Articles tagged with Biomedical Engineering
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new heart monitoring system featuring dry 3D-printed electrodes and AI software can diagnose up to 10 types of arrhythmias, reducing testing time and medical waste. The system's reusable design improves patient comfort and compliance during long-term monitoring.
Researchers created a miniaturized replica of carotid arteries using 3D printing, mimicking the geometry and fluid dynamics of human blood vessels. The model revealed that platelet movement is crucial in blood clot formation, and high stress on blood vessels triggers significant platelet activity.
Researchers have successfully engineered functional brain-like tissue without animal-derived materials, opening doors to more controlled and humane neurological drug testing. The new material functions as a scaffold for donor brain cells and can be used to model traumatic brain injuries or neurological diseases like Alzheimer's.
Researchers have developed an innovative antibody-based enzyme switch called 'Switchbody', which is activated upon antigen binding. The switch's mechanism relies on a 'trap-and-release' process, offering new opportunities in diagnostics and therapeutics.
A new biomimetic mRNA delivery platform improves PTEN expression levels in patients with colorectal cancer. The system boosts precision immunotherapy by targeting tumors and evading the immune system.
Researchers at UGA engineered a live bacterium to deliver Levodopa steadily from the gut to the brain, alleviating motor deficits in models of Parkinson's disease. This breakthrough could lead to fewer pills, steadier symptom control, and better quality of life for patients.
Matricelf is manufacturing the world's first engineered nerve tissues for paraplegics, aiming to enable patients to walk again. The company partnered with Tel Aviv Sourasky Medical Center (Ichilov) to produce the implants in cleanrooms, meeting regulatory requirements.
Researchers have summarized recent breakthroughs in theranostic nanomaterials, engineered nanoparticles that can both diagnose and treat TBI. These materials can deliver drugs precisely where damage occurs while monitoring biological changes inside the brain.
Researchers developed a 'humanized' model of aortic valve calcification, enabling testing of potential treatments. The breakthrough could lead to new therapies to stop or reverse calcium buildup, improving outcomes for people with heart disease.
Researchers have developed a new surgical instrument called the CAP-LIFT cannula that completely transforms arthroscopic procedures in the hip region. The device solves existing problems with limited space and allows for easier maneuverability of tools, reducing complications and recovery time.
A new study by Carnegie Mellon University's Wood Neuro Research Group uses advanced brain imaging and a digital visualization tool to better understand how pain is processed in the brain for people with sickle cell disease. The team found that patients had reduced connectivity across key brain networks linked to pain perception, partic...
Researchers at TUM have developed a method to transform stem cells into bone cells using nanorobots that exert external pressure on specific points in the cell wall. This process can be completed within three weeks and has the potential to produce cartilage and heart cells as well.
Scientists from Delft University of Technology have developed living materials that can detect disease biomarkers, catalyze environmental pollutant breakdown, and function as self-healing composites. The materials are made by embedding bacterial spores in a protective barrier and can be programmed to perform specific tasks.
The partnership designates JMIR Bioinformatics and Biotechnology as the official journal of MCBIOS, ensuring high-visibility publication of cutting-edge bioinformatics research. The agreement also provides benefits such as a discount on article processing fees and virtual education and training for MCBIOS members.
Researchers developed a novel exoskeleton CASIA-EXO with subject-adaptive control, enabling efficient motor relearning and enhancing neural plasticity. The system uses intention-based trajectory planning and performance-based intervention adaptation to individualize training trajectories and intervention levels.
A swarm of miniature magnetic soft robots, inspired by fish schools, can coordinate their movements to deliver targeted drug therapy to diseased tissue. The robots can navigate through narrow passages and adapt their shape to conform to the lesion's boundaries for optimal drug delivery coverage.
Researchers uncover tandem allosteric effect enabling efficient deacetylation of proteins by Sir2, a key enzyme for biological processes. This finding reveals new target for modulating Sir2, potentially leading to novel cancer treatments and therapeutic applications.
Recent research in pathological foundation models has demonstrated robust representation learning capabilities and generalization performance. These models enable multi-task transfer with minimal data, significantly enhancing clinical utility and generalizability.
The researchers developed a chromatic filtration strategy to narrow the emission spectrum of mechanoluminescent materials, resulting in high spectral resolution and reduced noise. The new technology has significant potential for applications such as wearable sensors and healthcare motion monitoring.
Researchers aim to identify new neurobiological factors for potential intervention in AUD, including a connection between endogenous retroviruses (ERVs) and neuroinflammation. The study seeks to investigate ERV expression and genotypes in AUD pathophysiology using innovative bioinformatics tools.
A recent study published in Chinese Medical Journal reveals that dihydroartemisinin upregulates CHAC1 through H3K9 acetylation modification, inducing ferroptosis in hepatic stellate cells and suppressing liver fibrosis progression. This discovery identifies molecular targets for developing new anti-fibrotic drugs.
The ERC Synergy Grant aims to create a detailed molecular and spatial map of the blood-nerve barrier, which shields nerve cells from harmful substances. The project seeks to understand how to deliver drugs across this barrier using homing peptides to improve treatments for chronic nerve pain.
Researchers found that selective enrichment of adhesion proteins like fibronectin and vitronectin maximizes optimal cell adhesion on plastic surfaces. The optimal UVO treatment time creates a mix of hydrophilic and hydrophobic regions, promoting attachment protein replacement and secure cell binding.
Scientists discovered that eIF1A and eIF5B suppress toxic protein synthesis implicated in frontotemporal dementia and amyotrophic lateral sclerosis. The study sheds light on the mechanisms behind RAN translation, a process linked to neurodegenerative disorders.
Researchers have identified iron-manganese alloys as promising candidates for temporary bone fixation. These alloys combine strength, biocompatibility, and degradation properties, allowing them to support bone healing while degrading naturally. However, challenges remain, including controlling the release of manganese, which can pose t...
A new study published in the Chinese Neurosurgical Journal explores an AI tool that identifies medulloblastoma subgroups based on magnetic resonance imaging scans. The model achieved impressive accuracy in predicting molecular subtypes and genetic risk factors, with 91% accuracy for TP53 mutations and 87% accuracy for chromosome 11 loss.
Researchers discovered a threefold reduction in harm among patients with coronary artery stenosis who experience pulmonary embolism. Patients with CAS had lower signs of right ventricular strain, including heart rate and biomarker levels.
A new project led by University of Delaware engineer Michael Hast aims to develop radiation-free imaging techniques that identify problems with bone healing sooner. The team uses 3D computational models and recent advances in magnetic resonance imaging (MRI) to estimate the strength of a healing bone and simulate real-world stresses.
A new, fully degradable cranial clamp made from poly-L-lactic acid has been developed to address traditional fixation system drawbacks. The study compared its performance to Aesculap CranioFix through laboratory tests and a clinical trial involving 90 patients, showing improved safety and healing outcomes.
Researchers at Syracuse University have developed a novel method using ultrasound to trigger chemotherapy drugs in targeted areas, minimizing damage to healthy tissues. The approach could lead to safer and more effective cancer treatment, potentially reducing side effects and improving patient outcomes.
The University of Houston is designing robotic hands with dexterity for industries such as healthcare, agriculture, and manufacturing. The team, part of the NSF Convergence Accelerator program, has received $5 million in funding to develop hybrid polymeric materials that can mechanically retract and perform motions like flexion.
Researchers have developed a novel vaccine strategy using biomaterial scaffold vaccines to protect against Staphylococcus aureus infections in orthopedic device implants. The vaccines, made with immune cell-attaching molecules and S. aureus-specific antigens, create a beneficial immune response that significantly lowers bacterial burden.
Researchers developed a gel-like material that mimics the softness and microstructure of slow-twitch muscle tissue, successfully cultivating cells with genetic and metabolic traits of slow-twitch fibers. The technology has far-reaching implications for regenerative medicine, drug screening, and muscle transplantation therapies.
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
Researchers at ETH Zurich have successfully produced muscle tissue using a new biofabrication system called G-FLight in microgravity. The process enables rapid production of viable muscle constructs with similar cell viability and muscle fibers as those printed under gravity.
Scientists at MedUni Vienna and Imperial College London have created a new method to precisely detect nerve signals remaining after an arm amputation, allowing for the control of artificial arms. This breakthrough could form the basis for the development of next-generation prostheses.
The article argues that a universal 30 mL/kg fluid bolus is no longer appropriate and instead calls for a balanced, individualized approach to fluid management in septic shock. This approach considers the patient's comorbidities, infection source, and estimated fluid losses, and guides management by frequent reassessment.
A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.
A team of researchers has developed an artificial retina model using 3D printing technology, which closely replicates the pathological microenvironment of retinal vein occlusion. The model exhibited responses similar to those observed in clinical cases, validating its potential as a preclinical drug evaluation system.
A new study presents a tumour-customizable mRNA nanomedicine platform that demonstrated efficient mRNA delivery to cancer cells while minimizing harm to healthy tissues. The platform elicited a strong immune response, effectively turning
The Lehigh University team created a computational model to predict the hemodynamic response of patients with AFib, helping tailor neurostimulation dosages. The model validated against clinical data and predicted accurate effects on blood pressure, heart rate, and stroke volume.
A new study suggests that collecting and testing cancer cells in patients' blood could help doctors choose the right breast cancer treatment. The 'labyrinth chip' technology separates cancer cells from other blood cells, allowing researchers to identify biomarkers that distinguish aggressive treatments from less invasive ones.
A new broad-spectrum antivenom developed by DTU researchers covers 17 African snake species and provides better protection against tissue damage, with a lower risk of immune reactions. The antivenom has shown impressive results in laboratory studies and could revolutionize the treatment of venomous snakebites in Africa.
The partnership creates a stable, high-impact venue for MCBIOS members to publish their research, particularly the output from the Society's annual conference. The designation of JMIR Bioinformatics and Biotechnology as the official journal provides maximum visibility for cutting-edge work in bioinformatics and computational biology.
Researchers at the University of Missouri are exploring the use of extracellular vesicles to target lung cancer. By manipulating these tiny messenger particles, scientists can deliver specific instructions to kill cancer cells while sparing healthy ones.
Researchers have developed bioelectronic hydrogels made from conducting polymer microparticles that can be injected into the body or used as injectable therapies. The material has the potential to emulate properties of the body and leverage its functions for more sophisticated ways of doing it.
Researchers developed a generative AI model, BIGE, to generate optimal motions for athletes to avoid injuries and aid in rehabilitation. The model can produce realistic videos of motions that athletes can mimic during training or execute while injured.
Researchers developed a nanoparticle system combining lenalidomide and melarsoprol to activate the cGAS-STING pathway, promoting immunotherapy for HCC. The combination therapy significantly reduced tumor growth and improved survival in mouse models.
A team of Pitt engineers has created self-powered spinal implant technology capable of transmitting real-time data from inside the body. The innovation utilizes new human-developed composites known as metamaterials to harvest energy and transmit signals wirelessly.
The Stowers Institute has appointed its first AI Fellow, Sumner Magruder, to harness the potential of artificial intelligence in biological research. He will collaborate with researchers to design new algorithms and unlock insights from large datasets.
Researchers used boron isotope fingerprinting to track the release of boron from two glass compositions. The findings show that the formation of a protective altered layer controls long-term contaminant release, with magnesium-driven secondary mineral precipitation enhancing dissolution rates.
Researchers at FAU Engineering have developed foot-mounted wearable sensors and a 3D depth camera that accurately measure how people walk, even in busy clinical environments. The study findings reveal that these technologies match the accuracy of traditional tools but are more scalable, remote, and cost-effective.
Research on per- and polyfluoroalkyl substances (PFASs) in drinking water has evolved through three distinct phases, with a focus on monitoring and treatment challenges. The study reveals growth in research, with cumulative publications expected to reach 7,689 by 2030.
A team of researchers has proposed a novel ultrathin flexible sensor inserted endovascularly to detect Type-I endoleaks with maximum rupture risk. The sensor is robust enough to withstand dynamic processes and exhibits long-term stability and functionality.
A team of researchers developed a battery-free wearable patch that measures bioimpedance to detect skin lesions, distinguishing between healthy and abnormal skin. The patch's effectiveness was tested on 10 volunteers, showing significant differences between healthy and suspicious moles.
Boston University researcher Brian Cleary has been awarded a five-year, $2.25 million NIH grant to investigate how gene expression changes over time in single cells. His project aims to develop new computational-experimental approaches to track RNA velocity vector fields and deepen understanding of cell physiology.
Researchers at Cincinnati Children's propose a unified approach to understand blood cell formation, identifying rare cell populations and gene regulatory networks. This breakthrough advances targeted therapies and stem cell engineering.
Researchers developed a non-destructive tool for evaluating loblolly pine disease resistance, achieving 81.5% training accuracy and 68.7% testing accuracy with NIR spectroscopy. The study demonstrates the potential of vibrational spectroscopy to transform forestry phenotyping and precision forestry.
A Moroccan ICU study shows that the plethysmographic perfusion index can help identify fluid responsiveness in critically ill patients with acute circulatory failure non-invasively. Two-thirds of patients were fluid responders, and PPI correctly identified responders with 70% sensitivity and 82% specificity.
Researchers have identified 57 unique proteins in urine that can indicate active damage to the kidneys, enabling non-invasive monitoring of lupus nephritis. This breakthrough could transform diagnosis and treatment for millions worldwide affected by systemic lupus erythematosus.