Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new long-acting local anesthetic, neosaxitoxin, has been shown to significantly reduce postoperative pain and speed up recovery in surgical patients. The compound, derived from algae, provides local anesthesia for more than 24 hours, potentially eliminating the need for opioid analgesics.
A new balloon kyphoplasty procedure provides rapid pain relief, increased mobility, and reduced need for painkillers compared to standard non-surgical care. Cancer patients with spinal fractures experience improved spinal function, quality of life, and pain during the study period.
A study compared balanced propofol sedation with conventional sedation for therapeutic GI endoscopic procedures, finding higher health care provider satisfaction and better patient cooperation in the BPS group. The results show that BPS provided similar adverse event profiles to conventional sedation.
The AVERROES trial found apixaban to be superior to aspirin in reducing stroke risk by 61.4% in patients with atrial fibrillation and high stroke risk. Apixaban was also shown to be safe with a lower rate of major bleeding incidents compared to aspirin.
Researchers found that women administering their own patient-controlled epidural analgesia (PCEA) used 30% less analgesia than those with continuous epidural infusion (CEI), while reporting similar levels of satisfaction. The study also showed a trend toward reduction in instrumented vaginal deliveries.
A recent McMaster University-led study published in the New England Journal of Medicine has found that apixaban significantly reduces stroke or embolism risk in high-risk patients with atrial fibrillation, preventing one stroke for every 20 patients treated. The drug also reduces major bleeding risk compared to aspirin.
Research found that folic acid lowers homocysteine in the blood, which should reduce heart attack risk. However, clinical trials showed no extra benefit due to high aspirin use by participants. The study suggests folic acid may still be beneficial for those not taking aspirin.
A new study published in the journal Drug and Alcohol Dependence found that retired NFL players misuse painkillers at a higher rate than the general population, with 7% currently using opioid drugs. The study also found that players who experienced undiagnosed concussions were more likely to misused opioids.
Researchers identify TRPA1 receptor as the culprit behind olive oil's unique sensory irritation and cough sensation. The receptor is also activated by ibuprofen, an over-the-counter NSAID, revealing a potential mechanism for the anti-inflammatory compound's action.
A team of K-State researchers is working to reduce the percentage of cattle affected by bovine lameness, a common health issue in US feedlot and stocker calves. They are developing models to assess lameness and identify risk factors for prevention, as well as analyzing indicators of pain to determine effective treatment options.
Researchers at Harvard Medical School identified a new aspirin-derived molecule that reduces levels of pro-inflammatory molecules and cells in mice. This finding suggests that the molecule could contribute to the beneficial effects of aspirin.
A new experimental drug, morphine-6-0-sulfate, has been found to be more potent and longer-lasting than standard morphine, with less likelihood of causing constipation. The study, led by Dr. Joseph Holtman Jr., tested the drug on rats and demonstrated its potential clinical advantages compared to morphine.
University at Buffalo researchers discover that removing a class of potassium channels from nociceptors during inflammation reduces hyperalgesia, providing a potential therapeutic target for pain relief. This breakthrough could lead to the development of non-addictive, less-toxic painkillers.
Primary care providers experience stress and guilt when managing chronic pain, often feeling ineffective and frustrated. Strategies to ease these frustrations are crucial for improving pain management from both patient and provider perspectives.
Researchers found that opioid users experienced higher rates of serious adverse events, such as fractures and cardiac risks, compared to those taking coxibs or non-steroidal anti-inflammatory drugs. The study suggests that opioids may be associated with greater cardiovascular risk than other analgesics.
Researchers found that a depression drug, duloxetine, reduced joint and muscle pain in women taking aromatase inhibitors for breast cancer treatment by at least 30%. The study suggests that duloxetine may be an effective treatment option for this type of pain, with only mild additional side effects.
A study found that low-dose aspirin use is associated with improved sensitivity and specificity of fecal occult blood tests in detecting advanced colorectal tumors. The findings suggest that temporary use of low-dose aspirin may enhance test performance, but further research is needed to confirm the results.
A study published in The Lancet found that daily low-dose aspirin reduced death rates from a range of common cancers by 21% during trials. Long-term follow-up showed that the risk of cancer death remained 20-60% lower in groups who had previously been allocated aspirin.
A study published in The Lancet found that low-dose aspirin reduces mortality from various cancers, including oesophagus, lung, stomach, pancreas, and possibly brain cancer, by 20-30% regardless of dose or smoking status. Benefit is seen with increasing age and may require at least five years of use for significant impact.
A study by Case Western Reserve University found that emergency department doctors are less likely to prescribe pain medication to patients with a history of crime, drug abuse, or poor health status. The researchers surveyed 398 physicians and analyzed the data to identify social biases in prescription practices.
A study of 200 top-selling children's liquid medications found high variability in labeling and measuring devices, with nearly all products containing at least one inconsistency. The researchers highlight three critical areas for improvement: standardized measuring devices, consistent dosing directions, and standardized measurement units.
Researchers found that 25% of top-selling pediatric oral liquid medications lack dosing devices, while 99% have directions on labels and device markings that don't match. The study recommends standardizing abbreviations and ensuring matching instructions and devices to reduce parent confusion and ensure safe medication use.
Research suggests that ziconotide may worsen mental health conditions, particularly in vulnerable patients. Two new cases highlight the need for careful analysis of psychic disorders before treatment and close monitoring of patients treated with ziconotide.
A study published in Archives of Internal Medicine found that dual antiplatelet therapy increases the risk of bleeding, particularly nosebleeds or minor hemorrhages. The study compared emergency department visits for hemorrhage-related adverse events among patients taking dual antiplatelet therapy versus those taking warfarin.
Researchers found that injecting a platelet inhibitor directly into the heart through a coronary artery may restore blood flow more effectively than conventional administration after a severe heart attack. In contrast, erythropoietin did not reduce heart damage but may increase it in patients over 70 years old. Additionally, measuring ...
Studies show that prenatal drug exposure, maternal smoking, and early-life infections can alter brain development, increasing the risk of learning disabilities, behavioral problems, and mental disorders. The research highlights the importance of educating mothers on avoiding harmful substances during pregnancy.
Researchers identified a common pain gene across species, including humans, which is linked to synesthesia and acts primarily in the brain, not peripheral nerves. The discovery opens up new avenues for understanding pain and developing more effective treatments.
Research found a seven-fold increased risk of undescended testicles in sons born to women taking multiple painkillers during pregnancy. The study suggests that exposure to certain chemicals, including mild analgesics, can disrupt testosterone production and lead to poor semen quality and testicular cancer.
The University of Rochester Medical Center has been awarded a $1 million contract to launch an initiative that aims to accelerate the identification of improved pain treatments. The partnership, known as Analgesic Clinical Trial Innovations, Opportunities, and Networks (ACTION), will analyze clinical trials to identify problems in tria...
A new Stanford University School of Medicine study reveals that intense, passionate feelings of love can significantly alter mood and impact pain perception. The research found that love-induced analgesia involves primitive aspects of the brain, activating deep structures to block pain at a spinal level.
A nationwide clinical trial is underway to test the effectiveness of ranolazine in treating ventricular arrhythmias. The study aims to determine if ranolazine decreases death and cardiac arrhythmias, as well as hospitalizations from cardiac causes.
Experts advocate for phasing out codeine due to its significant risks and unpredictable pharmacokinetics. Morphine, its active metabolite, is proposed as an alternative, offering more predictable metabolism and cost savings.
A phase II clinical trial found tanezumab to be effective in reducing osteoarthritis knee pain, with a 62% reduction in walking knee pain compared to placebo. The drug also showed promise in improving physical function and relieving stiffness.
A new drug, tanezumab, significantly reduces knee pain in osteoarthritis, but a small number of participants developed worsening arthritis and bone changes requiring joint replacements. The FDA is examining data to decide on the drug's future use.
Researchers found that high-dose intravenous aspirin significantly reduced pain in patients with severe withdrawal headaches caused by medication overuse. The study showed that 25% of participants experienced a significant reduction in pain, while 40% reported a modest pain reduction.
A new trial aims to determine if taking daily doses of a fish oil extract and aspirin can shrink existing polyps and prevent new ones from forming in the bowel. If successful, this treatment could reduce the need for frequent colonoscopies in patients at risk of developing bowel cancer.
Researchers have discovered a novel compound that amplifies the effects of anandamide, a natural chemical in the body similar to THC found in marijuana. The synthetic drug URB937 inhibits FAAH enzyme, enhancing anandamide levels and producing analgesic effects without sedation or addiction.
A new study found that intravenous aspirin was associated with a 25% reduction in pain scores and moderate effectiveness in treating severe headaches. The treatment had six percent side effects, mostly nausea and vomiting.
The study aims to find a difference in how a susceptible person responds to hydrocodone compared to a nonsusceptible one. The researchers hope to discover an indicator of susceptibility to dependence on painkillers like hydrocodone.
Research published online in journal Gut found that taking even a very low dose of regular aspirin (75 mg) can reduce the risk of developing bowel cancer. After one year, daily low-dose aspirin was associated with a 22% reduced risk of developing bowel cancer, which increased to 30% after five years.
A team of UC Davis scientists discovered a novel mechanism behind Vioxx's link to heart attacks and strokes, finding that the drug increases a regulatory lipid that contributes to cardiovascular events. The research may pave the way for safer coxibs for millions of arthritis patients.
A new study published in The Lancet Neurology suggests that cilostazol is at least as effective as aspirin in preventing secondary strokes, but with significantly less major bleeding. The trial involved 2757 patients and found a 26% reduced risk of stroke compared to aspirin.
Researchers at Purdue University have developed a new type of pump for drug-delivery patches that uses arrays of microneedles to deliver a wider range of medications. The pump is activated by touch and can exert pressure to force drugs through the needles, with prototypes exerting pressures of up to 4.87 psi.
A double-dose regimen of clopidogrel was found to be more effective than the standard dose in reducing ischemic events and stent thrombosis in patients undergoing PCI for acute coronary syndromes. However, major bleeding increased by 41% with double-dosing.
Researchers have found that boosting brain levels of 2-AG, a natural painkiller, soon leads to loss of its therapeutic effect due to receptor downregulation. This discovery has implications for drug development and basic science, suggesting that more modest elevations in 2-AG may produce sustained pain relief.
A study of opioid detoxification patients found that 31 out of 75 patients first got hooked on prescribed painkillers. The majority continued using street drugs due to lower costs and greater effectiveness, with comments revealing the role of 'pill parties' in their initial use.
Researchers discover small RNAs regulate genes involved in chronic pain, offering a new avenue for developing drugs to treat debilitating conditions like arthritis and back pain. Small RNAs may serve as possible drug targets to restore normal pain thresholds.
A recent study by the University of Michigan Health System found that black patients are prescribed fewer pain medications than whites, while women receive weaker doses. The research highlights racial and gender gaps in pain care and suggests changes are needed to address these disparities starting in primary care.
Monthly acetaminophen use in adolescents may more than double the risk of asthma, with yearly use associated with a 50% increase. The study found a significant association between acetaminophen use and increased risks of asthma, eczema, and allergic rhinoconjunctivitis.
Research suggests that women experience chronic pain longer, more intensely, and more often than men due to hormonal and social factors. Treating both physical and mental symptoms is crucial for effective management of chronic pain in women.
A University of Florida researcher found that acetaminophen alleviates social pain from hurt feelings, suggesting an interrelation between physical and emotional pain. Participants who took acetaminophen daily for three weeks reported fewer emotional sufferings and less brain activity linked to social rejection.
Researchers have discovered a novel approach to ease chronic and acute pain caused by sickle cell disease, using cannibinoids that equally lessen pain in animals as opioids, but with much smaller doses. The treatment has great promise for patients with this genetic blood disorder.
Experts call for decriminalization of drug users, alongside a massive scale-up of opioid substitution, needle and syringe programs, and antiretroviral treatment. Current treatment programmes only reach around 10% of people who use drugs worldwide, highlighting the need for reform in justice systems and policy decision making.
The ASPREE study aims to assess whether aspirin can prolong a life free of physical disability and dementia in healthy older people. The trial will enroll 6,500 participants in the US and Australia and monitor changes in health markers, functional ability, and cognitive function over five years.
A pre-emptive multimodal pain regimen reduced opioid analgesic use in robotic prostatectomy patients. The study found a mean opioid dose of 49.1 mg for those receiving the regimen, compared to 75.3 mg for standard care.
Researchers have discovered a new group of drugs that could provide effective cancer pain relief with minimal side effects. The drugs, developed in collaboration between the Universities of Leicester and Ferrara, act on two targets simultaneously to reduce tolerance.
A recent study found that patients taking celecoxib (a COX-2 selective NSAID) had lower rates of gastrointestinal adverse events compared to those taking diclofenac slow release plus omeprazole. The CONDOR study suggests that celecoxib may be a safer option for arthritis patients at increased gastrointestinal risk.
A systematic review shows that topical non-steroidal anti-inflammatory drugs (NSAIDs) are more effective than placebos for treating short-term pain, reducing pain by 50% or more in over six out of ten cases. The researchers found that topical diclofenac, ibuprofen, ketoprofen, and piroxicam provided the best results with few side effects.
A European survey found that up to 45% of cancer patients with breakthrough pain do not adhere to medication despite severe episodes. Patients want medications that relieve pain quickly and cause few side effects, yet current treatments often fail to meet these needs.
Experts now advise against low-dose aspirin therapy for men under 50 and women under 60 with diabetes, citing risks of stomach bleeding and other side effects. Generic medications for high blood pressure and cholesterol control may be more effective in preventing heart attacks.