Articles tagged with Drug Studies
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Researchers found that black high-risk patients were more likely to receive older treatments and less likely to receive newer drugs, including glycoprotein IIb/IIIa inhibitors and clopidogrel. Despite these disparities, short-term outcomes did not differ significantly between blacks and whites.
The new £6m biocentre will pioneer a novel approach to genomics, combining theoretical models with experimental data. This will enable pharmaceutical companies to develop safer medicines more efficiently by predicting human reactions in advance.
Researchers found that postmenopausal breast cancer survivors have a higher risk of bone fractures, with 68.6 excess fractures per 10,000 person-years compared to the general population. The study also identified factors associated with increased fracture risk, including age, ethnicity, and depression.
A new study published in JAMA Network found that computerized order entry (CPOE) systems can facilitate up to 22 types of medication error risks. The researchers identified issues such as fragmented displays, pharmacy inventory mistakes, and inflexible ordering formats as contributing factors.
A University of Pennsylvania study identified 22 ways in which CPOE systems facilitate medication errors, including information errors and human-machine interface flaws. The researchers recommend that institutions focus on the organization of work within the hospital and continuously evaluate and improve their technology.
A Mayo Clinic study establishes a threshold for valve repair surgery in patients with severe mitral regurgitation, indicating that those with large regurgitant orifice areas are at high risk of death if treated medically. The study suggests that valve surgery can restore normal life expectancy and reduce mortality by up to five times.
A study analyzing data from four clinical trials found that older patients with lymph node-positive breast cancer can tolerate standard and intensive chemotherapy regimens similarly to younger patients. The findings suggest that age is not a barrier to the effectiveness of adjuvant chemotherapy in healthy older women.
The NHGRI has approved a plan to sequence the genomes of 12 new organisms, including marmoset, skate, and disease-carrying insects, to gain insights into human health and disease. The project aims to identify genetic variations associated with common illnesses and develop powerful tools for biomedical research.
A study involving genetically altered mice has found similarities with essential tremor disease in humans, suggesting that the GABA system plays a role in the condition. The findings may lead to new treatments for essential tremor, which affects an estimated 5 million Americans.
Researchers at Mount Sinai School of Medicine discovered that alpha-defensin-1, a protein found in cells, can directly inactivate HIV virus and block infection in vulnerable cells. The findings offer insight into the function of alpha-defensin-1 on both the virus and the cell, potentially leading to new avenues for prevention and therapy.
A recent study published in the Archives of Internal Medicine found that medication errors are a significant issue in hospitalized patients. The study examined 151 patients who took at least four prescription medicines at home and had unplanned hospital admissions, revealing that 53.6% had at least one unintended medication discrepancy.
A study found that 53.6% of patients had at least one unintended medication discrepancy upon hospital admission. The most common error was omitting a regularly used medication, with 38.6% having the potential to cause moderate to severe discomfort or clinical deterioration.
A new study on Rhesus monkeys found that a gender gap in spatial memory decreases with age and can be overcome with simple training. Young female monkeys showed significant improvements in spatial memory when trained, closing the gap between males and females.
A new study published in the New England Journal of Medicine found that treatment with recombinant activated factor VII (rFVIIa) significantly reduces bleeding in brain, decreases mortality by nearly 40%, and reduces long-term disability for patients with intracerebral hemorrhage (ICH). The study showed a significant improvement in cli...
A new investigational transplant drug called LEA29Y has been shown to selectively block the co-stimulatory signal that triggers an immune response, thereby preventing organ rejection and preserving kidney function. This approach avoids the toxic side effects associated with current immunosuppressant medications like cyclosporine.
A large clinical trial found that menopausal hormone therapy increased the incidence of urinary incontinence, particularly stress UI, and worsened its characteristics among symptomatic women. The study suggests that MHT should be reevaluated as a treatment option for UI.
A recent study analyzed 231 articles on weight loss studies, revealing inadequate reporting of subject characteristics. The findings show that 92% of studies missed medication use, 34% ignored health status, and 86% failed to indicate ethnicity.
A study of 34,133 patients found that only 55.7% received antimicrobials within an hour before incision, while 9.6% started treatment more than four hours post-incision. The results highlight opportunities to improve the use of antimicrobial prophylaxis to prevent surgical site infections.
Researchers found that women with diabetes had over two and a half times the risk of heart disease compared to women without diabetes. Men with diabetes had about a 90% higher risk of dying from CHD as men without diabetes.
Researchers found that adding a vaccine targeting the Philadelphia chromosome protein can reduce residual disease and increase molecular response in patients with chronic myeloid leukaemia. The vaccine was shown to be effective in combination with imatinib and interferon alfa treatments.
Researchers confirm Vioxx increased cardiovascular risk by nearly doubling events, including heart attacks and strokes, in patients with recurrent colon polyps. The trial was stopped early due to safety concerns.
A meta-analysis of 19 randomized trials found COX-2 inhibitors significantly associated with blood pressure elevation compared to NSAIDs and placebos. This increased risk may be clinically significant for patients at elevated cardiovascular risk, particularly in the elderly population.
Researchers discovered that prostaglandin PGD2 has protective effects in the brain, potentially outweighing its negative consequences. The study suggests that targeting this prostaglandin may lead to new therapeutic approaches for conditions involving brain damage, such as stroke and Parkinson's disease.
A large-scale trial is underway to test two topical microbicides, PRO 2000 and BufferGel, for preventing HIV and other STIs. The study aims to evaluate the safety and effectiveness of these microbicides, which could provide a valuable woman-controlled means of slowing the pace of the HIV/AIDS epidemic.
A new study found that a once-daily treatment of the antibiotic tobramycin is effective in treating cystic fibrosis patients, particularly in reducing kidney-related side effects. The trial recruited 219 patients and showed similar results in both children and adults.
Researchers found that ximelagatran was as effective as warfarin in preventing venous thromboembolism, but had a lower risk of bleeding. In another study, ximelagatran also showed promise for stroke prevention in patients with atrial fibrillation, with a lower rate of major and minor bleeding
The SPORTIF V trial found ximelagatran effective in preventing strokes and systemic embolic events, but with higher mortality rates compared to warfarin. The study results suggest a solid clinical benefit for ximelagatran, but more research is needed to safely bring it to market.
A phase II clinical research study uses VEGF-2 gene therapy to stimulate growth of new blood vessels, relieving angina symptoms. The study aims to improve quality of life for patients with refractory chest pain.
The study found that low pulmonary function and allergic inflammation are key factors in responding well to inhaled corticosteroids. Younger patients with fewer years of asthma tend to respond better to leukotriene receptor antagonists.
Researchers found that two drugs, risperidone and olanzapine, have the best evidence for effectiveness in treating dementia-related behaviors. However, these effects are modest and come with a risk of stroke. Non-drug therapies like music therapy and caregiver education may also be effective.
A new JAMA study found that brain tumor treatment varies greatly among patients, with inconsistent use of chemotherapy and anti-convulsant medication. The study also highlights the need for improved communication between healthcare providers and patients, as well as increased participation in clinical trials.
A randomized, placebo-controlled trial showed etanercept was ineffective in preventing disease flares for patients with Wegener's granulomatosis. The study found that most patients experienced disease remissions at a high cost due to treatment-associated adverse effects.
Reviparin significantly reduced the composite outcome of death, heart attack, and stroke at 7 and 30 days. Its benefits persisted even when initiated very early after symptom onset, with a 13% lowered risk. Reviparin is considered a moderate but important advance in managing patients with acute myocardial infarction.
A study published in Archives of Internal Medicine found that communication between primary-care physicians and patients can reduce medication-related problems. The researchers discovered that 25% of patients experienced adverse drug events, many of which were preventable, due to a lack of reporting or inadequate doctor response.
Recent studies on COX-2 inhibitors have found that celecoxib may not increase blood pressure, while rofecoxib does, and that these drugs are safe for patients with type 2 diabetes. However, patients taking warfarin with COX-2 inhibitors or NSAIDs have an increased risk of upper gastrointestinal hemorrhage.
A study published in Archives of Internal Medicine found that 63% of growth in COX-2 use came from patients with low risk of gastrointestinal bleeding. Heavy marketing and the tendency to equate 'newer' with 'better' medicines contributed to the overuse of these drugs.
The Insulin Resistance Intervention after Stroke (IRIS) trial aims to investigate the effectiveness of pioglitazone in reducing recurrent stroke and myocardial infarction among eligible participants. The trial will enroll 3,136 participants over three years and tests the hypothesis that pioglitazone reduces risk by 20 percent.
Common antidepressants lower effects of tamoxifen in many women, with different SSRIs affecting active tamoxifen byproducts in the blood. Genetic testing may help identify groups that benefit more from one SSRI than another.
A meta-analysis of two trials suggests that COX-2 inhibitor Bextra elevates the combined incidence of heart attack and stroke three-fold in patients undergoing coronary artery bypass graft surgery. The researchers also found that another COX-2 inhibitor caused changes in atherosclerotic plaques, potentially increasing the risk of rupture.
A recent study by Emory University Health Sciences Center found that patients with depression are less likely to clear the hepatitis C virus from their blood after six months of treatment. Only 34% of those experiencing a significant increase in depression were able to clear the virus, compared to 59-69% of those with milder increases
A study by Northwestern Memorial HealthCare found that non-cardiologists prescribed fewer medications to heart patients, including ACE inhibitors and beta-blockers, than cardiologists. The study suggests that cardiologists are more likely to order diagnostic tests without increasing hospital stays.
Researchers identified adherence to medication regimen as key factor in developing HIV drug resistance. High adherence levels were associated with faster development of resistance, emphasizing the importance of strict medication adherence in maintaining treatment efficacy.
A new study suggests that insufficient sleep may be a contributing factor to weight gain and the development of metabolic syndrome. This condition increases the risk of serious diseases such as diabetes and cardiovascular disease.
A study by U-M researchers found that night-time splinting can effectively improve hand and wrist discomfort for active workers with early symptoms of carpal tunnel syndrome. The results showed significant improvement in symptoms for half of the splinted group after six weeks.
Researchers found that drinking chamomile tea increased urinary levels of hippurate, a compound associated with antibacterial activity, and glycine, an amino acid that relieves muscle spasms. The compounds remained active for up to two weeks after stopping tea consumption.
Researchers discovered impaired lung function test results and low exhaled nitric oxide levels in school-age BPD survivors, indicating distinct pathophysiologic pathways. Meanwhile, individuals with beryllium sensitization progressed to chronic beryllium disease at a rate of 6-8% per year.
The author highlights the need for more trials to assess cardiovascular risks of COX-2 inhibitors in clinical settings. The FDA's authority is crucial in ensuring the safety profile of prescription medicines and restoring public trust.
OHSU researcher recommends increasing public access to FDA's clinical trials registry and results database. This would provide a comprehensive view of drug efficacy and safety, benefiting healthcare providers, researchers, and the public. The FDA could make its reviews more user-friendly with minimal staffing increases.
Researchers found that urinary calcium levels play a significant role in the formation of both calcium oxalate and calcium phosphate stones. The studies suggest that patients with elevated intestinal calcium absorption and urinary calcium levels may need to limit their calcium intake to prevent kidney stone formation.
The NIH has suspended the use of celecoxib, a COX-2 inhibitor, in its large-scale cancer prevention trial after finding a two-fold increased risk of cardiovascular toxicities. The decision was made following a September 2004 report that highlighted concerns over the safety of rofecoxib, another COX-2 inhibitor.
A study of high-risk asthma patients shows that hospitalization can lead to a rapid decrease in prescribed medication use. Another study finds that inhaled corticosteroids may contribute to reduced bone density, particularly in individuals with COPD. Researchers also identify occupational exposure to insecticides and moldy environments...
A study found that women at high risk of breast cancer have difficulty deciding whether to take tamoxifen, with factors such as personal history, physician advice, and perception of risk playing a significant role. Anxiety and psychological distress also influence decision satisfaction.
Researchers identified phenolic compounds in pine bark extract with high biological activity, including potent inhibition of nitric oxide and prostaglandin production. The study suggests that consuming pine bark-based food supplements may help alleviate arthritis symptoms.
A large phase III trial showed that sequential treatment with ELLENCE delivered superior disease-free and overall survival compared to FEC 100 alone. The sequential regimen resulted in a 17% reduction in relapse risk and a 23% reduction in mortality risk.
A new antibiotic shows promise in treating tuberculosis by shortening treatment time and fighting drug-resistant strains. The drug, called R207910, operates differently than other antibiotics and appears to inhibit the bacteria's energy supply.
A recent study published in NEJM found that levodopa did not accelerate Parkinson's disease progression but may actually slow it. The multi-center trial involved 361 newly diagnosed patients and showed a clear-cut benefit of levodopa, with higher dosages producing more beneficial results.
U of MN researchers have developed a new approach to adult cord blood transplantation, achieving high engraftment rates and low complications. The treatment uses combined use of two cord blood units from different donors, offering potentially life-saving therapy to patients previously denied treatment.
Two studies found that physicians who cared for more terminally ill patients were less likely to support assisted suicide, but more supportive of terminal sedation. Attending religious services also appeared to increase opposition to assisted suicide. The findings suggest a complex relationship between medical ethics and personal beliefs.
Researchers have discovered that BMS-354825 and AMN107 can effectively treat patients with leukemia who are resistant to Gleevec therapy. The studies found remarkable activity in these novel compounds, with high response rates and improved survival outcomes.
The new compound BMS-354825 successfully overcomes Gleevec resistance in patients with chronic myeloid leukemia, showing an 85% success rate in phase I clinical trials. Researchers believe the drug's unique mechanism of action may provide a solution to this common problem.