Articles tagged with Cancer Treatments
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Researchers discovered a potential biomarker, PKCi, which predicts outcome in non-serous ovarian cancer when combined with Cyclin E. High levels of the protein correspond to reduced survival rates.
A 15-year longitudinal study found that individuals diagnosed with minor depression were more likely to develop major depression, particularly among young adults (18-29 years old) and women. The study also revealed that cancer and other chronic illnesses did not increase the risk of developing major depression.
Researchers at VCU's Massey Cancer Center have discovered a key enzyme involved in the spread of breast cancer cells. The study, published in the Journal of Biological Chemistry, suggests that sphingosine kinases are potential new targets for cancer therapy.
Contracting with non-state entities like NGOs has been shown to improve health services in developing countries through substantial, rapid improvements. Studies have found that contracting costs between $3 and $6 per head per year can increase immunisation coverage by up to 40 percentage points compared to government provision.
Researchers found improved patient outcomes in open nephron-sparing surgery (NSS) over time, attributed to increased surgeon experience and perioperative care. Open NSS showed benefits compared to laparoscopic NSS, particularly in complex tumor cases.
Researchers used diffusion MRI to measure water movement in treated fibroids, showing significant signal intensity and ADC values. This non-invasive technique may improve monitoring of ultrasound treatment success and be useful for other focused ultrasound treatments.
A study published in Cancer journal found that tumor size decreased significantly between 1975 and 1999, explaining 61% of the increased survival rate in localized breast cancer. Adjusting for tumor size diminished the magnitude of the survival increase within each stage category.
Dr. Gragoudas is being recognized for his groundbreaking work on protein beam irradiation and photodynamic therapy for intraocular melanoma and neovascular age-related macular degeneration. He has made significant contributions to the clinical practice of ophthalmology, particularly in the study of retinal vascular diseases.
Scientists at Ohio State University created a mouse model of lung cancer that loses the FHIT gene's protein early in development, leading to larger and more numerous tumors. The study suggests that even low levels of the protein might prevent lung cancer.
Researchers found that many cancer survivors make significant modifications in diet and physical activity after a diagnosis. Despite this, many continue to struggle with healthy behaviors, particularly males, less educated individuals, and those over 65.
The study reveals that hyperactive Stat3 shuts down a vital controller of stomach cell growth, leading to cancer formation. Lowering Stat3 hyperactivity suppresses stomach cancer formation without affecting other roles in the body.
A study analyzed data from 18 published studies on TP53 protein and mortality rates, finding selective reporting biases that may have fabricated strong associations. The authors caution that the findings highlight limitations of current research methods and call for more transparent reporting and better study design.
Resistant tumor cells can be sensitized to ONYX-015 replication by inducing a heat shock response, which could greatly augment the therapy's clinical utility. This study suggests that clinical strategies focusing on tumor-selective replication would favor the use of ONYX-015.
Researchers found that the p16 gene inactivates key enzymes JNK 1 and JNK 2, keeping them from activating proteins that promote cell growth. A small protein mimicking p16 has been designed to mimic its action, showing promise for anti-cancer activity.
Men with prostate cancer are 10% less likely to be working six months after diagnosis compared to those without the disease. However, approximately two-thirds of patients continue to work due to fear of losing health insurance coverage, often at reduced hours and with decreased productivity.
Researchers found that African Americans and Native Americans are more likely to be diagnosed with advanced disease and die of their disease compared to Asian Americans and non-Hispanic whites. The study highlights the importance of considering heterogeneity within broad racial/ethnic categories when evaluating cancer risks.
A study of 360 women with borderline ovarian tumours found that conservative surgery can preserve fertility, especially for younger women with unilateral BOT. However, the recurrence rate was high at 16.6% over an average 70-month period.
Researchers found that insomnia prolongs bouts of sadness and hopelessness, making recovery less likely. Elderly patients with insomnia are nearly 11 times more likely to still be depressed at six months than those sleeping well.
A study published by Massachusetts General Hospital found that radiofrequency ablation (RFA) is an effective long-term treatment for kidney tumors, with success rates of 100% for surface tumors and 78% for central tumors. The procedure has been used to treat over 100 renal cell carcinomas in 85 patients with similar results.
Researchers found that the immune system can control disease by increasing cell renewal in the intestine, allowing parasites to be expelled naturally. This discovery may lead to new ideas for treating inflammatory bowel diseases and bowel cancer.
A study found that disease reinfection rates for TB were four times higher than new cases in South Africa. Additionally, researchers discovered that low-dose spiral computer-based tomography (CT) screening can lead to an early diagnosis of lung cancer in a high proportion of cases.
Researchers discovered that EGFR interacts with STAT3 in the cell nucleus, leading to increased expression of inducible nitric oxide synthase (iNOS) and a new transcriptional mechanism in human cancers. This interaction provides a potential target for anticancer therapies against EGFR, STAT3, and iNOS/NO.
Researchers at Oregon Health & Science University found elevated levels of leptin may be the cause of cachexia, a common complication of CKD. Blocking the MC4-R pathway in the brain may provide a novel therapeutic strategy to combat this life-threatening complication.
Researchers found that removing the spleen and suppressing related factors can prolong survival in mice with leukemia. The study suggests a potential treatment model for human hematological malignancies, but further research is needed.
The study reveals the first complete look at the structure of SUMO-1 and its conjugation to other molecules within the complex. Understanding this process could lead to novel anticancer therapies by targeting sumoylation, which promotes cell division.
Researchers identified an 11-gene BMI-1-pathway signature that consistently predicts disease recurrence, metastasis, and death after therapy in cancer patients. The presence of this gene expression pathway is associated with a high probability of poor therapy outcome and metastasis.
A new University of Georgia study analyzed existing data and found that airbags are associated with slightly increased probability of death in accidents, particularly at high speeds. The analysis contradicts earlier studies on the effectiveness of airbags, which have been required for drivers and front-seat passengers since 1998.
A home-based physical activity program increased physical activity levels and improved fitness among breast cancer survivors. Participants reported reduced fatigue, increased vigor, and improved body image after 12 weeks of counseling via weekly phone calls and mail-delivered tip sheets.
A new treatment approach for complicated grief, developed by University of Pittsburgh researchers, has shown significant promise in improving symptoms and reducing emotional pain. The treatment, which combines elements of interpersonal psychotherapy with a unique two-pronged approach, was found to be more effective than a comparison th...
A study by Beth E. Meyerowitz and colleagues found that cancer survivors are twice as likely to experience cognitive deficits, including dementia, compared to their cancer-free twins. The authors suggest that cancer treatments may lower survivors' cognitive reserve, leading to increased risk of long-term cognitive dysfunction.
The UK Appalachia Community Cancer Network will focus on prevention and early detection of specific cancers with high incidence rates in the region. The network builds on the progress made by a previous program and aims to address the high cancer burden in Appalachian communities.
The Tri-Institutional Stem Cell Initiative aims to decipher molecular codes responsible for human cellular diversity and design cell-based therapies. This collaboration will bring together researchers from Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, and The Rockefeller University to explore stem cell biology.
A study examining Seroquel treatment for bipolar depression found significant improvements in quality of life measures, with the most common adverse events including dry mouth and sedation. The results are promising for managing depressive symptoms associated with bipolar disorder.
A clinical trial by Mayo Clinic found that shark cartilage did not demonstrate any efficacy in patients with advanced breast or colorectal cancers. In fact, some quality of life measurements worsened among patients treated with shark cartilage.
A study found that men with prostate cancer who are in a relationship report better mental health, greater spirituality, and fewer urinary symptoms. The researchers conclude that clinicians should address coping mechanisms to encourage the benefits of partnership and mitigate the negative effects of being single.
A study examined the effect of SEROQUEL on cognitive function in patients with schizophrenia, showing improved overall cognition. Another analysis found that patients taking atypical antipsychotics had better treatment compliance compared to those taking conventional antipsychotics.
Prostate cancer patients who have a spouse or partner report lower levels of depression and emotional distress. Support groups can also benefit single men in improving their quality of life.
Researchers found prostate cancer in 45% of high-risk men, including those with low PSA levels. The study's findings challenge traditional screening guidelines and suggest more aggressive screening for these individuals.
A recent study at Fox Chase Cancer Center found that doctors and patients have differing perceptions of clinical trial participation. While both groups agree that clinical trials are crucial for improving cancer treatment, patients are more likely to cite fear of side effects as a barrier to participation.
Sebastian Nijman's research reveals the molecular mechanism underlying cylindromatosis, a rare genetic condition causing skin tumors. The study also identifies a key protein in Fanconi anaemia, a form of inherited cancer, and finds potential treatment through inhibition of NF-kappa B signalling route.
A study led by Daniel W. Cramer found that high blood levels of antibodies against MUC1 protein are associated with lower incidence of ovarian cancer. These events include bone fractures and gynecological surgeries, suggesting a potential link between immune system activation and cancer protection.
Low-grade DCIS lesions can evolve to invasive breast cancer within 15 years of diagnosis, with a regional risk and high mortality rate. The study found that 30% of women with untreated low-grade DCIS developed invasive breast cancer in the same breast within 15 years.
A study published in JAMA Network found that men with low-grade prostate cancer have a small risk of progression even after 20 years of observation or androgen withdrawal therapy. The results suggest that localized, low-grade prostate cancer patients may not require aggressive treatment.
Researchers identified 18 genes that predict which patients will respond to Hepatitis C treatment, offering a potential simple blood test for early diagnosis. The study found that these genes are key to the body's ability to eliminate the virus.
A study of 717,000 postmenopausal women found that oestrogen-only HRT and tibolone increase the risk of womb cancer, while combined HRT does not. The risk also varies according to bodyweight and is reduced in obese women
Georgetown University is helping create a national cancer biomedical informatics grid to link research centers in real time, sharing data and results more rapidly. The $20 million grant aims to improve cancer research and treatment through the adoption of common research tools.
Researchers found that selenium metabolite methylseleninic acid (MSA) enhances TRAIL-induced apoptosis in prostate cancer cells, providing a potential novel therapeutic strategy. The study suggests that the combination of TRAIL and MSA may be effective in targeting apoptosis-resistant forms of prostate cancer.
A large cohort study found that high consumption of processed meats was associated with a significant increase in pancreatic cancer risk. The study, which followed over 190,000 participants, suggests that chemical reactions during meat preparation may be responsible for this link.
Researchers at Fox Chase Cancer Center found that reducing BRCC36 expression by 80 percent increases the number of breast cancer cells killed by radiation. This discovery holds promise for future breast cancer treatments, targeting radiation-resistant cancer cells.
Researchers say virtual colonoscopy may be the answer to improving screening rates for colorectal cancer. The non-invasive test is highly sensitive and specific, while also being convenient and cost-effective, with minimal risk of side effects.
Researchers at Fox Chase Cancer Center have developed a non-invasive test to monitor kidney cancer patients by analyzing DNA methylation patterns in urine samples. The test, called methylation-specific polymerase chain reaction (PCR), can detect even a few cancer cells among healthy cells with high specificity.
A team of researchers at the University of Nevada, Reno has developed a proton beam with 100 times higher quality than conventional particle accelerators, fitting on a tabletop. This breakthrough technology could enable precise treatment for cancers previously untreatable, such as those in the head region.
A novel monoclonal antibody targeting S1P has shown promising results in eliminating cancerous tumors in some cases. The therapy not only blocks the effects of S1P on cancer cells but also prevents tumor angiogenesis, a key factor in tumor growth.
Researchers at Georgetown University Medical Center discovered a chocolate compound that stops cancer cell cycles in lab experiments. The compound, pentamer, deactivates tumor suppressor genes and proteins involved in regulating the cell cycle, preventing cancer cells from dividing.
Researchers at Ludwig Institute for Cancer Research found that Smad7 protein levels may predict therapy response to 2-ME compound. The study suggests that artificially lowering Smad7 levels in prostate cancer cells reduces the compound's ability to cause cell death, leading to potential breakthroughs in personalized cancer treatment.
Researchers have discovered a new treatment that uses a chemical to prevent PARP repair, making recombination essential for cancer cell growth. This approach shows promise as a potential breakthrough for women with hereditary breast cancer.
Researchers developed nanoshells that can detect breast cancer biomarkers and destroy cancer cells using near-infrared light absorption. This combined imaging and therapy method offers a faster and less expensive alternative to existing medical imaging techniques.
Researchers at Boston University have discovered a new gene, STAT6(B), that regulates vascular endothelial growth factor (VEGF) and affects TNF-alpha levels. This finding offers new opportunities for treating cancer and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.
Researchers found that sociocultural and racial factors independently predicted treatment patterns in early-stage prostate cancer. Married men were more likely to receive curative treatment than unmarried men, regardless of ethnicity.
Scientists have identified two populations of immune cells in the liver that can cause scarring and break it down. This discovery may lead to future treatments for liver damage and cirrhosis, a condition that affects more women in the UK than cervical cancer.