Biodistribution

Three-dimensional visualization of nanoplastic distribution in the neonatal mouse brain

A new method for three-dimensional visualization of nanoplastic distribution in the neonatal mouse brain has been established, revealing particle-size-dependent biodistribution patterns. The study found that smaller particles (50 nm) were widely distributed throughout the brain, while larger particles (500 nm) showed weaker accumulation.

SourceNational Institute for Environmental Studies·JournalJournal of Hazardous Materials Advances·TypeExperimental study·DateJul 29, 2026

Consensus paper: Carcinogenicity of gene therapies

Researchers have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease. The treatment approach may represent a potential long-term universal treatment for MSUD.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·TypeCommentary/editorial·DateAug 29, 2024

SAMSUNG T9 Portable SSD 2TB

SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

Nanoparticles can improve stroke recovery by enhancing brain stimulation, study shows

Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.

SourceXi'an Jiaotong-Liverpool University·JournalMaterials Today Chemistry·TypeExperimental study·DateSep 28, 2022

Biodistribution of AAV gene transfer vectors in nonhuman primate

The study investigates the biodistribution of AAV gene transfer vectors in nonhuman primates using quantitative positron emission tomography (PET). The results show that both AAVrsh.10 and AAV9 vectors distribute primarily to the liver, with lesser detection in the brain after intravenous administration.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·DateJan 15, 2021

Total-body PET imaging successfully identifies antibodies up to 30 days after injection

Researchers used total-body PET imaging to track the distribution of 89Zr-labeled antibodies in preclinical trials, achieving excellent image quality up to 30 days after injection. The study demonstrates the potential of this technique for extended imaging windows and low-dose radioactivity.

SourceSociety of Nuclear Medicine and Molecular Imaging·JournalJournal of Nuclear Medicine·DateMar 31, 2020