Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
The AACR-Bardos Awards program offers financial support to third-year undergraduate students majoring in science, allowing them to attend the Annual Meeting 2007 and present their research. Winners also participate in the Undergraduate Student Caucus and Poster Competition.
The study reveals that nanobubbles formed by the collapse of one bubble become new nucleation sites for later bubbles, allowing them to form earlier and at lower temperatures. This discovery may impact technologies such as inkjet printing and thermal cancer therapies.
Researchers, Lucille Sanzero Eller and Elise Lev, are developing a targeted intervention to address physical and psychological symptoms in men with prostate cancer. The study aims to improve quality of life by reducing symptoms such as urinary and bowel incontinence and depression.
A study found that survivors of acute lymphoblastic leukemia have a significantly increased risk of secondary cancers developing over time. The cumulative incidence of secondary neoplasms increases from 4.17% at 15 years to 10.85% at 30 years, with the majority being low-grade tumors.
A study by St. Jude Children's Research Hospital found that adults who survived childhood acute lymphoblastic leukemia (ALL) are at a higher risk of developing secondary neoplasms during adulthood. Most of these late-onset tumors are low-grade and curable, but some can cause significant health issues.
A University of Missouri study found that negative news stories about clinical trials deter people from participating in medical research. The study analyzed 216 New York Times and 124 Washington Post articles, revealing a significant correlation between negative coverage and decreased willingness to participate.
Researchers from the University of Washington developed a new antibacterial strategy using Gallium, which inhibits the growth of Pseudomonas aeruginosa and prevents biofilm formation. Additionally, studies suggest that Nutlin-3a may reactivate the p53 pathway to treat Kaposi's sarcoma virus-induced lymphomas. Another study found that a...
The Damon Runyon-Rachleff Innovation Award provides seed funding for junior scientists with high-risk, high-reward ideas in cancer research. The program aims to apply a venture capital philosophy to scientific research, investing in fresh perspectives and innovative approaches.
Researchers discovered Nutlin-3a induces apoptosis in human PEL cell lines by disrupting LANA-p53 interaction, causing substantial tumor regression in mice with established PEL. This reactivation of the p53 pathway may provide a viable therapeutic option for individuals with KSHV-induced lymphomas.
Researchers at the University of Helsinki have discovered a new effective treatment modality for KSHV-infected lymphomas by reactivating the p53 pathway. The study shows that Nutlin-3a, a small-molecule inhibitor, selectively induces massive apoptosis in PEL cells.
Researchers have discovered a peptide that can free the protein p73, which induces tumor cell death, and effectively kills both p53-sufficient and p53-deficient human tumor cell lines. The study suggests targeting the p73-mediated pathway could provide a new avenue for developing anticancer therapeutics.
A multi-center study found that CT screening for current and former smokers did not reduce deaths from lung cancer, despite finding nearly three times as many lung cancers. The study also found an increased risk of invasive procedures and unnecessary treatments due to false positives.
Researchers found that a combination of green tea polyphenol EGCG and COX-2 inhibitor celecoxib can slow the growth of human prostate cancer. The study demonstrated a synergistic effect, where both agents triggered cellular pathways that were more powerful when combined.
Nanotechnology has the potential to provide less-industrialized countries with powerful new tools for diagnosing and treating disease. The technology could revolutionize health care in developing countries by making treatments more readily available for diseases that claim millions of lives annually.
Research suggests treating HSV-2 infections reduces genital and systemic levels of HIV-1 RNA, with potential implications for treatment and management of co-infections.
A global survey of healthcare professionals found that they rank childhood immunization and cancer treatment for smokers lowest, while prioritizing spending on younger populations. The study highlights the disconnect between professional priorities and actual spending patterns in most countries.
Researchers found that telomere length shortens with every successive generation in families with Li-Fraumeni syndrome, resulting in more severe cancers at an earlier age. This discovery could represent the first biological marker for clinical monitoring in these families.
Researchers have identified the liver as a promising target for cancer gene therapy using viral vectors, taking advantage of the structural disorganization in cancer cells. The study demonstrates that adenoviral vectors can selectively infect cancer cells while leaving normal liver cells unharmed.
The Mayo Clinic team has proposed a system of lung surgery quality indicators to demonstrate best practices for positive patient outcomes. The proposed measures include patient-centered processes prior to, during, and after surgery, such as pulmonary function testing, electrocardiogram, smoking history documentation, and timely pain co...
Researchers investigate fatigue in various populations, finding distinct definitions for tiredness, fatigue, and exhaustion. The study aims to prevent progression from tiredness to exhaustion, emphasizing the importance of recognizing changes consistent with fatigue and exhaustion.
Researchers have adapted bacteria in the human gut to produce human growth factors that repair colon cells, reducing inflammation in IBD. The treatment uses a plant sugar called xylan, found in tree bark, to control the release of the medicine.
Researchers developed a simple and non-invasive gene probe to diagnose early stage lung cancer in current and former smokers. The test identified 76% of stage I lung cancer patients whose tumors also showed the same genetic loss, outperforming existing sputum cytology tests.
Scientists identified an approach to boost the activity of dasatinib, a potent anti-cancer agent, by combining it with PD184352. This combination resulted in increased apoptosis in leukemia cells, particularly those resistant to imatinib mesylate.
Researchers at VCU Massey Cancer Center created a new method to improve leukemia treatment by triggering programmed cell death in cancer cells. The study found that combining agents like ABT-737 with those that reduce Mcl-1 levels can activate pro-apoptotic proteins and induce apoptosis.
Researchers have found a selective marker in nestin that could lead to earlier detection and better treatment of basal epithelial breast tumors, a highly aggressive form of breast cancer. High levels of nestin were detected in 14 out of 16 tumor samples examined.
Researchers have identified pancreatic polypeptide as a potential solution to appetite suppression, which may lead to a new obesity treatment. The hormone is naturally released in the gut and acts as a neurotransmitter to indicate fullness to the brain.
Researchers found that 201 patients (23%) lived five years after surgery, with at least half being 65 years old or older. Of those survivors, 65% lived another five years, nearly matching the general population's survival rate.
Researchers found a significant increase in soft tissue sarcoma cases among hereditary retinoblastoma survivors, with leiomyosarcoma being the most common subtype. Regular medical surveillance is crucial for these patients to detect potential cancers early.
Researchers found that inactivating TNFa significantly reduced blood vessel impairment and cell death in aged vessels, suggesting a link between increased TNFa levels and cardiovascular disease. The study's findings could lead to the development of new treatments for age-related vascular diseases.
Researchers discovered that imatinib mesylate inhibits the synthesis of extracellular matrix proteins and prevents tissue fibrosis in patients with systemic sclerosis. The study provides promising results for a new treatment approach, but more extensive studies are needed to confirm its efficacy.
Research from Rockefeller University reveals that unfolded protein response serves a protective role, shielding cells from death. The study focuses on autosomal dominant retinitis pigmentosa, where unfolded proteins accumulate in the endoplasmic reticulum, indicating their protective mechanism.
A study by the Human Pain Research Group at the University of Manchester found that individuals' expectations and beliefs play a crucial role in their response to pain relief. The researchers discovered that 67% of volunteers who expected pain relief continued to perceive less pain after applying a placebo cream, highlighting the power...
A new study reveals that health-care delivery, particularly screening tests and surgical treatment, contribute to poorer outcomes for African-American patients with colorectal cancer. The study found that African-Americans were more likely to have advanced disease and received less surgical treatment compared to other ethnicities.
Researchers at Mayo Clinic Cancer Center have led efforts to test new therapies in multiple myeloma, improving effectiveness and reducing toxicity. Studies show high response rates with lenalidomide and bortezomib, and a synergistic effect when targeting both tumor cells and microenvironment.
A study of over 36,000 women found that regular exercise can lower a smoker's lung cancer risk by 28%, but quitting smoking remains the most effective way to reduce risk. The absolute risk of developing lung cancer is still higher for current and former smokers, regardless of activity level.
Researchers with Bank On A Cure identified genetic pathways associated with venous thromboembolisms in patients treated with thalidomide for multiple myeloma. These findings may lead to screenings and tailored interventions to prevent blood clots, as well as the development of new treatments.
Researchers have identified genetic markers that can predict which patients with major depression are more likely to respond to treatment. Polymorphisms in genes related to serotonin and neurogenesis were found to be associated with improved treatment outcomes.
A study by University of Rochester Medical Center researchers found that black patients are more likely to prefer life-sustaining care when faced with an incurable illness or serious disabilities. In contrast, white patients were less inclined to accept such care. The differences in attitudes suggest a need for healthcare policies sens...
A survey of 591 youth tobacco cessation programs across the US found that most were school-based and provided effective treatment with highly skilled staff. However, fewer programs existed in low-income and rural communities where youth smoking rates are higher.
Researchers suggest repairing abnormal blood vessels in retinopathy using adult bone marrow–derived myeloid progenitor cells. Dendritic cells form part of granuloma walls containing Listeria monocytogenes, maintaining integrity through immunosuppressive protein IDO.
A study of nearly 600,000 men aged 70 and older reveals that 56 percent had a routine PSA screening, despite lack of recommendation. Health status had little impact on whether a test was performed, with even those in poor health receiving the test.
A study published in CANCER reveals that adolescent and young adult cancer patients value social connections with peers as a high priority, contrary to physician beliefs. Researchers found that meeting other young people who share a common experience helps address concerns such as coping with uncertainty and body changes.
A large-scale study involving over 7,500 men with prostate cancer has concluded that a rise in PSA levels after treatment, known as PSA bounce, does not impact overall survival. The study found no statistical difference in survival rates between patients who experienced a bounce and those who did not.
Patients treated with IMRT had significantly fewer moderate and serious side effects, including urethral stricture and catheterization, compared to those who received I-125 seed brachytherapy. The study found excellent PSA outcomes after treatment in both groups.
Researchers at Wake Forest University School of Medicine have identified changes in brain chemistry associated with post-cancer radiation-induced dementia. They found that whole-brain radiation causes changes in glutamate receptors, which may lead to cognitive deficits.
Dr. Stephen S. Hecht is recognized for over three decades of research on tobacco carcinogenesis, identifying nicotine's role in lung cancer formation. His work has led to the development of biomarkers for exposure to tobacco smoke and informed public policies on smoking restriction.
A new study found that women with disabilities are less likely to undergo breast-conserving surgery after a breast cancer diagnosis. In contrast, older adults with three or more chronic diseases may not benefit from colorectal cancer screening due to shortened life expectancy.
The Mayo Clinic Cancer Center's Specialized Programs of Research Excellence (SPORE) grant has been renewed for an additional five years. The grant will fund translational research projects aimed at identifying biomarkers to predict response to therapy and developing non-invasive imaging options for diagnosis and treatment.
Researchers have found that three popular laboratory breast cancer cell lines share a similar genetic profile with human breast tumors. This discovery provides evidence for the accuracy of laboratory cell line models and their potential to inform treatment outcomes.
Researchers discovered a critical regulatory link between hypoxia and heat shock responses, with HIF-1 at the center. The gene's activity was found to be crucial in both normal and pathological changes, making it a promising target for health promotion and cancer treatments.
The St. Jude technique enables blood stem cells from parents or unmatched adult siblings, reducing the need for harsh treatments and boosting the chance of cure. The modified transplantation method accelerates immune system recovery and reduces the risk of infections.
Researchers at UW-Madison discover 2-deoxy-glucose blocks epileptic seizures in lab rats, a potential cure for up to half of all epileptic patients. The compound works by clogging cellular enzymes, allowing the body to use alternative energy sources.
A new study found that many primary care trusts in the UK are refusing to fund adequate treatment for rheumatoid arthritis (RA) patients, despite NICE approval. The study revealed a postcode lottery, where funding and access to effective treatments like anti-TNF therapy vary widely across the country.
A molecule called TBK-1 helps keep cancer cells alive, and blocking it may be a promising approach to treating cancer. Researchers at UT Southwestern Medical Center found that TBK-1 is essential for cancer cell survival, even though its normal function is in the immune response.
New data reinforce the safety profile of ENBREL, confirming its efficacy for up to 2.5 years with no significant increase in adverse events. The study also shows that patients who experience interruption in treatment can regain similar positive efficacy results after re-initiating therapy.
A recent European survey of post-menopausal women with early breast cancer found that information needs are not being met, leading to low levels of patient involvement in treatment decisions. The survey revealed significant knowledge divides among patients, particularly older women and those with lower education levels.
Women under 45 who have both ovaries removed are at higher risk of death from hormone-related cancers and neurological diseases. The risk increases with age, suggesting that oestrogen may be protective at younger ages but less important after menopause.
A Georgetown University researcher warns of a growing epidemic of hookah smoking, citing equivalent toxic effects to cigarette smoking and a disproportionate impact on young women. Studies show that waterpipe tobacco smoke can penetrate deeper into the respiratory tract than cigarette smoke, increasing cancer risk.
The Geoffrey Beene Cancer Research Center will focus on two complementary programs at Memorial Sloan-Kettering, one in Cancer Biology and Genetics, the other in Human Oncology and Pathogenesis. The center aims to translate revolutionary advances in understanding cancer into dramatic progress in controlling it.
A study found that less than one-third of gastric cancer patients had adequate lymph node assessments, leading to compromised survival. Median survival in regions with the highest ALNA rate was 33 months, while in regions with the lowest rate it was only 17 months.