A new study investigates the effects of a multimodal intervention combining individualized neuromodulation with functional training on supraspinal functional characteristics and sensorimotor function in individuals with chronic ankle instability. The intervention, which includes transcranial direct current stimulation and functional co...
A new smartphone app called Mobilio uses AI, machine learning, and personalized audio cues to provide turn-by-turn directions, path guidance, and obstacle avoidance for people with blindness or low vision. The app completed outdoor navigation tasks 13% faster and reduced obstacle contact by 41% compared to Google Maps and a white cane.
A joint team from NJU and PKU achieves single-shot high-fidelity lensless dynamic imaging by merging physical modeling with neural representation. This approach enables the recovery of clear and high-resolution images of moving samples, paving the way for flexible and practical lensless imaging applications.
Robotic gastrectomy reduces complications, blood loss, and hospital stay compared to laparoscopic surgery for gastric cancer patients, with benefits seen in both distal and total gastrectomy procedures. Longer procedures may be offset by improved visualization and enhanced dexterity.
USC researchers have developed custom, 3D-printed MRI sensors that provide clearer images of small organs in infants and children. The sensors, which can be customized to individual patients, are made in under 10 minutes and cost around $30.
Approximately 1 in 9 individuals in China will develop a digestive system cancer in their lifetime, with a staggering 1 in 12 succumbing to these diseases. The study reveals a profound 'risk transition' with colorectal cancer presenting the highest lifetime incidence risk.
A new flu vaccine, made using baker's yeast, has shown strong immune responses in mice, protecting against three different strains of flu, including those that mutate slowly. The vaccine targets the M2 protein, which is less likely to mutate and could provide broader protection against future flu strains.
Researchers develop technology to capture 3D molecular snapshots of hair follicles and reconstruct time to visualize organ formation. By analyzing hair follicle development, scientists may gain insights into congenital conditions and develop new treatments for hair loss.
A large-scale study in China found the prevalence of PCOS among pregnant women increased from 0.79 to 19.0 per 10,000 between 2012 and 2021, with significantly higher risks of adverse maternal and neonatal outcomes. Women with PCOS had increased risks of diabetes, hypertension, preeclampsia, and cesarean delivery, as well as fetal risk...
Researchers found that NF1 loss in ER+ breast cancer cells promotes bone metastasis by inducing osteoclast formation and immunosuppression, leading to a self-reinforcing cycle of cancer growth and bone damage.
A team from Osaka Metropolitan University created a coconut oil-based fuel that can be added to jet fuel without lowering performance. The fuel blend showed comparable thermal efficiency and reduced hydrocarbon emissions, making it a promising alternative.
A new technology developed by TAU's Sagol Center for Regenerative Medicine is approaching its first implantation in a person with paralysis following spinal cord injury. The implant, produced from the patient's own cells and tissues, aims to restore ability to stand, walk, and regain independence.
A new analysis found that only 3 out of 1,357 AI medical devices authorized by the US FDA were tested on patient outcomes, while most were only evaluated on substantial equivalence to existing devices. The study suggests that existing policies for AI device authorization should be redesigned to prioritize clinical effectiveness.
Researchers at Hiroshima University found that changing the carbon source for bacterial fermentation produces high-value biomaterials with promising biomedical and industrial applications. The study shows that sugarcane molasses produces EPSs with superior antioxidant and antibacterial activities.
Researchers developed a wearable patch that uses room light to treat skin wounds, promoting wound closure and tissue regeneration. The patch, made of a stretchable silicone elastomer, emits red light that activates a photosensitizer, inducing collagen crosslinking and alleviating inflammation.
Researchers at Penn State have developed genetic 'switches' that can program 3D-printed bone tissue to grow blood vessels, enabling the regeneration of bone tissue in severe trauma or infections. The technique uses microRNA molecules to push cells down a differentiation pathway optimized for either tissue growth or vascularization.
A new study reveals that fluctuations in estrogen influence brain connections in rats, using a specialized imaging technique called magnetic resonance elastography (MRE). Researchers hope to translate the findings to humans, exploring how hormonal changes affect brain health in women, particularly during menopause.
WPI researchers develop new models to study uterine fibroids with NIH funding, building on student projects. The models will help researchers better understand and develop treatments for fibroids, which affect millions of women.
The Australian facility aims to accelerate the use and availability of ASO therapeutics for genetic and acquired chronic diseases, including rare diseases. The PMC will establish educational and outreach programs to boost awareness among healthcare professionals, families, and policymakers.
A new robotic system demonstrates superior accuracy and geometric fidelity compared to traditional methods, preserving more surrounding bone and reducing unnecessary removal. The technology has potential to make tooth autotransplantation more predictable and less dependent on operator experience.
Scientists create a biomimetic zona pellucida coating called BZP to mimic the natural barrier on egg cells, protecting donor islets from the immune system and reducing blood sugar levels in diabetic mice for 100 days. This approach could lead to a promising commercial cell therapy platform for treating various diseases.
Researchers developed Film-Rupture Actuated Capillary Enrichment (FACE) to collect airborne samples, achieving detection sensitivity 100 times higher than traditional systems. The device uses surface tension and a bioinspired physical mechanism, eliminating the need for pumps or batteries.
Researchers found that astrocyte shape and molecular characteristics vary across brain regions, influencing their distinct roles. The study reveals that the Nfix gene coordinates two parallel pathways involving GABA, which is essential for astrocyte-neuron communication, and its absence impairs memory consolidation.
A coral-inspired 3D-printed scaffold reprograms immune cells to promote angiogenesis and bone regeneration, shifting macrophages from inflammatory M1 state to reparative M2 state. The scaffold also enhances angiogenesis, new bone formation, and reconstruction of bone defects.
Researchers developed a flexible microsystem to deliver light directly to internal cancer treatment sites, overcoming the limitation of traditional PDT. The system, powered wirelessly and containing tiny light-emitting components, shows promising results in laboratory tests, paving the way for more precise and effective cancer treatments.
Researchers developed a new high-resolution light-sheet imaging system that can document seizures in 3D in real-time, offering insights into seizure propagation and brain function. The study provides the first high-resolution 3D video of a seizure event from start to finish.
A research team at Case Western Reserve University is developing a non-invasive oral cancer test that can diagnose the disease in minutes. The test uses a simple oral swab and measures the ratio of two naturally occurring peptides, offering a promising alternative to current biopsy methods.
Researchers at USC have developed a genetic tool called the Mechano-Recorder to measure tumor cell softness. This insight can help target hard-to-reach cancer stem-like cells for destruction, potentially improving cancer treatment outcomes.
The UH Health initiative expands training, accelerates research and innovation, and improves access to care in Texas. It brings together medicine, nursing, pharmacy, optometry, psychology, social work, population health, and others under one interprofessional vision.
A team of researchers has developed a new way to study heart valve disorders by creating miniature, working models of the heart. The models, called assembloids, were grown from pluripotent adult stem cells and can be used to simulate various types of valve disorders, including mitral valve prolapse.
Researchers have developed a new stretchable catheter that can reveal features of arterial plaque not visible with conventional imaging. The device uses electrical measurements to identify metabolically active plaques, allowing doctors to spot potentially deadly buildup before it causes a heart attack.
Researchers from the University of Rochester's TraCe-bMPS have developed tissue chips that can predict dangerous immune reactions to cancer therapies. The technology, which uses human cells and sensors, has been accepted into the FDA's Innovative Science and Technology Approaches for New Drugs pilot program.
The study found that LVIS stent-assisted coiling provided effective aneurysm occlusion while producing measurable hemodynamic changes and maintaining procedural safety. Treatment reduced blood-flow activity within the aneurysm, with sustained improvements at 6 months.
Researchers have developed a new hydrogel made from peptides that can transport ions, generate electrical signals when squeezed, or interact with cells and biological molecules. The gel has tiny water channels and is electrically polarized due to its highly organized structure made from nanofibers.
Researchers used high-resolution ultrasound to measure a statistically significant reduction of 23.8% in measured scar depth after one treatment with DC microcurrent stimulation. The study found potential implications for tissue mobility and rehabilitation, but larger controlled studies are needed to confirm durability.
A BCM-led team will receive a $10 million award over five years to build FORECAST, an integrated system to study the emergence and expansion of deadly pathogens in human populations. The project aims to identify never-before-seen relationships between deadly pathogens and environmental drivers.
The collaboration aims to improve human tolerance to xenogeneic organs and reduce the risk of organ rejection. Researchers will explore immunomodulatory interventions to support patients with high unmet needs who face additional barriers to receiving timely liver transplants.
Light-field microscopy (LFM) enables snapshot volumetric acquisition, allowing for faster synchronous three-dimensional information. Recent advances have made LFM practical for high-speed neuroimaging, particularly in calcium imaging and voltage imaging.
ASTRA-Net helps reconstruct overlooked peripheral airways, creating more complete maps for bronchoscopy procedures. The AI framework demonstrates strong performance in identifying fine peripheral airways and supports navigation to difficult-to-reach lung lesions.
A new portable blood testing device connects via Bluetooth and uses AI to analyze blood samples, providing real-time health insights. This technology allows for regular monitoring of patients undergoing chemotherapy or taking medications with potential side effects.
Researchers developed a new drug called CS18 that targets TopBP1, a biological switchboard controlling multiple cancer-driving pathways. CS18 reduces defenses helping cancer cells survive therapy and increases genes stopping uncontrolled growth.
A new wearable electric-field device has been shown to slow the growth and spread of aggressive breast cancer in preclinical models. The technology uses low-intensity electric fields that interact with cancer cells in a controlled way, reducing tumor growth and increasing immune responses.
Researchers developed realistic skin-like test models to reproduce a range of skin tones and simulate blood flow, helping device developers identify biases in light-based medical technologies. The models showed improved optical signals detection across different pigmentation levels.
A new study found that children preparing for stem cell transplantation already have subtle respiratory abnormalities, including increased small-airway resistance and greater lung stiffness. These abnormalities are likely related to their underlying disease or previous therapies rather than the transplant itself.
A team at Pusan National University created a stretchable organic electrochemical transistor that can be easily reprogrammed to perform different functions. The device combines logic, memory, and a visible color readout without complex circuitry.
Researchers developed an AI model capable of generating accurate, high-resolution pressure maps using just a few anatomical landmarks, enabling lower-cost foot health monitoring in rural and remote regions. The study demonstrates the potential for AI to overcome challenges associated with traditional plantar pressure monitoring systems.
Researchers explore how engineered lanthanide carriers can tune the optical and magnetic properties of ions for improved signal contrast and reduced background signals in biomedical imaging. The study highlights opportunities for multimodal imaging, theranostics, and AI-guided probe design.
Researchers at Institute of Science Tokyo developed strategies to overcome xenophagocytosis, which eliminates living donor cells in interspecies organ generation. By blocking this response, they significantly improved donor cell survival and generated rat pancreas in mice.
Researchers propose a four-stage pathway to evaluate AI for intracranial aneurysm detection, including lesion-level testing, reader performance evaluation, and surveillance after deployment. The framework aims to assess the tool's net clinical benefit in specific care settings.
Recent progress in lanthanide carriers is mapped to improve biomedical imaging and diagnosis, combining optical, X-ray, and magnetic resonance imaging techniques. These carriers enable high-resolution imaging with tunability for different applications, reducing tissue damage and enhancing image clarity.
Researchers at the University of Manchester have developed a new family of antifungal agents that are more potent and less toxic than existing treatments. The compounds, which were discovered through genome mining, showed increased antifungal activity and improved solubility compared to existing drugs.
Researchers at the University of Queensland have developed ultra-wideband radar sensors to measure muscle forces in a non-invasive way. This technology has the potential to improve rehabilitation, injury prevention, and recovery for people with motor neuron disease or aging. The goal is to eventually use real-time sensor data to assist...
Researchers have developed a way to quickly create customizable synthetic blood vessel grafts in just minutes using additive manufacturing. The new technique, called Focused Rotary Jet Spinning, allows for precise control over diameter and wall thickness, making it ideal for acute trauma situations and complex pediatric heart surgeries.
Scientists at the University of Osaka have created a new technique to build blood supply systems for artificial tissues. They successfully fabricated tubular hydrogel structures with controlled lumen sizes and complex geometries, paving the way for creating vascular models that can investigate the development of fully synthetic tissues.
Dr. Yi Li receives CPRIT funding to develop treatments for solitary fibrous tumor, a rare cancer driven by gene fusions. Researchers are working on novel therapies, including immunotherapy and antisense oligonucleotides, to reduce cancer-causing signal activity.
A new study from Reichman University found that a short three-week digital training program improved motor function and brain activity in Parkinson's patients. The program, called DopApp, strengthened connectivity between brain regions responsible for movement and induced localized changes in neural circuits.
A Chinese research team has proposed a novel approach to separate dimethyl carbonate from methanol using a tailor-made ionic liquid and heat pump-assisted distillation. The method significantly reduces energy consumption and costs compared to traditional methods, making it an attractive solution for the chemical industry.
Emerging non-endocytic delivery strategies enable direct cytosolic delivery of proteins, nucleic acids, and gene-editing tools, providing new opportunities for biomedical therapies. The review discusses their application prospects in gene therapy, macromolecular drug delivery, and cellular engineering.
The US Naval Research Lab is developing continuous biomanufacturing technologies to produce critical materials more efficiently and sustainably. The approach uses surface-bound microbial cells to generate valuable compounds over extended periods, reducing energy requirements and equipment size.
Researchers at HKUST develop a biocompatible chemical reaction to create targeted anticancer prodrugs, enabling precise drug activation in cancer cells. The breakthrough uses the EBB group and gold catalysts, offering a promising strategy for reducing collateral toxicity.