Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Researchers discovered that the HER2/ERBB3 pathway regulates androgen receptor function, contradicting previous beliefs about EGFR's role. This finding may explain limited success of Gefitinib, an EGFR inhibitor, in treating hormone-refractory prostate cancer.
Research investigates the relationship between antioxidants and carcinogenesis, including the use of ß-carotene in cancer prevention. Studies also explore the formation of aldehydes as a central concern of oxidant stress for cancer therapy. Key findings include varying levels of individual antioxidants according to disease status.
Researchers challenge traditional hypotheses on Crohn's disease, suggesting a more complex role for cytokines in the immune response. This could lead to new treatment strategies involving the blockade of multiple cytokines.
The Weizmann Institute will receive a $8 million grant from FAMRI to focus on lung cancer research related to second-hand and mainstream tobacco smoke. Researchers from the institute and Sheba Medical Center will collaborate to advance treatment protocols.
Researchers found a correlation between the presence of the CXCR3 protein and increased survival in Stage III metastatic melanoma patients. This discovery may lead to improved vaccines that 'turn-on' cancer-killing immune cells and instruct them to find tumors.
Researchers found that adding alcohol injections to RFA significantly improved treatment outcomes, eradicating 34 of 41 liver tumors with no bowel-related complications. The combination therapy also showed promise for treating large tumors and other types of tumors in the body.
Cryptosporidium hominis is a highly contagious parasite that causes watery diarrhea and can lead to dehydration, weight loss, and stomach cramps. The decoded genome sequence holds promise for developing preventive vaccines and pharmaceutical treatments.
Researchers at Children's Hospital of Philadelphia found that family therapy significantly reduced post-traumatic stress symptoms in adolescent cancer survivors. The treatment combined cognitive-behavioral therapy with family therapy and showed strongest effects on adolescents and their fathers.
A pilot study found that Cenestin reduced hot flashes and night sweats in post-menopausal women by 79% and improved overall sleep quality. The study also showed a significant reduction in galvanic skin responses, indicating better sweat gland activity.
Researchers used a mouse model to show that TGF-b production in tumor-infiltrating T lymphocytes is crucial for colon cancer progression. Inhibition of IL-6 trans-signaling prevented tumor growth, suggesting novel therapeutic approaches for colorectal cancer.
Researchers discovered a previously undiscovered variant of tumor-suppressor TrkA, called TrkIII, associated with childhood cancer progression. Elevated TrkIII levels in advanced stage tumors suggest its role in cancer progression, and preventing its generation may inhibit disease progression.
A recent study published by the American Association for Cancer Research found that men with high-grade prostate intraepithelial neoplasia (PIN) are at a higher risk of developing invasive prostate cancer. Within one year, men in the placebo group had a 31.4% risk of being diagnosed with prostate cancer.
A new study links increased domestic production of betel quid to the incidence of head and neck cancer in Taiwan, with a strong cohort effect observed for men born between 1972-1980. The study suggests a correlation between betel quid usage and head and neck cancer incidence.
A new study identifies actinonin-based antibiotics as a potential treatment for cancer. Human mitochondrial peptide deformylase is found to be a key target in this approach, offering new avenues for cancer research and therapy.
Researchers at Massachusetts General Hospital found that patients use laughter to convey emotional intensity during psychotherapy, while therapists' laughter magnifies this effect. The study suggests that therapists should pay attention to when patients laugh, as it may indicate the need for further exploration of emotions.
A study found that CyberKnife radiosurgery successfully controls growth and progression of symptomatic benign tumors, improving symptoms in 78% of patients. The treatment has a high local control rate of 96%, offering a promising option for patients not candidates for surgery.
A study found that even healthy subjects experience declines in sexual function over five years, but patients treated for prostate cancer show much greater decline with significant impact on urinary function. Men undergoing radical prostatectomy are particularly affected.
A study has identified two distinct subclasses of liver cancer with differing survival rates, providing new molecular insight into the pathogenesis of hepatocellular carcinoma. The findings suggest that gene expression profiles can accurately predict patient survival and may lead to the development of more targeted therapies.
A study by Thomas Stamey and colleagues found that the correlation between PSA levels and prostate cancer severity has decreased over time, making the test less useful for early detection. Instead, they recommend a yearly digital rectal exam for men over 50.
Researchers found that Stat3 is required for skin cancer initiation and maintains cellular growth through expansion of initiated cells. Inhibiting Stat3 function impairs tumor growth, suggesting its potential as a target for cancer therapy.
A Nordic study found statins decrease mortality rate and incidence of cancer over 10-year follow-up. Statin therapy with simvastatin reduced cardiovascular and coronary mortality, with a 17% reduction in cardiovascular mortality.
The study provides new insights into Epstein-Barr virus and its role in autoimmune diseases such as lupus, arthritis, and multiple sclerosis. Researchers found that the virus causes abnormal survival and activation of B cells, leading to excess auto-antibodies.
Researchers found that short-term hormone therapy can be beneficial for women with mild to severe menopausal symptoms, but may not be suitable for those at high risk of cardiovascular disease. The study suggests that the decision to use hormone therapy should be based on individual goals and CVD risk.
PET scans improved detecting distant metastases with an accuracy of 85%, compared to 55% for current standard diagnostics. The technique also showed high accuracy in diagnosing locoregional disease, surpassing current practice by 24 percentage points.
YY1 regulates p53 at multiple levels, decreasing its amount in cells and blocking its interaction with cofactors. This discovery offers new targeting options for therapies to prevent transcription factors from interacting with other proteins.
Recent court cases show patients sued doctors for delayed breast cancer diagnosis, with average awards being $250,000. Dr. Berlin argues that mammography is not perfect and overzealousness in radiology communities led to unfounded fears among women.
Studies identified 13 mutations on the PIK3CA gene in various types of brain tumors, including anaplastic oligodendrogliomas and glioblastomas. The findings suggest a link between PIK3CA mutations and brain cancer development.
In Harare, Zimbabwe, cancer survival rates are disturbingly low, with black patients facing significantly lower survival rates than white patients. The study's findings highlight the need for better access to early detection and treatment methods.
Researchers have identified a more effective treatment for people with both HIV and hepatitis C. The new therapy, peg-interferon with ribavirin, showed a sustained response rate of 27% compared to 12% in those who received standard interferon treatment.
The American Association for Cancer Research is accepting nominations for the 2005 Landon-AACR prizes, which recognize seminal basic and translational cancer research discoveries. The recipient of each prize will receive a $200,000 unrestricted cash award and present a lecture at the 96th AACR Annual Meeting in Anaheim, Calif.
Researchers engineered a decoy Met receptor that successfully competes for HGF binding, inhibiting tumor growth and survival. The Sema domain of the Met receptor is also necessary for activation, offering a new therapeutic target for cancer treatment.
Researchers discovered a synthetic peptide that mimics a protein linkage crucial for melanoma cell migration and angiogenesis. The peptide inhibits this interaction, significantly deterring tumor cell growth and formation of new blood vessels.
A recent study found a significant correlation between active Stat5 protein and high-grade prostate cancer. The research suggests that blocking the signals that turn on Stat5 may lead to effective treatment strategies for advanced prostate cancer.
A new study reveals gene microarray technology can accurately diagnose acute myeloid leukemia subtypes, leading to better treatments. The signatures of gene expression identified in pediatric leukemias also apply to adult cases, improving diagnosis and treatment outcomes.
Warren Pharmaceuticals has synthesized molecules exhibiting only tissue-protective effects of EPO, with no impact on the classical EPO receptor. These compounds show promise in treating various diseases including stroke, spinal cord compression, diabetic neuropathy, multiple sclerosis, and congestive heart failure.
A new treatment using radiofrequency ablation has been shown to be effective in eliminating kidney tumors, with complete ablation achieved in 83% of patients. The treatment is particularly promising for patients who are not ideal candidates for surgery due to other health-related conditions.
Researchers used nanoshells to destroy tumors with heat from near-infrared light, showing promising results in a first animal test. All tumors disappeared within 10 days in the treated group, while untreated and saline-treated groups continued to grow.
Cedars-Sinai researchers found that laminin-8 expression is linked to tumor aggressiveness and patient outcomes. High levels of laminin-8 are associated with shorter survival times and increased risk of tumor recurrence.
The study reveals that mice lacking the Mus81 protein are fertile and can help monitor health more closely. Researchers explore whether the mutation is tied to human tumour formation, allowing for targeted treatment strategies.
A new method developed by UK researchers allows for accurate prediction of a woman's remaining reproductive life-span based on ovarian volume measurements. The technique uses mathematical models and computer analysis to estimate follicle numbers, providing a direct assessment of ovarian reserve.
A new study by Cancer Research UK found that common mutations in genes regulating estrogen metabolism are not associated with breast cancer risk. However, a separate study suggests that inhibition of hypoxia-inducible factor 1alpha (HIF-1alpha) activity may be a target for future gastric cancer treatments.
A study of 223 patients with early-stage, initially untreated prostate cancer found that disease progression increased significantly after 15 years of follow-up. After 10-15 years, most cancers had an indolent course, but progression rates decreased over time.
A study of 192 patients with advanced gastrointestinal stromal tumor (GIST) found that Glivec(R) interruption was associated with a high risk of re-progression. In contrast, continuous treatment showed no signs of re-progression within a year. Continuous Glivec(R) treatment is recommended for patients with advanced GIST.
Researchers discovered a molecular marker, the HOXB13:IL17BR ratio, that accurately predicts the reoccurrence of tumors in breast cancer patients treated with tamoxifen. This finding suggests that HOXB13 may contribute to tumor invasion and metastasis.
A decade-long study found improved five-year, event-free survival rates of 63% in Recife, Brazil, compared to the US and Europe. The increase was attributed to adapted St. Jude treatments and supportive care, including housing and travel subsidies for families.
A study of over 500 smokers found a significant association between sequence variations in the macrophage scavenger receptor gene and airways obstruction. The researchers hope this discovery will help understand why some smokers develop COPD and improve treatment options.
The study found a significant increase in male breast cancer incidence over 25 years, with men being diagnosed at an older age than women. Larger tumor size and axillary lymph node disease were associated with shortened survival, while hormone receptor status and tumor grade did not have independent prognostic effects.
The European Society for Medical Oncology (ESMO) has launched a new charitable foundation with the goal of making the best treatment available to every cancer patient. The ESMO Foundation will provide much-needed funds for education, research, and patient care.
A study found that African-Americans are 1.67 times more likely to die within five years and 1.52 times more likely to die within ten years after surgical treatment for CRC compared to Caucasians. Racial differences were most pronounced in patients with stage II disease.
A research study found that inhibition of cathepsin cysteine proteases impairs tumor growth and progression in transgenic mouse models of cancer. Treatment with a pharmacological inhibitor also disrupted both early and late stages of tumor development, suggesting its potential as an anticancer therapeutic.
A study published in Cancer Research identified a cancer-causing gene, HMG-I, that contributes to the development of leukemia and lymphoma in humans. The researchers found that overexpression of the gene led to the rapid development of tumors in genetically engineered mice.
A study found that over half of men taking part in a prostate cancer risk assessment program reported using dietary supplements to prevent the disease. The most commonly used supplements were vitamins and minerals, with saw-palmetto being one popular option.
A recent multi-center trial has shown cryoablation to be effective in killing cancerous cells in small tumors, offering a promising alternative to traditional surgery for early-stage breast cancer. The study found that the procedure was equally effective for tumors between 1.0 and 1.5 centimeters in diameter, but not larger than 1.5 cm.
A study by the American College of Radiology found that thoracic PET scans are suitable for diagnosing some lung cancer patients with localized disease. This approach reduces radiation exposure and saves time compared to whole-body PET examinations, which cover a broader area of the body.
A study found MRI to be highly useful in the evaluation of patients with uterine fibroids. The imaging technique offers advantages over sonography, including a larger field of view and better contrast resolution. MRI can help identify subsets of patients who may not benefit from UAE treatment, allowing for more personalized care.
Researchers at the University of Pittsburgh Medical Center have discovered a molecular mechanism that enhances the ability of stem cells to fight disease. By blocking the function of p18, a molecule critical for cell cycle control, scientists found improved long-term engraftment of stem cells in bone marrow tissue.
The article discusses Fox Chase Cancer Center's implementation of certified nursing assistant (CNA) positions to support experienced nurses. The CNA program has led to a significant decrease in turnover rates, with a reduction of over 20% since its introduction in 2001.
The partnership aims to educate junior, cadette and senior girl scouts about the responsibilities of nurses, educational requirements and general health and wellness information. The program showed increased interest in pursuing nursing careers among participating scouts.
Epileptic seizures result from brain dysfunction, with early diagnosis and treatment crucial to preventing irreversible damage. The stigma surrounding epilepsy exacerbates the condition's impact on daily life and quality of life.
A randomized, prospective study found that tacrolimus + mycophenolate mofetil and steroids significantly reduce incidence of treated rejection and improve graft function compared to other regimens. The combination therapy also showed better lipid profiles and reduced risk of certain infections.