Articles tagged with Antibiotics
Researchers discovered high levels of antibiotic resistance among war-wounded patients in Ukrainian hospitals, with nearly 10% resistant to colistin. The study highlights the challenges posed by resistant bacteria in times of war, particularly the highly resistant Klebsiella pneumoniae bacteria.
Researchers discovered how two new compounds attack TB-causing bacteria, providing insights into future therapies. The study found that one compound binds better to ATP synthase than existing treatment, while another targets a previously unknown site.
The updated guidance emphasizes the importance of antimicrobial stewardship to reduce MRSA infection rates. It also recommends surveillance for asymptomatic carriers and decolonization for those colonized with MRSA. Effective hand hygiene and cleaning practices remain crucial in preventing MRSA transmission.
Researchers at the University of California - Riverside have developed a low-cost technology using biochar to remove harmful compounds from reclaimed water, making it safe for agricultural reuse. The biochar-based polishing systems have shown promising results in removing antibiotics and resistant bacteria, potentially reducing the spr...
Researchers found that probiotics help preterm babies achieve a balanced gut microbiome and eradicate harmful bacteria. The study also shows that probiotic-supplemented preterm newborns have lower risk of carrying antimicrobial resistant bugs despite frequent antibiotic treatment.
A recent study published in JAMA found that continuous meropenem administration did not improve mortality rates or reduce the emergence of drug-resistant bacteria in critically ill patients with sepsis. The results suggest that intermittent administration may be a more effective treatment strategy for this condition.
Researchers at Nagoya University have discovered that targeting Fusobacterium bacteria can reduce the formation of lesions associated with endometriosis. The study suggests an effective non-hormonal antibiotic treatment for this gynecological disorder, which affects one in ten women between 15 and 49 years old.
A study found that even insured patients with diabetes use crowdfunding platforms like GoFundMe to cover excess medical expenses, including uncovered co-pays and life-saving care. Researchers urge policymakers to consider these needs when developing affordable diabetes care policies.
A statewide pay-for-performance intervention based on Choosing Wisely reduced rates of inappropriate antibiotic prescriptions for acute respiratory tract infections from 43% to 25%. This reduction occurred without measurable harms at safety-net hospitals serving disadvantaged patients.
A global observational study found high mortality among infants with culture-positive sepsis, highlighting the need for effective antibiotics. The study developed tools to identify at-risk newborns and inform WHO guidelines on treatment.
SMART researchers have discovered a novel combination therapy using rifaximin and clarithromycin to treat antibiotic-resistant Mycobacterium abscessus infections. The study found that rifaximin potentiates clarithromycin against M. abscessus, increasing its sensitivity and effectiveness in killing the bacteria.
Researchers investigated how gut bacteria respond to repeated antibiotic disruptions, finding that they evolve antibiotic-resistant variants and adapt through slowing of cell growth. The study reveals the complex response of the microbiome to antibiotics, including ecological effects and induction of prophages.
Scientists at the University of Illinois Chicago have discovered a peptide from fruit flies that protects insects from bacterial infections by binding to ribosomes in bacteria. The peptide, called drosocin, inhibits translation termination when the ribosome reaches the stop signal at the end of the gene.
A new study reveals that previously unknown antibiotic resistance genes are widespread in bacteria across various environments, including the human microbiome. The findings suggest that these genes can pose a significant threat to human health, highlighting the need for enhanced understanding of their development and spread.
Researchers at the University of Zurich have developed a new class of antibiotics that target novel targets in bacterial metabolism, effectively fighting resistant bacteria. The peptides are highly effective, safe, and immune to resistance, offering hope for treating bacterial infections in patients.
Researchers found two antimicrobial agents that are more effective in treating the disease-causing agent Treponema pallidum in a laboratory setting. The discovery opens new doors in understanding the disease and finding ways to prevent infection and intervene.
Researchers discovered that oxalic acid helps create a sticky, gel-like extracellular matrix in fungi and bacteria. The more oxalic acid present, the more viscous the matrix becomes, allowing microbes to control nutrient uptake and resistance to antibiotics.
Researchers used AI to identify a compound that kills Acinetobacter baumannii, a bacterium responsible for many drug-resistant infections. The new antibiotic shows promise in combating this growing public health threat.
Researchers at the University of Adelaide have discovered a failed antibiotic that can effectively kill two of Australia's most problematic weeds, annual ryegrass and wild radish, without harming bacterial or human cells. This finding could lead to faster development of new weed killers, saving farmers billions of dollars each year.
A new international clinical trial is evaluating new antibiotic combinations for newborn babies with sepsis, which affects up to 3 million babies globally. The NeoSep1 trial will assess the safety and efficacy of three new antibiotic treatments against existing standard regimens.
A machine learning model trained on clinical text notes can effectively categorize patients into 10 risk groups, allowing for targeted care. The study found that patients in lower-risk groups had lower rates of lung inflammation and were less likely to receive antibiotics or chest X-ray referrals.
A new study shows public acceptance of phage therapy is moderately high and can be increased through education. The study found that describing phage therapy in a more positive light increases its acceptance, while exposure to information about antibiotic resistance also plays a role.
Researchers developed a new method combining palmitoleic acid, gentamicin, and non-invasive ultrasound to improve drug delivery in chronic wounds infected with S. aureus. The strategy reduced bacterial burden by 94% and successfully sterilized wounds in diabetic mice.
A new method called 5PSeq has been developed to quickly assess bacterial response to antibiotics, with potential implications for treating antibiotic-resistant infections. The method measures mRNA translation and decay, revealing how bacteria interact with environmental factors and stressors.
A large-scale clinical trial has found that spironolactone is an effective treatment for persistent acne in women, offering an alternative to antibiotics. The study, funded by the National Institute for Health and Care Research, recruited over 400 women with acne that had persisted for more than six months.
The novel combination antibiotic sulbactam-durlobactam has been found to combat dangerous pneumonia at least as well as the best currently approved treatment. The drug has shown significant tolerability and dosing advantages over existing treatments, making it a promising option for combating hospital-acquired infections.
Researchers at Beth Israel Deaconess Medical Center have found an effective treatment for multi-drug resistant bacteria, a major concern in the fight against superbugs. The newly discovered antibiotic, streptothricin, has shown potency against several drug-resistant strains of bacteria and may deserve further exploration as a potential...
Researchers have discovered a compound that can combat multidrug-resistant bacteria within one hour, including the ESKAPE group of pathogens. The compound, Pln149-PEP20, is a synthetic peptide inspired by molecules secreted by Lactobacillus plantarum and has been found to be highly active against MDR bacteria.
Researchers tracked antimicrobial resistance in E. coli isolated from swine between 2013 and 2019, finding an increasing trend of resistance to ceftriaxone. The study highlights the need for surveillance systems to monitor microbes and develop mitigation strategies to address this growing concern.
A new study led by Intermountain Health and University of Utah Health found that an antibiotic stewardship program significantly reduced prescribing rates of antibiotics at urgent care centers in Utah. The program, implemented for 38 clinics, included education, electronic health record tools, and transparent benchmarking dashboards, r...
Researchers from Hefei Institutes of Physical Science propose a novel approach to treat antibiotics using low-temperature plasma technology, achieving higher efficiency than single antibiotics. The method involves combining CAPJ with PAW, resulting in ecologically safe degradation products.
Interactions between gut bacteria may limit antibiotics' effectiveness in treating C. difficile infections, a study suggests. Researchers found that certain bacterial species make the bacterium tolerant to metronidazole and increase its abundance.
A patient in Cleveland was diagnosed with a corneal ulcer caused by Pseudomonas aeruginosa, a drug-resistant bacterium that's rarely found in eye infections. The contaminated eye drops were identified as the source of infection, and treatment required strong antibiotics to prevent vision loss.
Scientists have engineered plants to produce peptides with antibiotic activity against drug-resistant pathogens, which also enhances stability and prolongs activity. The resulting plants yield potent drugs at significantly lower costs than traditional methods, making them an environmentally friendly option for pharmaceutical production.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
A UNIGE team has developed small beads encapsulating fecal bacteria for treating a serious intestinal infection. The technology overcomes obstacles in current treatments, allowing for easier and more comfortable administration.
A recent study found that exposure to antibiotics before age 5 triples the risk of pediatric IBD, while a Western diet high in sugars and ultra-processed foods increases the risk, and lower socioeconomic status provides protection. Conversely, having more siblings, being exposed to pets, and consuming vegetables reduce the risk.
Researchers identify OmpU protein variants associated with antimicrobial resistance in Vibrio cholerae bacteria. Understanding the evolutionary origins of AMR can inform the development of effective therapeutics against resistant infections.
Updated guidelines recommend discontinuing antibiotics immediately after a patient's incision is closed. Continuing antibiotics increases risk of C. difficile infection and antimicrobial resistance, but does not prevent surgical site infections.
A study published in Science Translational Medicine suggests that preterm infants' gut microbiomes play a role in the development of dangerous bacterial bloodstream infections. The researchers found that the most common bacteria causing these infections are also commonly found in the gut, and that antibiotics can disrupt the balance of...
Researchers at Harvard Medical School discovered a new cellular sensor that allows dormant bacteria to detect nutrients and quickly spring back to life. This breakthrough could inform the design of ways to prevent dangerous bacterial spores from lying dormant for months before waking up again and causing outbreaks.
A new Cochrane Review found that stool transplantation can increase the number of people recovering from Clostridioides difficile (C. diff) infection by 77%, compared to 40% with standard antibiotic treatment. The study also showed a decrease in side effects with stool transplantation.
Researchers have developed a fast, cheap, and easy method to test antibiotic resistance in bacteria, using optical nanomotion detection. The technique can determine sensitivity or resistance of bacterial cells to antibiotics in under two hours, with significant implications for clinical and research applications.
According to a new joint study, most children diagnosed with Lyme disease (75%) fully recovered within six months of completing antibiotic treatment. However, 22% of children experienced persistent symptoms after treatment, including some classified as post-treatment Lyme disease (PTLD) syndrome.
Researchers discovered that gut bacteria's F-pili are stronger in harsh conditions, enabling efficient gene transfer and biofilm formation. The findings highlight the challenge of combating antibiotic resistance and suggest exploiting similar molecular properties for precise drug delivery.
A new liposome-based method aims to kill periodontitis-causing leukotoxin while protecting immune cells, providing an alternative treatment for aggressive gum infections. The approach has potential applications against a range of bacteria and could help combat antibiotic resistance.
A study by Florida Atlantic University researchers found a significant 'antibiotic culture' in US hospital ICUs, with up to 70% of patients receiving unnecessary antibiotics. The preference for antibiotics is driven by urgency, hierarchy, and uncertainty, leading to increased use despite antimicrobial stewardship guidelines.
A global study published in Cochrane Reviews found that consuming cranberry products reduces the risk of repeat symptomatic UTIs in women by more than a quarter. The review also showed benefits for children and people susceptible to UTIs following medical interventions, with minimal side effects reported.
Researchers at Linköping University developed a nanocellulose wound dressing that reveals early signs of infection through pH monitoring. This technology can lead to more efficient care and reduce unnecessary antibiotic use.
Researchers at Aalto University developed a drug that undercuts antibiotic resistance by blocking key toxins involved in the infection process. The treatment sequesters toxins and disrupts biofilms, making bacteria more vulnerable to antibiotics. Initial results show promising protection against bacterial infections.
Research highlights devastating impact of war injuries on civilians and soldiers, resulting in complex bone and soft-tissue infections. Doctors describe treating patients with highly complex musculoskeletal infections caused by multidrug-resistant pathogens.
A study from Lund University reveals how antibiotic-resistant bacteria acquire resistance through two molecular mechanisms. The researchers identified a novel protein that conveys resistance to specific antibiotics, and found that certain antibiotics induce the production of this factor, providing clues for designing new medicines.
Researchers identified protective drugs that shield two abundant gut bacterial species without compromising antibiotic effectiveness against disease-causing bacteria. The study found a novel combination of antibiotics with antidote drugs, such as dicumarol and tolfenamic acid, which protected the gut microbiome and maintained antibioti...
A Spanish study found that 40% of supermarket meat samples contained multidrug-resistant E. coli, including strains capable of causing severe infections in people. The study highlights the need for regular assessment and farm-level interventions to reduce the presence of antibiotic-resistant bacteria in food-producing animals.
A growing number of European countries have experienced diphtheria outbreaks primarily associated with recently arrived migrants. Key findings indicate that whole genome sequencing and phylogenetic analysis reveal that the toxin-producing bacteria were acquired during migration rather than in their home country or Germany.
The Society for Healthcare Epidemiology of America recommends hospitals establish antimicrobial stewardship programs to prevent Clostridioides difficile (C. difficile) infections, which cause difficult-to-treat diarrhea, longer hospital stays, and higher costs. The updated guidance provides evidence-based strategies for identifying and...
New research at ECCMID 2023 presents 19 gold complexes effective against at least one hard-to-treat bacterium, including MRSA and Pseudomonas aeruginosa. The gold-based drugs use a multimodal mechanism to kill bacteria, preventing antimicrobial resistance from developing.
Researchers at Texas Biomedical Research Institute have identified a potential host-directed therapy targeting the immune system to bolster the body's ability to control TB infection. Blocking IDO enzyme helped nonhuman primates completely eliminate active TB infection, improving health metrics compared to antibiotics alone.
Researchers have developed a new ear tube design that combines liquid-infused materials with optimized geometry to improve treatment outcomes for patients with ear infections. The design enables better performance and reduces complications such as impaired hearing and scarring of the eardrum.
The study found that antibiotics slow down biofilm growth and QS molecule production across both strains, with surface type having a significant effect on the non-mucoid strain. The patterned structure was associated with longer latencies before expression of QS molecules were at their peak.