Articles tagged with Biotechnology
A new study reveals that the mammalian stomach absorbs dietary miRNAs via SIDT1, a transmembrane family member. This finding uncovers a novel physiological function of the stomach and sheds light on orally delivered small-RNA therapeutics.
Researchers have developed a method to produce the coral-antibiotic erogorgiaene in a laboratory using genetically optimized bacteria. The production costs are significantly lower than conventional methods, making it an environmentally friendly and cost-effective alternative.
A study by IBS researchers compared 13 SpCas9 variants and identified optimal PAM sequences, finding evoCas9 has highest specificity but low activity. A computational tool, DeepSpCas9variants, was developed to predict SpCas9 variant activities, providing a useful guide for researchers.
Telemedicine Reports will publish articles on telemedicine and telehealth advancements, offering innovative solutions for practitioners and medical centers. The journal will provide a dedicated forum for authors to share research, reviews, and practical solutions.
A new partnering agreement will finance a multi-centre Phase 2/3 adaptive clinical trial in Colombia, Panama, and Thailand to assess the safety and immunogenicity of the BBV87 vaccine candidate. The investment aims to accelerate the development of an effective Chikungunya vaccine for equitable access.
Researchers have visualized the single-molecule level operation of cellulosomes during cellulose degradation using time-lapse atomic force microscopy. This breakthrough provides new perspectives for applications in industrial biorefineries by exploiting the synergies between cellulosome and free enzymes.
Novotech was recognized for its expertise in Asia-Pacific and commitment to meeting customer needs. The CRO won awards in key categories including Compatibility, Capabilities, Quality, and Reliability.
Neurotrauma Reports is a peer-reviewed open access journal publishing research on traumatic brain and spinal cord injury. The journal aims to provide a dedicated forum for the neurotrauma field, including original papers, review articles, and studies on regional scope or patient populations.
The Asia-Pacific region has launched expedited review processes for COVID-19 treatment and vaccine trials, with South Korea offering approval in under 9 days. Novotech is a leading contract research organization (CRO) in the region, supporting vital research with its fast-track services.
Researchers have created a force balance model to understand material behavior under stress, enabling better design of wearable and biomedical devices. The study found that the thickness ratio between film layers and substrates affects wrinkling and buckling patterns.
Researchers developed a ground-breaking method to detect sepsis 2-3 days before clinical symptoms appear using endogenous signals (biomarkers). The test has high accuracy and may increase survival chances for sepsis patients. Approval in the US FDA is underway, with clinical trials starting soon.
Novotech Research reveals that the top 10 biotech sites in Australia are open for clinical trial activity. The country's favorable environment is supporting clinical research during the global COVID-19 crisis, with many sites modifying their practices to ensure continuity of operations.
A new study examined anesthesiologists' knowledge and attitudes towards treating suspected or confirmed COVID-19 patients requiring surgery. The majority expressed correct attitudes towards airway management, emphasizing the importance of theoretical and practical training to ensure patient safety.
A new study introduces Memote, a community-maintained tool to assess and improve metabolic models. It addresses issues such as annotations, conceptual integrity, and experimental validation, promoting openness and collaboration among researchers.
Researchers produce lipase enzyme from mustard seeds by-product, offering a low-cost alternative to commercial enzymes. The enzyme is stable and effective in removing oil stains, making it a prospective additive for laundry detergents.
The Center for Advancing Point of Care Technologies aims to improve quality of life and reduce hospital time for patients with these conditions. Innovations supported by CAPCaT include devices and technologies that help manage hypertension, promote mindfulness and support holistic disease management.
The new journal will publish peer-reviewed articles on end-of-life care and relief of suffering, focusing on improving quality of life for patients and their families.
Scientists at the Universitat Autonoma de Barcelona have developed artificial protein granules that can sustainably release therapeutic proteins in lab animals. These 'artificial inclusion bodies' mimic natural bacterial structures and hold great potential for vaccines and controlled-release drug delivery systems.
The 'substantially human' concept proposes a legal boundary for living organisms with human characteristics. This approach would help courts, scientists, and physicians navigate emerging biotechnologies.
The study reveals that locomotion mode is a strong predictor of cerebellar size, shape, neuron organization, and gene expression levels, indicating a specific type of brain shared by animals with similar lifestyles. High-definition 3D models of lizard and snake brains were used to uncover these correlations.
A phase III study shows that HLX02, a Chinese-made biosimilar of trastuzumab, has an overall response rate of 71% at week 24, comparable to the reference medication. The treatment is safe and effective, with similar rates of adverse events and no differences in safety profiles or immunogenicity.
Researchers at Chalmers University of Technology have developed a new nanoreactor that allows them to map catalytic reactions on individual metallic nanoparticles, enabling the design of more effective catalysts. This breakthrough could lead to significant improvements in chemical processes and the creation of more sustainable technolo...
ORNL's Dan Jacobson and team designed algorithms to improve crop resilience to climate change. The AI technology enhances crop yields under variable weather conditions.
Asrar Damdam, a KAUST Ph.D. student, has developed a silicon-based platform that can change shape and stretch in various directions, exceeding human skin's 20% stretchability limit. Her design has potential for integration into wearable electronics devices and soft robotics.
A new study found that children of fathers with poor mental health have a higher risk of poor mental health and overall health, highlighting the significant role fathers play in their children's well-being. The researchers emphasize the need for interventions to improve father involvement in children's lives.
The company has proposed a new family of prior distributions: TRIP, which improves Fréchet Inception Distance for GANs and Evidence Lower Bound for VAEs. The model was experimentally validated in cells and animals, demonstrating its potential for accelerating drug discovery.
A pioneering clinical trial will assess the safety and efficacy of cannabidiol (CBD) in alleviating hallucinations and delusions associated with Parkinson's-related psychosis. The study aims to determine whether CBD can correct abnormal brain functioning and improve quality of life for affected individuals.
A new study at the University of Copenhagen reveals that bacteria prioritize cooperation over competition, leading to stronger and more resilient communities. This discovery challenges Darwin's theory of evolution and has significant implications for biotechnology and disease treatment.
Researchers at Stanford University and the Exploratorium developed an immersive exhibit allowing visitors to interact with single-cell organisms called Euglena. Visitors spent twice as much time engaging with interactive exhibits compared to traditional microscope-only displays.
Researchers at the University of Portsmouth have created a biosurfactant using rice straw, providing a natural replacement for chemical surfactants in household products. The process is environmentally friendly and cost-efficient, with potential applications in various industries.
Researchers have uncovered a new mechanism for tooth repair by identifying a new population of mesenchymal stromal cells that contribute to dentin formation. These cells send signals to control cell production through the molecular gene Dlk1.
A research team has elucidated the complex degradation pathway of the polysaccharide Ulvan from marine algae, revealing the biochemical function of 12 enzymes. The findings have significant implications for future biotechnological applications and improve our understanding of the marine carbon cycle.
Parkinson's UK is partnering with NRG Therapeutics to develop a potential drug that could safeguard dopamine cells and slow down the progression of Parkinson's. The partnership will support the identification of novel molecules to protect mitochondria within dopamine-producing cells.
A broadly effective dengue vaccine is still a substantial challenge due to the disease's complexity. However, experts suggest that rethinking existing concepts and developing live attenuated vaccines could lead to more effective solutions.
GlycoNet researchers Drs. Alexey V. Pshezhetsky and Christopher Cairo have been awarded half a million dollars to advance research on human neuraminidase inhibitors for treating cardiovascular and autoimmune diseases. The funding will support the development of novel treatments for these complex diseases.
The Massachusetts Medical Device Development Center's $200K Challenge recognized innovative medical device solutions for treating blood clots, congestive heart failure, and other conditions. The competition drew entrants from around the world and awarded shares of a $200,000 purse to 12 winners.
Biotechnologists and medical researchers at FAU have developed a miniaturized multi-photon microscope that can be used in endoscopes, illuminating the body's own molecules to enhance imaging. This technology offers high-resolution three-dimensional images of living tissue, supplementing or even making biopsies superfluous.
Research finds that high levels of hygiene promote resistance to antibiotics, with microbiome diversity decreasing in areas with strict controls. Regular measures such as airing, houseplants, and reducing antibacterial cleaning agents may counteract this trend.
Researchers at IBS have identified the mistake-rate of DNA editing tools using CRISPR and adenine base editors. The study reveals that ABE7.10, a widely used gene engineering tool, has an average of 60 off-target mistakes in the human genome.
Artist Heather Dewey-Hagborg collaborated with scientists to create a custom virus that increases oxytocin production, associated with feelings of love and empathy. The 'Lovesick' virus is a harmless, non-replicating vector that expresses the hormone oxytocin and a fluorescent protein, allowing cells to glow bright red.
A new computational method called CATCH enables scientists to design molecular probes that can capture genetic material of various microbes, including viruses. This approach has been successfully tested in detecting low-abundance viruses like Zika, improving the detection of viral content in clinical samples.
Researchers from UTokyo and RIKEN developed a device that performs logic operations using electric fields and UV light. The device has the potential to create less heat and power consumption than current semiconductor chips.
Researchers have developed a prosthetic arm that can detect and replicate phantom limb movements, revolutionizing amputee rehabilitation. The device uses muscle activity generated by mobilization of the phantom limb to achieve precise control, allowing patients to interact with their prostheses without extensive training or surgery.
Researchers have purified and visualized the Cyclic Electron Flow supercomplex, a critical part of photosynthetic machinery, to advance solar-powered microalgae-based biotechnologies. This discovery provides new insights into how plants capture and store solar energy at the molecular level.
Researchers at Ural Federal University developed new adsorbents and enzymatic catalysts using modified halloysite nanotubular materials with unique functional properties. The breakthrough technology enables cost-effective extraction of non-ferrous metals and efficient biotechnological hydrolysis processes.
A new machine-learning algorithm, Best Match, has been introduced to improve the search results in PubMed, the world's largest biomedical literature database. The algorithm draws on user responses and click-through rates to provide more relevant results, increasing the click-through rate by 20% compared to chronological ordering.
A new AI model, CytoReason, has created the largest library of inter-cellular communications, mapping over 3,000 previously unlisted cellular interactions. This analysis provides valuable clues for drug development and sheds light on immune system dynamics.
Professor Lee recognized for his work on metabolic engineering to develop sustainable chemical materials, with notable research in drug-drug and food interactions using AI and novel enzymes. He is the second Asian recipient of the prestigious award, honoring Professor Peter V. Danckwerts.
Bielefeld chemists create a biocatalytic method to selectively reduce sulfur-containing heterocycles, yielding highly enantioselective synthesis of target compounds. The discovery has potential applications in developing new active substances and sustainable pharmaceutical production.
Researchers at IU School of Medicine are working on printing 3D pig liver tissue for xenotransplantation research. The collaboration with Lung Biotechnology aims to accelerate the development of unlimited organs for life-saving transplants.
Researchers have developed an AI algorithm that can accurately predict biological age and mortality risk using wearable sensor data from a large dataset. The model outperforms previous models and has the potential to refine health risks for life and health insurance programs.
The Osher Collaborative for Integrative Medicine has launched a new quarterly column in JACM, discussing strategies to advance health justice through integrative medicine principles. The inaugural column highlights the need to address bias and discrimination in intrapersonal attitudes and behaviors.
Researchers review hypothetical uses of biosurfactants, safe and affordable molecules that can produce effective detergents at low temperatures. They have potential applications in industries such as biodiesel production and natural gas harvesting from ice crystals.
Parkinson's UK is providing over $1 million in funding to Neurolixis to accelerate the development of a promising new drug for people with Parkinson's. The project aims to address L-DOPA-induced dyskinesia, a disabling side effect of long-term L-DOPA treatment.
The World Health Organization has prequalified the India-made rotavirus vaccine ROTAVAC, which will be available for procurement by UN agencies and Gavi for use in low-resource countries. The vaccine is the result of a unique social innovation partnership between Indian and international researchers, public, and private sectors.
The team built larger objects, including gears for nanomotors and microtubes with sizes comparable to bacteria. They also constructed closed cage structures with discrete-size cages attaining molecular weights and sizes comparable to viruses and small cell organelles.
Biologists found a new substance, isocitric acid, with anti-oxidant properties that increased the survival rate of infusoria by 25-31 times compared to untreated cells. The compound also surpassed the effects of ascorbic acid, offering a promising solution for protecting living organisms from various toxic compounds.
The shift from public to private funding in biomedical research poses significant challenges, including collaborative research models, intellectual property rights, and oversight. Researchers must navigate conflicts between private benefactors, institutions, and scientists to ensure the integrity of research.
A new review article examines the effectiveness of lipid-based products, including liposome lid sprays and emulsion eye drops, in treating dry eye disease. The studies found that these products provide immediate relief of symptoms and improve the structure and stability of the tear film lipid layer.
The new eMAGE method eliminates DNA breakage errors, enabling efficient genetic modifications with high accuracy. This technology has the potential to revolutionize disease treatment, antibiotic production, and industrial biotechnology applications.