Articles tagged with Antibiotics
Researchers have identified five LpxC inhibitors that can bind to and inhibit the enzyme, leading to accumulation of inactive enzyme and bacterial cell death. Compound-specific differences were observed in membrane composition and stress responses.
A new study published in PLOS Medicine found distinct patterns of antimicrobial resistance prevalence by age and sex across Europe. The study analyzed data from nearly one million people in 29 European countries, revealing that peaks in resistance varied by bacterial species and often occurred at the youngest and oldest ages.
A team of international scientists has developed an effective treatment for preventing infection in chronic wounds that does not involve antibiotics. The new method involves the plasma activation of hydrogel dressings, producing a unique mix of chemical oxidants that are effective in decontaminating and aiding healing.
A CABI-led study found that 55-89% of respondents answered correctly about antibiotic risks and safe use. Despite this, certain knowledge gaps remain, posing a significant threat to effective infection treatment.
A new study finds that the high burden of typhoid fever in sub-Saharan African countries calls for stronger prevention strategies, including the use and implementation of typhoid conjugate vaccines. The study estimates that there are 12.5 to 16.3 million cases of typhoid every year with 140,000 deaths.
A new study published in npj Antimicrobials and Resistance found that pathogenic bacteria E. coli and A. baumannii employ shared and unique mechanisms to acquire resistance to antibiotics ciprofloxacin and GP6. The researchers developed a method to track the acquisition of drug resistance using whole genome sequencing, which revealed t...
A new cellphone app developed by physician-scientists uses artificial intelligence to accurately diagnose ear infections in young children, reducing unnecessary antibiotic use. The AI tool is more accurate than trained clinicians and offers a simple solution for healthcare providers.
A new material has been developed that can degrade the widely used antibiotic levofloxacin, considered an emerging pollutant in aqueous environments. The material, comprising iridium dioxide and niobium oxide films on a titanium substrate, showed excellent photoelectrocatalytic activity and stability.
Researchers found duplicated antibiotic resistance genes in bacteria from environments with higher antibiotic use, increasing the likelihood of evolution and resistance to new treatments. The study suggests using antibiotics more efficiently could address the growing antibiotic resistance crisis.
Researchers used AI tool AlphaFold to predict and model over 1,400 protein-protein interactions essential for bacterial survival. The study reveals previously unknown details and offers potential targets for developing new antibiotics.
Rumbaugh's lab aims to understand the effects of dispersing bacteria from a biofilm on their susceptibility to antibiotics and on the host. They will use enzymes as tools to break up biofilms, allowing researchers to better comprehend the relationship between bacterial dispersal and infection outcomes.
Researchers have developed a new class of antibiotics that can overcome drug-resistant bacteria by targeting the physical and functional integrity of the bacterial cell wall. This could be a game-changer in treating infections, particularly those caused by resistant strains.
The American Gastroenterological Association recommends fecal microbiota transplant (FMT) as a safe and effective treatment for most patients with recurrent Clostridioides difficile infection. FMT offers hope to patients suffering from debilitating C. diff, enabling them to lead happy and healthy lives.
Researchers found an association between the number of ciprofloxacin prescriptions and the emergence of antibiotic-resistant S. Typhi isolates with QRDR mutations. The study suggests that increased antimicrobial use contributed to the emergence of resistance, highlighting the need for better diagnostics and vaccines.
A team of scientists has developed a new treatment for chronic wounds that uses ionized gas plasma to decontaminate and heal wounds. The technology shows promise in treating diabetic foot ulcers, internal wounds, and potentially cancerous tumours.
A rapid diagnosis protocol using a luminescent paper-based platform has been developed to detect the presence of antibiotic-resistant bacteria. The approach uses a supramolecular hydrogel matrix containing terbium cholate that emits green fluorescence when UV light is shined on it.
Researchers at Harvard University have developed a new antibiotic compound, cresomycin, that effectively targets and kills multiple strains of drug-resistant bacteria. The breakthrough demonstrates improved ability to bind to bacterial ribosomes, overcoming resistance mechanisms.
Scientists at UIC and Harvard developed an antibiotic that effectively suppresses pathogenic bacteria resistant to many commonly prescribed antimicrobial drugs. The new antibiotic, cresomycin, binds strongly to ribosomes, disrupting their function and overcoming several common types of drug resistance.
A study found that antibiotic use and high-fat diets reduced Clostridia gut microbes, leading to sorbitol intolerance. Restoring the balance with mesalazine may treat the condition.
Researchers use bacteriophages to target and kill drug-resistant bacteria, with a patient experiencing complete resolution of infection after combination therapy. However, immune response may lead to recurrence, highlighting need for further clinical trials.
Research at Duke University reveals that sex hormones allow Neisseria gonorrhoeae to produce more pumps to fight off antibiotics, increasing the risk of infection. The bacteria can sense its hormonal environment and colonize during specific phases of the menstrual cycle.
A new study found that one bacterial species, Streptococcus mitis, dominates in IPF patients not treated with antibiotics and is associated with better lung function and survival. This protective relationship does not apply to patients who received antibiotics.
A study found that a common food preservative called nisin, which kills pathogens in food, also harms beneficial gut bacteria. The researchers identified six different lantibiotics produced by the gut microbiome and tested their effects on both pathogens and commensal bacteria.
The University of Texas at Arlington is advancing its understanding of deadly disease tuberculosis (TB) with a new research project led by associate professor Kayunta Johnson-Winters. The project aims to understand why certain types of Mycobacterium tuberculosis bacteria do not respond to treatments.
Researchers found that resistant bacteria like Klebsiella pneumoniae and Escherichia coli can remain in the body for up to nine years after initial infection. The study's key findings highlight the need for tailored treatment approaches to combat persistent infections.
Researchers from Columbia University found that bacteria in biofilms have a highly structured arrangement, allowing them to control physiological states and survive during antibiotic treatment. This discovery could lead to developing new drugs targeting antibiotic-resistant bacteria.
A machine learning technique called LASSO was used to analyze blood samples from six countries, identifying seven genes that can predict the risk of developing a secondary respiratory bacterial infection. The findings aim to guide clinicians in making more informed decisions about antibiotic use.
A study of over 80,000 children found that high fish and vegetable intakes early in life are associated with a lower risk of inflammatory bowel disease. High sugar beverage intake, on the other hand, was linked to a higher risk.
Northwestern University researchers successfully engineered a virus to destroy itself from the inside out, killing a deadly bacterium. The study represents a critical step towards creating new therapies to treat antibiotic-resistant infections.
Researchers at ETH Zurich have identified a virus called Paride that can infect and destroy dormant bacteria, including Pseudomonas aeruginosa. The study found that the combination of Paride and an antibiotic called meropenem was effective in killing bacteria in both laboratory cultures and mice with chronic infections.
Researchers discovered that antibiotics can activate a molecular defense system in bacteria, called CBASS, which enhances the effect of specific antibiotics against Vibrio cholerae. This finding has significant implications for the effective use of antibiotics and preventing antibiotic resistance.
Researchers have gained decisive insights into treating bloodstream infections with Staphylococcus aureus, finding that early oral antibiotic therapy is as effective and safe as intravenous standard treatment. This approach enables easier treatment and faster discharge for patients at low risk of developing infectious complications.
Sezáry syndrome patients face a vicious circle where cancer and treatment weaken the immune system, allowing bacteria like S. aureus to thrive. Eliminating these bacteria may make cancer cells more susceptible to anti-cancer drugs.
Researchers found that E. coli can evolve to produce increased persister cells, leading to increased survival and antibiotic failure. Persister cells contribute to poor patient outcomes when classic antibiotic resistance does not explain such failure.
Researchers at St. Jude Children's Research Hospital have designed a new version of the drug spectinomycin that overcomes efflux, a key mechanism driving antibiotic resistance in Mab infections. The modified compound, eAmSPCs, shows enhanced antimicrobial efficacy and works well with various classes of antibiotics.
Researchers discovered new antibiotic molecules targeting Mycobacterium tuberculosis, reducing its pathogenicity. These substances also enhance the activity of conventional antibiotics like ethionamide, offering a renewed treatment approach.
A recent study reveals that two-thirds of babies born with sickle cell disease are born in areas scoring high or very high on the scale of social vulnerability. This highlights the need for targeted efforts to support families affected by this genetic blood disease.
A new synthetic antibiotic teixobactin has been shown to be highly effective against 'superbugs' such as MRSA and bacterial biofilms, which are associated with serious chronic infections. The study's findings provide promising hope for the development of new treatments against multidrug-resistant bacteria and biofilm-related infections.
Matabele ants can recognize infected wounds and effectively treat them with their own produced antibiotics, drastically reducing mortality. The ants' sophisticated healthcare system has medical implications for humans, as the primary pathogen in ant wounds is also a leading cause of infection in humans.
Researchers at UNIST developed a novel one-pot process for growing Bdellovibrio bacteriovorus, a predatory bacterium with potential as 'living antibiotics'. This approach eliminated the need for multiple vessels and reduced growth time by over 50%, enabling large-scale cultivation without compromising efficacy.
Researchers from Osaka University have identified erythromycin as a potential treatment for myotonic dystrophy type 1, a genetic disease characterized by progressive muscular weakness. The antibiotic showed acceptable safety and tolerability profiles in a phase 2 clinical trial, with some patients experiencing significant improvements ...
Scientists unravel DnaA's role in DNA replication initiation, shedding light on bacterial cell growth and reproduction. The discovery reveals a previously unknown binding pocket within DnaA, enabling the capture of single DNA strands.
A recent study found that doxycycline prophylaxis did not prevent bacterial sexually transmitted infections (STIs) among cisgender women, despite being prescribed to 18% of participants. The study also revealed high rates of antibiotic-resistant gonorrhea, which may be due to low adherence and limited treatment options.
A recent study found that alterations in the human microbiome, including those in the gut, urinary, and salivary tracts, are linked to kidney stone formation. The research team discovered changes in these microbiomes were common among patients with kidney stones.
A team of researchers identified a new structural class of antibiotics using an AI-powered platform built around explainable deep learning. The discovery shows potential to address antibiotic resistance, with the newly discovered antibiotics showing potent activity against multidrug-resistant pathogens.
Researchers used deep learning models to identify compounds with strong antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). The models were trained on expanded datasets and an algorithm that allows for explainable predictions, enabling the discovery of potent antibiotics with minimal human toxicity.
The AGA releases its first comprehensive evidence-based guideline for managing pouchitis, a complication of ulcerative colitis surgery. The guideline recommends treatment with antibiotics and multi-strain probiotics to prevent recurrent pouchitis.
Photodynamic action weakens resistance to antibiotics in bacteria that attack airways, reducing the persistence of both standard and clinical strains. The study found that five cycles of PDI were sufficient to break the resistance of resistant bacteria.
A team of researchers led by UMASS Amherst developed a test to identify new drugs that can disable pathogens and make real gains in public health. They discovered a way to target the Type 3 secretion system, a communication system used by pathogenic microbes to infect host cells.
Researchers at NTNU have developed a new method to study how bacterial signaling proteins react to treatment, paving the way for effective killing of MRSA. The method has shown a combination of two substances kills MRSA more effectively than when used separately.
Researchers have solved the molecular structure of a complete tailed virus with a flexible tail at unprecedented detail. This discovery has significant implications for phage therapies and the development of alternative treatments to antibiotics.
Scientists have created a vaccine candidate against antibiotic-resistant Enterococcus faecium using membrane vesicles, which stimulate the immune system and are stable and non-infectious. The new vaccine showed promising results in killing resistant bacteria, including those resistant to Vancomycin.
Researchers at the Center for Development of Functional Materials created a sensor to monitor metronidazole levels in organisms and the environment. The sensor, combining magnetic fluorescent nanoparticles, showed good sensitivity and practical advantages, enabling real-time analysis and ease of handling.
Researchers have developed a photoswitchable bactericide that can target either Gram-positive or Gram-negative bacteria using a light-driven 'switch'. The nanomaterial was shown to be effective in healing MRSA-infected wounds in mice models, offering a potential new solution to combat antibiotic-resistant infections.
A team of researchers successfully synthesized a 1.5-million-year-old antibiotic called paleomycin, which displays potent properties against human pathogens. By tracing the evolutionary path of glycopeptide antibiotics, the team gained insights into the development of new drugs and uncovered a common precursor molecule.
Researchers at Norwegian University of Science and Technology have developed a simple tool to identify all genetic material in bacteria. This allows for quicker detection of pathogens, enabling informed decisions on antibiotic use.
Researchers at the University of Copenhagen discovered that phages use small RNAs to disarm bacterial CRISPR-Cas immune systems, making them vulnerable to infection. This finding has significant implications for phage therapy and could lead to more specific and controlled CRISPR-Cas treatments.
The study analyzed 170 known bacterial languages, grouping them into clusters based on molecular structure. Bacteria can understand related languages, but not those with vastly different languages. This understanding will aid in refining treatment approaches and developing biotechnology applications.
Researchers found that treating C. elegans with mitochondrial inhibitors extended their lifespan, improved pharyngeal muscle contraction, reduced lipofuscin content, and decreased energy consumption. The study suggests that these drugs could abrogate aging and extend human lifespan, offering a potential therapeutic approach.
A new study by the University of Plymouth reveals that chlorine disinfectants used in hospitals are no more effective at killing off hospital superbugs than water. The research highlights the need for alternative strategies to tackle Clostridioides difficile, which causes diarrhoea, colitis and other bowel complications globally.