Articles tagged with Biomedical Engineering
A new framework proposes a 'three-strata' model to classify gastrointestinal tract cancers, guiding more precise and effective strategies. The review advocates for chemotherapy-free approaches in highly immunogenic tumors and explores optimized combinations with chemotherapy for intermediate-sensitive tumors.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
A study by University of Texas at Dallas bioengineers found that both cancerous and noncancerous colon tissue from young patients with colorectal cancer was mechanically stiffer than in older patients. This stiffness may promote the development of early-onset colorectal cancer, a condition rising over the past 30 years.
A new review highlights the cytokine storm's key role in lung injury and multi-organ dysfunction in acute respiratory distress syndrome (ARDS). The review emphasizes biological heterogeneity, subphenotypes, and the need for biomarker-guided patient stratification.
Researchers found that participants initially overestimated the awkwardness of their gait but improved as they practiced using the prosthetic device. Despite significant performance gains, participants remained inaccurate in assessing their own body movement, focusing on torso position rather than prosthetic behavior.
A study revealed a path of molecular events that can lead to Alzheimer's disease, including the formation of amyloid plaques and tau tangles. Researchers identified genes involved in immune and synaptic regulatory mechanisms as potential therapeutic targets.
Researchers developed an AI-driven pipeline to create functional intracellular antibodies, overcoming major barriers in intrabody development. The approach successfully redesigned structures compatible within the cellular environment, enabling high target specificity and stability.
A team from the Universitat Politècnica de València and Corify Care has developed the first whole-heart mapping technology that provides real-time views of cardiac arrhythmias. This innovation enables physicians to make faster decisions, target ablations more effectively, and potentially reduce procedure time.
Microtubule researchers reveal how tubulin isotypes regulate luminal accessibility through reversible protofilament separation. The findings provide insights into mechano-transduction and could lead to novel biomaterials development.
Researchers discovered how bacteria Pseudomonas sp. SZ40 and Paenibacillus sp. SZ31 work together to produce a toxic substance against an amoeba predator. The study revealed the role of DL peptidases in converting lipopeptides into a substance that is harmful to the amoeba.
Researchers at the University of Arkansas developed an AI diagnostic tool to detect masked hypertension, a condition where people have high blood pressure but normal readings during exams. The tool uses machine learning and health indicators to predict masked hypertension with accuracy, potentially saving lives and improving patient care.
Researchers at NTU Singapore develop a new orally taken, gut-based compound that reduces dietary fat absorption in the intestines. The technology supports weight loss while minimizing effects on other organs and reducing stress on the liver when dietary fat intake is high.
The University of Missouri has launched its first human clinical trial using Eye90 microspheres, a radiopharmaceutical breakthrough device manufactured on campus. The study aims to assess the safety and effectiveness of Eye90 in treating unresectable liver tumors, including hepatocellular carcinoma and metastatic colorectal cancer.
Scientists have identified the FOXO1-KLHL6 axis as a novel therapeutic target to enhance T cell-mediated immune response against tumors. The research found that persistent T cell receptor signaling suppresses the transcription factor FOXO1, leading to the downregulation of the E3 ubiquitin ligase KLHL6 and promoting T cell exhaustion.
Researchers used advanced imaging to uncover early molecular changes in bone associated with osteoarthritis. The study found that subchondral bone beneath damaged cartilage showed strong upregulation of specific collagen fragments, suggesting that disease-related bone changes begin earlier than previously recognized.
Scientists have developed a novel computational framework for real-time, personalized heart rate variability monitoring. The framework provides robust, adaptive alerts and improves the accuracy of HRV analysis by excluding artifact-prone periods.
Halle Zhang joins Insilico Medicine to lead global clinical development strategy for the company's oncology portfolio. She brings over 20 years of experience in oncology clinical development and a track record of advancing therapies through registrational trials.
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
Researchers at Kyushu University discovered that cancer cells use a previously unrecognized physical mechanism called CODE to create water pressure that aids in their migration. This finding opens new avenues for therapies targeting amoeboid movement, a key strategy used by most advanced cancer cells.
Researchers developed a light-sensitive oligonucleotide probe that selectively detects 5-formylcytosine, an epigenetically important intermediate. The probe demonstrates stable cross-linking with 5fC across various conditions, enabling its detection in target DNA and complex biological samples.
Researchers developed smart 4D-printed vascular stents that expand naturally at body temperature, eliminating the need for external heating. The stents balance mechanical flexibility and radial strength, demonstrating long-term biomechanical compliance.
The review explores how next-generation sequencing can enhance early disease detection in newborns by analyzing DNA from dried blood spots. This genomic approach expands the benefits of NGS by identifying conditions not detectable through traditional biochemical testing.
Scientists have successfully grown human norovirus in the lab for up to 15 consecutive passages, enabling comprehensive studies of viral structure, antiviral drug screening, and vaccine development. The breakthrough uses a drug called TAK 779 to overcome host restrictions, allowing researchers to produce stable virus stocks.
Researchers at Flinders University developed a high-performance coating made from peppermint essential oil that protects against infection, inflammation, and oxidative stress. The coating demonstrates strong antibacterial action against key pathogens, including E. coli and Pseudomonas aeruginosa.
The ESMT Berlin DEEP Institute and Creative Destruction Lab will be launched in Doha to support technology transfer and innovation. The initiative aims to connect the innovation ecosystems of Germany and Qatar, fostering entrepreneurial growth and driving economic growth.
Researchers at Adelaide University have uncovered a crucial new mechanism controlling heart development by regulating key growth signals. Neural crest cells fine-tune Wnt signalling to ensure proper heart formation, and disruptions lead to serious congenital heart defects.
Researchers have developed an open-source pressure myography tool, HemoLens, which reduces the cost of vascular research to $750 from $40,000. The tool uses affordable manufacturing processes and customizable components, making it easier for researchers to study vascular function.
Researchers found that carrying one mutant copy of ATP13A2 and GBA1 drives a slow, progressive neurodegeneration in flies, leading to movement problems, neuron loss, and disruption in neural communication. Accumulation of glucosylceramide in glial cells is linked to the disease process.
A new platform developed by VIB and UGent researchers allows for more accurate prediction of antibody drug effects in humans. The platform uses a next-generation mouse model that closely reflects human immune biology, enabling better decisions early in drug development.
The University of Ottawa has launched the Ottawa Medical Artificial Intelligence Research Institute (OMARI), a center for research, education, and innovation in medical Artificial Intelligence. Led by Dr. Khaled El Emam, OMARI aims to facilitate cross-cutting collaborations and sharpen the university's competitive edge in AI-driven hea...
A review decodes the comprehensive role of GDF15 in prostate cancer metabolism, chemoresistance, and clinical applications, highlighting its involvement in cachexia, bone metastasis, and drug resistance. The study also explores the synergistic power of combining GDF15 with established markers for improved diagnosis and prognosis.
The FIU-Florida Heart Research Foundation Center for Innovation in Cardiovascular Health brings together experts in various fields to uncover the fundamental drivers of cardiovascular disease. The center will focus on AI-powered diagnostics, regenerative tissue technologies, and workforce development.
A team at Chalmers University of Technology has discovered biomarkers for Parkinson's disease in the blood, which could lead to early diagnosis via blood tests within five years. The study found distinct gene activities linked to DNA damage repair and stress response in patients in the early phase of the disease.
A UBCO research team has developed a lightweight, wearable brace that reduces involuntary hand tremors in people with Parkinson’s disease. The passive vibration-absorbing mechanism offers an accessible alternative to existing treatments.
The B-STING silica nanocomposite acts as a nanofactory of reactive oxygen species, activating itself in response to changes in the chemical environment. This material can be used to create biocidal coatings that are safe, durable, and resistant to dirt, with potential applications in medicine and other industries.
A study reveals that alternative splicing (AS) and genetic variation contribute to feed efficiency differences in fish. AS variants were linked to superior feed utilization, providing new molecular targets for breeding more efficient strains.
The article discusses the integration of heart imaging and proteomics to identify potential drug targets for cardiovascular diseases. The expert panel consensus guidelines establish a foundation for clinical practice, education, and future research in microbiota medicine.
Researchers at Brown University discovered that the shape of spheroid aggregates influences cell behavior, with cells invading outward from sharper ends. The study used fluorescent proteins to track cell movement and measured forces exerted by cells as they move.
Researchers have developed a flexible, hair-like device that tracks vital signs of a fetus in real-time during surgery. This innovation provides continuous monitoring without invasive access, enabling faster interventions to prevent complications.
Researchers at Koç University have developed a next-generation, safe, and wireless stimulation technology for retinal degenerative diseases. The system converts near-infrared light into precisely controlled electrical stimulation without causing damage to ocular tissue.
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
This article analyzes the interplay between multimorbidity and immunosenescence, finding that centenarians can serve as a model of immune resilience. The authors propose using Immune Microenvironment Enhancement Therapy (IMET) to optimize patients' immune systems.
A new study develops a video-based method to measure cardiopulmonary coupling, synchronizing heartbeat and breathing variations without contact. This approach produces consistent results with traditional devices, offering a promising solution for long-term monitoring and comfort.
A study reviews decades of research on Hsp70's role in neurodegenerative diseases, highlighting its protective effects and potential therapeutic value. The review reveals that different Hsp70 isoforms interact with co-chaperones and cellular pathways to determine protein clearance.
Researchers developed a new imaging technology called fast-RSOM that captures detailed images of the smallest blood vessels directly through the skin. This technology can detect early signs of cardiovascular risk, enabling doctors to intervene sooner and guide personalized therapies.
Smoking exposure induces tumor microenvironment promoting sorafenib resistance in HCC by modifying the 14-3-3η proteome. Arsenic trioxide suppresses tumor progression with synergistic effect when combined with sorafenib.
A new theory of proprioception challenges traditional understanding by incorporating frontier bionic evidence. The proposed framework reconceptualizes proprioception as a dynamic augmentable interface, enabling functional movement and potentially improving rehabilitation outcomes in sports injuries and neurological diseases. Researcher...
Researchers at the University of Missouri are developing AI models to accurately detect melanoma by analyzing images of skin abnormalities. The technology can help dermatologists identify cases that may require closer attention, leading to earlier treatment and improved health outcomes.
Researchers developed an AI model called DiaCardia that accurately identifies individuals with prediabetes using only ECG data. The model achieves impressive accuracy and generalizability, even in single-lead ECG data, opening possibilities for home-based screening.
Researchers have developed a new class of engineered nanoparticles that can bind to and degrade specific disease-related proteins. This technology has the potential to treat diseases such as dementia and brain cancer by eliminating harmful proteins.
A study reveals that IgE⁺ plasmablasts are the key drivers of rapid, potent immune responses in seasonal allergies, triggering symptoms upon allergen re-exposure. By targeting these cells, new 'on-demand' treatment strategies may prevent or mitigate allergy relapse.
The Rice University's SynthX Center has received a $18 million award from ARPA-H to develop innovative solutions for lymphatic diseases. The project aims to enable early, high-resolution imaging and biomarker-based diagnostics to facilitate accurate diagnoses and improve patient outcomes.
A new study from Tsinghua University and Beijing Tiantan Hospital demonstrates a strategy to deliver therapeutic materials directly to the brain, bypassing the blood-brain barrier. Researchers 'hijack' immune cells in the skull bone marrow to transport nanoparticles into the brain, achieving efficient delivery for stroke treatment.
A team of researchers has created an object identification system for prosthetic hands to guide appropriate grip strength decisions in real time. The system uses a camera and EMG sensor to determine the user's intent and predict the required grip strength, enabling users to focus on daily tasks without complex training or calibration.
The use of next-generation sequencing in newborn screening can detect a wide range of genetic disorders, some of which are not currently testable through traditional means. This approach enables earlier disease detection and long-term health planning.
A partnership between University of Copenhagen and Danish Technical University aims to improve Europe's resilience and competitiveness by boosting innovation. The initiative seeks to develop the innovation ecosystem, drive urban development, and attract talent, companies, and investors.
A new scientific review suggests Polygonum multiflorum, a traditional Chinese herb, may promote hair regeneration through multiple mechanisms. The herb blocks dihydrotestosterone, protects follicle cells, switches on regrowth signals, and improves blood flow to the scalp.
Researchers have developed a breakthrough light-responsive Janus dural patch using photocurable hyaluronic acid, providing strong wet adhesion and preventing unwanted tissue adhesion. The patch seals wounds within five seconds with minimal swelling and high biocompatibility.
A new diagnostic platform enables rapid and accurate detection of drug-resistant C. auris pathogens using CRISPR technology, allowing for more effective treatment and prevention of hospital outbreaks. The dSHERLOCK test can detect the presence of mutations causing antimicrobial resistance in just 40 minutes.