterial activities.
Researchers developed a wearable patch that uses room light to treat skin wounds, promoting wound closure and tissue regeneration. The patch, made of a stretchable silicone elastomer, emits red light that activates a photosensitizer, inducing collagen crosslinking and alleviating inflammation.
Researchers at Penn State have developed genetic 'switches' that can program 3D-printed bone tissue to grow blood vessels, enabling the regeneration of bone tissue in severe trauma or infections. The technique uses microRNA molecules to push cells down a differentiation pathway optimized for either tissue growth or vascularization.
A new study reveals that fluctuations in estrogen influence brain connections in rats, using a specialized imaging technique called magnetic resonance elastography (MRE). Researchers hope to translate the findings to humans, exploring how hormonal changes affect brain health in women, particularly during menopause.
WPI researchers develop new models to study uterine fibroids with NIH funding, building on student projects. The models will help researchers better understand and develop treatments for fibroids, which affect millions of women.
The Australian facility aims to accelerate the use and availability of ASO therapeutics for genetic and acquired chronic diseases, including rare diseases. The PMC will establish educational and outreach programs to boost awareness among healthcare professionals, families, and policymakers.
A new robotic system demonstrates superior accuracy and geometric fidelity compared to traditional methods, preserving more surrounding bone and reducing unnecessary removal. The technology has potential to make tooth autotransplantation more predictable and less dependent on operator experience.
Scientists create a biomimetic zona pellucida coating called BZP to mimic the natural barrier on egg cells, protecting donor islets from the immune system and reducing blood sugar levels in diabetic mice for 100 days. This approach could lead to a promising commercial cell therapy platform for treating various diseases.
Researchers developed Film-Rupture Actuated Capillary Enrichment (FACE) to collect airborne samples, achieving detection sensitivity 100 times higher than traditional systems. The device uses surface tension and a bioinspired physical mechanism, eliminating the need for pumps or batteries.
Researchers found that astrocyte shape and molecular characteristics vary across brain regions, influencing their distinct roles. The study reveals that the Nfix gene coordinates two parallel pathways involving GABA, which is essential for astrocyte-neuron communication, and its absence impairs memory consolidation.
A coral-inspired 3D-printed scaffold reprograms immune cells to promote angiogenesis and bone regeneration, shifting macrophages from inflammatory M1 state to reparative M2 state. The scaffold also enhances angiogenesis, new bone formation, and reconstruction of bone defects.
Researchers developed a flexible microsystem to deliver light directly to internal cancer treatment sites, overcoming the limitation of traditional PDT. The system, powered wirelessly and containing tiny light-emitting components, shows promising results in laboratory tests, paving the way for more precise and effective cancer treatments.
A research team at Case Western Reserve University is developing a non-invasive oral cancer test that can diagnose the disease in minutes. The test uses a simple oral swab and measures the ratio of two naturally occurring peptides, offering a promising alternative to current biopsy methods.
Researchers developed a new high-resolution light-sheet imaging system that can document seizures in 3D in real-time, offering insights into seizure propagation and brain function. The study provides the first high-resolution 3D video of a seizure event from start to finish.
The UH Health initiative expands training, accelerates research and innovation, and improves access to care in Texas. It brings together medicine, nursing, pharmacy, optometry, psychology, social work, population health, and others under one interprofessional vision.
A team of researchers has developed a new way to study heart valve disorders by creating miniature, working models of the heart. The models, called assembloids, were grown from pluripotent adult stem cells and can be used to simulate various types of valve disorders, including mitral valve prolapse.
Researchers have developed a new stretchable catheter that can reveal features of arterial plaque not visible with conventional imaging. The device uses electrical measurements to identify metabolically active plaques, allowing doctors to spot potentially deadly buildup before it causes a heart attack.
Researchers from the University of Rochester's TraCe-bMPS have developed tissue chips that can predict dangerous immune reactions to cancer therapies. The technology, which uses human cells and sensors, has been accepted into the FDA's Innovative Science and Technology Approaches for New Drugs pilot program.
The study found that LVIS stent-assisted coiling provided effective aneurysm occlusion while producing measurable hemodynamic changes and maintaining procedural safety. Treatment reduced blood-flow activity within the aneurysm, with sustained improvements at 6 months.
Researchers have developed a new hydrogel made from peptides that can transport ions, generate electrical signals when squeezed, or interact with cells and biological molecules. The gel has tiny water channels and is electrically polarized due to its highly organized structure made from nanofibers.
Researchers used high-resolution ultrasound to measure a statistically significant reduction of 23.8% in measured scar depth after one treatment with DC microcurrent stimulation. The study found potential implications for tissue mobility and rehabilitation, but larger controlled studies are needed to confirm durability.
A BCM-led team will receive a $10 million award over five years to build FORECAST, an integrated system to study the emergence and expansion of deadly pathogens in human populations. The project aims to identify never-before-seen relationships between deadly pathogens and environmental drivers.
Researchers at USC have developed a genetic tool called the Mechano-Recorder to measure tumor cell softness. This insight can help target hard-to-reach cancer stem-like cells for destruction, potentially improving cancer treatment outcomes.