Articles tagged with Cancer Treatments
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Scientists discovered that SNF5 is a tumor suppressor gene responsible for malignant rhabdoid tumors, a rare and aggressive childhood cancer. The study used a novel knockout technique to create mice with reversible, inverting conditional SNF5 genes, which developed cancers quickly.
A recent study found that pravastatin treatment reduced coronary death, non-fatal heart attack, and fatal or non-fatal stroke by 15% in adults aged 70-82. The benefits were most pronounced for reducing death from heart disease, with a nearly 25% relative risk reduction.
Researchers found that overexpressed LPAAT-beta is highly tumorigenic and causes cancer cells to die when inhibited. The small molecule inhibitors induce apoptosis in various tumor cell lines, including lung and colon cancers.
A study analyzing patient deaths and survivors in German hospitals found that nearly 40% of total expenditures went towards the care of just 10% of patients. The most expensive group were young female cancer patients, while old and terminally ill patients accounted for the lowest costs.
Research found that chronic stress impairs immune function, particularly glucocorticoid sensitivity in parents of children with cancer. Social support mitigated some immunologic consequences, suggesting a novel mechanism for psychological stress's influence on inflammation.
A new study found that synthetic hormone estren can build bone in animals without affecting reproductive organs. The researchers tested estren, estrogen, and testosterone in mice with and without sex organs, showing estren's potential to provide a safe form of hormone replacement therapy.
A study by Dr Zeba Aziz found that socio-economic status significantly impacts breast cancer treatment and survival rates in developing countries. Women from lower socio-economic backgrounds often delay seeking medical help, resulting in delayed diagnosis and inadequate treatment, leading to poor survival rates.
As new genetic components are identified, clinical services must adapt to cope with the increasing demand. The role of genetic information in managing inherited cancers is becoming increasingly important, enabling tailored therapies for individual patients.
A study by Professor Lesley Degner found that Canadian women with breast cancer and men with prostate cancer fare better emotionally and socially due to their positive attitude towards illness. The most important information patients want is 'What are my chances of a cure?' and 'How far has my disease spread?'.
Daily estradiol treatment for three weeks reduces mammary cancer incidence by 90% in rats. The study suggests a simple and safe hormonal prevention method for human breast cancer, comparable to full-term pregnancy or tamoxifen treatment.
Scientists have developed a novel treatment using neural stem cells to track and target brain tumor cells that spread into normal brain tissue. The therapy involves genetically engineering neural stem cells to produce interleukin 12, an immune-stimulating chemical known to kill glioma cells. Mice treated with this approach survived sig...
Physicians must consider ethical obligations when treating patients using alternative medicine, including risks and benefits of therapies. A list of factors to aid risk-benefit analysis has been provided by authors, emphasizing the need for thorough investigation and in-depth discussions with patients.
A team led by Purdue University's David Sanders has developed a promising system to deliver genes to diseased liver and brain cells using a modified Ross River Virus (RRV) as a Trojan horse. This approach avoids the harmful side effects associated with other retroviruses, bringing gene therapy closer to treating human diseases.
Researchers have found a new avenue of HIV damage that affects the structure of CD4 T cells, making it impossible for them to function normally. This discovery may lead to improved disease staging and therapy, as therapies targeting inflammation and scar tissue accumulation could enhance current antiviral treatment.
A new computer model suggests that regular visual inspections every five years can save lives and reduce costs compared to DNA testing or traditional Pap smears. In Thailand, where cervical cancer is a major public health concern, this low-tech screening strategy could be an effective and affordable solution.
Researchers at Mayo Clinic developed a new calculator to determine baseline prognosis and treatment benefits for patients with resected melanoma. The tool calculates patient potential living with no recurring cancer or after surgery and interferon therapy, empowering informed treatment decisions.
Researchers identified a green tea compound that may block a key cell receptor involved in allergic responses, potentially providing an anti-allergenic effect. The study found that the compound, methylated EGCG, is more potent than previously discovered compounds and may work against various allergens.
Smokers are less sensitive to future health consequences than nonsmokers, prioritizing immediate health gains over long-term risks. Smoking cessation therapies should focus on illustrating the immediate consequences of not smoking, such as contingency management therapy.
Researchers found that rats treated with adult human stromal cells experienced significant improvements in function after a stroke, including enhanced motor and sensory abilities. The study suggests a potential new treatment approach for stroke patients, offering a longer time window for effective treatment.
A recent study by Ohio State University researchers found that cancer patients with a history of mood disorders are most at risk for developing post-traumatic stress disorder (PTSD). The study suggests that doctors should screen all cancer patients for depressive and anxiety symptoms, particularly those with past mood disorders.
A study of 536 patients found that women reported poorer physical and psychological functioning after hospital treatment, with lower quality of life associated with feelings of loneliness. The absence of social support was a key factor in this difference, highlighting the importance of friendship and companionship for women's well-being
A randomized controlled trial found that early laser treatment of uncomplicated childhood haemangiomas offered no significant benefits in terms of clearance or cosmetic concerns. However, treated lesions were at a higher risk of skin atrophy and hypopigmentation compared to untreated children.
Researchers found that MSI-1436, a natural compound derived from dogfish shark liver, helped normal and obese mice and rats lose fat without losing muscle mass. Phase I trials are expected to begin next year to test its safety and effectiveness as an anti-obesity treatment.
The Lancet Oncology and Infectious Diseases examine the effectiveness of cancer prevention strategies, including chemoprevention and lifestyle changes. Researchers also explore the impact of HIV treatment on reducing epidemics and developing vaccines against the virus.
A UK population study suggests a possible link between colorectal cancer and human growth hormone therapy, with treated patients at an increased risk of death from the disease. The study found significant risks of incidence and mortality associated with colorectal cancer in patients treated during childhood and early adulthood.
The Prostate Interactive Educational System (PIES) is an interactive, computer-based program designed to provide comprehensive information tailored to the patient's preferences. The program will present disease and treatment information, a virtual support group, and allow patients to jot down notes in a virtual notebook.
A study of 44,241 women found that postmenopausal estrogen-only therapy increases the risk of ovarian cancer by 60%, with a greater risk for those using therapy for 10 or more years. The relative risk was highest for women who used estrogen for 20 or more years.
Anastrozole, an aromatase inhibitor, has been shown to be more effective than tamoxifen in reducing the risk of breast cancer recurrence, hot flushes, and thromboembolic events. The treatment also reduces the incidence of endometrial abnormalities and vaginal bleeding, providing a significant benefit for postmenopausal women with early...
Researchers at Stanford University found that briefly disrupting a single mutant gene can permanently alter the course of cancer. The study, led by Dean Felsher, used a gene called MYC to induce cancer cells to revert to normal bone cells after treatment was stopped.
New findings from the Heart Protection Study (HPS) reveal substantial benefits of statins among high-risk patients, including those with normal or low blood cholesterol levels. The study found a significant reduction in death rates from heart attack and stroke, with simvastatin also showing well-tolerated benefits.
A computer-based system is being developed to assist astronauts on extended missions with conflict resolution and mild depression. The system uses problem-solving therapy and computer simulations to help users identify and address problems.
The Society for Women's Health Research is launching a new series on women and pharmacology, covering topics such as sex differences in drug metabolism and the risks of polypharmacy. The seven articles will provide valuable information to the public on how drugs affect women and inform efforts to improve women's health.
The article highlights the significant impact of behavioral factors on various diseases, including coronary heart disease, diabetes, obesity, and asthma. Research shows that negative emotions can lower immunity, while stress and depression can provoke the release of hormones that affect immune function.
Researchers argue that NY-ELCAP cannot determine if spiral CT screening saves lives due to a lack of control group. The study's design flaw could lead to overdiagnosis and unnecessary treatment for some participants.
Researchers argue that the NY-ELCAP program cannot determine if screening saves lives due to a lack of control group. The study may harm participants, lead to overdiagnosis and make it harder to learn the true effect of spiral CT screening.
Researchers at Temple University discovered that the Rb2 gene's lack of expression could be an early indicator of prostate cancer. A study found lower expression levels of Rb2 in prostate tissue as it progresses from normal to cancerous, suggesting its potential use as a diagnostic marker.
A study by University of Virginia researchers reveals that journals and authors are protected by various measures, including court rulings, state shield laws, and constitutional provisions. This protection helps prevent corporate power and pressure from tainting peer review.
A survey of oncologists reveals that most enroll patients in clinical trials for access to advanced treatment options rather than advancing future therapy. This challenges the conventional view that research is conducted primarily for scientific progress and improving treatments.
Scientists have overcome technical difficulties by linking ribozymes to helicases, allowing for efficient inhibition of target RNAs and enabling the development of a method for investigating random RNA functions.
Research findings link insulin-like growth factor I (IGF-I) to decreased lung cancer risk when bound by IGFBP-3. Environmental factors influence DNA methylation patterns in tumor suppressor genes, which may impact cancer incidence. Electro-gene therapy enhances IL-12 protein delivery, triggering long-lasting antitumor responses.
A case study highlights the importance of early detection of testicular cancer, with a 17-year-old patient's death attributed to delayed medical advice. Medical professionals and men need to be educated to recognize testicular lumps as medical emergencies.
Researchers found a 16% increased risk of death for blacks compared to whites with comparable treatment, which narrowed to 7% after adjusting for other causes. The disparity was eliminated in most cancers, except for breast and two rare types.
Research suggests that defects in 'orphan' inositol polyphosphates may contribute to diseases such as manic depression and cancer. Dr. York's work identifies biological roles for these molecules and provides a basis for designing more specific drugs with fewer side effects.
A combination treatment of Pegasys and ribavirin has shown an unprecedented 61% sustained virologic response rate, the highest ever recorded. The treatment regimen should be based on hepatitis C virus genotype rather than traditional weight-based methodology.
Postmenopausal women with higher serum concentrations of estrogen and testosterone have twice the risk of developing breast cancer as those with lower levels. This is according to an international study published in the Journal of the National Cancer Institute.
A new study has found that women with the highest levels of sex hormones are at roughly twice the risk of developing breast cancer compared to those with lower levels. Additionally, researchers have discovered a potential therapy for glioblastomas using a fusion protein that shows little toxicity. Reproductive hormones have also been l...
A University of Pittsburgh Medical Center study reveals that the protein cdc42 plays a crucial role in suppressing dendritic cell activity in cancer. The findings provide a new direction for therapeutic molecular immunopathology and may lead to the development of highly efficient vaccines for cancer therapy.
Researchers investigate the remarkable resilience of the mummichog fish to chronic pollution in the Elizabeth River. The study reveals that these fish have adapted through genetic changes, but this comes at a cost, such as increased cancer risk and reduced ability to thrive in clean environments.
Researchers found that when treatment outcomes were impaired quality of life, such as severe functional or cognitive impairment, a significant number of patients (74.4% and 88.8%) lost their willingness to receive treatment. In contrast, the impact on preferences was more nuanced with mortality, where only when the likelihood increased...
A new study found that hormone replacement therapy, particularly estrogen alone, may increase the risk of epithelial ovarian cancer in postmenopausal women with an intact uterus. Women who used sequential progestins with estrogens had a higher risk of developing ovarian cancer compared to those who never used HRT.
A recent study found that women with lower incomes and those insured by Medicaid had worse breast cancer treatment outcomes, including later-stage diagnoses, reduced radiation therapy, and higher mortality rates. Socioeconomic factors accounted for most of the disparities in these outcomes.
A long-term follow-up study of over 800 postmenopausal women found that stopping hormone replacement therapy resumes bone loss at a rate similar to those who never took the drugs. The study showed that while bone mass increased in the first 36 months after starting hormone replacement therapy, there was little gain after that.
Scientists have developed a test to identify breast abnormalities that are more likely to develop into breast cancer. The test analyzes biological signals in cells and can help doctors determine whether certain women should receive prophylactic anti-oestrogen treatment or more frequent screening.
A new booklet aims to improve communication and support between doctors, patients, and partners in cancer care. The booklet was developed with input from patients and healthcare professionals, resulting in a user-friendly document that enhances patient understanding of research and clinical trials.
Researchers found that thrombocytosis correlates with more aggressive ovarian cancer and poorer response to treatment. Patients with thrombocytosis had higher CA-125 levels, advanced stage disease, and greater tendency of cancer spread.
A study of 224 children found that young children were more likely to acquire H. pylori infection, particularly those from black communities. Early childhood appears to be the critical period for acquiring most infections, and racial differences may impact the risk of developing related health issues.
Researchers have developed a portable ultrasound device that uses high-intensity focused ultrasound (HIFU) to target and destroy unwanted tissue or cauterize lesions. The device has the potential to revolutionize emergency medical care, particularly in remote areas or on battlefields where traditional treatment is not possible.
Researchers found that clot-busting drugs were associated with increased mortality in elderly patients, particularly those over 80 years old. The study highlights the need for more selective use of these drugs and alternative treatments like primary coronary angioplasty.
A study published in The Lancet found that simian virus 40 (SV40) was present in 43% of non-Hodgkin lymphoma patients, with lower rates in Hodgkin lymphoma cases. Researchers discovered a potential link between SV40 and human cancer, which could lead to new detection and treatment methods.
A study by Dr. Jennifer Grandis and colleagues identified a protein associated with lung cancer also expressed in head and neck cancer, leading to potential therapeutic strategies. The researchers found increased GRPR expression in head and neck cancer tissues compared to healthy controls.