Articles tagged with Biotechnology
Researchers at the University of Cincinnati have developed a new at-home test that uses saliva to detect early signs of gingivitis, the earliest form of gum disease. The device can identify periodontal disease caused by bacteria in saliva, providing an opportunity for consumers to protect their oral health.
Researchers at University of Oxford have developed a miniaturized soft power source that can alter the activity of cultured human nerve cells, paving the way for miniature bio-integrated devices. The device uses internal ion gradients to generate energy, producing a current that persists for over 30 minutes.
A ferrocene-based capsule with unusual charge-transfer interactions has been synthesized, allowing for reversible encapsulation and release of guest molecules. The capsule can bind to a variety of organic and inorganic dyes and electron-accepting molecules, demonstrating its potential applications in medicine, biotechnology, and chemic...
The Texas Heart Institute has received a five-year, $2 million grant from the National Institutes of Health to advance organ bioengineering. The project aims to develop transplantable bioartificial hearts to combat end-stage heart failure.
Researchers developed a platform that allows engineered biosensor bacteria to safely pass through the gastrointestinal tract in animal models. The platform enables real-time monitoring of gut health and can be used to diagnose and monitor various diseases, including inflammatory bowel disease. It has the potential to revolutionize pati...
The researcher aims to bridge completeness, efficiency, and applications in 3D graphs to solve problems in physics, fluid dynamics, and biotechnology. Geometric graphs can represent molecules, proteins, and drugs, enabling the prediction of their behavior and properties.
LSU Health researchers found combining an investigational oral drug with standard-of-care medications reverts hormone resistance and increases effectiveness in experimental models of ER+ and TNBC. The study's findings suggest a new approach for treating treatment-resistant breast cancers.
A £1.75m project led by Professor Chenyu Du aims to develop new processes for recovering polyester and cellulose from mixed cotton and polyester fibres. The goal is to create a roadmap towards net-zero for the textiles industry, reducing plastic waste and increasing recycling rates.
A miniature human heart model, approximately half a grain of rice in size, has been developed to transform drug testing and cardiovascular research. This self-paced, multi-chambered model provides real-time measurements of essential parameters, enabling unprecedented insights into heart function and diseases.
A team of researchers developed a novel method that leverages temporal characteristics of blood pulse to estimate heart rates with improved accuracy, especially in scenes with ambient light fluctuations. The proposed method showed a 36.5% improvement in estimation accuracy compared to conventional methods.
A recent study discovered the complex circadian clock mechanisms in soil bacteria Bacillus subtilis, regulating multiple genes and behaviors. The findings have significant implications for industrial applications, human health, and plant science.
Insilico Medicine's inClinico platform uses generative AI to predict Phase II to Phase III clinical trial success with an accuracy of 79%. The tool has been validated in various studies and can provide valuable insights for investors and biotech/pharma companies.
A new study by Prof. Yossi Paltiel and colleagues reveals that nuclear spin significantly affects oxygen dynamics in chiral environments, particularly in transport. This finding challenges long-held assumptions and opens up possibilities for advancements in biotechnology and quantum biology.
Researchers developed a blood test to detect nerve injury in MS and found it works for children, even when symptom-free. The test measures neurofilament light chain levels, which reflect nerve cell injury.
Researchers found fungi can effectively degrade low-density polyethylene (LDPE) plastic without wood present. In the absence of wood, fungal biodeterioration of LDPE increased, suggesting a potential natural method for plastic waste management.
Researchers have developed a novel DNA-filtering system using α-hemolysin nanopores to reduce contamination in single-molecule DNA extraction. The technique, which uses phospholipids and the PCR clamp method, achieved a 99.98% reduction in DNA contamination.
Researchers developed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering, demonstrating potential for clinical applications. The scaffolds can reconstruct desired tissue EM through non-invasive ultrasonic stimulation, promoting cell adhesion and osteogenic differentiation.
Researchers found that young and healthy human glial progenitor cells can outcompete older and diseased cells in the adult brain, replacing them with healthier ones. This breakthrough has strong therapeutic implications for treating neurological disorders like Huntington's disease.
The project aims to develop a sustainable hemp-based supply chain in Pennsylvania, focusing on manufacturing and deployment of bio-based products. The goals include reducing greenhouse gases through carbon capture strategies and promoting diversity and inclusion.
Research discusses challenges and future directions for porous metallic implant fabrication, focusing on microstructure, biocompatibility, and mechanical properties. The review aims to promote metabolite and nutrient exchange, bone ingrowth, and improved implant-tissue anchorage.
Researchers at MIT are developing a continuous mRNA manufacturing platform to improve vaccine development and production. The pilot-scale system aims to reduce costs, increase efficiency, and facilitate collaboration in the biopharmaceutical industry.
Biotechnology holds promise for saving endangered tree species through a combination of traditional breeding approaches and innovative genetic engineering. The study emphasizes the need for public acceptance and regulators' support to harness biotech's potential.
The Leipzig research team has developed a process to convert phenol into adipic acid using electrochemical synthesis and microbial conversion, achieving high yields of electrons and cyclohexanol. The technology has the potential to replace fossil-based nylon production, reducing emissions and energy consumption.
Researchers have successfully predicted and created a new enzyme with improved heat tolerance by inserting mutations from a pig enzyme into an Antarctic bacterial variant. The hybrid enzyme showed a 6°C higher optimum temperature and increased catalytic activity compared to the original variants.
The June special issue of SLAS Technology highlights the latest developments in bioprinting, a transformative technology poised to revolutionize many aspects of medicine. Bioprinting is advancing at a rapid pace, with novel materials, fabrication techniques, and bio-ink compositions being developed.
The technique has the potential to overcome major shortcomings associated with conventional bioprinting, allowing real-time wound treatment and immediate anastomosis with native tissue. However, challenges remain, including integration with surrounding tissues and limited access to defect sites in articular joints.
A pioneering device captures single proteins stochastically, detecting them digitally at high concentrations. This breakthrough could lay the foundation for personalized disease prevention and treatment.
Cartesian Therapeutics has successfully treated patients with generalized myasthenia gravis using an RNA CAR-T therapy. The trial demonstrated marked and long-lasting clinical improvement, with three patients achieving complete or near-complete eradication of disease symptoms.
Researchers found a link between short telomeres in ATII cells and lung fibrosis in post-COVID-19 patients. The study revealed loss of ATII cellularity and shorter telomeres concomitant with increased fibrotic lung parenchyma remodeling.
A handheld bioprinter has been developed to address limitations of previous designs, paving the way for applications in regenerative medicine, drug development, and custom orthotics. The device's modular design allows for control over printing mixture and properties, enabling repair and regeneration of defective tissues and organs.
Researchers at Karolinska Institutet have developed a new method called single-particle profiling (SPP) to study bioparticles in health and disease. The SPP enables the measurement of thousands of particles between 5 and 200 nanometres in size, with potential applications in vaccine development and creating more effective nanocarriers.
A new research centre will focus on developing new types of RNA medicine for treating metabolic diseases. The centre, led by Professor Jørgen Kjems at Aarhus University, aims to create targeted treatments for conditions like diabetes and atherosclerosis.
Researchers have deciphered the biosynthetic pathway of orcinol glucoside from Curculigo orchioides and successfully engineered its production in Yarrowia lipolytica. The resulting yields are significantly higher, exceeding 6,400-fold that of natural plant extraction.
A new partnership between Patrick Reed and Kenneth Eilertsen is putting a focus on translational research and commercialization at Pennington Biomedical. The team aims to evaluate patentability and marketability of potential disclosures, promoting public benefit from scientific discoveries.
Researchers developed high-performance culture media using machine learning to predict superior medium compositions that yield higher cellular activity. The optimized medium promoted higher cell growth than commercial medium.
Biomedical engineers at UTS have developed an intervertebral disc-on-a-chip, a precision-engineered toolbox for low back pain studies. The device simulates the complex mechanobiology of native tissue, enabling accurate evaluation of experimental methods for treatment or regeneration.
A new method called 5PSeq has been developed to quickly assess bacterial response to antibiotics, with potential implications for treating antibiotic-resistant infections. The method measures mRNA translation and decay, revealing how bacteria interact with environmental factors and stressors.
Researchers have developed a novel computational approach to design protein-peptide ligand binding complexes that can trigger complex cellular responses. The new biosensors can sense flexible compounds and provide optimal sensing of molecular signals, potentially leading to improved therapeutic applications.
Researchers found that GPR141 enhances cell migration and proliferation in breast cancer by activating the p-mTOR/p53 signaling pathway. Silencing GPR141 restores p53 expression and attenuates tumor growth, suggesting its role in regulating breast cancer progression and metastasis.
Researchers developed predictive models to design RNA-binding inhibitors for disease treatment by regulating protein production. The study identified three key features for effective oligonucleotides: thermostability, serum resistance, and RNase H sensitivity.
Researchers have developed an automated calling algorithm for determining B and T cell clonality from NGS data with greater sensitivity than previous models. The new model increases the assay's sensitivity in detecting clonality, allowing for more accurate diagnosis and monitoring of lymphoproliferative disorders.
Researchers at Washington University in St. Louis have found a way to enhance glymphatic transport using focused ultrasound with microbubbles, opening new opportunities for studying brain diseases and function. The non-invasive method shows promise for potentially mitigating neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers at the University of Exeter have captured the structure of a commonly used phage, filamentous phages, which will enable the development of new biotechnology applications. The new insights gained from this research will help improve phage display and other uses in drug discovery.
Researchers at Nanyang Technological University found that cells near wavy shaped wounds moved in a swirling manner, while those near straight wounds moved in straight lines. This discovery reveals that the swirling motion is crucial for gap-bridging and accelerates wound healing in wavy wounds.
Researchers have created a detailed map of human retinal organoid development, revealing information on cell types, proteins, and gene expression. The study uses advanced imaging techniques to visualize multiple proteins simultaneously and provides insights into retinal diseases such as retinitis pigmentosa.
Researchers have engineered bacteria to combine natural enzymatic reactions with the carbene transfer reaction, producing new-to-nature carbon products that can be used in biochemicals and advanced biofuels. This breakthrough could reduce industrial emissions by providing sustainable alternatives to chemical manufacturing processes.
Researchers from Integrated Biosciences developed an AI platform to discover novel senolytic compounds, a class of molecules targeting age-related processes. The platform identified three highly selective and potent compounds with favorable medicinal chemistry properties.
Researchers reconstruct bacterial genomes of Ice Age microorganisms, reviving ancient natural products and discovering new chemical diversity. The team uses synthetic molecular biotechnology to produce chemicals encoded by ancient genes, unlocking the secrets of Earth's past microbes.
Researchers from Graz University of Technology have developed a novel method for producing central components of mRNA vaccines using biocatalytic synthesis. This approach achieves a yield of 92-95% compared to 40-50% for chemical processes, making it more efficient and cost-effective.
Researchers have developed enzymes that can efficiently break down plastic, reducing its environmental impact. However, over-reliance on these technologies may not address the root issue of excessive plastic production.
A research group has successfully developed an adsorbent material that can selectively recover rare earth elements from hot spring water, a process expected to contribute to a metal resource-circulating society. The method uses environmentally friendly and inexpensive materials, such as baker's yeast and trimetaphosphate.
Researchers have developed a new method called Nano-tRNAseq to measure both the abundance and modification of tRNA molecules in a single step. This technology has significant advantages over conventional techniques, offering rapid, cost-effective, and high-throughput analysis with single-molecule resolution.
Researchers at TUM have developed a method to create mini-hearts in Petri dishes using stem cells. The resulting organoids mimic the earliest stages of human heart development and can be used to investigate congenital heart defects, potentially leading to new treatment methods.
A recent study published in PLOS ONE found that academic institutions receive significantly lower royalty rates, total payments, and pre-commercial payments for biotechnology licenses compared to commercial firms. The disparities were observed even after accounting for differences in product stage development.
A research team from Pohang University of Science & Technology has engineered an artificial kidney to detect adverse drug reactions and provide personalized treatment. The team successfully fabricated a glomerular microvessel-on-a-chip that recapitulates the kidney's filtering function and evaluates its response to various toxins.
Researchers have found lab-made antibodies that can strengthen the body's fight against yellow fever, a disease with no current treatment. The monoclonal antibody infusions were able to remove all signs of infection from research animals, offering potential hope for a cure.
A team of researchers at ETH Zurich has created an implantable fuel cell that uses excess blood sugar to generate electrical energy. The device powers artificial beta cells that produce insulin, effectively regulating blood glucose levels.
James Chappell, a Rice University bioscientist, has won a National Science Foundation CAREER Award to create RNA programming methods for microbial communities in natural habitats. His research aims to improve human health and the environment by genetically manipulating microbial communities.
A team of researchers from POSTECH and Georgia Tech developed a biohybrid 3D printed heart model with integrated sensors to monitor drug-induced cardiotoxicity. The platform enables real-time, continuous monitoring of heart contractions, facilitating the testing of acute and chronic pharmacological effects.
Richard McIndoe is leading a national research initiative to advance understanding of diabetes and obesity through the National Centers for Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD). The MPMOD initiative provides access to advanced testing services, including bariatric surgery on mice, to enable new insights ...