Articles tagged with Cancer Treatments
A new study by Cancer Research UK found that common mutations in genes regulating estrogen metabolism are not associated with breast cancer risk. However, a separate study suggests that inhibition of hypoxia-inducible factor 1alpha (HIF-1alpha) activity may be a target for future gastric cancer treatments.
A study of 223 patients with early-stage, initially untreated prostate cancer found that disease progression increased significantly after 15 years of follow-up. After 10-15 years, most cancers had an indolent course, but progression rates decreased over time.
A study of 192 patients with advanced gastrointestinal stromal tumor (GIST) found that Glivec(R) interruption was associated with a high risk of re-progression. In contrast, continuous treatment showed no signs of re-progression within a year. Continuous Glivec(R) treatment is recommended for patients with advanced GIST.
Researchers discovered a molecular marker, the HOXB13:IL17BR ratio, that accurately predicts the reoccurrence of tumors in breast cancer patients treated with tamoxifen. This finding suggests that HOXB13 may contribute to tumor invasion and metastasis.
A decade-long study found improved five-year, event-free survival rates of 63% in Recife, Brazil, compared to the US and Europe. The increase was attributed to adapted St. Jude treatments and supportive care, including housing and travel subsidies for families.
A study of over 500 smokers found a significant association between sequence variations in the macrophage scavenger receptor gene and airways obstruction. The researchers hope this discovery will help understand why some smokers develop COPD and improve treatment options.
The study found a significant increase in male breast cancer incidence over 25 years, with men being diagnosed at an older age than women. Larger tumor size and axillary lymph node disease were associated with shortened survival, while hormone receptor status and tumor grade did not have independent prognostic effects.
The European Society for Medical Oncology (ESMO) has launched a new charitable foundation with the goal of making the best treatment available to every cancer patient. The ESMO Foundation will provide much-needed funds for education, research, and patient care.
A study found that African-Americans are 1.67 times more likely to die within five years and 1.52 times more likely to die within ten years after surgical treatment for CRC compared to Caucasians. Racial differences were most pronounced in patients with stage II disease.
A research study found that inhibition of cathepsin cysteine proteases impairs tumor growth and progression in transgenic mouse models of cancer. Treatment with a pharmacological inhibitor also disrupted both early and late stages of tumor development, suggesting its potential as an anticancer therapeutic.
A study published in Cancer Research identified a cancer-causing gene, HMG-I, that contributes to the development of leukemia and lymphoma in humans. The researchers found that overexpression of the gene led to the rapid development of tumors in genetically engineered mice.
A study found that over half of men taking part in a prostate cancer risk assessment program reported using dietary supplements to prevent the disease. The most commonly used supplements were vitamins and minerals, with saw-palmetto being one popular option.
A recent multi-center trial has shown cryoablation to be effective in killing cancerous cells in small tumors, offering a promising alternative to traditional surgery for early-stage breast cancer. The study found that the procedure was equally effective for tumors between 1.0 and 1.5 centimeters in diameter, but not larger than 1.5 cm.
A study by the American College of Radiology found that thoracic PET scans are suitable for diagnosing some lung cancer patients with localized disease. This approach reduces radiation exposure and saves time compared to whole-body PET examinations, which cover a broader area of the body.
A study found MRI to be highly useful in the evaluation of patients with uterine fibroids. The imaging technique offers advantages over sonography, including a larger field of view and better contrast resolution. MRI can help identify subsets of patients who may not benefit from UAE treatment, allowing for more personalized care.
Researchers at the University of Pittsburgh Medical Center have discovered a molecular mechanism that enhances the ability of stem cells to fight disease. By blocking the function of p18, a molecule critical for cell cycle control, scientists found improved long-term engraftment of stem cells in bone marrow tissue.
The article discusses Fox Chase Cancer Center's implementation of certified nursing assistant (CNA) positions to support experienced nurses. The CNA program has led to a significant decrease in turnover rates, with a reduction of over 20% since its introduction in 2001.
The partnership aims to educate junior, cadette and senior girl scouts about the responsibilities of nurses, educational requirements and general health and wellness information. The program showed increased interest in pursuing nursing careers among participating scouts.
Epileptic seizures result from brain dysfunction, with early diagnosis and treatment crucial to preventing irreversible damage. The stigma surrounding epilepsy exacerbates the condition's impact on daily life and quality of life.
A randomized, prospective study found that tacrolimus + mycophenolate mofetil and steroids significantly reduce incidence of treated rejection and improve graft function compared to other regimens. The combination therapy also showed better lipid profiles and reduced risk of certain infections.
The study found that CellCept significantly reduced the risk of malignancy in patients following heart transplantation, with a 27% lower relative risk compared to azathioprine (AZA). The use of CellCept was also associated with a reduced risk of certain rare cancers, particularly skin cancer.
Researchers have found that blocking the action of the HFE gene can reduce anemia caused by chronic inflammation, providing a potential new treatment for patients. This breakthrough aims to alleviate the negative effects of withholding iron while preserving the body's natural defense mechanisms.
A new study published in Urology found that men taking AVODART for four years experienced a significant reduction in urinary symptoms and prostate volume, with an average symptom improvement of 6.1 points on the AUA-SI. Long-term treatment also resulted in low incidence of drug-related side effects.
A 10-year study found that laparoscopic surgery for colorectal cancer has the same prognosis as conventional surgery, with a 76% 5-year survival rate. The procedure resulted in shorter postoperative recovery times but longer surgery durations compared to conventional surgery.
A recent study has revealed a connection between FAP, a protein involved in tadpole tail resorption, and accelerated tumor growth in humans. Researchers found that producing high levels of FAP in the tumor microenvironment promotes cancer growth. The study also explores the potential use of antibodies to block FAP's action.
A Canadian study found that breast cancer patients who participated in clinical trials had a 60% lower risk of dying, compared to those who did not. Larger treatment centers also showed better survival rates, attributed to participation in research.
Scientists have discovered that breast cancer metastases have a strikingly similar genetic profile to their primary tumours. This breakthrough discovery could enable doctors to choose the best treatment for each patient based on their unique tumour characteristics.
The Journal of Clinical Oncology (JCO) will provide free online access to its archived research, including articles published from January 1999 to the present. This move aims to improve cancer care worldwide by increasing access to essential information.
Researchers have developed a gene expression profiling method that predicts clinical outcome in prostate cancer patients. The study's findings suggest that this approach can improve our ability to stratify patient populations and optimize disease treatment.
Patients with stage I disease experienced longer intervals than those with more advanced disease. A multidisciplinary approach could help reduce anxiety and mistrust by allowing sufficient time for information digestion and procedure recovery.
Researchers at Mayo Clinic developed a pretreatment test to identify patients at high risk for urinary tract difficulties after brachytherapy. The study found that 37% of high-risk patients developed some urinary difficulties, while 85% of low-risk patients did not experience problems.
The study, published in Pharmacological Reviews, reveals that activation of certain melanocortin receptors can modulate the inflammatory process, reducing major molecules involved. This discovery has implications for treating localized and systemic inflammatory disorders, including organ transplantation and chronic inflammatory diseases.
USC researchers have discovered a unique DNA structure linked to follicular lymphoma, the second-most common form of non-Hodgkin's lymphoma. The fragile site on chromosome 18 is responsible for 4% of all cancers and leads to the translocation 14;18, making cancer cells invincible.
Researchers found ACR scores improved for symptom relief after 6 months with combination treatment, and remission occurred in 35% of patients compared to 16% and 13% with individual therapies. Combination therapy also showed a statistically significant improvement on joint erosion.
A study of 92 patient cases found that laparoscopy can diagnose abnormalities earlier, reducing the need for hormone therapy and in vitro fertilization. Women with painful menstrual periods, previous natural contraception use, or a history of pelvic disorders are at higher risk.
A recent finding reveals a frequent abnormal cellular event occurring in about half of all myeloma cases, identifying c-maf as an attractive target for therapeutic intervention. Inhibition of c-maf function blocks tumor formation in mice, suggesting its potential as a novel target for future therapies.
Researchers developed a novel tumor cell-specific therapy that restores p53 protein function in cancer cells. This approach eliminates tumors and increases animal survival by up to six times, offering promising implications for targeted therapies.
The American Association for the Advancement of Science recommends physicians consider risk factors and prevention options when prescribing hormone replacement therapy. Women with a high risk of chronic diseases may benefit from alternative treatments, while those with menopause-related symptoms may still be suitable candidates for HRT.
A new study presents promising results for acute stroke treatment using desmoteplase, a genetically engineered blood clot-dissolving protein. MRI techniques also play a crucial role in identifying patients who can benefit from this therapy.
A UK study estimates that diagnostic X-rays contribute to around 700 cancer cases annually in the UK, with similar but higher risks observed in other developed countries. The researchers emphasize the importance of avoiding unnecessary X-ray procedures and weighing benefits against risks for patients.
The American Academy of Family Physicians proposes a palliative care model for elderly patients, focusing on proactive and team-oriented care. The TLC model aims to relieve physical and emotional suffering throughout the aging process.
A review of 26 studies found that cancer patients enrolled in clinical trials did not have significantly better health outcomes compared to those not participating. The studies highlighted the importance of clinical trials in advancing treatment and improving options for patients with cancer.
A national survey found that most US adults believe routine cancer screening is 'almost always a good idea'. However, respondents also expressed concerns about the potential risks and harms of screening, including false positives and overtreatment. The study highlights the need for balanced information about cancer screening to inform ...
A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR, potentially improving pharmaceutical treatments for neonatal jaundice. Additionally, a viral cure for type 1 diabetes has been discovered, where infection with lymphocytic choriomeningitis virus completely abolishes the diabetic process i...
The International HapMap Project aims to map the locations of representative tag SNPs in DNA samples from diverse populations. The project's results will increase the power and reduce the cost of future genetic association studies, significantly speeding up the discovery of genes involved in common diseases.
The report analyzes survival data from 23,000 children diagnosed between 1990 and 1994, showing significant differences in overall cancer survival rates. The Nordic countries had the highest survival figures for four major childhood tumor types, with an average five-year survival rate of 71.8% across all European countries.
A new urine-based test has been developed to detect kidney cancer, showing promising results in early diagnosis. The test identified gene changes in the urine of patients with kidney cancer that matched those found in tumor samples, indicating its potential as a diagnostic tool.
A new animal model of pancreatic cancer has been developed, which mimics both non-invasive and invasive forms of the disease. The study identified a unique protein signature in the blood of animals with precancerous lesions, offering potential for early detection and therapeutic targets.
A higher dose of Gleevec was found to lead to increased remission in patients with chronic myeloid leukemia (CML), with 28% of patients achieving complete molecular response after 18 months. The treatment showed improved results over time, with a significant reduction in disease progression.
The American Society of Hematology presents the 2003 Public Service Award to Sen. Dianne Feinstein for her leadership on medical research and patient care issues. ASH also awards Dr. Claude Lenfant with its first-ever Lifetime Service Award for his decades-long dedication to hematology research and training.
AstraZeneca scientists have discovered selective and potent inhibitors of Aurora kinase activity that may have potential application in human cancer treatment. New pre-clinical research presents a combination of vascular targeting agents with EGFR tyrosine kinase inhibitors, showing greater anti-tumor activity than either agent alone.
A UCLA study has found that younger women with breast cancer often experience persistent energy loss and psychological difficulties, despite overall good quality of life. The study highlights the need for targeted interventions to support these subgroups.
The new guidelines call for searches within the National Marrow Donor Program registry conducted by histocompatibility specialists, with patients HLA typed to a high degree of resolution. High-resolution HLA typing is essential for all transplant patients, and the guidelines encourage considering transplants even without a perfect match.
Researchers at the Beckman Laser Institute are developing a laser-based technology to detect and analyze tumors, providing detailed information on blood, fat, and water composition. The center aims to transform this cutting-edge science into a versatile tool for cancer research.
A new study by Georgetown University Medical Center researchers found that low-dose CT screenings can accelerate smoking cessation rates by 14%, significantly higher than the national average. This promising finding suggests it's never too late to treat nicotine dependence, and further research may lead to more effective interventions.
A multi-center study led by Fox Chase Cancer Center oncologist aims to develop an interactive internet-based tool to assess patient values and information needs, providing education on cancer treatment and communication skills training. The goal is to improve doctor-patient communication and patient satisfaction.
A new study by St. Jude Children's Research Hospital found that black children with acute lymphoblastic leukemia (ALL) can achieve high cure rates comparable to those of white children, contradicting previous clinical studies. The research suggests that personalized risk-directed therapy played a key role in overcoming disparities in t...
Researchers used DNA microarray technology to identify seven major subtypes of pediatric acute lymphoblastic leukemia, including six known prognostic subtypes. This discovery enables more accurate diagnoses and personalized treatment plans based on a patient's unique expression profile.
Researchers at Duke University Medical Center have developed a strategy using erythropoietin to enhance heart function and prevent cell death after ischemic injury. A novel protective effect of erythropoietin has been shown in the infarcted heart, demonstrating a therapeutic window of opportunity for acute protection and long-term pres...
A study published by the University of Pittsburgh found that hormone therapy has no benefit to postmenopausal women, even those at high risk of fracture. The research suggests that estrogen plus progestin increases bone mineral density but does not outweigh risks associated with breast cancer and heart disease.