Articles tagged with Biomedical Engineering
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The review explores how next-generation sequencing can enhance early disease detection in newborns by analyzing DNA from dried blood spots. This genomic approach expands the benefits of NGS by identifying conditions not detectable through traditional biochemical testing.
Scientists have successfully grown human norovirus in the lab for up to 15 consecutive passages, enabling comprehensive studies of viral structure, antiviral drug screening, and vaccine development. The breakthrough uses a drug called TAK 779 to overcome host restrictions, allowing researchers to produce stable virus stocks.
The ESMT Berlin DEEP Institute and Creative Destruction Lab will be launched in Doha to support technology transfer and innovation. The initiative aims to connect the innovation ecosystems of Germany and Qatar, fostering entrepreneurial growth and driving economic growth.
Researchers at Adelaide University have uncovered a crucial new mechanism controlling heart development by regulating key growth signals. Neural crest cells fine-tune Wnt signalling to ensure proper heart formation, and disruptions lead to serious congenital heart defects.
Researchers have developed an open-source pressure myography tool, HemoLens, which reduces the cost of vascular research to $750 from $40,000. The tool uses affordable manufacturing processes and customizable components, making it easier for researchers to study vascular function.
Researchers found that carrying one mutant copy of ATP13A2 and GBA1 drives a slow, progressive neurodegeneration in flies, leading to movement problems, neuron loss, and disruption in neural communication. Accumulation of glucosylceramide in glial cells is linked to the disease process.
A new platform developed by VIB and UGent researchers allows for more accurate prediction of antibody drug effects in humans. The platform uses a next-generation mouse model that closely reflects human immune biology, enabling better decisions early in drug development.
The University of Ottawa has launched the Ottawa Medical Artificial Intelligence Research Institute (OMARI), a center for research, education, and innovation in medical Artificial Intelligence. Led by Dr. Khaled El Emam, OMARI aims to facilitate cross-cutting collaborations and sharpen the university's competitive edge in AI-driven hea...
A review decodes the comprehensive role of GDF15 in prostate cancer metabolism, chemoresistance, and clinical applications, highlighting its involvement in cachexia, bone metastasis, and drug resistance. The study also explores the synergistic power of combining GDF15 with established markers for improved diagnosis and prognosis.
The FIU-Florida Heart Research Foundation Center for Innovation in Cardiovascular Health brings together experts in various fields to uncover the fundamental drivers of cardiovascular disease. The center will focus on AI-powered diagnostics, regenerative tissue technologies, and workforce development.
A team at Chalmers University of Technology has discovered biomarkers for Parkinson's disease in the blood, which could lead to early diagnosis via blood tests within five years. The study found distinct gene activities linked to DNA damage repair and stress response in patients in the early phase of the disease.
A UBCO research team has developed a lightweight, wearable brace that reduces involuntary hand tremors in people with Parkinson’s disease. The passive vibration-absorbing mechanism offers an accessible alternative to existing treatments.
The B-STING silica nanocomposite acts as a nanofactory of reactive oxygen species, activating itself in response to changes in the chemical environment. This material can be used to create biocidal coatings that are safe, durable, and resistant to dirt, with potential applications in medicine and other industries.
A study reveals that alternative splicing (AS) and genetic variation contribute to feed efficiency differences in fish. AS variants were linked to superior feed utilization, providing new molecular targets for breeding more efficient strains.
The article discusses the integration of heart imaging and proteomics to identify potential drug targets for cardiovascular diseases. The expert panel consensus guidelines establish a foundation for clinical practice, education, and future research in microbiota medicine.
Researchers at Brown University discovered that the shape of spheroid aggregates influences cell behavior, with cells invading outward from sharper ends. The study used fluorescent proteins to track cell movement and measured forces exerted by cells as they move.
Researchers have developed a flexible, hair-like device that tracks vital signs of a fetus in real-time during surgery. This innovation provides continuous monitoring without invasive access, enabling faster interventions to prevent complications.
Researchers at Koç University have developed a next-generation, safe, and wireless stimulation technology for retinal degenerative diseases. The system converts near-infrared light into precisely controlled electrical stimulation without causing damage to ocular tissue.
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
This article analyzes the interplay between multimorbidity and immunosenescence, finding that centenarians can serve as a model of immune resilience. The authors propose using Immune Microenvironment Enhancement Therapy (IMET) to optimize patients' immune systems.
A new study develops a video-based method to measure cardiopulmonary coupling, synchronizing heartbeat and breathing variations without contact. This approach produces consistent results with traditional devices, offering a promising solution for long-term monitoring and comfort.
A study reviews decades of research on Hsp70's role in neurodegenerative diseases, highlighting its protective effects and potential therapeutic value. The review reveals that different Hsp70 isoforms interact with co-chaperones and cellular pathways to determine protein clearance.
Researchers developed a new imaging technology called fast-RSOM that captures detailed images of the smallest blood vessels directly through the skin. This technology can detect early signs of cardiovascular risk, enabling doctors to intervene sooner and guide personalized therapies.
Smoking exposure induces tumor microenvironment promoting sorafenib resistance in HCC by modifying the 14-3-3η proteome. Arsenic trioxide suppresses tumor progression with synergistic effect when combined with sorafenib.
A new theory of proprioception challenges traditional understanding by incorporating frontier bionic evidence. The proposed framework reconceptualizes proprioception as a dynamic augmentable interface, enabling functional movement and potentially improving rehabilitation outcomes in sports injuries and neurological diseases. Researcher...
Researchers at the University of Missouri are developing AI models to accurately detect melanoma by analyzing images of skin abnormalities. The technology can help dermatologists identify cases that may require closer attention, leading to earlier treatment and improved health outcomes.
Researchers developed an AI model called DiaCardia that accurately identifies individuals with prediabetes using only ECG data. The model achieves impressive accuracy and generalizability, even in single-lead ECG data, opening possibilities for home-based screening.
Researchers have developed a new class of engineered nanoparticles that can bind to and degrade specific disease-related proteins. This technology has the potential to treat diseases such as dementia and brain cancer by eliminating harmful proteins.
A study reveals that IgE⁺ plasmablasts are the key drivers of rapid, potent immune responses in seasonal allergies, triggering symptoms upon allergen re-exposure. By targeting these cells, new 'on-demand' treatment strategies may prevent or mitigate allergy relapse.
The Rice University's SynthX Center has received a $18 million award from ARPA-H to develop innovative solutions for lymphatic diseases. The project aims to enable early, high-resolution imaging and biomarker-based diagnostics to facilitate accurate diagnoses and improve patient outcomes.
A new study from Tsinghua University and Beijing Tiantan Hospital demonstrates a strategy to deliver therapeutic materials directly to the brain, bypassing the blood-brain barrier. Researchers 'hijack' immune cells in the skull bone marrow to transport nanoparticles into the brain, achieving efficient delivery for stroke treatment.
A team of researchers has created an object identification system for prosthetic hands to guide appropriate grip strength decisions in real time. The system uses a camera and EMG sensor to determine the user's intent and predict the required grip strength, enabling users to focus on daily tasks without complex training or calibration.
The use of next-generation sequencing in newborn screening can detect a wide range of genetic disorders, some of which are not currently testable through traditional means. This approach enables earlier disease detection and long-term health planning.
A partnership between University of Copenhagen and Danish Technical University aims to improve Europe's resilience and competitiveness by boosting innovation. The initiative seeks to develop the innovation ecosystem, drive urban development, and attract talent, companies, and investors.
A new scientific review suggests Polygonum multiflorum, a traditional Chinese herb, may promote hair regeneration through multiple mechanisms. The herb blocks dihydrotestosterone, protects follicle cells, switches on regrowth signals, and improves blood flow to the scalp.
Researchers have developed a breakthrough light-responsive Janus dural patch using photocurable hyaluronic acid, providing strong wet adhesion and preventing unwanted tissue adhesion. The patch seals wounds within five seconds with minimal swelling and high biocompatibility.
A new diagnostic platform enables rapid and accurate detection of drug-resistant C. auris pathogens using CRISPR technology, allowing for more effective treatment and prevention of hospital outbreaks. The dSHERLOCK test can detect the presence of mutations causing antimicrobial resistance in just 40 minutes.
Scientists have developed a method to create functional retinal organoids that contain human retinal ganglion cells and allow the development of light-signal pathways. The vascularized organoids demonstrated improved cell survival, increased functional maturity, and the ability to respond to hypoxia.
Researchers have identified a previously unknown mechanism that can reduce the risk of allergies and asthma in children. Certain bifidobacteria produce a substance called 4-hydroxyphenyl lactate (4-OH-PLA), which dampens immune responses to allergens, reducing the production of IgE antibodies.
A Korea University study successfully mimics heart mechanics in organoids using three-dimensional magnetic torque, enhancing cardiac differentiation, maturation, and vascularization. This breakthrough could improve drug safety testing by providing more accurate human-relevant models for cardiotoxicity screening.
A phase 1/2 trial investigating autologous T cell therapy targeting multiple tumor antigens showed promising results in patients with advanced and surgically resectable disease. Patients responded well to the therapy, with high disease control rates and low adverse side effects.
A multidisciplinary team of world-leading experts is developing an off-the-shelf engineered product that could address liver failure in millions of patients. The ImPLANT project aims to create synthetic biology-based gene circuits in human induced pluripotent stem cells to drive cell differentiation into all required liver cell types.
A Carnegie Mellon-led team has secured a $28.5 million award from ARPA-H to develop a functional, 3D bioprinted liver for patients with acute liver failure. The project aims to provide a temporary liver that supports regeneration of a patient's own liver, reducing the need for full organ transplants.
A machine-learning-based approach has been developed to map real-time tumor metabolism in brain cancer patients, helping doctors discover effective treatment strategies. The digital twin uses patient data to calculate metabolic flux, predicting which treatments are likely to work for individual cases of glioma.
A machine-learning-based algorithm developed by Tokyo Metropolitan University researchers can accurately count sister chromatid exchanges (SCEs) in chromosomes, giving a more objective measurement. The accuracy rate is 84%, which could help diagnose disorders like Bloom syndrome with greater consistency.
Researchers at MIT have designed a pill that can report when it has been swallowed, using a biodegradable radio frequency antenna to communicate with an external receiver. This technology could improve medication adherence for patients who need to take immunosuppressive drugs or treatment for extended periods.
A Mizzou researcher developed an antibody that attaches to and lights up EphA2 protein in cancerous tumors, allowing for non-invasive detection and identification of patients who can benefit from targeted treatments. This innovation could save time and money while advancing precision medicine.
The study developed subgroup-specific mortality prediction models for high and low ventilatory ratio (VR) subgroups, achieving improved accuracy in short-term mortality prediction. Minute ventilation is a key predictor for the high VR subgroup, while respiratory rate, hypocapnia, and acidemia are unique predictors for the low VR subgroup.
A Northwestern University study found an injectable regenerative nanomaterial helps protect the brain during a vulnerable window after most common type of stroke. The therapy successfully crossed the blood-brain barrier and reduced brain damage, showing no signs of side effects.
Researchers discover giant virus that infects amoeba, providing further support for nuclear virus origin hypothesis. The new virus, ushikuvirus, has distinct features and unique caps on its surface, which may hold clues to the evolution of complex cells.
Researchers found that male fish exposed to vitamin C and potassium perchlorate showed improved fertility and less damage to their testes compared to those exposed only to the chemical. The study suggests a potential safeguard for individuals regularly exposed to these chemicals, including military personnel.
A study demonstrates that combining silybin and carvedilol synergistically suppresses hepatic stellate cell activation and reverses liver fibrosis by targeting Wnt4/β-catenin signaling. This clinically feasible combination strategy has a promising new therapeutic approach for liver disease.
Researchers developed a soft, wireless implant that modulates the splenic nerve to restore immune balance in patients with chronic inflammatory diseases. The device showed excellent biocompatibility and reduced inflammation in a rat model of chronic colitis.
Researchers reviewed magnetic materials preparation, structural design and actuation systems for medical applications, highlighting potential in targeted drug delivery, minimally invasive surgery and disease diagnosis. Despite challenges, the authors emphasize magnetic soft robots' potential to reshape future healthcare practices.
Researchers outline breakthrough strategies to address poor infiltration of CAR-T cells into solid tumor microenvironments. Vascular normalization and chemokine modulation enhance T cell penetration, while combination therapies with chemotherapy and oncolytic viruses amplify results.
A new class of engineered extracellular vesicles can induce antigen-specific regulatory T cells, potentially paving the way for next-generation therapies for autoimmune and allergic diseases. The system uses peptide-MHC complexes to display disease-relevant antigens, allowing for precise control over immune responses.
Researchers at the University of Arizona developed a mesh sleeve that monitors leg movements using AI to detect early warning signs of frailty. The device sends only the analyzed results, reducing transmission and internet requirements.
Composite copper oxides La₂CuO₄ and Y₂Cu₂O₅ demonstrate exceptionally high antiviral activity against non-enveloped viruses, outperforming individual constituent oxides. The oxides' cation-rich surfaces enhance electrostatic adsorption of viruses, leading to protein inactivation and viral neutralization.
A new study uses AI to regulate mechanical ventilation for patients with ARDS, aiming to provide personalized support. The tool combines live patient monitoring with historical data to modulate ventilation parameters and reduce lung injury.
Researchers at Rice University and MD Anderson Cancer Center developed patient-specific models to predict stress and deformation in reconstructed pelvises. The study found that larger bone grafts experience lower stresses and smaller deformations than thinner bones.