Articles tagged with Antibiotics
Postoperative wound infections in the head and neck region are common complications, with risk factors including age, smoking, and comorbidities. Aseptic operating conditions and peri/postoperative antibiotics can help minimize infection rates.
A clinical trial published in the New England Journal of Medicine found that adding a second antibiotic, vancomycin, did not protect against infection and may have led to more infections. The study showed no clear benefit from using two antibiotics instead of one.
EMBL researchers have systematically profiled over 10,000 drug combinations for their effectiveness against common multidrug-resistant bacteria. The team identified over a thousand interactions, including both synergies and antagonisms, with distinct effects on Gram-positive and Gram-negative bacteria.
A new study reveals a multi-drug resistant strain of E.coli, MDR ST131, can outcompete and displace other strains in the human gut. The research provides evidence that certain types of E.coli are more prone to developing antibiotic resistance, posing significant health risks.
Researchers at Vanderbilt University Medical Center found that cefepime did not significantly increase the risk of kidney failure compared to piperacillin/tazobactam in critically ill patients. However, cefepime was associated with more neurological dysfunction and shorter survival rates.
A randomized clinical trial found that cefepime increased neurological dysfunction in adults hospitalized with acute infection, while piperacillin-tazobactam did not. The study involved 2,511 participants and suggested that cefepime may be associated with adverse outcomes.
Researchers at the University of Virginia Health System are developing computer models to better understand the cellular processes and gene activity of multi-drug resistant bacteria Staphylococcus aureus and Pseudomonas aeruginosa. The goal is to identify vulnerabilities in these bacteria and advance the development of new treatments.
A study by Professor Mark Webber and his team found that the NRCS-A strain of Staphylococcus capitis is commonly carried on the skin and in the gut of uninfected neonatal babies, making transmission between babies within NICUs likely. The bacteria's unique genes allow it to survive in the gut, making cleaning the skin ineffective.
A new study has identified commonly prescribed antibiotic, antipsychotic and prokinetic drugs as being associated with a higher risk of sudden cardiac arrest (SCA) in individuals with type 2 diabetes. Low fasting blood sugar levels are also linked to SCA, a leading cause of death.
A University of Melbourne research team is developing an oral therapeutic to restore the activity of common antibiotics used to treat community-acquired bacterial pneumonia. The project aims to combat antibiotic-resistant bacteria and reduce healthcare costs, with potential applications in low- and middle-income countries.
Researchers have developed a wearable sensor patch capable of continuously monitoring vancomycin levels, a critical antibiotic used to treat severe bacterial infections. The sensor system detects changes in vancomycin concentration using aptamers and gold wires, providing real-time measurements for effective treatment.
Researchers at the University of Sheffield have discovered a genetic scar that enables pneumonia-causing bacteria to become resistant to antibiotics. The study found that mutations in the pde1 gene act as an evolutionary gateway for this resistance, threatening patient treatment and highlighting the need for control measures.
Researchers have discovered a new plasmid in epidemic Vibrio cholerae samples that introduces genes encoding resistance to multiple antibiotics. The finding underscores the importance of genomic surveillance and suggests that the strain's stability poses a concerning factor for future outbreaks.
Researchers developed an integrated microfluidic chip for rapid antimicrobial susceptibility testing from positive blood cultures, reducing diagnosis time to under 3.5 hours. The chip demonstrated high accuracy in diagnosing clinical cases with a 93.3% agreement rate.
Researchers at Linköping University develop a new method to deliver strong compounds specifically to bacteria, allowing for efficient and safe treatment of infections. The TOUCAN strategy uses nucleases to target bacterial DNA, reducing side effects associated with current antibiotics.
Researchers at the University of Exeter found that certain antibiotics can alleviate stress and help prevent bacterial decline, allowing more bacteria to survive longer. The study, published in PNAS, suggests that these drugs can promote bacterial longevity and growth efficiency.
Researchers found that patients prescribed amoxicillin-clavulanate had higher rates of gastrointestinal symptoms and yeast infections than those prescribed amoxicillin. The study showed no difference in treatment failure rates between the two antibiotics, with treatment failure occurring in less than 2% of cases.
The September issue of the CHEST journal features research on long COVID, including a review on exercise pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2. Original studies also explore asthma treatment with albuterol-budesonide inhalers and sleep therapy using oronasal masks.
Researchers use genomic surveillance to identify distinct sexual networks for syphilis transmission in England, highlighting the presence of drug resistance. The study reveals information beyond standard epidemiological surveillance data, aiding public health strategies to break transmission chains.
A survey of 10,981 US adults found that toxic molds, fossil fuels, and antibiotics are common causes of chemical intolerance. The study suggests that reducing exposure to mold, pesticides, and other contaminants may help prevent future cases.
Researchers have made a significant advancement in the synthesis of β-lactam scaffolds, structural components frequently found in essential antibiotics. The breakthrough uses nickel catalysts to overcome challenges in β-lactam synthesis, enabling more efficient and simplified production of high-value materials.
Researchers from the University of Bonn and international partners have discovered a new antibiotic called clovibactin that effectively attacks the cell wall of bacteria, including multi-resistant 'superbugs'. The compound has been shown to target bacterial cell wall components with high specificity, minimizing resistance development.
A new powerful antibiotic, Clovibactin, has been discovered that can combat harmful bacteria and multi-resistant superbugs. It targets three different precursor molecules essential for bacterial cell wall synthesis, making it difficult for bacteria to develop resistance.
A new study reveals that using big data and machine learning can improve antimicrobial resistance surveillance in livestock production. The research found correlations between environmental variables, microbial communities, and antimicrobial resistance, suggesting multiple routes for improving surveillance.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have discovered dozens of small protein sequences with antibiotic qualities in extinct organisms like Neanderthals and Denisovans. They then synthesized these molecules using artificial intelligence and tested their efficacy against pathogens.
The researcher aims to bridge completeness, efficiency, and applications in 3D graphs to solve problems in physics, fluid dynamics, and biotechnology. Geometric graphs can represent molecules, proteins, and drugs, enabling the prediction of their behavior and properties.
Researchers develop single-use nanoscale system that targets specific bacterium causing ear infections, eliminating most cases without antibiotic use. The system uses hypohalous acid similar to bleach and has shown promise in tests on chinchillas, with potential for future adaptation to prevent recurrent infections.
A new imaging method developed by UC researchers can identify specific lung infections in real time, reducing diagnosis time from 2-3 days to hours. The method uses injectable probes that light up under a nuclear imaging machine, enabling faster treatment for critically ill patients.
A new study reveals that bacterial resistance to albicidin is caused by an increase in the number of copies of a specific gene, leading to up to a 1,000-fold increase in resistance. This discovery highlights the growing threat of antibiotic resistance and underscores the need for effective strategies to combat it.
Researchers used phage PASA16 to treat tough Pseudomonas aeruginosa infections, achieving an impressive 86.6% success rate. The study demonstrated the potential effectiveness of phage therapy as a valuable alternative to conventional antibiotics in combating antibiotic-resistant pathogens.
A new antibiotic strategy has been found to defeat gram-negative bacteria like Salmonella and E. coli by interfering with the outer lipid layer of the bacteria. The compound, LPC-233, is a small molecule that works fast and is durable in animal tests, with potentially vital applications against stubborn urinary tract infections.
A new study suggests that controlling air pollution could reduce antibiotic resistance, which is responsible for 480,000 premature deaths annually. The analysis indicates a significant link between PM2.5 levels and antibiotic resistance globally.
Researchers at the University of Tokyo have developed a continuous-flow manufacturing method for producing cefazolin, an essential antibiotic. This new approach reduces time, cost and waste, making it ideal for flexible production and improving global health access.
Researchers find that Acinetobacter baumannii can achieve significant functional modifications in protein complexes over short evolutionary time spans, particularly in hair-like cell appendages. This diversity may affect the pathogen's interaction with its environment and inform personalized therapies.
A recent study discovered the complex circadian clock mechanisms in soil bacteria Bacillus subtilis, regulating multiple genes and behaviors. The findings have significant implications for industrial applications, human health, and plant science.
Scientists have developed a new liquid metal coating that can treat and kill bacteria, offering a potential solution to the growing threat of antimicrobial resistance. The coating, made from gallium liquid metal particles, has improved biocompatibility and low cytotoxicity, making it safe for human cells.
Researchers have discovered a new way to combat fatal fungal infections by blocking the production of fatty acids, a major component of fats. The breakthrough could lead to more effective treatments against species-resistant fungi.
A team of researchers at the University of Oklahoma has made a groundbreaking discovery in overcoming antimicrobial resistance by developing a new class of molecules that inhibit efflux pumps. These inhibitors work as 'molecular wedges' targeting the area between bacterial cell membranes, increasing the effectiveness of antibiotics.
Researchers at UMass Amherst have discovered a potential new medical therapy for Lyme disease using lactate dehydrogenase inhibitors typically used to combat cancer. The study found that these inhibitors substantially impacted Borrelia burgdorferi growth, making them promising candidates against Lyme infections.
Researchers at the University of Copenhagen have discovered how a bacterium called Vibrio alginolyticus moves using sodium ions, which could lead to new targets for antibiotics. The study provides insights into the flagellum's movement and may help develop novel antibiotics to combat antibiotic resistance.
A new study suggests that bacterial testing in children with sinusitis could greatly reduce unnecessary antibiotic use. By identifying which children are likely to benefit from antibiotics, doctors can avoid prescribing medications to those who wouldn't see improvement in symptoms.
A meta-analysis of 221 randomized controlled trials reveals oral isotretinoin as the most effective treatment for acne, followed by triple therapies containing antibiotics and retinoids. The study also found that monotherapies like antibiotics and retinoids have comparable efficacy for inflammatory lesions.
Female beewolves release toxic nitric oxide to kill mold fungi in brood cells, but their symbiotic bacteria are protected by hydrocarbons secreted from their antennae. These hydrocarbons block the diffusion of nitric oxide and prevent bacterial harm.
A report from University of Queensland researchers highlights promising developments in new antibiotics, with 62 in development. However, experts warn that current pace is not enough to avoid a crisis due to rising deaths from resistant bacteria, with potential solutions including subscription payment models and non-antibiotic approaches.
Researchers at ETH Zurich have developed a rapid test that detects bladder infections using bacteriophages, which can identify the pathogenic bacteria in under four hours. The test also allows for tailored phage therapy, predicting patient response and increasing treatment effectiveness.
Researchers at IISc designed a short peptide that targets topoisomerases in disease-causing bacteria, including antibiotic-resistant species. The peptide effectively killed bacterial cells and reduced infection in animal models, providing leads for combination therapy with existing antibiotics.
Researchers developed a novel metal-derived complex to treat Avian Pathogenic Escherichia coli (APEC), a serious respiratory infection resistant to antibiotics. The treatment, manganese carbonyl, showed protective effects in chickens with APEC, reducing bacterial shedding and killing.
Researchers at Tokyo University of Science successfully synthesized tanzawaic acid B in large amounts, paving the way for new antibiotic development. The breakthrough method could lead to creation of various compounds for pharmaceuticals, including new antibiotic candidates.
A recent study found that women with Lyme disease experience longer diagnostic delays, more severe symptoms, and increased misdiagnoses compared to men. The study also revealed no significant differences in antibiotic treatment response or side effects.
A novel stress signalling system has been discovered by SMART researchers, enabling bacteria cells to adapt and survive against the immune system and certain antibiotics. The breakthrough discovery of RlmN as a stress sensor may lead to the development of new therapies to combat antimicrobial resistance.
The study identified significant differences in antibiotic resistance trends and associated factors depending on bacterial species and antibiotic resistance to certain antibiotics. High health system quality was linked to low levels of resistance, while high temperatures were associated with increased resistance in Enterobacteriaceae.
A new study led by Vanderbilt University Medical Center has shown that a simple direct oral challenge can safely remove penicillin allergy labels from low-risk patients. This method performs as well as traditional skin testing and oral challenges, with no serious adverse events reported.
Researchers discuss treatment refractory forms of chronic sinusitis, highlighting the importance of interdisciplinary diagnostics and therapy. Fungal infections are a rare cause, yet crucial to consider when treating this condition.
A study published in the Journal of Hospital Infection reveals that pharmacist-led multi-faceted interventions can optimize antimicrobial prescriptions in dental clinics, reducing the incidence of serious infectious diseases. The intervention increased penicillin usage and decreased the use of broad-spectrum antimicrobials.
Researchers found that antimicrobial resistance emerges from selection for pre-existing resistant clones, not new mutations. Infections with multiple pathogen clones show increased resistance to antibiotics, but also potential for faster loss of resistance when no antibiotics are present.
Researchers have discovered a new target for antibiotics that could treat multi-drug resistant superbugs. The antibiotic AMC-109 affects the cell membrane of bacteria by disordering its organization, leading to the death of the bacterium. This approach may also break down resistance to old-fashioned antibiotics.
A recent study found that Kenyan patients who spend more than three days in hospitals are more likely to harbor antibiotic-resistant bacteria. The research team identified three risk factors associated with colonization, including hospitalization for extended periods and intubation.
Researchers identified a new drug treatment option for peritonitis in patients on peritoneal dialysis, showing that a low dosage of ceftazidime and avibactam is sufficient to treat the infection. The study's findings could help gain control over peritonitis in patients with difficult-to-treat germs.
Researchers discovered that using fat-free mass for gentamicin dosage calculation yields more effective results than traditional methods. This method is particularly beneficial for premature babies, who have weaker kidneys and require adjusted dosing.
A study published in Frontiers in Microbiology found that administering vaginal suppositories with Lactobacillus crispatus can restore a healthy balance of vaginal microbiota and prevent recurrent cystitis. The researchers discovered that postmenopausal women with RC had significantly different bacterial communities compared to those w...