Articles tagged with Biomedical Engineering
A new study found that while nutritional screening and dietitian involvement have increased, early oral feeding remains low, and total parenteral nutrition use is still high in China. This suggests that continued education and guideline promotion are needed to improve patient outcomes.
Researchers have developed biodegradable films from engineered honeybee silk, which can be programmed to respond to wound conditions. The material is safe, well-tolerated, and doesn't impede healing, making it a promising solution for preventing infections in chronic wounds.
Researchers at Aarhus University have developed a tiny sensor that responds to touch in a similar way to our sensory cells. The sensor, made from a soft, silicone-like material, can convert touch into an electric potential and potentially stimulate nerves directly, allowing for prosthetic limbs with a sense of touch.
Zhen Xu, U-M Engineering professor, wins Golden Goose Award for development of histotripsy, a noninvasive cancer treatment. The technology has been used to treat over 5,000 patients worldwide and has the potential to treat various diseases, including brain diseases and cardiovascular diseases.
Researchers identified BRSK1 gene variants as a diagnosis for a rare neurodevelopmental disorder, characterized by developmental delays, neurological symptoms, and variable expressivity. Fruit fly studies connected the gene to the human condition, revealing essential role for BRSK1 in normal nervous system function.
Researchers from CityUHK have developed a sequencing-free approach for spatial omics analysis, enabling routine clinical use. The method, Spectrum-FISH, preserves spatial information in freshly prepared tissue samples and offers advantages in affordability and scalability.
Researchers have developed a laser-powered technology that accelerates antibody-antigen interactions to detect tiny amounts of a colorectal cancer biomarker within minutes. This technology has the potential to improve cancer diagnosis by increasing detection sensitivity and speed.
A University of California, Davis-led project aims to develop a 'cyborg' cell technology that can store and transport cellular therapies at room temperature, reducing costs and increasing accessibility. The CYBORGEL project, funded by up to $36.5M from ARPA-H, has the potential to make life-saving cell therapies more affordable and acc...
A novel wearable device, HELP, tracks breathing and heart activity using liquid-metal technology, enabling clinical-grade home monitoring for chronic respiratory and heart conditions. The patch features a unique analog constriction gate architecture, providing sensitivity and linearity across its entire physical range.
Researchers at MIT have developed a handheld device to collect living cells from specific locations in patient samples, enabling early cancer detection and personalized medicine development. The device uses a microfluidic channel to gently detach living cells from tissue, allowing for targeted sampling and cultivation for diagnostics a...
Researchers developed a gene-delivery system that converts reactive astrocytes into functional neurons, improving motor recovery in mice and rats. The system, TRANsCre-DIONE, selectively targets scar-forming cells and reprograms them into neurons, which generate nerve impulses and receive signals from other neurons.
Researchers identified a protein-degradation mechanism that contributes to the development of inherited CPVT, a disease that affects children and young people. The study suggests that inhibiting calpain, an enzyme involved in protein degradation, may restore normal heart function and reduce arrhythmias.
Researchers developed physics-embedded inverse learning (PEIL) to supervise parameter estimation in wireless communications and MRI. PEIL uses signal recovery to estimate intermediate parameters without labels, achieving strong symbol recovery and comparable performance to parameter-supervised baselines.
Recent advances in engineered mitochondrial delivery aim to improve stability, efficiency, and precision of mitochondrial transplantation. Four strategies have been proposed, including surface-engineering, cell-mediated delivery, vesicle-encapsulation, and cell-type-specific targeting.
A UCF researcher and her team used AI to screen existing FDA-approved drugs for potential treatments of schwannoma tumors in children with Neurofibromatosis type 2. The research identified 10 promising candidates, with the most favorable targets stopping tumor cell growth by impacting different cellular mechanisms.
The grant will support research experiences for 12 WPI undergraduates in Solomon Mensah's lab, aiming to determine the molecular mechanisms behind sepsis-induced blood clotting. The goal is to rescue a damaged glycocalyx barrier, paving the way for sepsis treatments.
A team of researchers has developed nanoparticles that can activate nerve cells in degenerated retinas, potentially leading to a new type of retinal prosthesis. The nanoparticles, made from graphitic carbon nitride, trigger electrical and chemical processes that activate nerve cells and prompt signals towards the brain.
A review in Biomedical Analysis highlights the integration of microfluidic technologies to bring flow cytometry closer to point-of-care testing, enabling blood cell counting, leukocyte differential analysis, and imaging-based white blood cell classification
The Terasaki Institute faculty has developed a next-generation immunomodulatory wound dressing platform designed to accelerate healing in chronic wounds. The platform is designed to deliver oxygen directly to the wound and use a specialized peptide to encourage immune cells to support healing.
The University of Rhode Island Biomedical Engineering department has received a $1.015 million NIH grant to develop a multimodal neurotechnology framework for understanding and enhancing motor brain function. The project will integrate electroencephalography, functional near-infrared spectroscopy, and behavioral measurements to investi...
Finalists in the 2026 Blavatnik National Awards for Young Scientists have been recognized for their groundbreaking research in Life Sciences, Chemical Sciences, and Physical Sciences & Engineering. The 18 Finalists will compete for three $250,000 Laureate prizes, with the remaining 15 receiving $15,000. The Awards aim to support innova...
Researchers develop a new approach combining probiotics with T cells to improve tumor localization and coordination of local immune responses. The therapy, called T-FOLactis, shows improved tumor control and median survival in mouse colorectal cancer models.
A new brain-computer interface (BCI) allows people with vocal tract and bodily paralysis to convey both speech and upper-body gestures simultaneously. The BCI successfully translated the thoughts of patients into commands that dictated the expressions of a full-body virtual avatar.
Researchers developed a new culture membrane that recreates the biochemical composition and soft physical environment of native intestinal tissue, enhancing intestinal cell growth and behavior. The membrane, combined with human colon organoid-derived epithelial cells, exhibited increased characteristics associated with intestinal stem ...
A portable handheld terahertz three-dimensional spectral scanner has been developed to diagnose burn wounds and predict wound-healing outcomes. The device uses an asynchronous optical sampling system to achieve short scan times and can acquire three-dimensional spectroscopic images in the terahertz range.
A Korea University study investigated plasma p-tau217 as an early marker of treatment response in early Alzheimer's disease. The study found that patients with greater reductions in p-tau217 levels had more favorable cognitive trajectories.
Professor Shin's research focuses on developing tissue-adhesive, electrically conductive hydrogels for muscle and brain tissue repair. Her AYSF-supported project aims to engineer an injectable hydrogel filler for brain tumor recovery, addressing the limited capacity for neural tissue regeneration in the adult brain.
Researchers at CU Anschutz have developed CAR T-cell therapy to target two pathways that help colorectal tumors grow and evade the immune system, B7-H3 and IL-8. The therapy aims to provide a more durable response than traditional chemotherapy.
Researchers have developed a technology that combines aminoglycoside antibiotics with PKZ18 analogs, resulting in up to an 8-fold increase in efficacy and reduced risk of microbial resistance. This synergy enables targeting of bacteria in various environments, expanding the therapeutic window.
Researchers developed a biodegradable metal-polymer composite stent that outperforms traditional stents in a 5-year clinical trial involving 1,108 patients. The stent's polymer coating reduces inhomogeneity of degradation but increases corrosion rate, leading to faster degradation and later device fracture.
This DNA nanoswitch technology detects RNases using a simple mix-and-read methodology, offering a cost-effective solution for biological samples. The nanoswitch changes shape in response to RNase presence, making it a useful tool for RNase-sensing applications.
A new saliva-based assay rapidly and accurately assesses flavivirus immunity by measuring multiple antibody classes in saliva. The test can distinguish between individuals with polytypic dengue virus immunity and those who have previously experienced both dengue virus and Zika virus infections.
Researchers developed a device called MetaboSense that continuously tracks key indicators of lung health, providing transplant teams with more detailed information than current hourly testing. The technology could help identify more viable donor lungs and potentially rehabilitate organs that might otherwise be rejected.
A novel laser-fabricated plasmonic chip combines 185 nm Raman resolution with deep learning to identify and sort cancer cells. The developed sorter achieves precise cell sorting without labeling, using spatially resolved Raman signals.
A new method uses hybrid bright-dark field imaging to enhance digital pathology resolution, improving diagnostic sensitivity and AI-assisted analysis. It achieves 2.1x spatial resolution enhancement with minimal hardware upgrades and improved efficiency.
Researchers discovered that β1 integrin and DDR2 form a cooperative collagen-sensing system in skeletal progenitor cells, regulating their migration, proliferation, and differentiation during bone regeneration. Targeting both receptors may provide a more effective strategy for enhancing bone repair in degenerative or injury-related ske...
mRNA-LNPs are shifting the paradigm of drug delivery, enabling vaccines, personalized cancer vaccines, and in vivo gene editing. CAR-engineered cells can be directly generated in vivo, offering a streamlined alternative to ex vivo CAR-T manufacturing.
A new review in Medicine Plus traces the development of deep brain stimulation, mapping mechanisms and clinical targets across 16 disorders. It highlights future personalized strategies and calls for validated biomarkers and standardized reporting.
A modular nano-adaptor approach tunes T-cell activation to control CD3 activation and prevent toxicity, increasing therapeutic effectiveness in solid tumors. The platform has identified promising lead designs for multispecific nanoantibody configurations.
Researchers develop biodegradable nanobone material that activates body's own healing properties to regrow bone, reducing need for invasive procedures. The material generates 80% more new bone than a material control and activates a key bone-repair growth factor with 10 times the level achieved using conventional methods.
A new study found that urban rivers in Beijing harbor the highest burden of antibiotic resistance genes, while receiving waters show stronger mobilization signals, indicating a high risk of resistance exchange. The study highlights the need for risk-oriented water management in megacities.
Researchers developed a bio-based Fe-MOF nanoreactor that combines natural-ligand chemistry with multimetallic redox catalysis, biomimetic targeting and MRI visibility. The nanoplatform produced a strong ROS response, increased apoptosis, and tumor inhibition in breast cancer cells and mice.
Researchers identified referral gaps, diagnostic waits, and service pressures that can delay action after early autism concerns emerge. The study suggests practical changes to improve coordination and timely support for families, including repeat surveillance, closed-loop referral tracking, and needs-based support.
Engineered microbe-based micro/nanorobots can revolutionize clinical intervention for luminal cancers by navigating and adapting to hostile luminal cavities. The review categorizes this living robotic paradigm into four synergistic capabilities, including active navigation, environmental sensing, and continuous biosynthesis.
Researchers developed a portable AI-assisted microfluidic platform to detect sub-resistant bacteria, combining machine learning with the ancient 'six-four water diversion' principle. The platform provides a more refined view of bacterial drug response and can identify sub-resistant populations that conventional tests may overlook.
A new parametric design framework transforms flat paper sheets into self-folding helical sensors that measure biosignals. The approach combines sustainable materials with a simple software-guided design process, enabling rapid production of customized wearable electronics.
Researchers at the University of Missouri-Columbia have discovered a protein, TG2, that contributes to arterial stiffening and inflammation linked to high blood pressure. By blocking TG2 activity, they found that inflammation can be reduced, potentially leading to more precise treatments for cardiovascular disease.
Researchers developed protein-coated CuS nanoparticles with excellent colloidal stability, pH-responsive behavior, and effective near-infrared-induced killing of breast cancer cells. The protein coating improved biocompatibility and reduced dark toxicity.
Eric Perreault, a renowned research executive and academic leader, will lead the Morgridge Institute for Research, a biomedical research organization affiliated with the University of Wisconsin-Madison. The institute focuses on improving human health through cross-disciplinary research and collaborations.
Dunpeng Cai is leading the search for a treatment for aortic valve calcification, a disease that affects millions of older adults worldwide and causes the heart's aortic valve to harden and narrow over time. His team plans to test a drug compound to slow or prevent the disease by blocking a protein called DOCK2.
A mathematical model developed by researchers from Hasanuddin University suggests that combining vaccination, treatment, quarantine, and educational campaigns could curb Mpox transmission. The model showed that a full-control strategy produced the greatest reduction in infections, with a 97.85% decrease in the total number of infected ...
A study published in Advanced Materials Interfaces reveals that proteins with exposed arginine residues selectively accumulate on protein-resistant coatings, compromising biocompatibility of medical devices. Researchers developed a new design guideline for predicting and controlling protein corona formation at the molecular level.
Researchers from HKUST develop 'one-pot' testing platform TEMPO for rapid, single-step nucleic acid testing, reaching attomolar sensitivity comparable to laboratory methods. The platform has potential applications in infectious disease surveillance and genetic screening.
Researchers developed a microneedle patch that can detect early signs of kidney injury, stabilizing biomolecules in high-heat settings. The patch, coated with a metal-organic framework, preserves NGAL antibodies, a clinically validated biomarker for kidney damage.
Researchers at Penn State have developed a new approach to diagnose sepsis-causing bacteria in blood infections, which can rapidly identify the specific pathogens and ideal antibiotics. This new approach, called STREAM, enables faster diagnosis and treatment, potentially reducing antibiotic resistance and improving patient outcomes.
The RENI-1 study found durable and clinically meaningful outcomes for niraparib maintenance therapy in ovarian cancer patients, with median PFS reaching 36.5 months. Long-term niraparib use was feasible, particularly in patients with BRCA1/2 mutations, and did not adversely affect quality of life.
A research team created an ultrathin artificial lung that reproduces the movement of alveoli, air sacs inside the lung, and demonstrates the response to influenza virus. The lung operated stably through 240,000 breaths and showed promise for studying lung disease and drug responses.
A tiny optical imaging probe designed for optical coherence tomography (OCT) imaging inside blood vessels in the brain has been developed. The probe can acquire full 360-degree images by using a tiny piezoelectric actuator to rotate an optical lens, eliminating rotational distortion.
A study published in Virologica Sinica identifies three candidate antiviral compounds that interfere with different stages of the chikungunya virus life cycle. The compounds, MDL-12330A, bazedoxifene acetate, and anidulafungin, show distinct antiviral profiles, suggesting that CHIKV infection can be inhibited through different mechanisms.
Researchers developed a spatially programmable microfluidic chip for temperature-controlled separation of particles of multiple sizes in a single device. The device successfully separated multiple particle populations and isolated viable cancer cells, white blood cells, and red blood cells from diluted whole blood.