Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The new centre will investigate mechanisms of pain in arthritis, develop new treatments, and target individual patients. Researchers will use a multi-disciplinary approach to gain a better understanding of how people experience pain.
A new study suggests that high aspirin dosing levels during the 1918-1919 influenza pandemic may have contributed to increased mortality. Autopsy reports from 1918 support this theory, as they show signs consistent with aspirin toxicity and viral causes of death.
A 12,500-person trial will assess daily low-dose aspirin on health in Australian and US seniors. The study aims to inform health guidelines for older adults, considering aspirin's potential benefits and side effects.
A new study by Queen's University researchers found that taking an anti-seizure drug and an antidepressant together is a more effective treatment for neuropathic pain than taking either individually. Patients experienced less pain and improved sleep when given both drugs, with significant improvements also seen in sleep interference.
A new study published in The Lancet found that combining gabapentin and nortriptyline is more effective than using either drug alone in reducing neuropathic pain. The treatment resulted in a significant reduction in pain scores, with patients experiencing relief from their symptoms.
Researchers found that acetaminophen intervention restored Akt activity in aged muscles, improving cell size and reducing death. The study's results suggest the pain reliever may be beneficial for treating age-related muscle dysfunction.
Researchers have developed a new vaginal device that delivers at least 10 times more medication to the uterus than existing oral medications, reducing side effects and potentially alleviating menstrual cramp pain. Phase II clinical trials will assess efficacy of the treatment in reducing pain.
Scientists have created an implantable device that utilizes magnetism to control the release of medication, allowing for precise and repeatable dosing. The device uses nanoparticles that heat up when exposed to a magnetic field, causing the drug to be released into the body.
A study published in the Journal of the American Geriatric Society found that people with persistent pain develop functional limitations at an earlier age than those without pain. The study revealed that individuals with pain have higher rates of mobility limitations and are more likely to experience disability.
University of Minnesota researchers identified genes producing THC, a psychoactive substance in marijuana, to create a drug-free Cannabis plant for hemp fiber and oil. The study also aims to develop new pain and nausea treatments.
Researchers have discovered that applying capsaicin to specific skin locations can trigger signals in the nervous system, activating cellular pathways that protect the heart. This technique has shown promise in reducing cardiac cell death by up to 85%.
A recent study published in Archives of Internal Medicine found that 29% of chronic angina patients experience angina chest pain at least once a week. Despite treatment options, many patients report limited enjoyment of life due to the symptom.
The first results of the European survey show that breakthrough cancer pain episodes are frequent, short-lived, and intensely painful, with 96% described as moderate to severe. The study suggests that fast-acting pain relief routes like intranasal opioids could be more effective for BTCP, improving patient compliance.
A head-to-head study confirms Instanyl's superiority over oral transmucosal fentanyl citrate (OTFC) in managing breakthrough cancer pain. Instanyl demonstrated significant pain relief at all time points, with patients preferring its ease of administration and faster onset of action.
Researchers found that the endothelin receptor plays a role in vaso-occlusive pain in sickle cell disease, with males more sensitized to pain. Females have more of the ETB receptor, which may explain better pain control and reduced sensitivity.
A study by Johns Hopkins Bloomberg School of Public Health found a significant increase in deaths from unintentional injuries, particularly among middle-aged white women and men. The death rate from falls increased by 38% for white men and 48% for white women 65 and older.
A surgically implanted capsule-sized pump has been developed to provide continuous pain relief for big cats, reducing the need for daily injections. The pump was successfully used on two leopards at a Tennessee sanctuary, demonstrating its effectiveness in delivering pain medication quickly and efficiently.
Recent studies suggest that aspirin may not provide significant benefits for primary prevention in all diabetics. However, the European Society of Cardiology recommends its use for individuals with a high cardiovascular risk profile. Aspirin has been shown to reduce the risk of myocardial infarctions and strokes in this population, par...
A landmark international study found that high doses of clopidogrel significantly reduce stent thrombosis and heart attacks in patients undergoing angioplasty. The study showed a 30% reduction in stent thrombosis risk and a 22% lower risk of heart attack with the higher dose regimen.
The PLATO study demonstrated that ticagrelor reduced cardiovascular events by 16% compared to clopidogrel, with no increase in major bleeding. The efficacy of ticagrelor was observed across all major acute coronary syndromes patient types, with a consistent benefit seen in secondary endpoints.
The Aspirin for Asymptomatic Atherosclerosis study found no statistically significant difference in primary endpoint events between those subjects allocated to aspirin or placebo. Vascular events and all-cause mortality were similar in both groups, but major bleeding occurred more frequently in the aspirin group.
A recent study by the Medical College of Wisconsin found that ibuprofen is as effective as acetaminophen with codeine in treating pain in children with arm fractures. The study showed that children treated with ibuprofen reported better functional outcomes and higher satisfaction rates than those receiving acetaminophen with codeine.
Regular postdiagnosis aspirin use may reduce the risk of dying from colorectal cancer, with a nearly 30% lower risk seen in patients taking aspirin at least twice a week. The benefit is strongest among patients with COX-2-positive tumors.
A new computer system has been successfully tested at Heidelberg University Hospital to improve pain therapy for cancer patients. The system, AiDPainCare, was found to have little variance from international guidelines and reduced patient pain.
Regular aspirin use after diagnosis was associated with reduced risks of colorectal cancer-specific death and overall mortality. Participants who regularly used aspirin had a 29% lower risk of colorectal-specific mortality compared to nonusers.
Researchers at the University of Michigan used brain imaging to study the effects of acupuncture on chronic pain. They found that traditional Chinese acupuncture increases binding availability of mu-opoid receptors in regions processing and dampening pain signals, leading to reduced pain levels.
A newly discovered compound from a soft coral may hold the key to developing effective treatments for neuropathic pain. The research suggests that inflammation in the nervous system is a major factor in this condition, and the compound has been shown to reduce pain-related activities in isolated microglia and experimental rats.
A study of high school seniors found that most who took opioid medications without a prescription did so for reasons other than pain relief, including relaxation and getting high. Students who used the drugs only for pain relief were less likely to engage in heavy drinking or other substance use.
A study of heart disease patients reveals those with prior atherosclerosis are more likely to die in the hospital and receive less recommended therapy. Researchers found these patients were also more likely to have high blood pressure, diabetes, and earlier stroke and heart failure incidence.
A new treatment method, Vesselplasty, has been shown to reduce pain and improve mobility in patients with vertebral compression fractures. The study, which included 29 patients, found significant improvements in pain scores and mobility, with no clinical complications reported.
Scientists have developed a more efficient method to produce a novel form of acetaminophen with reduced liver toxicity risk, offering a potential solution to the growing concern over the drug's effects.
The review examines the prevalence of prescription opioid addiction among patients and healthcare providers, citing risks and consequences. New approaches to minimize abuse and promote recovery are discussed, emphasizing the importance of awareness and treatment.
A phase III randomised controlled trial found that famotidine reduces the development of stomach ulcers by 90% and upper-intestinal ulcers by 95% compared to placebo. The study also showed fewer adverse events in the famotidine group.
A randomized trial of 200 patients found that midline and transverse incisions had the same healing process and post-surgical pain perception. However, wound infections were more frequent for transverse incisions, possibly due to circulatory problems.
Cancer patients often suffer from severe pain due to tumors releasing signal substances that make nerve cells sensitive; a new approach involves injecting proteins that block these effects. This discovery opens up new prospects in the fight against cancer pain and potentially reduces side effects for patients.
A study of 133 women with rheumatoid arthritis found that symptoms such as pain and depression significantly impacted sleep quality. Treating depression may also improve pain and medication adherence, according to researchers.
According to a University of Pittsburgh study, African-American seniors are two times more likely than whites to prefer life-prolonging treatments when faced with a terminal illness. The majority of Medicare beneficiaries surveyed preferred not to die in a hospital or receive life-sustaining measures at the end of life.
Aspirin use in primary prevention reduces non-fatal heart attacks by around 12%, mainly due to reduced risk of non-fatal heart attack. However, it also increases the risk of internal bleeding by around a third in healthy individuals.
A combined pharmacological and behavioral intervention improved depression and pain in patients with musculoskeletal pain and co-existing depression. The intervention significantly reduced symptoms of both conditions at 12 months.
Researchers developed a strategy to improve both depression and pain management by closely monitoring antidepressant therapy and providing pain self-management training. The study found that this approach led to substantial improvements in both conditions, with benefits lasting six months after treatment was completed.
Scientists at Yale School of Medicine and Hydra Biosciences have discovered that a protein called TRPA1 may be a trigger of allergy-induced asthma in mice. Inhibiting this protein with a drug known for reducing pain could also reduce asthma symptoms, providing new hope for treatment.
A study published in PNAS identified TRPA1 as playing a key role in allergic asthma and demonstrated that HC-030031 effectively treated the condition in mice. This breakthrough research could represent a new avenue of treatment for asthma.
A new study comparing three different types of aspirin has found that chewable aspirin consistently shows greater and more rapid absorption, potentially leading to improvements in heart attack care. Researchers measured blood levels of aspirin after administering regular and chewed aspirin to volunteers.
A new study by the University of Pennsylvania School of Medicine found that women with chest pain are less likely to receive recommended treatments, such as aspirin and nitroglycerin, from paramedics. This disparity in care may be due to differences in symptom interpretation or patient communication, emphasizing the importance of direc...
A meta-analysis of studies on aspirin therapy found a 12% reduced risk of nonfatal stroke in patients with peripheral artery disease, although this finding was not statistically significant. Aspirin monotherapy was also associated with a lower risk of nonfatal stroke, but no significant reductions were seen in other cardiovascular events.
A study has found a genetic marker linked to the risk of acetaminophen-induced liver injury in humans. The researchers used a genetically diverse population of mice to identify a gene called CD44, which is significantly associated with elevated serum ALT levels.
A University of Rochester Medical Center survey found teens lack knowledge about over-the-counter pain medications, with only 35% correctly identifying acetaminophen and Tylenol. Chronic misuse can lead to liver damage and accidental overdose
A recent report by the Royal College of Physicians found that up to a quarter of stroke patients do not receive optimal treatment in specialist units. The editorial advocates for increased public awareness and priority for stroke care, citing the importance of rapid recognition and admission to acute units.
The HJF has released the Military Advanced Regional Anesthesia and Analgesia Handbook, providing education on advanced battlefield regional anesthesia techniques and acute pain medicine. The handbook aims to manage the pain of combat trauma and is intended for use by deployed medical forces.
Researchers at Hebrew University found that administering morphine with a drug blocking interleukin-1 provides effective long-term pain relief without increasing dosages. This breakthrough could lead to better pain management with lower side effects.
Researchers studied 2,736 participants over 12 years and found a 66% higher risk of dementia among heavy NSAID users. The study suggests that earlier findings suggesting NSAIDs prevent or delay Alzheimer's disease may have been due to younger age groups.
Researchers found that heavy NSAID use increased the risk of dementia by 66% among study participants. Despite initial findings suggesting a potential preventive effect, this new study indicates that NSAIDs only delay the onset of Alzheimer's disease. The study analyzed data from over 2,700 individuals and followed them for 12 years.
Researchers have discovered that proton pump inhibitors, commonly used to treat ulcers, have significant neuroprotective properties and can enhance the effects of ibuprofen when used together. This finding suggests a new treatment potential for Alzheimer's disease.
A low-dose of naltrexone reduced symptoms of pain and fatigue by an average of 30% in women with fibromyalgia, according to a Stanford pilot study. The drug's use was found to be particularly promising due to its low cost and limited side effects.
Cerebral microbleeds, small deposits of hemosiderin in the brain, are more common among older adults taking anti-clotting medications like aspirin. The study found an association between these medications and brain microbleeds, particularly among those taking higher doses.
Researchers found that acupressure wristbands reduced nausea by 23.8% in cancer patients undergoing radiation treatment, with no difference between the two wristband groups.
Researchers found that repeated exposure to similar temptations can enhance self-control, while a single tempting experience can wear down resistance. The studies showed that participants who had previously faced similar options performed better in subsequent decisions.
A polypill containing a statin, aspirin, and three blood pressure-lowering drugs significantly reduced systolic and diastolic blood pressure in healthy individuals. The formulation also lowered LDL cholesterol, heart rate, and urinary 11-dehydrothromboxane B2, but to a lesser extent than with individual components alone.
A study published in the journal Pain found oxycodone to be an effective treatment for acute shingles pain, with patients experiencing a significant reduction in pain levels. The medication was more than twice as effective as a placebo in reducing pain, making it a promising option for treating this debilitating condition.
Research suggests that aspirin can reduce the risk of polyps forming in the colon or rectum, a precursor to colorectal cancer. Studies have shown mixed results regarding the optimal dose and duration of use, but experts call for more evidence on the effects of aspirin on cancer.