Articles tagged with Biotechnology
Researchers at Pusan National University have created a portable molecular sensor that detects biogenic amines released from spoiled food using polydiacetylene-based beads. The sensor, which changes color to red upon binding with BAs, can be used for rapid visual detection of spoiled food during storage and distribution.
A study by IMBA researchers links muscle degeneration to a deficiency in the enzyme PCYT2, essential for lipid synthesis. PCYT2 depletion affects mitochondrial function and muscle energetics, highlighting the importance of lipid balance in muscle health.
Researchers at Harvard University developed a novel RNA sense-and-respond circuit, DART VADAR, which utilizes an enzyme to detect specific molecular markers of disease and cell types. This enables highly specific treatments for various diseases by triggering the translation of therapeutic genetic payloads.
Researchers explore biotechnologies that use microbes to extract rare minerals and fuels from wastewater. This innovation has the potential to reduce greenhouse gas emissions by utilizing previously unused resources.
A new coating material developed by Korean researchers facilitates bone regeneration and attracts osteo-progenitor cells, significantly improving the success rate of dental implants. The coating, loaded with BMP-2, prevents non-osteogenic cell invasion and induces high bone differentiation in a short period.
Researchers at Garvan Institute of Medical Research found that introducing bacteria to a tumor's microenvironment triggers an immune response, activating neutrophils to destroy tumors in animal models. This breakthrough therapy targets neutrophils to improve cancer treatment outcomes.
A new technology uses light-induced convection to enhance the permeability of cell membranes, allowing for efficient and selective delivery of biofunctional molecules to targeted cells. This results in lower concentrations of drugs needed for testing and potentially reduced costs and faster drug discovery.
Scientists discovered that 12 strains of cyanobacteria can passively collect rare earth elements from wastewater through a process called biosorption. This process has great potential for the circular recovery and reuse of rare earth metals in industries such as mining, electronics, and chemicals.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
Researchers have developed nanofluidic devices to study single molecule chemical reactions in solution. These devices provide a test tube-like environment to confine individual molecules and enable high temporal resolution for investigating fast single molecule reactions. By integrating various fields using nanofluidics, scientists can...
Scientists at the Wyss Institute and Gameto develop a living, fully human ovarian organoid that supports egg cell maturation and secretes sex hormones. This technology enables the study of human ovarian biology without tissue from patients and could lead to new treatments for infertility and ovarian cancer.
Scientists from SUTD design a novel thermal-based therapy nano-system that destroys over 20% of pancreatic cancer cells using microsecond electrical pulses, improving cancer cell targeting accuracy and bio-compatibility. The introduction of the M13 virus enhances electro-thermal therapy performance by assembling more on cancer cells.
Verkko software assembles gapless human genome sequences quickly and precisely, enabling better assessment of genomic diversity and comparative genomics. This innovation accelerates efforts to generate complete genome sequences of various species, improving research and discovery in the field.
A study found that an allele of the HLA Class 1 gene may protect individuals from severe COVID-19. The researchers compared the immune systems of patients in different waves of the pandemic and discovered a link between the HLA-A*01:01 allele and effective T-cell immunity against new variants.
AAHI will develop a prototype nasal spray using its novel adjuvant formulation platform, promising to shorten timelines for emergency response to and mitigate impacts from biological threats. The project aims to create a temperature-stable and broadly protective nasal spray against multiple respiratory viruses.
Researchers have developed a new synthetic skin, made of hydrogels, to study how mosquitoes transmit deadly diseases. The hydrogel system can mimic different blood vessel patterns, allowing for more consistent testing and analysis. This breakthrough may help identify ways to prevent the spread of disease.
A study published in PLOS ONE found that common microbiome analysis techniques can yield erroneous results due to incomplete DNA databases. The researchers used computer simulations to test the consistency of current methods, showing that a large number of detected species are not actually present in the community.
Researchers at the University of Missouri have designed a soft and breathable material that can be worn on the skin without causing discomfort. The material, made from liquid-metal elastomer composite, has integrated antibacterial and antiviral properties to prevent the formation of harmful pathogens.
The study uses artificial intelligence to generate new molecules with optimized properties, applicable to various industries. The method enables finding Pareto-optimal solutions, leading to more efficient materials for optoelectronics, solar energy, and other fields.
The ISSCR 2023 Annual Meeting will showcase the year's most compelling stem cell research and clinical breakthroughs. Attendees can participate in dedicated poster sessions and interact with presenters.
Researchers at the University of Oklahoma are designing a customized device to better treat unique brain aneurysms. The device uses advanced biomedical 3-D printing to tailor the treatment to the specific shape, size, and location of each aneurysm.
Researchers developed a computational analysis method to detect and identify somatic SVs in leukemia patients, gaining insights into molecular consequences and potential therapies. The approach enables understanding of individual somatic mutations and may lead to targeted treatments.
The 30-year history of metabolic engineering has progressed significantly, enabling microorganisms to efficiently produce chemicals and degrade recalcitrant contaminants. Recent breakthroughs in systems metabolic engineering and data science have driven advancements in sustainability and health.
Researchers at Aston University are working with Isterian Biotech to develop small molecule inhibitors targeting transglutaminase 2, a key enzyme in fibrosis. The goal is to stop or reverse pathological crosslinking of proteins that lead to fibrotic diseases such as idiopathic pulmonary fibrosis.
Researchers at the University of Reading are working on a £2 million project to increase UK-grown faba beans in bread, improving nutritional quality and sustainability. The 'Raising the Pulse' project aims to encourage farmers to switch wheat-producing land to faba bean for human consumption.
Researchers have designed a treatment that uses a modified bacterium to target and dissolve biofilms caused by Pseudomonas aeruginosa, a leading cause of hospital mortality. The treatment has shown significant efficacy in mice, reducing lung infections and doubling survival rates.
Biomedical engineers at UC Davis have created semi-living cyborg cells that can carry out novel functions, such as producing therapeutic drugs and cleaning up pollution. The cyborg cells are more resistant to stressors and can invade cancer cells, making them a promising tool for various applications.
Hiroshima University researchers have generated a high-quality genome assembly of red perilla, allowing scientists to harness its abundance of potentially useful bioactive chemicals. The study enables targeted gene editing for enhanced phytochemical production, paving the way for new medical applications.
Researchers identified the molecular mechanism underlying Weiss-Kruszka syndrome, a rare neurodevelopmental disorder characterized by craniofacial anomalies and autistic features. The study reveals that the ZFP462 gene mutation leads to a failure to safeguard neural lineage specification during early embryonic development.
A cross-disciplinary team at Northwestern University has developed a sensor platform that can detect environmental contaminants like fluoride in real-world samples. The team used an established riboswitch to build a biosensor for fluoride, encapsulating the sensor inside a fatty membrane to protect it from contaminants.
Researchers at Duke University discovered that glassfrogs store nearly 90% of their circulating red blood cells in their liver when they want to be transparent. This helps them blend in with their surroundings and avoid predation during the day.
Osaka Metropolitan University scientists have developed a novel protein detection method that allows for ultra-fast and highly sensitive detection of proteins, enabling early disease diagnoses. The method uses light-induced acceleration of antigen-antibody reaction to detect attogram-level proteins within 3 minutes.
A team of researchers has created a new method for fabricating nanodevices by shrinking hydrogels to create 3D patterns. This technique uses ultrafast two-photon lithography and can produce high-resolution patterns up to 13 times larger than the original size, enabling the creation of complex nanostructures.
Researchers have developed an edible plant-based ink derived from food waste to create cost-effective scaffolds for culturing meat. This innovation could significantly reduce the cost of large-scale cultured meat production, making it more affordable and environmentally friendly.
A global registry for gene-drive modified organisms could facilitate transparent communication, monitor ecological impacts, and inform local decision-making. Experts agree that a registry is necessary for the fair development, testing, and use of gene-drive technologies.
Researchers uncovered distinct DNA methylation profiles in ocean microbes, shedding light on population dynamics and interactions. The study's findings have significant implications for understanding pathogenicity and developing new approaches to monitoring environmental health.
Researchers at Osaka Metropolitan University have successfully created the smallest mobile lifeform, a synthetic bacterium named syn3, capable of swimming. By introducing seven proteins, they were able to reconstitute a minimal motility system based on Spiroplasma swimming, revealing that only two proteins were necessary for movement.
A global Phase 2/3 clinical trial found that vaccination with SCB-2019 reduced the risk of transmitting SARS-CoV-2 infection to household members. The study showed a significant reduction in symptomatic cases among vaccinated household contacts and indicated that vaccines can play an important role in controlling future outbreaks.
Researchers have developed an AAV-based gene therapy to treat glutaric aciduria type I (GA-I), a rare genetic disorder causing accumulation of glutaric acid in the central nervous system. The treatment has shown promising results, with a survival rate of 100% in mice treated intracerebroventricularly.
Scientists at Osaka Metropolitan University developed a new system to control the behavior of nematode worms using two different light-sensitive proteins called opsins. The researchers found that exposing the worms to white light triggered avoidance behavior, while UV light stopped movement and green light restarted it.
A Rutgers study found that COVID-19 patients, especially those treated with antibiotics, experience significant disruptions in their gut microbiome balance. This imbalance may lead to the development of targeted probiotic supplements to improve treatment outcomes.
The Euglena International Network (EIN) has launched a decade-long effort to sequence genomes of all known species of euglenoids, with the goal of understanding basic biology and translational applications. This will aid in exploring products for ecological and environmental management, as well as human welfare through biotechnology.
The UC San Diego Alpha Stem Cell Clinic will receive $8 million in funding to launch new clinical trials and improve accessibility of stem cell therapies. The clinic has already launched 59 clinical trials and treated 277 patients with various diseases.
Inducing a hibernation-like state in mice using Q neuron activation has been shown to protect kidneys from oxygen deprivation and avoid harmful side effects. This technique could lead to new methods of performing heart surgery with reduced organ damage.
The West Texas Pharmacology Core laboratory at TTUHSC will focus on two primary areas: drug development and pediatric cancer. The core aims to address obstacles in drug development, including limited pharmacology expertise for small biotech companies and low profitability for pediatric cancer drugs.
MU researchers, including Jay J. Thelen and Dong Xu, are exploring genetic modification to increase seed oil production in camelina and pennycress for biofuel use in the aviation industry. The team aims to create a sustainable 'green energy' source as an alternative to petroleum-based fossil fuels.
The HUSH complex is involved in normal brain development, neuronal individuality, and connectivity. The complex also regulates repetitive-like gene clusters, including protocadherin gene clusters, which are essential for neuron-to-neuron interactions.
Researchers from Osaka University have developed an AI-powered method to identify optimal amino acid mutations in enzymes. This approach accelerates the enzyme engineering process, allowing for tailored enzyme designs suitable for various biochemical environments.
Researchers developed a single-cell Raman-based tool to efficiently mine live functional microbes from nature, eliminating the need for traditional culturing methods. This technique, called scRACS-Culture, allows for the direct screening and cultivation of cells with specific metabolic functions.
A comparison of two cancer drugs reveals that life cycle management strategy is crucial for a drug's commercial success. The research found that product sales are closely linked to the number of approved indications and inter-organizational alliances.
Researchers at MIT have developed a new control system for synthetic genes that can precisely regulate protein production in mammalian cells. The system uses CRISPR proteins to activate target genes and can be tuned to produce specific quantities of proteins, such as monoclonal antibodies.
A research group at Osaka Metropolitan University developed a nanovaccine that delivers cancer antigens to dendritic cells, inducing strong cellular immunity. The new system, using positively charged cationic lipids, increases cytokine production by approximately 100 times compared to previous designs.
Researchers at the University of New South Wales have developed optrodes that can measure neural activity using light, potentially revolutionizing medical technologies like nerve-operated prosthetics. The new approach addresses long-standing issues with impedance mismatch and crosstalk, paving the way for more complex neural networks.
Researchers have developed a method that uses urea from urine to trigger the production of proteins in bacteria, replacing costly 'inducer' molecules. The new system produces similar quantities of protein as standard methods while being cheaper and easier to use, opening up new avenues for biotech industries.
Researchers at the University of Sydney have developed a method to manufacture materials that mimic the structure of living blood vessels, with promising implications for future surgery. The technology allows the body to accept and transform the implanted material into a functional 'living' blood vessel.
Researchers found that American participants had the most positive perception of gene-edited food, while German participants saw it as less beneficial and riskier. Japanese participants' perceptions were intermediate between Germans and Americans. The study suggests that public attitudes towards emerging science are influenced by regul...
The Vilcek Foundation has awarded $250,000 in prizes to four leading immigrant scientists: Alejandro Sánchez Alvarado, Edward Chouchani, Biyu J. He, and Shixin Liu. They received the 2023 Vilcek Foundation Prizes in Biomedical Science for their groundbreaking work in regeneration, metabolic disease, cognitive neuroscience, and nanoscal...
A German Research Foundation-funded research unit is developing switchable polymer gels for biomaterial applications, including tissues for biotechnological or biomedical uses. The team has successfully explored the nature of amphiphilic co-networks and will now focus on material design.
Researchers at IMBA found that Kipferl helps distribute Rhino to piRNA clusters, avoiding sequestration to Satellite arrays. This control mechanism ensures the effective silencing of jumping genes and maintains genome stability.
Researchers have discovered a novel sexual reproduction process in Galdieria microalgae, which has significant implications for biotechnology applications. The discovery could lead to the development of new industrial uses for microalgae, including wastewater treatment and food ingredient production.