Lexiva demonstrated durable anti-viral response through 48 weeks, significantly less grade 2-4 drug-related diarrhea than nelfinavir. In PI-experienced patients, Lexiva/r showed fewer nucleoside reverse transcriptase inhibitor (NRTI) mutations after virologic failure compared to lopinavir/ritonavir.
Researchers at Kansas State University have been chosen to sequence the red flour beetle's genome as part of a multimillion-dollar project. This will enable new experimental approaches and strategies for controlling harmful insects.
A 10-year study found high doses of radiation improved outcomes for patients with localized prostate cancer, regardless of risk group. Minimal side effects were observed despite higher radiation doses.
A study of 1,204 men treated with radiation therapy found that hormone therapy significantly increases the risk of moderate to severe genitorurinary and gastrointestinal side effects. Hormone therapy can extend lives but complicates treatment decision-making.
A six-month study found that eszopiclone significantly improved patients' ability to fall asleep, stay asleep, and function well during the day. The results suggest eszopiclone has potential as a long-term treatment option for chronic insomnia.
Researchers identified a single gene, glutathione S-transferase omega-1 (GSTO1), as a key factor influencing the age of onset for both Alzheimer's and Parkinson's diseases. The study used genomic convergence to narrow down the genome region associated with age at onset, providing potential new targets for treatment.
A recent NHLBI study found that hostility and impatience are associated with a higher risk of developing high blood pressure. The study, which followed over 3,000 young adults for 15 years, found that those who exhibited higher levels of time urgency and hostility had an increased risk of developing hypertension.
Researchers found that while black and white Americans have the same amount of early kidney disease, black patients are five times more likely to progress to end-stage renal disease. This disparity may be due to differences in blood pressure control, quality of care, and access to healthcare.
Researchers at the Beckman Laser Institute are developing a laser-based technology to detect and analyze tumors, providing detailed information on blood, fat, and water composition. The center aims to transform this cutting-edge science into a versatile tool for cancer research.
Researchers used computer-assisted MRI technology to visualize gray matter structures in the brain of MS patients, finding T2 hypointensity associated with iron deposits. The study found correlations between T2 hypointensity and impaired walking ability and cognitive impairment, suggesting a new potential target for treatment.
Researchers have discovered that smaller protein structures called protofibrils are more toxic to cells than mature fibrils in type II diabetes and other age-related diseases. The study suggests that targeting earlier stages of protofibril formation may be a more effective approach to developing treatments.
A recent study found that whole-breast irradiation after lumpectomy significantly reduces the risk of recurrence in other parts of the breast. The use of tamoxifen in addition to radiation was associated with the lowest risk of recurrence.
The Florida Sea Grant is supporting research to develop more efficient methods for raising marine ornamental fish, such as angelfish and anemonefish. This focus on sustainable aquaculture aims to reduce the industry's impact on coral reefs and promote environmentally friendly practices.
Gefinitib, a designer drug targeting the epidermal growth factor receptor, has shown efficacy in treating advanced non-small cell lung cancer. In a phase II clinical trial, 43% of patients experienced symptom improvement and 12% showed partial radiographic responses.
A nationwide initiative aims to support nursing staff in quitting smoking, with $100 free services and partnerships with organizations. The program seeks to expand nursing leadership in tobacco control, addressing a long-standing barrier in the profession.
Two UCSD scientists, Bing Ren and Xiang-Dong Fu, receive NIH funding to investigate the human genome. Their projects aim to develop new technologies for mapping transcriptional regulatory elements and identifying functional DNA elements.
Researchers have developed doped liquid crystals that allow for real-time holography with significantly improved optical properties. These materials can be used in various applications, including focusing optical telescopes and creating real-time holographic movies, due to their high sensitivity to light.
A recent investigation found that a Texas salvage store was the source of a foodborne botulism outbreak. Food safety experts advise customers to inspect packaging for signs of decay and spoilage, as well as to maintain standards of health when shopping at any facility.
A UCLA study found 54 genes produced differently in male and female mouse brains prior to hormonal influence, suggesting genetic influences on sexual differences. The research may help explain why people feel male or female and inform the development of treatments for intersex infants.
A study by Pollack and colleagues finds that a high Ki-67 biomarker is linked to increased risk of distant metastasis and death in prostate cancer patients. The researchers also suggest that Ki-67 can help identify high-risk patients who may benefit from alternative treatment strategies.
A recent study found that practice type and patient race are significant predictors of enrollment in clinical trials. Academic settings and white patients showed higher rates of trial participation, while non-academic sites and African-Americans had lower rates.
Operations researchers at Delta Air Lines used simulations to optimize boarding processes, resulting in a 25% reduction in aircraft turnaround time. The study's findings suggest improved utilization and increased convenience for passengers.
A study published in JAMA compared screening mammography performance in the US and UK among similar aged women, analyzing 5.5 million mammograms. Despite lower recall rates in the UK, both countries showed similar cancer detection rates, but US women experience more anxiety and false-positive scares.
Researchers at University of Kalyani discovered that homeopathic remedy Arsenicum Album can reduce liver damage in mice with arsenic poisoning. The treatment showed positive effects in both low and high doses, suggesting its potential to address the global health issue of arsenic contamination.
Dr. Parada, a renowned researcher, receives the American Cancer Society's Research Professorship award for his work on brain cancers and nerve growth. The five-year award provides flexible funding to enhance visibility of cancer research at UT Southwestern.
Researchers at MIT developed a device that reduces nitrogen oxide emissions by up to 90% and halves the fuel needed for removal. The plasmatron reformer could lead to increased gasoline engine efficiency and significant oil consumption savings.
The study assesses the impact of integrated care management systems on Medicare patients with end-stage renal disease (ESRD). It examines patient outcomes, including hospitalization rates, mortality, satisfaction, and quality of life, across two distinct payment models: capitation and fee-for-service.