Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A Mayo Clinic study found a correlation between inadequate vitamin D levels and the amount of narcotic medication taken by patients with chronic pain. Patients with low vitamin D levels were taking nearly twice as much pain medication, experiencing worse physical functioning and overall health perception.
The USPSTF updated its guidelines to recommend aspirin use for primary prevention of heart attack and stroke in specific age and gender groups. The task force emphasizes the importance of discussing the benefits and risks of daily aspirin use with patients, particularly those between 45-79 years old.
The US Preventive Services Task Force (USPSTF) recommends taking aspirin in at-risk patients to prevent heart attacks and strokes. However, the quality of care in nursing homes remains suboptimal, and creating a specialized physician training program may help address this issue.
A new study by the Women's Health Initiative (WHI) found that regular aspirin use reduced the risk of death from cardiovascular disease by 25% in postmenopausal women. The study also suggested a lower dose of aspirin (81mg) is as effective as a higher dose (325mg) in reducing mortality rates.
Aspirin inhibits H. pylori growth and enhances susceptibility to metronidazole, clarithromycin and amoxicillin by affecting outer membrane protein expression and increasing endocellular antimicrobial concentrations.
Researchers at University at Buffalo link capsaicin's analgesic effects to PIP2 lipid in cell membranes. The receptor's adaptation property allows it to continuously respond to varying stimuli, providing a novel strategy for developing safe pain-relieving medications.
Researchers found that H2RA therapy was effective in preventing and treating low-dose aspirin-induced peptic ulcers, while PPIs showed similar results. Cytoprotective anti-ulcer drugs were ineffective in preventing peptic ulcers. The study suggests a therapeutic strategy for managing this condition.
Researchers measure discomfort in cattle undergoing procedures like castration and dehorning using equipment similar to a jogger's heart rate monitor. The study aims to improve pain management in livestock by assessing the effectiveness of pharmaceuticals and recommending proper dosing. By analyzing various measurements, including skin...
Researchers at the University of Liverpool found that 15% of hospital patients experience adverse drug reactions, increasing hospital stay length. The study suggests that elderly patients on multiple medications are most susceptible to ADRs.
A study found that lack of general treatment failure and distant metastases 3 years after treatment initiation may be surrogate endpoints for long-term survival in early prostate cancer patients. Another study identified netrin-1 as a potential therapeutic target for non-small cell lung cancer.
The American Pain Society and American Academy of Pain Medicine have published comprehensive clinical practice guidelines to assist clinicians in prescribing potent opioid pain medications for patients with chronic non-cancer pain. The guidelines emphasize the importance of monitoring patients on chronic opioid therapy to weigh benefit...
The new guideline provides recommendations for clinicians on how to safely prescribe potent opioid pain medications for patients with chronic non-cancer pain. Key findings include the importance of careful patient selection, monitoring, and ongoing assessment to minimize risks of abuse and addiction.
A Yale study suggests simple aspirin can prevent liver damage from common drug side effects, alcohol abuse, and obesity-related diseases. The study found that aspirin reduced mortality caused by an overdose of acetaminophen and blocked inflammation pathways.
Overdoses of acetaminophen lead to two waves of liver cell destruction and immune system activation. Aspirin is found to downregulate pro-inflammatory cytokine production, providing substantial protection from acetaminophen-induced liver damage.
Fibromyalgia patients experience disability and reduced quality of life due to chronic pain and fatigue. Antidepressant medications have been found to improve symptoms by reducing pain, improving sleep, and boosting mood.
COX2 in brain and spinal cord nerve cells plays a crucial role in pain caused by inflammation, particularly mechanical inflammatory pain. Mice lacking COX2 in nerve cells have impaired hypersensitivity to pain caused by physical insult, suggesting COX2 is central to this type of pain.
A recent study published in the World Journal of Gastroenterology investigated the gastrointestinal side effects of high-dose acetaminophen and NSAIDs. The research found that gastric lesions were similar between groups, indicating that acetaminophen is not entirely free of gastrointestinal side effects at high doses.
A study by Seong-Hyun Park and Richard H. Mattson found that hospital patients with plants in their rooms had fewer intakes of pain medication and more positive physiological responses. Patients interacted with the plants, such as watering and pruning, indicating a therapeutic benefit.
Researchers have discovered that people naturally produce salicylic acid (SA) in their bodies, which is also found in fruits and vegetables. This finding suggests SA may play a role as an animal bioregulator in fighting inflammation and disease.
A commonly-prescribed drug for men suffering from pelvic pain failed to significantly reduce symptoms in a 12-week international study. Researchers can now focus on more promising therapies.
A proteomics study found that numbing drugs can have profound effects on the developing nervous system, even after minimal exposure. The study highlights the need for caution when administering sedatives or anesthetics to pregnant women or infants.
A new study reveals a sharp decline in NIH pain research funding, now accounting for only 0.6% of all grants awarded, despite the high prevalence of chronic pain in the US population. The American Pain Society calls for increased funding to address this pressing public health issue.
Researchers developed a new class of anti-inflammatory drugs with fewer side effects than aspirin, targeting the later stage of arachidonic acid biosynthesis. These dual mPGES-1/5-LO-Inhibitors effectively target both prostaglandins and leukotrienes, promising more effective results for inflammatory reactions.
A study found that most unintentional overdose deaths in West Virginia were associated with the nonmedical use and diversion of pharmaceuticals, primarily pain relievers. The majority of decedents had a history of substance abuse and used multiple contributory substances.
Two pivotal Phase 3 trials evaluating HZT 501 met primary endpoints, showing a statistically significant reduction in gastrointestinal ulcers compared to ibuprofen alone. The treatment also demonstrated good tolerability and was well-received by patients.
Scientists have determined that pain and itch are regulated by different molecular mechanisms. Researchers at WashU Medicine separated itch and pain sensations in mice, a finding that could have important implications for treating both pain and chronic itching. GRPR gene plays key role in transmitting itching sensations.
Researchers found that men taking aspirin had significantly lower PSA levels, especially among those with prostate cancer. However, this may affect the ability to detect early-stage prostate cancer through PSA screening.
A new study published in JAMA found that low-dose aspirin did not significantly reduce the risk of atherosclerotic events, including coronary and cerebrovascular events, in patients with type 2 diabetes. However, aspirin was effective in reducing fatal coronary and fatal cerebrovascular events.
Medication overuse headaches (MOH) are associated with severe disability and unmet treatment needs. Recent research suggests that treatments developed to prevent migraine may be effective in patients with MOH before withdrawal, pointing to the need for clinical trials to re-evaluate current strategies.
A GSU study confirms that administering morphine prior to a painful procedure in infancy blocks long-term negative consequences of pain in adult rodents. Infant rodents who did not receive preemptive pain medication were less sensitive to morphine in adulthood, highlighting the need for pain relief in newborns.
A novel nerve stimulator alleviates pain in patients with hemicrania continua, a rare form of chronic daily headache. The study found that five of six patients reported sufficient benefit to recommend the device.
Researchers discovered a new therapeutic target for pain control, identifying a protein that acts in pain-sensing neurons to convert chemical messengers into ones that suppress pain. The protein, PAP, is eight times more effective at suppressing pain than morphine and has longer-lasting effects.
A new study published in Pediatrics shows that implementing simple changes to hospital procedures can significantly reduce the harm caused by opiate use in children's hospitals. The study found that reducing prescription overrides and ensuring caregivers have up-to-date drug lists led to a 67% decrease in adverse events.
A recent study found that aspirin increases the expression of paraoxonase 1 and apolipoprotein A1, two proteins that help remove bad cholesterol from the bloodstream. This increase can lead to reduced risk of atherosclerosis, a condition characterized by the buildup of plaque in arteries.
A study published in The Lancet found that using paracetamol in the first year of life increases the risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years. The study analyzed data from over 200,000 children across 31 countries.
A new type of drug targets CB2 receptors to alleviate pain in human sensory nerves without affecting the brain. This research offers a promising alternative to opioids, which can have serious side effects such as dependency and nausea.
Regular NSAID use can reduce serum PSA levels, potentially altering prostate cancer detection in individuals taking these medications. Chronic inflammation linked to prostate cancer may be masked by NSAIDs, which inhibit COX enzymes.
Common painkillers such as aspirin and ibuprofen appear to lower a man's PSA level, the blood biomarker used to gauge prostate cancer risk. However, the study does not prove a direct link between the medications and reduced risk of prostate cancer.
A new study confirms Pycnogenol's effectiveness in reducing knee osteoarthritis symptoms, with a 20.9% improvement rate and significant reductions in pain and joint stiffness. After treatment cessation, the joints showed no relapse, suggesting a potential lasting effect on joint health.
A new study found that college freshmen believe occasional nonmedical use of prescription pain killers and stimulants is less risky than cocaine, but more risky than marijuana. Sensation-seekers are more likely to use these drugs nonmedically regardless of their perceived harm.
The APPRAISE-I trial found a non-statistically significant trend that patients taking apixaban with aspirin or clopidogrel had lower incidence of heart attack, stroke, and cardiovascular death, compared to those taking a placebo. However, bleeding complications were a concern, especially at higher doses.
Patients with suboptimal response to aspirin and/or clopidogrel showed a significant reduction in myocardial damage during percutaneous coronary intervention when treated with tailored infusion of tirofiban. This treatment strategy aims to modulate intensity of treatment based on individual platelet reactivity.
A Phase II study found trends suggesting apixaban reduces heart attack, stroke risk but increases bleeding among higher doses, warranting further study.
A randomized-controlled trial of 20,332 patients with ischaemic stroke found that anti-clotting regimens aspirin plus dipyridamole and clopidogrel showed no significant difference in reducing disability after recurrent stroke. Telmisartan, an angiotensin II receptor antagonist, also did not demonstrate neuroprotective effects.
A new guideline developed by the American Academy of Neurology recommends surgery as a treatment option for people with extreme face pain due to trigeminal neuralgia. The guideline suggests that patients who don't respond well to drugs should consider surgical interventions to target the root of the trigeminal nerve.
A U-M study finds that proton pump inhibitors (PPIs) are a cost-effective way to prevent upper GI bleeding in patients taking aspirin for cardiac events. Starting PPI therapy at age 50 or older is estimated to be highly cost-effective, while starting at younger ages may only be marginally so.
Researchers developed a predictive model using clinical data to identify individuals aged 40 and older who are at high risk of emergency hospital admissions. The model considers various factors such as age, gender, social deprivation, medication use, and previous hospitalizations.
A study examining anti-clotting therapy following cardioembolic stroke found that warfarin treatment appears to be safe and can begin at any point during hospital stay. In contrast, bridging with full doses of heparin or enoxaparin may carry high risk of intracranial and systemic bleeding.
USC School of Dentistry researchers found that aspirin can inhibit bone resorption and promote osteoblast formation in mice with osteoporosis. The study's findings suggest that aspirin may be a potential alternative to current treatments for osteoporosis, which affect both men and women.
A combination of sumatriptan and naproxen sodium taken within an hour of migraine onset significantly relieved symptoms in patients. The study, published in Neurology, showed that 50% of those who received the drug were pain-free after two hours, compared to 16% of those who took a placebo.
A study of newborn intensive care found that many painful procedures are performed without pain medication or therapy. Neonates experience high rates of repeated and prolonged pain exposure, which can alter their subsequent pain processing and behavior.
Researchers found that general anesthetics activate and sensitize specific receptors on neurons in the peripheral nervous system, increasing post-operative pain. The study suggests that this mechanism may be the reason why patients often experience increased discomfort after waking up from surgery.
A new study by Imperial College London found that people with IBS have a higher number of TRPV1 nerve fibers, which can cause abdominal pain and bloating. The study suggests that blocking this receptor could lead to new therapies for treating IBS symptoms.
Recent studies on pain medicine highlight the need for personalized treatment approaches. Researchers found that opioid therapy often lacks sufficient trial duration to determine its effectiveness for chronic pain sufferers.
A new study uses a graph-based approach to understand consumer preferences for over-the-counter pain relievers. The model identifies three distinct segments: price-conscious consumers, the athletic segment, and anti-medication users.
Researchers found NSAID use reduced Alzheimer's disease risk by 23% compared to non-users. The type of NSAID did not affect the risk reduction, challenging current theories about ibuprofen's benefits.
Lubiprostone has been shown to significantly improve all IBS-C symptoms in women, including abdominal pain, bloating, and constipation severity. The drug is also effective in treating IBS-C for up to one year, with improved stool consistency and reduced nausea and diarrhea.
A recent Australian study found that over 40% of parents have used cough medicine for children under 2 years old, despite warnings from health authorities. The most commonly used medication was paracetamol, and nearly half of parents gave their children anti-histamine-containing medications to treat colds.
The American Pain Society has expanded its low back guideline to include recommendations on surgery and interventional treatments for chronic pain. The new guidelines suggest that epidural stenosis injections may be an option for short-term pain relief, while other procedures have limited evidence supporting their benefits.
Research presented at the American Pain Society annual meeting found that less than 3% of patients with no history of drug abuse who are prescribed opioids for chronic pain will show signs of possible drug abuse or dependence. Most chronic pain patients do not rely on drugs as a sole solution, and multi-faceted treatment involving phys...