Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Research reveals that group visits can significantly improve blood pressure in diabetics with hypertension but not blood sugar levels. Colorectal cancer risk increases with age and birth cohort, suggesting a potential burden to society. Opioid treatment agreements may not reduce misuse, and a new complication from contaminated cocaine ...
The review article provides a comprehensive guide to pain management in cirrhotic patients, recommending reduced dosing of acetaminophen and avoiding NSAIDs due to risk of acute renal failure. The authors emphasize the need for diligent follow-up for toxicity and adverse effects.
A study by Boston University School of Medicine identified factors associated with prescription drug use disorder (PDUD) in primary care patients with chronic pain. Key findings include a history of jail time, disabling pain, cigarette smoking, and family history of substance abuse as predictors of PDUD.
Rush University Medical Center is conducting an international clinical trial to test celecoxib's effectiveness in preventing precancerous polyps in children with familial adenomatous polyposis. The five-year study aims to assess whether the drug can reduce or prevent polyp formation, offering hope for these patients.
Researchers have developed a Mouse Grimace Scale to measure spontaneous responses in mice resembling human pain expressions. The scale accelerates the development of new analgesics for humans while eliminating unnecessary suffering in lab animals.
Researchers at Duke Clinical Research Institute found that telaprevir significantly improves response rates in patients with difficult-to-treat hepatitis C cases. The study also suggests a potential link between aspirin use and the development of inflammatory bowel disease, including Crohn's disease.
A new study by the University of East Anglia found that regular aspirin use increases the risk of developing Crohn's disease by five times. The research, which followed 200,000 volunteers, suggests that aspirin may be a contributing factor to the development of this debilitating condition.
Researchers found biochemical mediators of inflammation produced by activated macrophages, which stimulate antioxidant and anti-inflammatory responses. These findings could lead to the development of new treatments for inflammatory diseases linked to omega-3 fatty acids and aspirin.
Nearly 85% of teens in a study would have overdosed on acetaminophen if given the option, despite 60% having never heard of it. Limited health literacy increases this risk even further.
Researchers at the University of Texas Health Science Center have discovered a family of endogenous capsaicin-like molecules that play an important role in pain biology. They have developed two new classes of analgesics using drugs that either block the synthesis or inactivate these substances.
Dr. Joel Hirsch's research provides new information on how calcium channels work and offers a framework for designing drugs that can modulate them to provide relief from chronic pain. The discovery has the potential to lead to new treatments for conditions such as backaches, sore limbs, and arthritis.
Telcagepant, a CGRP receptor blocker, provides similar pain relief as triptans but with fewer cardiovascular risks. Topiramate may also prevent migraine attacks in chronic sufferers.
A single dose of aspirin (900-1000mg) significantly reduces migraine headache pain in over half of people, with added metoclopramide improving nausea and vomiting symptoms. Aspirin plus metoclopramide is a reasonable option for acute migraine attacks, but may not be effective enough for some.
Researchers found that nicotine withdrawal syndrome is more common in agitated smokers than non-smokers, increasing risks of accidental tube removals. The study highlights the need for improved strategies to prevent agitation or treat it earlier in critically ill patients.
Researchers found dilated intercellular spaces in esophageal epithelium as a nonspecific ultrastructural feature of non-erosive reflux disease (NERD). This discovery suggests DIS is an early and sensitive marker for NERD diagnosis, providing new insights into its mechanism.
The new center will provide timely data on prescriptions to doctors, pharmacies, and regulatory agencies, helping identify best practices in prescription monitoring. The initiative aims to reduce the serious epidemic of drug abuse, taking thousands of lives.
Researchers at the University of Leeds have discovered how two proteins manipulate nerve cells to send pain signals, offering a new target for painkillers. This breakthrough could lead to more effective and safer pain treatments by targeting peripheral nervous system.
Researchers have discovered a new drug that targets the root cause of painful menstrual cramps, called dysmenorrhea. The compound, VA111913, has shown promise in Phase II clinical trials and could be available to patients in four years if studies continue to show positive results.
A new ultra-rapid acting mealtime insulin is orally inhaled for absorption via the lung, mimicking the natural early insulin response. This innovative technology uses a delivery system that applies to other drugs currently injected, with potential benefits including reduced hypoglycemia and weight gain.
A study of nearly 1,500 patients over seven years found that vertebroplasty significantly improves back pain within hours and provides long-term pain relief. Collaboration between interventional radiologists and medical experts is crucial for the best results.
Researchers have discovered the unique genes responsible for codeine and morphine production in the opium poppy, opening doors to alternative methods of producing these painkillers. The findings could lead to more efficient and cost-effective synthesis of pharmaceuticals using microorganisms.
A novel protein named haditoxin has been identified in King Cobra venom, showing promise for new drug discovery and advancing our understanding of disease mechanisms. The protein's unique structure suggests it may offer insights into treating various neurological disorders.
A study published in the Journal of Patient Safety found that non-traditional therapies can significantly impact pain levels in hospitalized patients, with reductions of up to 50%. The treatments included mind-body therapies, acupuncture, and massage, among others, which were found to be effective across various patient populations.
A study found that individuals with a low ankle-brachial index (ABI) did not significantly reduce their risk of cardiovascular or cerebrovascular events with aspirin use. Alternative therapies, such as statins or more potent antiplatelet agents, may be considered for these high-risk patients.
A European study finds inadequate access to opioid-based pain relief for cancer patients, with some countries restricting essential medicines. The authors conclude that restrictive regulations hinder medical care and recommend revising laws to improve accessibility.
A study published in the American Journal of Roentgenology found that the risk of major bleeding after image-guided percutaneous biopsies is low, even among patients taking aspirin. The study reviewed 15,181 biopsies performed over six years and found only 70 hemorrhages (0.5%) within three months of biopsy.
A new study found that women with low sexual desire experience personal and emotional distress, including negative emotions like dissatisfaction and guilt. The study identified 5,098 women with low sexual desire, who reported significant correlations between their level of desire and associated distress.
A study of 136,474 participants found that regular ibuprofen users were 40% less likely to develop Parkinson's disease. Higher doses of ibuprofen also showed a reduced risk of developing the disease.
According to a study published in Archives of Dermatology, regular use of non-steroidal anti-inflammatory drugs (NSAIDs) is not associated with an increased risk of squamous cell skin cancer. The study found that NSAID users were not at a higher risk for squamous cell carcinoma regardless of duration or dose.
A study published in the journal Thorax found that prenatal acetaminophen exposure is associated with an increased risk of asthma symptoms in children. The relationship was strongest in children with a variant of the glutathione S transferase gene involved in detoxification.
Researchers at Vanderbilt University Medical Center have discovered that acetaminophen can prevent oxidative damage and kidney failure after muscle injury in a rat model. The study's findings support further investigation into the drug's effects in patients with severe muscle injuries.
Researchers at the University of Liverpool have discovered a single low dose infusion of intravenous immunoglobulin (IVIG) significantly reduces pain in patients with Complex Regional Pain Syndrome (CRPS), improving quality of life. The treatment has few adverse effects and can be repeated every four weeks.
Research suggests NSAIDs like ibuprofen may be more effective for relieving period pain compared to paracetamol. The updated review of 73 trials involving 5,156 women found that NSAIDs are very effective for treating period pain, with some evidence suggesting they work better than paracetamol.
Research suggests that low vitamin D levels are an independent risk factor for cardiovascular disease and may contribute to higher cardiovascular risk among blacks. The study found that accounting for vitamin D levels reduced the race-based risk of cardiovascular mortality by 60 percent.
The International Headache Society has published new research guidelines to stimulate more research into headache treatment and reduce health risks associated with treatment. The guidelines focus on episodic and chronic tension-type headaches, aiming to identify more effective treatments and improve clinical trial safety for patients.
Health consumers must become informed advocates for comprehensive pain treatment as physicians struggle with inadequate training and fear of prescription drug abuse. Long-term solutions require education, responsibility, and collaboration among all parties involved.
A new study at Ben-Gurion University reveals that taking coxib medications like Celebrex with aspirin increases the risk of cardiovascular events. Researchers found that coxibs interfere with aspirin's effectiveness in preventing blood clots, potentially offsetting its protective benefits.
A study found that acetaminophen reduced self-reported social pain and neural responses to social rejection in brain regions associated with physical pain. The findings suggest that acetaminophen may mitigate the distress of social rejection, potentially reducing antisocial behavior.
A new study suggests that combining celebrex with low-dose aspirin may reduce the effectiveness of aspirin in preventing heart attack and stroke. Researchers found that celebrex interferes with aspirin's ability to block blood clots, particularly when taken in low doses.
A study found that 44% of patients believe they are receiving a medication they don't need, and 96% cannot recall at least one prescribed medication. The study highlights the importance of patient knowledge in preventing medication errors.
The American Society for Gastrointestinal Endoscopy has issued new guidelines for managing antithrombotic agents during endoscopic procedures. Aspirin and NSAIDs may be continued for all elective procedures, while temporary anticoagulation therapy should be completed before proceeding.
A study led by St. Michael's Hospital found that deaths from opioid use in Ontario doubled between 1991 and 2004, with a five-fold increase in oxycodone-related deaths after OxyContin was introduced in 2000. Most opioid-related fatalities were accidental, and most people who died had visited a doctor recently.
A new study found that opioid-related deaths in Ontario, Canada have doubled since 1991, with a significant increase in oxycodone-related deaths. Most of these additional deaths were accidental, and the study suggests that increased rates of opioid prescriptions are a major factor in these deaths.
A study found no association between antiepileptic drugs and increased suicidal thoughts or actions in individuals with bipolar disorder. In fact, antiepileptic drug treatment may have a protective effect on suicidality, particularly among those not receiving other treatments.
Recent studies on anticoagulants suggest that aspirin and heparin may not be effective in preventing unexplained, recurrent miscarriages. In contrast, a new study shows that dabigatran etexilate is as safe and effective as warfarin for treating venous thromboembolism.
A UCLA study found that nearly 20% of stroke survivors were not taking antithrombotic medications, with non-Hispanic, older, and male patients more likely to be on these medications. The study suggests further research is needed to understand the reasons behind this disparity in medication adherence.
A randomized study found that percutaneous disc decompression provides sustained pain relief up to two years, while conservative therapy only offers short-term benefits. Disc decompression involves deflating the bulging disc and relieving nerve root pressure, allowing for improved mobility and quality of life.
University of Missouri researchers found that aspirin and Tylenol block enzymes that inhibit vaccines. This could lead to reduced antibody responses and decreased protection against infections.
Despite increased availability of prescription antiplatelet medications, the overall use of blood-thinning agents among stroke survivors has plateaued. Aspirin remains the predominant agent used for secondary stroke prevention, with no improvements in antithrombotic agent usage over a 7-year period.
A recent study found that low-dose aspirin may offer mild protection from AMD, reducing the risk by 18% in women who took the medication. However, statins did not show a significant impact on advanced AMD risk, with patients taking statins actually at a slightly higher risk of developing advanced disease.
A new self-assessment score has been developed to predict diabetes risk, showing promise as a simple and effective tool. Additionally, researchers are considering alternative bacteria, Fusobacterium necrophorum, for sore throat treatment due to its association with a rare but life-threatening complication, Lemierre syndrome. Furthermor...
Researchers at Newcastle University have scientifically proven the pain-relieving properties of Hyptis crenata, a traditional South American herb. The study showed that the herbal tea was as effective as Indometacin in relieving pain, with results comparable to synthetic aspirin-style drugs.
The initiative seeks to improve care for patients with sickle cell disease by establishing medical homes, providing comprehensive education, and encouraging specialization in the field. The project aims to reduce pain crises and hospitalizations through better prevention and treatment strategies.
A study by Stanford researchers identifies a molecular pathway that counters acetaminophen toxicity, which can lead to liver failure. The discovery highlights the potential of S-methylmethionine, a common herbal medicine supplement, in preventing liver damage caused by acetaminophen overdose.
Researchers found that yoga significantly reduced pain intensity and pain medication use in minority populations with chronic low back pain. The study, which included 12 weeks of hatha yoga classes, showed promising results for this often underrepresented population.
Research from the University of Rochester Medical Center found that using common pain killers like Advil and Tylenol at the time of flu injection can blunt the vaccine's effect. The study suggests that timing and dosage of pain relievers also play a role in reducing antibody production, which is necessary for immune protection.
A Henry Ford study found that pregabalin effectively reduced abdominal pain and improved sleep in women with adhesions, a common complication after abdominal or pelvic surgery. The study results suggest that pregabalin may be a viable treatment option for this painful condition.
Researchers found that young animals treated with commonly-prescribed mood, pain, and epilepsy drugs developed behavioral abnormalities in adulthood. The study suggests these drugs may predispose to psychiatric disorders later in life.
A Duke University researcher has discovered a receptor that receives messages from astrocytes, which can form excitatory synapses in the brain. The discovery may explain why people develop epilepsy or have neuropathic pain, and could lead to new therapies for these conditions.
Researchers found that aspirin and folic acid do not affect inflammation markers in patients with colorectal adenomas. However, low-dose aspirin was found to stabilize C-reactive protein levels, which may be affected by high folate intake.