Articles tagged with Analgesics
Patients with suboptimal response to aspirin and/or clopidogrel showed a significant reduction in myocardial damage during percutaneous coronary intervention when treated with tailored infusion of tirofiban. This treatment strategy aims to modulate intensity of treatment based on individual platelet reactivity.
A randomized-controlled trial of 20,332 patients with ischaemic stroke found that anti-clotting regimens aspirin plus dipyridamole and clopidogrel showed no significant difference in reducing disability after recurrent stroke. Telmisartan, an angiotensin II receptor antagonist, also did not demonstrate neuroprotective effects.
A new guideline developed by the American Academy of Neurology recommends surgery as a treatment option for people with extreme face pain due to trigeminal neuralgia. The guideline suggests that patients who don't respond well to drugs should consider surgical interventions to target the root of the trigeminal nerve.
A U-M study finds that proton pump inhibitors (PPIs) are a cost-effective way to prevent upper GI bleeding in patients taking aspirin for cardiac events. Starting PPI therapy at age 50 or older is estimated to be highly cost-effective, while starting at younger ages may only be marginally so.
Researchers developed a predictive model using clinical data to identify individuals aged 40 and older who are at high risk of emergency hospital admissions. The model considers various factors such as age, gender, social deprivation, medication use, and previous hospitalizations.
A study examining anti-clotting therapy following cardioembolic stroke found that warfarin treatment appears to be safe and can begin at any point during hospital stay. In contrast, bridging with full doses of heparin or enoxaparin may carry high risk of intracranial and systemic bleeding.
USC School of Dentistry researchers found that aspirin can inhibit bone resorption and promote osteoblast formation in mice with osteoporosis. The study's findings suggest that aspirin may be a potential alternative to current treatments for osteoporosis, which affect both men and women.
A combination of sumatriptan and naproxen sodium taken within an hour of migraine onset significantly relieved symptoms in patients. The study, published in Neurology, showed that 50% of those who received the drug were pain-free after two hours, compared to 16% of those who took a placebo.
A study of newborn intensive care found that many painful procedures are performed without pain medication or therapy. Neonates experience high rates of repeated and prolonged pain exposure, which can alter their subsequent pain processing and behavior.
Researchers found that general anesthetics activate and sensitize specific receptors on neurons in the peripheral nervous system, increasing post-operative pain. The study suggests that this mechanism may be the reason why patients often experience increased discomfort after waking up from surgery.
A new study by Imperial College London found that people with IBS have a higher number of TRPV1 nerve fibers, which can cause abdominal pain and bloating. The study suggests that blocking this receptor could lead to new therapies for treating IBS symptoms.
Recent studies on pain medicine highlight the need for personalized treatment approaches. Researchers found that opioid therapy often lacks sufficient trial duration to determine its effectiveness for chronic pain sufferers.
A new study uses a graph-based approach to understand consumer preferences for over-the-counter pain relievers. The model identifies three distinct segments: price-conscious consumers, the athletic segment, and anti-medication users.
Researchers found NSAID use reduced Alzheimer's disease risk by 23% compared to non-users. The type of NSAID did not affect the risk reduction, challenging current theories about ibuprofen's benefits.
Lubiprostone has been shown to significantly improve all IBS-C symptoms in women, including abdominal pain, bloating, and constipation severity. The drug is also effective in treating IBS-C for up to one year, with improved stool consistency and reduced nausea and diarrhea.
A recent Australian study found that over 40% of parents have used cough medicine for children under 2 years old, despite warnings from health authorities. The most commonly used medication was paracetamol, and nearly half of parents gave their children anti-histamine-containing medications to treat colds.
Research presented at the American Pain Society annual meeting found that less than 3% of patients with no history of drug abuse who are prescribed opioids for chronic pain will show signs of possible drug abuse or dependence. Most chronic pain patients do not rely on drugs as a sole solution, and multi-faceted treatment involving phys...
The American Pain Society has expanded its low back guideline to include recommendations on surgery and interventional treatments for chronic pain. The new guidelines suggest that epidural stenosis injections may be an option for short-term pain relief, while other procedures have limited evidence supporting their benefits.
A study published in Neurology found that long-term use of ibuprofen and other NSAIDs was associated with a lower risk of Alzheimer's disease. The research analyzed data from over 49,000 veterans and showed that people who used ibuprofen for more than five years were 40% less likely to develop dementia.
A study published in The Lancet Neurology found that cilostazol is as effective as aspirin in preventing recurrent stroke, but causes fewer bleeding events. This suggests that cilostazol could be a more effective and safer alternative for Chinese patients with ischemic stroke.
A Princeton University survey found that 28% of Americans experience pain at any given moment, with those with less education and lower income spending more time in pain. The study also showed that pain can be a barrier to socializing, working, and overall well-being.
A study published in The Lancet found that nearly 30% of men and women reported feeling some level of pain at sampled times. People with lower incomes or less education spent more time in pain and had higher average pain ratings. Pain also imposes significant costs on the healthcare system, economy, and lost productivity.
Researchers found that daily aspirin use was associated with a small reduction in the risk of ER+ breast cancer, but not total breast cancer risk. Aspirin's irreversible effects on cyclooxygenase enzymes may disrupt breast cancer development by reducing estrogen production.
A hybrid technique combining dorsal column stimulator and peripheral nerve field stimulation effectively blocks body's pain signals, providing significant relief from chronic back and leg pain. The implantable procedure has shown promising results with patients experiencing 60-100% reduction in pain.
A new policy implemented in a Michigan clinic helped identify 35% of patients misusing opioid medications, while steering dependent patients to treatment. The approach logged and screened all patients receiving opioids for non-cancer pain, with the goal of protecting doctors' ability to prescribe these drugs.
A study by physiologists at Ball State University found that daily dosages of ibuprofen and acetaminophen increased quadriceps muscle mass and strength gained during three months of weight lifting. The findings suggest a positive effect on the metabolic response to resistance exercise, allowing for enhanced protein synthesis in muscle.
A new surgical technique, osteoprogenitor cellular grafting, has been used to treat steroid-induced osteonecrosis of the knee in three young patients. The procedure involves transplanting cellular material from the pelvic area into the knee, resulting in nearly normal activity and knee function with no complications.
A new study found that intensive antiplatelet therapy with prasugrel reduces ischemic events, including stent thrombosis, compared to standard clopidogrel. The treatment shows promise for patients undergoing percutaneous coronary intervention.
Researchers found that consumers with a relational processing mindset, which notices relationships between data, are shaped by context and can apply it to subsequent products. This contrasts with item-specific processing, where data is considered independently.
A study by Brown University scientists has found that activation of the pain receptor TRPV1 can trigger long-term depression, creating lasting changes in neural connections. This process is believed to be the cellular basis for memory making, with implications for drug development and potentially treating neural disorders.
A study published in the World Journal of Gastroenterology found that psychological intervention can effectively reduce post-embolization pain in patients undergoing hepatic arterial chemoembolization therapy. The research suggests that psychological intervention should be used as a complementary approach to pharmacological analgesia.
A large study published in Thorax found that regular low-dose aspirin use cuts the risk of developing asthma among women by 10%. The Women's Health Study involved over 40,000 female healthcare professionals and monitored their health for around 10 years.
Researchers at the University at Buffalo found that taking ibuprofen while taking aspirin for stroke prevention reduces its effectiveness. In a study of 28 patients, all took ibuprofen and had no anti-platelet effect from their daily aspirin.
A new class of painkillers that block the TRPV1 receptor may interfere with brain functions such as learning and memory, according to a recent study. The researchers found that the receptor regulates neural mechanisms involved in establishing memory pathways in the brain.
Researchers found that combining propofol and remifentanil with patient-controlled administration provides optimal pain relief while reducing staffing costs. This approach could help patients recover quicker and reduce healthcare expenses.
Patients receiving antiplatelet medications like aspirin after stroke show improved outcomes with clot-busting therapy. However, the study found a higher risk of brain hemorrhage in these patients, challenging existing guidelines.
A comprehensive review of 21 studies covering over 37,000 women found that anti-inflammatory drugs like aspirin may reduce breast cancer risk and provide a useful addition to treatment for existing sufferers
A new study by Rush University Medical Center found that women are significantly less likely to be treated with statins, aspirin, and beta-blockers for coronary artery disease compared to men. Despite similar prevalence of adverse drug reactions, the study suggests underutilization of medical therapies may contribute to this disparity.
A provocative study by Dan Ariely found that a 10-cent pill is less effective at killing pain than a $2.50 pill, even when they are identical placebos. The study suggests that patients' subjective ratings of pain are influenced by the perceived quality and cost of medications.
Researchers at the University at Buffalo found that up to 20% of patients taking aspirin for stroke and heart attack prevention do not respond to the medication, leading to increased risk of clinical failure. The study also identified factors associated with aspirin resistance, including younger age and underlying vascular disease.
Researchers present studies on the relationship between smoking and neuropathic pain, the benefits of physical conditioning in chronic pain patients, and the effectiveness of pain rehabilitation programs in reducing medication costs. These findings highlight the importance of addressing underlying causes of chronic pain and exploring n...
A study by Rush University Medical Center found that half of patients receiving cerebrovascular stents did not adequately respond to clopidogrel. The researchers identified a significant association between older age and diabetes with platelet activity, suggesting these patients may require alternative approaches.
Researchers demonstrated that microneedle patches can deliver clinically-relevant doses of drugs like naltrexone, reducing side effects and required dosage. The study also found lower production of metabolites, which may cause adverse reactions.
A new study published in Arthritis Care & Research found that taking two NSAIDs was associated with lower scores on a health-related quality of life assessment. Dual use was also linked to worse physical functioning and symptoms, highlighting the need for better pain management and patient communication.
Researchers have restored the naked mole-rat's ability to feel pain, particularly in response to capsaicin, but remain insensitive to acids. This unique resistance may hold key to developing new pain relief strategies.
Research with genetically modified mice shows that blocking a single cellular change can prevent morphine tolerance and dependence. The study suggests a new strategy to develop morphine derivatives with improved pain relief without addiction risk.
A study found that regular aspirin use lowers the risk of colorectal cancer in men, particularly at higher cumulative doses. However, the benefits of long-term aspirin use appear to diminish after four to five years and are not evident after discontinuing use.
Researchers at ETH Zurich have identified two subtypes of GABA receptors that mediate spinal pain control, opening up new possibilities for targeted pain therapy. This discovery could lead to the development of specific drugs with fewer side effects, making chronic pain treatment more effective.
A University of British Columbia study found that popular osteoporosis drugs like Actonel, Didrocal, and Fosamax nearly triple the risk of developing bone necrosis. Researchers also discovered that this condition primarily affects shoulders, knees, and hips.
Physicians must not participate in executions as it contradicts the core concept of ethics in medicine. Lethal injections used in executions raise concerns about pain and human suffering, with experts calling for improved procedures to ensure humane treatment. The Mayo Clinic Proceedings provides a forum for debate on this critical issue.
A new study found that black and Hispanic patients are less likely to receive strong pain drugs in emergency rooms, despite increased opioid use. Non-opioid pain relievers were prescribed more often to non-whites than whites.
A 20-minute evening back massage was found to decrease pain intensity and unpleasantness, as well as anxiety, in patients undergoing major surgery. The study suggests that massage may act through multiple mechanisms, including relieving anxiety and generating mood-boosting endorphins.
A new study published in JAMA found that the sedative drug dexmedetomidine improves intensive care sleep quality and reduces instances of coma and delirium compared to lorazepam. The study showed that dexmedetomidine resulted in 30% fewer patients experiencing coma and an average of four more coma-free days.
A new study found that treatment with ibuprofen is associated with a significantly slower rate of decline in lung function in children and adolescents with cystic fibrosis. The study showed a 29 percent reduction in loss of lung function compared to those who did not use the anti-inflammatory drug.
A study by Beth Israel Deaconess Medical Center has identified the atrogin-1 gene as a key player in statin-related muscle toxicity. The researchers found that statins activate this gene, leading to muscle damage and atrophy, with potential implications for patients taking these cholesterol-lowering drugs.
Physicians spend approximately 8 hours a week providing unreimbursed care outside of office visits, which can include talking with families or ordering medicines. Lumbar supports have been shown to reduce low back pain in healthcare workers with existing back pain, but not work absences.
Regular use of non-aspirin NSAIDs reduced Parkinson's disease risk by up to 60% compared to non-users. Women who regularly used aspirin also showed a 40% reduced risk, especially after two years of use.
A study by UC Irvine researchers has found that boosting the amounts of a marijuana-like brain transmitter called anandamide produces antidepressant effects in test rats. The drug URB597, which blocks anandamide degradation, was administered to chronically stressed rats and showed promising results.
Researchers have identified a unique pattern of gene expression in the blood that can indicate toxic levels of acetaminophen. This finding could lead to the development of a simple procedure for clinicians to estimate liver damage and prevent or treat resulting liver damage.
BioDelivery Sciences International has submitted its New Drug Application for BEMA Fentanyl, a treatment for breakthrough cancer pain, to the FDA. The application is based on positive results from clinical trials, including a Phase III efficacy trial that demonstrated significant pain reduction and low discontinuation rates.