Articles tagged with Cancer Medication
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The global financial crisis could reduce access to expensive cancer treatments, investment in drug discovery, and support for cancer sufferers and survivors. Cancer Research UK forecasts a 4% drop in income in 2009 compared with 2008.
The US stimulus package is unlikely to address the financial struggles of cancer patients, who face high costs for treatment and uncertain treatment outcomes. The package's limited funding for cancer research and care may exacerbate existing inequalities in healthcare access.
A new study found that goserelin treatment reduced the risk of disease recurrence and deaths by 13.9% and 8.5% respectively in premenopausal women with early breast cancer. The benefits were comparable to those seen with tamoxifen treatment, suggesting goserelin may be a viable alternative for some patients.
Women with higher calcium intake have a lower risk of cancer overall and specific digestive system cancers like colorectal cancer, according to the study. Calcium consumption was inversely associated with an increased risk of these types of cancers in both men and women.
Men with male factor infertility are 2.8 times more likely to develop testicular cancer than those without this condition. A total of 34 men diagnosed with testicular cancer were found in a study of 22,562 infertile men.
Researchers developed small molecules targeting Hsp90 in mitochondria to induce tumor cell death. This combinatorial approach may be more effective than targeting single signaling pathways. Gene therapy also restored muscle strength in a mouse model of muscular dystrophy by anchoring nNOS to the sarcolemma.
Researchers have developed a new class of cancer drugs that target multiple signaling networks controlled by mitochondrial Hsp90, leading to effective tumor cell death in mice. This combinatorial drug design approach may prove more effective than targeting single signaling pathways.
Researchers have created miniscule silicon flakes that glow brightly, slowly releasing cancer drugs before breaking down into harmless by-products. The particles showed promising results in mice, reducing tumor growth over several weeks.
Researchers have developed a new drug delivery technology that targets cancer cells specifically, leaving surrounding healthy cells intact. The technology utilizes tiny bubbles containing therapeutic drugs to deliver medication directly to cancer cells, enhancing treatment effectiveness and reducing side effects.
Scientists at Rensselaer Polytechnic Institute have identified a protein domain linked to tumor progression and tissue invasion. The discovery could lead to the development of targeted cancer therapies with fewer side effects.
Researchers at UC San Diego and Stanford University have identified a molecular mechanism that predicts the progression of chronic myeloid leukemia (CML) to its more dangerous blast crisis stage. This discovery may enable physicians to make more accurate prognoses and improve treatment choices.
A study led by Duke researchers found that compendia used by oncologists and pharmacists to guide off-label cancer drug prescribing often lack updated information and inconsistent evidence. The compendia's varying methods of reviewing and updating evidence can lead to confusion and incorrect treatment decisions.
A new study in Annals of Internal Medicine argues that Medicare's current method for covering off-label uses of cancer drugs is based on an inconsistent and outdated source. The researchers found that the compendia methods varied greatly from their actual practices, and little evidence was cited by the authors of the compendia.
Mayo Clinic researchers have found a promising drug candidate to prevent colon cancer development in mice. The study's senior investigator suggests that targeting PKCß and PKC/ isozymes could help prevent initial cancer development and progression, respectively.
The study reveals that PHD2-blockers can convert abnormal endothelial layers into tightly aligned cells, allowing anti-cancer medicines to reach their destination more easily. This improves the effectiveness of chemotherapy and reduces cancer cell migration.
Researchers have found that interferon-alpha triggers the activation of quiescent hematopoietic stem cells, which can help replenish blood cells. This mechanism may also be useful in treating certain types of cancer, such as chronic myelogenous leukemia.
A new study found that clinicians override over 90% of drug interaction and allergy alerts, highlighting the need for improved decision support systems to enhance patient safety. The researchers recommend reclassifying alert severity, providing an option to suppress alerts, and customizing them for a clinician's specialty.
The American Pain Society and American Academy of Pain Medicine have published comprehensive clinical practice guidelines to assist clinicians in prescribing potent opioid pain medications for patients with chronic non-cancer pain. The guidelines emphasize the importance of monitoring patients on chronic opioid therapy to weigh benefit...
Scientists at the University of California, San Francisco, have created a new drug that blocks cancer's main source of growth and has proven effective in mice. The drug succeeds where similar compounds fail by blocking both mTOR signal pathways, making it a major advance over existing rapamycin-based drugs.
A large study of nearly 162,000 postmenopausal women found that multivitamin use had no significant impact on the risk of common cancers and cardiovascular disease. The Women's Health Initiative study provides definitive evidence that dietary supplements do not offer long-term health benefits.
Researchers developed a 50-gene set to identify the four known types of breast cancer, allowing for personalized treatment. The test was found to be highly sensitive and predictive for chemotherapy response, particularly for poor-prognosis tumor types.
A study published in Archives of Internal Medicine found that multivitamin use was not associated with an increased risk of breast, colorectal, or cardiovascular diseases in postmenopausal women. No significant associations were found between multivitamin use and cancer or cardiovascular disease mortality rates.
The new guideline provides recommendations for clinicians on how to safely prescribe potent opioid pain medications for patients with chronic non-cancer pain. Key findings include the importance of careful patient selection, monitoring, and ongoing assessment to minimize risks of abuse and addiction.
Researchers used contrast agents in liposomes to determine if they could breach breast tumors. Tumors with better images of the contrast agents showed better therapeutic results when treated with a cancer drug called liposomal doxorubicin.
Researchers have discovered a new class of compounds that selectively inhibit protein phospholipase D (PLD), an enzyme linked to multiple human cancers. The inhibitors block invasive breast cancer cell migration and could be used as antimetastatic agents.
Researchers at the University of North Carolina have found that disrupting the circadian clock can slow the progression of cancer. The study suggests that altering one of four essential 'clock' genes can extend the lives of mice with cancer by 50% by making cancer cells more vulnerable to cell suicide.
Researchers at USC found that green tea extract (GTE) renders the cancer drug Velcade ineffective in treating multiple myeloma and mantle cell lymphoma. The study suggests that patients on Velcade should avoid green tea products to minimize side effects, which may be misattributed to the supplement's beneficial effects.
A new study found that PET/CT can identify precise location and extent of metastasis, offering a better prognosis for patients with inflammatory breast cancer. The imaging modality provides information on both primary disease site and disease involvement throughout the body.
Stat3 promotes pro-cancer immune responses and inhibits antitumor immunity by stimulating immunosuppressive factors and inhibiting expression of chemicals critical for antitumor immunity. The study reveals a mechanism by which oncogenic pathways regulate the immune microenvironment to promote tumor development.
Researchers at Duke University have developed a new technology that can detect how cancer cells respond to chemotherapy in just hours, rather than weeks. This allows for quicker diagnosis and potentially more effective treatment.
Research identifies Interleukin 6 (IL-6) and STAT3 as key players in colitis-associated cancer development. The study suggests that targeting these proteins may be effective in preventing and treating CAC, a serious complication of inflammatory bowel disease.
University of Michigan researchers are using mathematical modeling to develop a more complete understanding of how cancer develops and interacts with its environment. This approach has led to new insights into the complex signaling pathways involved in cancer growth and metastasis.
The counterfeit drugs market is expected to be worth £55 billion by 2010, with nearly 62% of prescription-only medicines being fakes. Harmful ingredients found in counterfeit medicines include arsenic, boric acid, and leaded road paint, which can have devastating consequences for patients with potentially fatal conditions.
Researchers from Université de Montréal have detected chemotherapy products and hypertension/cholesterol medications in wastewater released into the St. Lawrence River. The study highlights a growing concern about pharmaceutical waste's impact on the environment, with minimal quantities of these substances present in treated water.
Researchers discovered how anthracycline chemotherapy drugs block cancer cell growth by inhibiting HIF-1 protein. The findings suggest that these drugs may benefit a subgroup of cancer patients with high HIF-1 levels, leading to reduced tumor size and fewer blood vessels in mice.
Researchers at Mayo Clinic have found that the experimental drug RS5444 turns on the RhoB tumor suppressor gene in cancer cells, inhibiting cell growth and blocking tumor growth. This finding suggests that other cancers may respond to this therapy, offering new hope for deadly anaplastic thyroid cancer treatment.
Patients using a retinoid cream containing tretinoin were more likely to die than those using a placebo in the study. However, evidence does not suggest that the therapy caused the excess deaths, and alternative explanations such as smoking are possible.
A Northwestern University team created a model of how prices fluctuate in political prediction markets, revealing that partisan feeling can significantly impact trading. The researchers found that traders' emotions played a crucial role in the market's behavior, especially during the 2000 presidential election. By understanding these d...
Researchers at Scripps Florida have found a novel use for the old compound α-difluoromethylornithine (DFMO) in treating high-risk neuroblastoma. The study showed that even low doses of the drug could prevent cancer in animal models.
Researchers at Tel Aviv University have developed a nano-sized medical submarine that can target specific cells and deliver effective drugs to kill cancer cells and eradicate faulty proteins. The technology uses RNAi compounds and aims to treat various pathologies, including cancer, inflammation, and neurodegenerative diseases.
A randomized control trial of 150 healthy adult women showed that MyFitness Planner resulted in increased walking and total moderate-to-vigorous physical activity. The study found that participants who clicked more links in update emails trended toward greater activity, regardless of socio-economic or education status.
A new UNC study found that the circadian clock influences a cell's repair machinery, which can affect the potency of cancer drugs. By targeting the daily oscillations of this enzyme system, researchers believe clinicians can maximize treatment effectiveness and minimize side effects.
Researchers have discovered a new mechanism that regulates the production of type I interferon, an important protein for clearing viral infections. This mechanism involves a protein-protein interaction between surface receptors on plasmacytoid dendritic cells and class I major histocompatibility complex molecules.
Researchers from Boston College and Washington University School of Medicine report new evidence supporting the original Warburg Theory of Cancer. Abnormalities in cardiolipin content were found in all types of brain tumors, closely associated with significant reductions in energy-generating activities.
Researchers at McMaster University have discovered a way to distinguish between healthy stem cells and cancer stem cells in humans. This breakthrough could lead to more effective cancer treatments that spare healthy cells.
Johns Hopkins researchers found that digoxin, a heart medication, can inhibit HIF-1 protein crucial for cancer cell survival. Digoxin slowed prostate cancer cell growth and reduced tumor size in mice by lowering HIF-1 levels.
Researchers at MIT have designed gold nanoparticles that can deliver multiple cancer drugs in a controlled fashion using infrared light. The system allows for precise timing of release, enabling treatment of diseases commonly treated with multiple drugs.
A recent study published in the Journal of Clinical Oncology found that medication errors involving chemotherapy are common in outpatient cancer treatment settings. The study revealed that adults and children alike were at risk of receiving incorrect doses or experiencing other medication-related mistakes.
A comprehensive review of 241 gene variants and cancer risk identified only two statistically significant associations, including an XRCC1 allele and ERCC2 allele linked to lung cancer. The findings suggest that genetic risks are typically modest, and large-scale evidence is needed to establish specific associations.
Researchers at UC Davis Cancer Center have discovered a molecule called LXY1 that targets glioblastoma, a deadly form of brain cancer. The molecule binds to alpha-3 integrin on cancer cells, allowing for direct delivery of treatments and sparing normal tissues.
A new, portable ultrasound device created by Cornell graduate student George K. Lewis can treat prostate tumors and kidney stones by breaking them up, while also relieving arthritis pressure. The device is smaller, more powerful, and less expensive than traditional models, paving the way for its use in hospitals and medical research labs.
A recent study by Tel Aviv University researchers validates Prozac's potential in fighting cancer itself. Prozac dramatically enhances the effectiveness of doxorubicin, an anti-cancer drug, by blocking resistance mechanisms in cancer cells.
A team of researchers from VCU identified a new anti-tumor gene called SARI, which can inhibit the growth and survival of tumor cells by interfering with cancer cell molecules. The discovery highlights a previously unrecognized molecular pathway underlying the anti-tumor action of interferon.
Researchers at Michigan State University discovered a new method to analyze bacterial inclusion bodies using nuclear magnetic resonance spectroscopy. This breakthrough could streamline protein-based drug manufacturing, making it quicker and more efficient.
A growing number of older adults are expected to be diagnosed with and live longer with cancer due to the aging baby boomer population. Critical issues include prevention, screening, treatment, survivorship, and end-of-life care for older adults with cancer.
A Phase 2 clinical trial of pralatrexate found a complete or partial response in 27 percent of patients with recurrent or resistant peripheral T-cell lymphoma. The treatment, which mimics folic acid, showed durable responses in patients who had failed multiple prior treatments.
Researchers have discovered an experimental drug that successfully blocks an enzyme causing certain bone marrow cancers. The oral drug, CYT387, was tested in mice and human cells, blocking the growth of myeloproliferative disorders and normalizing blood counts.
New treatments for advanced kidney cancer have shown promising results but are unlikely to be adopted in the UK due to high costs. The National Institute for Health and Clinical Excellence has provisionally ruled out using four new drugs, citing cost-effectiveness concerns.
A study published in Cancer Prevention Research suggests that selenium may aid in the prevention of high-risk bladder cancer. Women, moderate smokers, and those with p53 positive bladder cancer had significant reductions in bladder cancer with higher rates of selenium.
Researchers have discovered that simultaneous inhibition of BCR-ABL and KIT proteins is crucial for suppressing leukemia cell growth. This finding may lead to the development of novel drugs targeting multidrug resistant mutants of BCR-ABL, as well as new treatment strategies for CML stem cells.