Articles tagged with Drug Studies
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Researchers at Mayo Clinic found that pyridostigmine improved patients' standing blood pressure and reduced symptoms without elevating blood pressure while lying down. The study showed significant results in reducing the need for other medications, particularly in those over age 70 with common causes like diabetes and Parkinson's disease.
A clinical trial investigates botanicals like black cohosh and red clover for memory loss in menopause, exploring their potential as alternatives to hormone therapy. The study aims to understand how these therapies may influence brain function and cognitive performance.
Researchers studied 31 healthy men with medication-induced hypogonadism, finding that acute testosterone suppression led to low blood levels of testosterone. Most participants showed no significant differences in symptoms between leuprolide plus placebo and leuprolide plus testosterone groups.
A systematic review and meta-analysis found that antioxidant supplements do not prevent gastrointestinal cancers and may actually increase mortality risk. The study analyzed data from 14 randomized trials involving over 170,000 participants.
Two studies strengthen the connection between chronic kidney disease (CKD) and cardiovascular disease, showing that reduced kidney function increases the risk of death, heart disease, and hospitalization. Early detection and treatment are crucial to slow CKD progression and prevent these complications.
The second-generation antisense cancer drug OGX-011 has shown promising results in a Phase I trial, inhibiting clusterin production in patients' cancers. The Phase II trials will investigate the effectiveness of OGX-011 combined with standard chemotherapy in patients with metastatic hormone refractory prostate, breast, and lung cancer.
The CYPHER Stent significantly reduces major adverse cardiac events in women, including diabetics and smokers, by up to 90% over conventional bare metal stents. The analysis of 345 female patients showed a low target lesion revascularization rate, indicating fewer procedures and better outcomes for women with heart disease.
Experts dispute FDA warnings on antidepressants and suicidal risk, citing limited data for children and adolescents. Studies show a decrease in suicides over years of growing SSRI use, but caution is advised when interpreting the data.
Researchers at Duke University Medical Center found that acupuncture is more effective than medication in reducing postoperative nausea and vomiting, as well as decreasing pain levels. The study, which used electro-acupuncture, showed significant improvements in patient satisfaction and comfort after major breast surgery.
Researchers at Thomas Jefferson University found a significant decrease in liver rejection rates using a monoclonal antibody, basiliximab, in combination with tacrolimus and low-dose steroids. The one-year survival rate improved to 88%, with no complications reported.
Two studies published in Science suggest that eosinophils play a crucial role in the development of asthma, but the exact mechanisms are not yet clear. The findings challenge previous theories and highlight the importance of considering individual genetic factors in treating asthma.
A study led by the University of Rochester Medical Center found that cancer drug rituximab significantly improves health in patients with lupus by reducing B cells. The treatment was effective for 11 out of 17 patients, with many able to reduce or discontinue traditional medications.
Researchers at the University of Alberta have found a promising treatment for premature ejaculation using gabapentin, which increases aminobutyric acid (GABA) levels in the brain. The study suggests that gabapentin can prolong ejaculation without significant side effects, making it a potential option for men with PE.
A team at Georgia Institute of Technology has developed heat-controlled drug implants that can release medication over an extended period, targeting conditions like diabetes. The films, made from microparticles, could be triggered by blood glucose monitors to administer insulin or other medications.
A study of 660 chronically ill adults found that many patients with high medical expenses underuse essential medications, leading to increased emergency department visits and poorer health outcomes. Despite this, healthcare providers often fail to address medication costs, leaving patients vulnerable to financial burden.
The ICMJE editors announce that major medical journals will require registration of clinical trials prior to patient enrollment, aiming for full transparency and accessibility. This policy applies to any clinical trial starting after July 1, 2005, and encourages other biomedical journals to adopt similar policies.
A new cancer drug, SAHA, has shown potential in reducing kidney disease in lupus patients by inhibiting the onset of lupus-related kidney disease and decreasing spleen size. Further studies are needed to confirm its effectiveness and understand its anti-inflammatory properties.
A randomized, double-blind trial found that galantamine hydrobromide did not provide a significant clinical benefit for patients with CFS. Despite being well-tolerated, the study confirmed the lack of effectiveness of this medication in addressing core symptoms.
Virtual colonoscopy shows significant promise for colorectal cancer screening, but practical issues must be addressed before widespread use. Issues include standardization of test performance and interpretation of results, as well as the potential need for multiple procedures to detect and remove polyps.
A study by Texas A&M University researchers suggests that women using nicotine therapy (NRT) may struggle to quit smoking due to various factors. NRT proved effective in the short term for both men and women, but long-term follow-up revealed that only men benefited from the treatment.
A five-year head-to-head trial of three common anti-epileptic drugs will enroll 439 children aged two to 13. The study aims to determine the best initial medicine for childhood absence epilepsy, which affects 10-15% of all epilepsy cases in children.
A new study highlights the long-term efficacy and safety of the angina drug nifedipine GITS, showing it can be used safely for the treatment of patients with coronary disease. The trial found similar mortality rates among those receiving the medication and a placebo, but lower incidence of heart failure and coronary interventions.
A new study suggests that early initiation of intensive statin treatment after a heart attack may lower the risk of future cardiovascular events. The research found that participants who received high-dose simvastatin had better outcomes than those on a placebo, despite an increased risk of muscle-related side effects.
The landmark PROVE IT-TIMI 22 trial found that a long-term regimen of antibiotics designed to kill Chlamydia pneumoniae does not reduce the risk of heart attacks or cardiovascular disease. Researchers recommend focusing on proven therapies like high-dose statin therapy and ACE inhibitors instead.
The ACTION study found that adding nifedipine to existing treatments for stable angina reduces the need for hospital interventions by 13% and prevents heart attacks and strokes. Nifedipine also reduces hospitalizations for heart failure in patients with stable angina.
Rimonabant has been shown to improve body weight, waist circumference, lipid profiles, and glycemic control. Patients taking rimonabant 20mg/day lost an average of 8.6kg, while those on placebo gained 4.8kg.
The EURIDIS trial demonstrated that dronedarone significantly lowers the risk of first recurrence of AF/AFL within the 12-month study period by 21.6% compared to placebo. Dronedarone proved effective for all recurrences of atrial fibrillation or flutter, including those that were symptomatic.
The ADONIS trial found that dronedarone significantly decreased the risk of a first recurrence of atrial fibrillation or flutter within the 12-month study period by 27.5% compared to placebo. The drug also displayed good cardiac tolerability with no cases of torsades de pointes.
Paediatric research is crucial for disease prevention and treatment, yet data are lacking due to a lack of legislation requiring companies to conduct trials on children. The UK Government's new initiative aims to invest £100 million in research networks but falls short of centre stage for acquiring research-based evidence.
A Nordic study found statins decrease mortality rate and incidence of cancer over 10-year follow-up. Statin therapy with simvastatin reduced cardiovascular and coronary mortality, with a 17% reduction in cardiovascular mortality.
A study found that Medicare beneficiaries who exceeded their capped drug benefits reported using less prescribed medication, while those who did not exceed their caps did not. The researchers also found that patients were more likely to call pharmacies for price comparisons and switch medications when they exceeded their caps.
A UCLA study of 1308 seniors found that 24% reduced or discontinued medications due to out-of-pocket costs. Many struggled to pay for essential medications and rent/bills.
A new compound called OSU 111 has been developed to target both cancer cells and the formation of new blood vessels that feed them. In laboratory experiments, it was found to be highly effective in killing prostate cancer tissue cells within three days.
A new study has identified five chromosomal regions that are likely to harbor prostate cancer susceptibility genes. The study found evidence of a gene on the long arm of chromosome 17 and four other regions that might hold susceptibility genes. Additionally, researchers have discovered that men who carry a specific mutation in the MIC-...
Researchers studied snake venom and found it blocks integrin receptors like human drugs, but leaves some activated. This may explain why some oral medications increase patient deaths – they don't bind to receptors inside platelets.
A Northwestern Memorial Hospital study demonstrates that medication reconciliation reduces patient harm and is cost-effective. Pharmacists play a critical role in reconciling medication discrepancies, which can occur during patient transfers or discharge.
A study found that nicotine therapy works as well for teens as for adults when used with behavioral skills training, but the effectiveness drops off for women. In contrast, adult smokers tend to maintain abstinence longer and are more successful in quitting with NRT.
Stanford and Packard researchers found that nicotine patches were equally effective in adolescents regardless of antidepressant medication. Most teens reduced tobacco usage, with some achieving complete abstinence after 10 weeks. The study marks a promising breakthrough in treating teen smoking addiction.
Researchers found topiramate effective in reducing drinking and craving in alcohol-dependent patients who were still drinking. The medication was also shown to decrease plasma GGT levels, a reliable biological marker of heavy drinking.
A meta-analysis of 11 randomised trials found that drug-eluting stents significantly reduced the rate of severe cardiac events by half, compared to bare-metal stents. Additionally, patients treated with drug-eluting stents experienced lower rates of restenosis, a common complication after stenting.
MGH cancer specialists propose a new 'selective approval' mechanism to identify most suitable patients for targeted therapies. This approach could improve treatment outcomes and reduce waste of resources.
A study by Duke University researchers found that over a year, one in five elderly Americans filled prescriptions for at least one 'drug of concern', including anti-depressants and anti-anxiety drugs with severe adverse effects. This highlights the need to improve education and screening of prescriptions to reduce risks.
A study published in Archives of Pediatric Adolescent Medicine found that antipsychotic medication prescriptions for children with attention-deficit/hyperactivity disorder (ADHD) increased dramatically between 1996 and 2001, from 23 per 10,000 to 45 per 10,000. The use of these medications for ASDHD/conduct disorders also rose signific...
The proportion of Tennessee children using antipsychotic medications for conditions other than psychosis nearly doubled between 1996 and 2001, with significant increases in ADHD and affective disorders. The study suggests an urgent need for well-controlled clinical studies to weigh the benefits against the risks.
A UK study found that a significant proportion of people with type 2 diabetes are managed solely through diet, receiving inadequate monitoring and care. This highlights the need for better routine surveillance and consistency in clinical practice to address the high rate of complications among these patients.
A new study has compared the efficacy of tacrolimus ointment and pimecrolimus cream in treating atopic dermatitis. The results show that tacrolimus ointment worked better for all severities of atopic dermatitis, including mild sufferers and severe patients. The six-week study involved 1,056 patients, aged 2 to 15, with mild to severe AD.
A groundbreaking study by Mount Sinai School of Medicine found that the combination of Pegasysα and Copegus significantly improved treatment response rates for patients co-infected with HCV and HIV. The study showed a sustained virological response rate of 40% among all patients, with even higher efficacy rates for those with genotypes...
A combination therapy of peginterferon alfa-2a and ribavirin achieved a 40% sustained virological response in co-infected patients, the highest ever reported. The treatment did not interfere with the effectiveness of HIV drugs, offering hope for previously untreated patients.
A new study shows that Frovatriptan is effective in preventing Menstrual Associated Migraine (MAM) headaches, significantly reducing their severity, duration, and functional impairment. The medication reduces MAM incidence by up to 50% and is well-tolerated with minimal side effects.
A study of 154 hospitalized stroke patients found that antihypertensive therapy was used more frequently than recommended by clinical guidelines. The majority of patients experienced relative hypotension, and one in 20 developed frank hypotension.
A new study led by Dr. Pierre Tariot found that quetiapine, an atypical antipsychotic, is effective in reducing agitation in patients with dementia, with a lower risk of side effects compared to other medications. The medication has shown no serious side effects so far and offers a new therapeutic option for patients and their families.
Researchers assessed the effectiveness of quetiapine in reducing agitation symptoms in Alzheimer's patients. A study also found a possible link between HIV treatment and increased risk of Alzheimer's disease due to abnormal protein deposits. An animal model has been developed to study tau protein tangles, a hallmark of Alzheimer's path...
Researchers have developed strategies to target beta-amyloid, a substance thought to kill brain cells in Alzheimer's. Preliminary success has been achieved with a drug candidate that appears safe and effective in reducing amyloid levels.
Researchers have discovered that N-acetylcysteine (NAC) can prevent cisplatin-induced ototoxicity, a type of progressive and irreversible hearing loss in patients undergoing chemotherapy for head and neck cancer. The study found that NAC was most effective when given 15 minutes before chemotherapy.
Cardiovascular patients who have undergone re-vascularization procedures tend to live longer and have a better quality of life, according to the study. The guidelines provide recommendations for pre-travel preparation, including medication management and airline security protocols.
A randomized study compared vitamin E and donepezil to placebo for delaying progression to Alzheimer's disease in patients with mild cognitive impairment. Patients treated with donepezil showed a modest delay in disease progression, but this effect was short-term.
The Alzheimer's Association and NIA are expediting prevention trials for Alzheimer's by developing more efficient tools, such as home-based testing. This will reduce costs and burdens on participants while gaining valuable information about the course of cognitive changes in late life.
A recent study demonstrated that a current Alzheimer drug may delay the transition from Mild Cognitive Impairment (MCI) to Alzheimer's disease, but only for the first 18 months. The treatment showed modest effects on progression to Alzheimer's, but more research is needed to confirm its efficacy.
The study found that participants on donepezil experienced a slower progression to Alzheimer's disease compared to those on placebo, with an average delay of 661 days. However, the effects were only observed during the first half of the study and further analyses are needed to confirm these findings.
A multi-site trial found that naltrexone injections significantly reduced drinking days and increased abstinence rates compared to placebo. The depot/injection form of naltrexone offered greater medication compliance, efficacy, and fewer adverse effects.