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Science News for October 28, 2005


What is the best treatment strategy for early rheumatoid arthritis?

Initial combination therapy with either prednisone or infliximab significantly reduces progression of radiographic joint damage and improves functional outcomes compared to DMARDs alone or step-up combination therapy. Patients treated with initial combination therapy also experience earlier relief from symptoms.

SourceWiley·JournalArthritis & Rheumatism·DateOct 28, 2005

Which drugs should health plans cover?

Experts from Group Health Research Institute outline five principles for making informed decisions on drug coverage, prioritizing true experiments, real health outcomes, and full ranges of alternatives. These evidence-based guidelines aim to protect patients and promote cost-effectiveness.

SourceGroup Health Research Institute·JournalJournal of General Internal Medicine·DateOct 28, 2005

Regular physical activity may strenghten knee cartilage

A study found that moderate exercise can improve knee cartilage strength and elasticity, reducing the progression of osteoarthritis. Regular physical activity has been shown to reduce knee pain and stiffness, as well as improve functional performance tests.

SourceWiley·JournalArthritis & Rheumatism·DateOct 28, 2005

Medical news tips

Researchers at Johns Hopkins Kimmel Cancer Center have found hormone therapy will not diminish the value of radiation for prostate cancer. Additionally, a leukemia drug shows modest benefits in suppressing PSA levels for some men with localized prostate cancer.

'Know thyself' — easier said than done

A recent study found that people generally overestimate their abilities and health risks, leading to poor decision-making in areas such as health management, education, and the workplace. This can have serious consequences, including underestimating susceptibility to health risks and overconfidence in professional competence.

SourceAssociation for Psychological Science·JournalPsychological Science in the Public Interest·DateOct 28, 2005

What makes the brain tick, tick, tick. . .

Researchers at Duke University explore the neural mechanisms of interval timing, a fundamental process involved in tasks like walking, speech recognition, and learning. They propose a new model involving the 'coincidence detection' of oscillatory patterns, which integrates information from various brain structures.

SourceDuke University·JournalNature Reviews Neuroscience·DateOct 28, 2005

Novel discovery of 'DCDC2' gene associated with dyslexia

Researchers identified the DCDC2 gene as a significant contributor to dyslexia, disrupting brain circuitry that enables reading. The study's findings have the potential to lead to early and accurate diagnoses, as well as more effective educational programs for individuals with dyslexia.

SourceYale University·JournalProceedings of the National Academy of Sciences·DateOct 28, 2005

Hepatitis C complicated by morphine withdrawal

Research by Chuan-Qing Wang and colleagues found that morphine withdrawal and precipitated withdrawal increase HCV replicon expression and inhibit IFN-alpha production in liver cells. This study suggests that opioid abuse may contribute to the chronicity of HCV infection and promote disease progression.

SourceAmerican Journal of Pathology·JournalAmerican Journal Of Pathology·DateOct 28, 2005