Articles tagged with Drug Studies
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A computer-automated monitoring system identified a drug-releasing stent with significantly higher rates of major adverse cardiac events compared to similar stents. The study found that automated surveillance of clinical registries can efficiently identify emerging postmarket safety risks.
A randomized trial found that mycophenolate mofetil was less effective than azathioprine in preventing relapses of antineutrophil cytoplasmic antibody-associated vasculitis. The study involved 156 patients with newly diagnosed AAV and followed them for a median of 39 months.
A recent clinical trial found that artesunate reduces deaths from severe malaria by 22.5% compared to quinine, and is associated with fewer complications such as seizures and low blood sugar in children. The findings have prompted a call for change to treatment guidelines worldwide.
Researchers found a Japanese asthma drug can stop the spread of breast cancer cells and reduce tumour growth by 50%. Tranilast targets a molecule in cancer cells that binds to the aryl hydrocarbon receptor, making it beneficial for treating allergies, inflammatory diseases, and cancer.
Researchers have discovered two new compounds that target neuronal nicotinic acetylcholine receptor subtype α3β4* to treat both alcohol and nicotine dependence. The compounds significantly decreased alcohol consumption in rodents without affecting their sucrose intake.
A new study suggests that bortezomib, a proteasome inhibitor, reduces disease severity and inflammation in an animal model of inflammatory arthritis. The drug promotes bone healing and displays favorable effects in targeting critical cell populations involved in the development of RA.
A study published in Health Affairs found that eliminating copayments for diabetes and vascular disease patients stabilized statin adherence rates, with a 2.8% increase in the Pitney Bowes group compared to a control group. Similarly, lower copayments for clopidogrel prescription led to an immediate stabilizing of adherence rates.
A new study published in the New England Journal of Medicine found that crizotinib caused tumors to stop growing, shrink or disappear in 57-33 percent of patients with a specific genetic mutation. This represents a significant improvement over the current standard treatment, which has a response rate of around 15 percent.
The University of Rochester Medical Center has been awarded a $1 million contract to launch an initiative that aims to accelerate the identification of improved pain treatments. The partnership, known as Analgesic Clinical Trial Innovations, Opportunities, and Networks (ACTION), will analyze clinical trials to identify problems in tria...
New data from Phase 3 studies demonstrated telaprevir-based combination therapy achieved higher viral cure rates (75%) compared to current therapies, with significant improvements in response to treatment across various patient groups. African Americans and those with advanced liver fibrosis or cirrhosis also showed improved SVR rates.
A clinical trial found that daily doses of crizotinib shrank tumors in over half of patients with ALK-rearranged non-small-cell lung cancer, and suppressed growth in another one-third. The treatment has been shown to significantly improve symptoms and quality of life for these patients.
A landmark study found that a high resting heart rate is associated with a higher risk of death from cardiovascular and all causes, even after adjusting for other risk factors. Patients with heart rates above 78 beats per minute had a 39% increased risk of major vascular events.
A new study found that statin use reduces the risk of developing epilepsy in people over 65 with cardiovascular disease. The study showed a 35% lower risk of hospitalization for epilepsy among those taking statins compared to non-users.
A study found significant variability in monacolin levels among commercial red yeast rice supplements, ranging from 0.31 to 11.15 milligrams per capsule. The presence of citrinin, a potentially toxic compound, was detected in one-third of the products.
Researchers found that smokers with anxiety disorders were less likely to quit smoking, even when using nicotine lozenges and patches. Anxiety diagnoses were common among study participants, with over a third meeting criteria for at least one anxiety diagnosis.
A landmark trial will recruit 500 children to test a patented extract of North American ginseng called COLD FX, with 60% expected to develop an infection and be eligible for the study. The trial aims to provide safe and effective treatment options for parents struggling with pediatric cold and flu medicines.
A systematic review found associations between exposure to pharmaceutical company information and higher prescribing frequency, costs, and lower quality prescribing. However, the authors did not find evidence of net improvements in prescribing behavior.
Researchers found that people with periodontal disease are at high risk for cardiovascular disease and that invasive dental procedures may raise this risk. However, studies have not consistently shown a link between these procedures and cardiovascular events. Meanwhile, peer support programs improved diabetes management in patients, su...
A study published in Annals of Internal Medicine questions the foundation of placebo-controlled trials, citing a lack of standardization and regulation for placebo ingredients. The researchers found that only 10% of cases disclose the makeup of placebos, leading to potential biases in study results.
Studies found that acid reflux and functional dyspepsia patients are more likely to experience disordered sleep, with exercise and routine decreasing the risk. Baclofen and esomeprazole show promise as treatments for improving sleep quality in nighttime heartburn sufferers.
A new study found that single-dose nevirapine can hamper the drug's effectiveness if used later to treat HIV-infected women. The WHO has revised its guidelines to advise against using nevirapine in combination with other drugs, if treatment begins fewer than 12 months after exposure.
A study of nearly 2,000 patients who had been treated for a heart attack found that many were not receiving the correct dose of beta blockers. The majority of patients were taking less than 50% of the target dose, which can lead to increased risk of subsequent heart attacks.
Experiments with artificial stomachs suggest that combining Compound X with Sprite improves its absorption. This could lead to better treatment outcomes for patients taking the oral anticancer drug.
Two studies found that African-American patients and those with Medicaid are at higher risk of first hospital readmission. Additionally, poor nutrition and depression increase the likelihood of further rehospitalizations. Researchers emphasize the need for targeted interventions to reduce preventable readmissions.
Two NIH-funded studies influenced the WHO's revision of its guidelines for treating HIV-infected women and infants. The studies found that a single dose of nevirapine to prevent mother-to-child transmission can hamper the drug's effectiveness if used later as part of a treatment regimen. As a result, the new guidelines advise against u...
A study found that buprenorphine implants significantly reduced opioid use over 16 weeks, with 65.7% of patients remaining in the study for 24 weeks and fewer withdrawal symptoms. The implants also showed promise in decreasing non-medical opioid use.
A Phase 3 trial showed patients receiving Probuphine had significantly less illicit opioid use and fewer withdrawal symptoms compared to placebo. The innovative implant formulation provided a steady, round-the-clock low dose of buprenorphine over six months.
A phase II clinical trial is underway to examine the efficacy of Revatio (sildenafil) in improving cardiac function for individuals with Duchenne muscular dystrophy. The six-month study aims to slow disease progression and increase life expectancy.
The Phase III trial confirms that abiraterone acetate extends life by four months for patients with advanced prostate cancer, improving median overall survival to 14.8 months. This breakthrough treatment challenges the standard care for men with advanced disease.
Global research has identified new genes associated with body fat distribution and obesity, shedding light on biological processes involved. The studies found 13 new gene regions linked to waist-hip ratio and 18 genetic variations associated with increased susceptibility to obesity.
A nationwide clinical trial is underway to test the effectiveness of ranolazine in treating ventricular arrhythmias. The study aims to determine if ranolazine decreases death and cardiac arrhythmias, as well as hospitalizations from cardiac causes.
A new Ohio University-led study suggests that combining preventive medication and behavioral changes offers significant relief from frequent, disabling migraines. The research found that the combination of these interventions resulted in a 77% reduction in migraine frequency, days with migraine, and improved quality of life.
A new definition of Alzheimer's disease has been proposed to diagnose the condition earlier and select patients for trials of disease-modifying treatments. The revised definition includes biomarkers as a key diagnostic feature, enabling diagnosis at an earlier stage, and allows for more precise selection of patients for clinical trials.
A new type of cancer treatment has shown encouraging activity as a first-line therapy in HER2-positive metastatic disease. The study demonstrated that T-DM1 has good anti-tumor activity and much lower toxicity compared to the older standard.
Researchers at U-M are investigating adaptive clinical trials to improve the efficiency of clinical trials. The goal is to accelerate drug and device evaluation, improve safety for patients, and reduce costs. Adaptive clinical trials make adjustments based on accumulated data to identify effective treatments more accurately.
A new nutritional supplement containing S-equol has been shown to reduce moderate to severe hot flashes, muscle and joint pain, and improve bone density in postmenopausal women. The supplement also lowers 'bad' LDL-cholesterol levels and is considered safe for long-term use.
A clinical trial of gene therapy for muscular dystrophy has uncovered an unexpected aspect of the disease, revealing that some patients mount an immune response to the dystrophin protein even before receiving treatment. The study suggests that tailoring treatment approaches to suit individual patient needs could lead to better outcomes.
The MU College of Veterinary Medicine is conducting a study to examine the efficacy of Attaxol in dogs with naturally occurring cancer. The study aims to determine the optimal dose and treatment duration for this cancer drug, which was developed specifically for canine use.
The new journal will publish theoretical and research papers on cognitive brain development, covering neurocognitive development, social and affective aspects, and various methodologies. Authors are encouraged to submit contributions using diverse neuroscience approaches.
Onconova Therapeutics has agreed with the FDA on a Special Protocol Assessment (SPA) for its Phase 3 trial of Estybon in patients with myelodysplastic syndromes. The trial is expected to begin in Q4 2010 and will compare Estybon to Best Supportive Care.
Researchers aim to determine if vigorous exercise can help people abstain from stimulant abuse and improve their health. The study, STRIDE, will monitor participants' drug abstinence and relapse rates, as well as physical and mental health outcomes.
A study by Boston University School of Medicine found no significant difference in visual acuity or anatomic outcomes between patients treated with Bevacizumab (Avastin) and Ranibizumab (Lucentis) for age-related macular degeneration. Patients receiving Avastin underwent more frequent injections, but the results showed similar improvem...
The TRUST study found that erlotinib significantly increased survival for patients with previously treated advanced NSCLC. Certain patient groups, such as adenocarcinoma, women, and Asian ethnicity, showed greater tumor responses to EGFR TK inhibitors.
Researchers found that adding rituximab to chemotherapy significantly prolongs lives of CLL patients. Chemoimmunotherapy showed improved response rates and disease progression rates compared to standard chemotherapy alone.
Researchers propose a new approach to combat cancer and autoimmune diseases by targeting the balance between NF-kB and p53 signaling pathways. This balance is believed to be a promising target for developing new drugs, with potential benefits including improved disease treatment outcomes.
A large international study has identified hundreds of genes contributing to human height, revealing that a combination of multiple genes determines an individual's stature. The research points the way for future studies exploring how these genes interact to impact growth and development.
A new drug, tanezumab, significantly reduces knee pain in osteoarthritis, but a small number of participants developed worsening arthritis and bone changes requiring joint replacements. The FDA is examining data to decide on the drug's future use.
A recent study published in Neurology found that intravenous treatment with dexamethasone can significantly reduce the mortality rate of patients with bacterial meningitis. The study revealed a 10% lower death rate among those treated with dexamethasone, highlighting its potential as an effective therapeutic option.
A recent study published in Arthritis & Rheumatism found that abatacept failed to prevent disease flares in patients with non-life threatening systemic lupus erythematosus (SLE). The medication was administered to 175 patients, but it did not show significant therapeutic benefits over placebo.
A phase II clinical trial found tanezumab to be effective in reducing osteoarthritis knee pain, with a 62% reduction in walking knee pain compared to placebo. The drug also showed promise in improving physical function and relieving stiffness.
A meta-analysis of 70 randomized trials found that disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids significantly reduced radiographic joint destruction, similar to biologic agents. Combination therapies also showed promise in reducing structural damage.
A new Stanford study examining pine-bark extract's effects on blood pressure found no significant benefit in lowering blood pressure or reducing other risk factors for heart disease. The study, which recruited 130 overweight individuals, used a Japanese-produced pine-bark extract and confirmed its safety but found no health benefits.
Researchers found improved lung function after inhaled steroids is related to breathing function measures, not genetic ancestry. The study suggests that a commonly used asthma medication is equally beneficial across racial groups.
A new study published in JAMA found that self-management counseling for patients with mild to moderate heart failure did not reduce the rate of death or hospitalization compared to educational materials alone. Despite advances in therapies, patient nonadherence remains a significant challenge.
Researchers found that high-dose intravenous aspirin significantly reduced pain in patients with severe withdrawal headaches caused by medication overuse. The study showed that 25% of participants experienced a significant reduction in pain, while 40% reported a modest pain reduction.
The LEADERS trial shows a biolimus A9-eluting stent with biodegradable polymer is non-inferior to a sirolimus-eluting stent with durable polymer in terms of safety and efficacy at 3 years. Researchers found that both stents have equivalent rates of target lesion revascularization, cardiac death, myocardial infarction, and clinically in...
A growing concern is the increasing volume of clinical trials and systematic reviews published every day. The authors propose reducing unnecessary trials to prioritize truly systematic reviews, ensuring that patient needs are met through valid answers. Open access to these resources is also emphasized.
A new study found that the effectiveness of anti-HIV drugs darunavir and ritonavir was similar between men and women. However, women dropped out of the trial at higher rates than men due to reasons other than drug failure. The study aims to improve retention of diverse populations in HIV treatment trials.
A new trial aims to determine if taking daily doses of a fish oil extract and aspirin can shrink existing polyps and prevent new ones from forming in the bowel. If successful, this treatment could reduce the need for frequent colonoscopies in patients at risk of developing bowel cancer.
A phase 2 trial found that pazopanib, an antiangiogenetic drug, significantly improved outcomes for patients with advanced differentiated thyroid cancers. Approximately 49% of patients experienced a partial response, with two-thirds likely to have a lasting response over 1 year.