Articles tagged with Antibiotics
Researchers developed a novel metal-derived complex to treat Avian Pathogenic Escherichia coli (APEC), a serious respiratory infection resistant to antibiotics. The treatment, manganese carbonyl, showed protective effects in chickens with APEC, reducing bacterial shedding and killing.
Researchers at Tokyo University of Science successfully synthesized tanzawaic acid B in large amounts, paving the way for new antibiotic development. The breakthrough method could lead to creation of various compounds for pharmaceuticals, including new antibiotic candidates.
A recent study found that women with Lyme disease experience longer diagnostic delays, more severe symptoms, and increased misdiagnoses compared to men. The study also revealed no significant differences in antibiotic treatment response or side effects.
A novel stress signalling system has been discovered by SMART researchers, enabling bacteria cells to adapt and survive against the immune system and certain antibiotics. The breakthrough discovery of RlmN as a stress sensor may lead to the development of new therapies to combat antimicrobial resistance.
The study identified significant differences in antibiotic resistance trends and associated factors depending on bacterial species and antibiotic resistance to certain antibiotics. High health system quality was linked to low levels of resistance, while high temperatures were associated with increased resistance in Enterobacteriaceae.
A new study led by Vanderbilt University Medical Center has shown that a simple direct oral challenge can safely remove penicillin allergy labels from low-risk patients. This method performs as well as traditional skin testing and oral challenges, with no serious adverse events reported.
Researchers discuss treatment refractory forms of chronic sinusitis, highlighting the importance of interdisciplinary diagnostics and therapy. Fungal infections are a rare cause, yet crucial to consider when treating this condition.
A study published in the Journal of Hospital Infection reveals that pharmacist-led multi-faceted interventions can optimize antimicrobial prescriptions in dental clinics, reducing the incidence of serious infectious diseases. The intervention increased penicillin usage and decreased the use of broad-spectrum antimicrobials.
Researchers found that antimicrobial resistance emerges from selection for pre-existing resistant clones, not new mutations. Infections with multiple pathogen clones show increased resistance to antibiotics, but also potential for faster loss of resistance when no antibiotics are present.
Researchers have discovered a new target for antibiotics that could treat multi-drug resistant superbugs. The antibiotic AMC-109 affects the cell membrane of bacteria by disordering its organization, leading to the death of the bacterium. This approach may also break down resistance to old-fashioned antibiotics.
A recent study found that Kenyan patients who spend more than three days in hospitals are more likely to harbor antibiotic-resistant bacteria. The research team identified three risk factors associated with colonization, including hospitalization for extended periods and intubation.
Researchers identified a new drug treatment option for peritonitis in patients on peritoneal dialysis, showing that a low dosage of ceftazidime and avibactam is sufficient to treat the infection. The study's findings could help gain control over peritonitis in patients with difficult-to-treat germs.
Researchers discovered that using fat-free mass for gentamicin dosage calculation yields more effective results than traditional methods. This method is particularly beneficial for premature babies, who have weaker kidneys and require adjusted dosing.
A study published in Frontiers in Microbiology found that administering vaginal suppositories with Lactobacillus crispatus can restore a healthy balance of vaginal microbiota and prevent recurrent cystitis. The researchers discovered that postmenopausal women with RC had significantly different bacterial communities compared to those w...
Researchers discovered high levels of antibiotic resistance among war-wounded patients in Ukrainian hospitals, with nearly 10% resistant to colistin. The study highlights the challenges posed by resistant bacteria in times of war, particularly the highly resistant Klebsiella pneumoniae bacteria.
Researchers discovered how two new compounds attack TB-causing bacteria, providing insights into future therapies. The study found that one compound binds better to ATP synthase than existing treatment, while another targets a previously unknown site.
The updated guidance emphasizes the importance of antimicrobial stewardship to reduce MRSA infection rates. It also recommends surveillance for asymptomatic carriers and decolonization for those colonized with MRSA. Effective hand hygiene and cleaning practices remain crucial in preventing MRSA transmission.
Researchers found that probiotics help preterm babies achieve a balanced gut microbiome and eradicate harmful bacteria. The study also shows that probiotic-supplemented preterm newborns have lower risk of carrying antimicrobial resistant bugs despite frequent antibiotic treatment.
Researchers at the University of California - Riverside have developed a low-cost technology using biochar to remove harmful compounds from reclaimed water, making it safe for agricultural reuse. The biochar-based polishing systems have shown promising results in removing antibiotics and resistant bacteria, potentially reducing the spr...
A recent study published in JAMA found that continuous meropenem administration did not improve mortality rates or reduce the emergence of drug-resistant bacteria in critically ill patients with sepsis. The results suggest that intermittent administration may be a more effective treatment strategy for this condition.
Researchers at Nagoya University have discovered that targeting Fusobacterium bacteria can reduce the formation of lesions associated with endometriosis. The study suggests an effective non-hormonal antibiotic treatment for this gynecological disorder, which affects one in ten women between 15 and 49 years old.
A statewide pay-for-performance intervention based on Choosing Wisely reduced rates of inappropriate antibiotic prescriptions for acute respiratory tract infections from 43% to 25%. This reduction occurred without measurable harms at safety-net hospitals serving disadvantaged patients.
A study found that even insured patients with diabetes use crowdfunding platforms like GoFundMe to cover excess medical expenses, including uncovered co-pays and life-saving care. Researchers urge policymakers to consider these needs when developing affordable diabetes care policies.
A global observational study found high mortality among infants with culture-positive sepsis, highlighting the need for effective antibiotics. The study developed tools to identify at-risk newborns and inform WHO guidelines on treatment.
Researchers investigated how gut bacteria respond to repeated antibiotic disruptions, finding that they evolve antibiotic-resistant variants and adapt through slowing of cell growth. The study reveals the complex response of the microbiome to antibiotics, including ecological effects and induction of prophages.
Scientists at the University of Illinois Chicago have discovered a peptide from fruit flies that protects insects from bacterial infections by binding to ribosomes in bacteria. The peptide, called drosocin, inhibits translation termination when the ribosome reaches the stop signal at the end of the gene.
SMART researchers have discovered a novel combination therapy using rifaximin and clarithromycin to treat antibiotic-resistant Mycobacterium abscessus infections. The study found that rifaximin potentiates clarithromycin against M. abscessus, increasing its sensitivity and effectiveness in killing the bacteria.
A new study reveals that previously unknown antibiotic resistance genes are widespread in bacteria across various environments, including the human microbiome. The findings suggest that these genes can pose a significant threat to human health, highlighting the need for enhanced understanding of their development and spread.
Researchers found two antimicrobial agents that are more effective in treating the disease-causing agent Treponema pallidum in a laboratory setting. The discovery opens new doors in understanding the disease and finding ways to prevent infection and intervene.
Researchers at the University of Zurich have developed a new class of antibiotics that target novel targets in bacterial metabolism, effectively fighting resistant bacteria. The peptides are highly effective, safe, and immune to resistance, offering hope for treating bacterial infections in patients.
Researchers discovered that oxalic acid helps create a sticky, gel-like extracellular matrix in fungi and bacteria. The more oxalic acid present, the more viscous the matrix becomes, allowing microbes to control nutrient uptake and resistance to antibiotics.
Researchers used AI to identify a compound that kills Acinetobacter baumannii, a bacterium responsible for many drug-resistant infections. The new antibiotic shows promise in combating this growing public health threat.
A new international clinical trial is evaluating new antibiotic combinations for newborn babies with sepsis, which affects up to 3 million babies globally. The NeoSep1 trial will assess the safety and efficacy of three new antibiotic treatments against existing standard regimens.
A machine learning model trained on clinical text notes can effectively categorize patients into 10 risk groups, allowing for targeted care. The study found that patients in lower-risk groups had lower rates of lung inflammation and were less likely to receive antibiotics or chest X-ray referrals.
Researchers at the University of Adelaide have discovered a failed antibiotic that can effectively kill two of Australia's most problematic weeds, annual ryegrass and wild radish, without harming bacterial or human cells. This finding could lead to faster development of new weed killers, saving farmers billions of dollars each year.
Researchers developed a new method combining palmitoleic acid, gentamicin, and non-invasive ultrasound to improve drug delivery in chronic wounds infected with S. aureus. The strategy reduced bacterial burden by 94% and successfully sterilized wounds in diabetic mice.
A new method called 5PSeq has been developed to quickly assess bacterial response to antibiotics, with potential implications for treating antibiotic-resistant infections. The method measures mRNA translation and decay, revealing how bacteria interact with environmental factors and stressors.
A new study shows public acceptance of phage therapy is moderately high and can be increased through education. The study found that describing phage therapy in a more positive light increases its acceptance, while exposure to information about antibiotic resistance also plays a role.
A large-scale clinical trial has found that spironolactone is an effective treatment for persistent acne in women, offering an alternative to antibiotics. The study, funded by the National Institute for Health and Care Research, recruited over 400 women with acne that had persisted for more than six months.
Researchers at Beth Israel Deaconess Medical Center have found an effective treatment for multi-drug resistant bacteria, a major concern in the fight against superbugs. The newly discovered antibiotic, streptothricin, has shown potency against several drug-resistant strains of bacteria and may deserve further exploration as a potential...
The novel combination antibiotic sulbactam-durlobactam has been found to combat dangerous pneumonia at least as well as the best currently approved treatment. The drug has shown significant tolerability and dosing advantages over existing treatments, making it a promising option for combating hospital-acquired infections.
Researchers have discovered a compound that can combat multidrug-resistant bacteria within one hour, including the ESKAPE group of pathogens. The compound, Pln149-PEP20, is a synthetic peptide inspired by molecules secreted by Lactobacillus plantarum and has been found to be highly active against MDR bacteria.
Researchers tracked antimicrobial resistance in E. coli isolated from swine between 2013 and 2019, finding an increasing trend of resistance to ceftriaxone. The study highlights the need for surveillance systems to monitor microbes and develop mitigation strategies to address this growing concern.
Interactions between gut bacteria may limit antibiotics' effectiveness in treating C. difficile infections, a study suggests. Researchers found that certain bacterial species make the bacterium tolerant to metronidazole and increase its abundance.
A patient in Cleveland was diagnosed with a corneal ulcer caused by Pseudomonas aeruginosa, a drug-resistant bacterium that's rarely found in eye infections. The contaminated eye drops were identified as the source of infection, and treatment required strong antibiotics to prevent vision loss.
A new study led by Intermountain Health and University of Utah Health found that an antibiotic stewardship program significantly reduced prescribing rates of antibiotics at urgent care centers in Utah. The program, implemented for 38 clinics, included education, electronic health record tools, and transparent benchmarking dashboards, r...
Researchers from Hefei Institutes of Physical Science propose a novel approach to treat antibiotics using low-temperature plasma technology, achieving higher efficiency than single antibiotics. The method involves combining CAPJ with PAW, resulting in ecologically safe degradation products.
Scientists have engineered plants to produce peptides with antibiotic activity against drug-resistant pathogens, which also enhances stability and prolongs activity. The resulting plants yield potent drugs at significantly lower costs than traditional methods, making them an environmentally friendly option for pharmaceutical production.
A UNIGE team has developed small beads encapsulating fecal bacteria for treating a serious intestinal infection. The technology overcomes obstacles in current treatments, allowing for easier and more comfortable administration.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
A recent study found that exposure to antibiotics before age 5 triples the risk of pediatric IBD, while a Western diet high in sugars and ultra-processed foods increases the risk, and lower socioeconomic status provides protection. Conversely, having more siblings, being exposed to pets, and consuming vegetables reduce the risk.
Researchers identify OmpU protein variants associated with antimicrobial resistance in Vibrio cholerae bacteria. Understanding the evolutionary origins of AMR can inform the development of effective therapeutics against resistant infections.
Updated guidelines recommend discontinuing antibiotics immediately after a patient's incision is closed. Continuing antibiotics increases risk of C. difficile infection and antimicrobial resistance, but does not prevent surgical site infections.
A study published in Science Translational Medicine suggests that preterm infants' gut microbiomes play a role in the development of dangerous bacterial bloodstream infections. The researchers found that the most common bacteria causing these infections are also commonly found in the gut, and that antibiotics can disrupt the balance of...
Researchers at Harvard Medical School discovered a new cellular sensor that allows dormant bacteria to detect nutrients and quickly spring back to life. This breakthrough could inform the design of ways to prevent dangerous bacterial spores from lying dormant for months before waking up again and causing outbreaks.
A new Cochrane Review found that stool transplantation can increase the number of people recovering from Clostridioides difficile (C. diff) infection by 77%, compared to 40% with standard antibiotic treatment. The study also showed a decrease in side effects with stool transplantation.
Researchers have developed a fast, cheap, and easy method to test antibiotic resistance in bacteria, using optical nanomotion detection. The technique can determine sensitivity or resistance of bacterial cells to antibiotics in under two hours, with significant implications for clinical and research applications.
Researchers discovered that gut bacteria's F-pili are stronger in harsh conditions, enabling efficient gene transfer and biofilm formation. The findings highlight the challenge of combating antibiotic resistance and suggest exploiting similar molecular properties for precise drug delivery.
According to a new joint study, most children diagnosed with Lyme disease (75%) fully recovered within six months of completing antibiotic treatment. However, 22% of children experienced persistent symptoms after treatment, including some classified as post-treatment Lyme disease (PTLD) syndrome.
A new liposome-based method aims to kill periodontitis-causing leukotoxin while protecting immune cells, providing an alternative treatment for aggressive gum infections. The approach has potential applications against a range of bacteria and could help combat antibiotic resistance.