Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
In a study published in the Journal of Acquired Immune Deficiency Syndromes, researchers found that African participants took on average 91-94% of prescribed HIV medications. The study, which followed 34 participants over 12 weeks, used multiple adherence measures and observed high rates of viral suppression.
A new study found that most phase I studies of targeted, non-cytotoxic anticancer agents used traditional toxicity endpoints to determine the recommended dose, while non-traditional endpoints were rarely incorporated. Researchers also identified a potential mechanism for acrylamide's mutagenicity and discovered genetic polymorphisms as...
The meta-analysis of 22,000 patients found that enoxaparin was more effective than unfractionated heparin in preventing combined rates of death or heart attack. However, the difference was not significant for major bleeding or transfusion rates.
A study published in Pediatrics found that over-the-counter cough medicines containing dextromethorphan and diphenhydramine were no better than a non-medicated placebo syrup in providing nighttime relief for children with coughs. The study showed significant improvements in symptoms regardless of treatment, suggesting that natural hist...
The American Academy of Ophthalmology published significant studies in the July 2004 issue, shedding light on innovative treatments and technologies for various eye conditions. These groundbreaking findings have the potential to transform the field of ophthalmology and improve patient outcomes.
A clinical trial in Cameroon shows a generic fixed-dose antiretroviral tritherapy to be as effective as conventional therapies, with good patient compliance and high quality of the treatment. The treatment, which costs $20 per month, is well tolerated and provides a cost-effective solution for HIV treatment in developing countries.
The PROactive study assesses the effect of ACTOS on cardiovascular disease progression in patients with type 2 diabetes. The study examines whether pioglitazone reduces cardiovascular mortality and morbidity in a high-risk population.
A long-term study of 8,000 seniors found that those who cut back on prescription medicines due to cost had significantly worse overall and heart-related health outcomes. The study also showed that patients with depression over age 70 were more likely to experience a worsening of their condition if they cut back on their medications.
A nationwide study found that restricting medication use due to cost can lead to significant declines in self-reported health status and increased rates of depression among older adults. The study, which included over 7,900 participants, highlights the importance of access to prescription medications for older patients.
The Meharry-Penn State U54 Cooperative Reproductive Science Center aims to address health disparities in women's reproductive endocrinology. Four research studies currently recruiting participants will investigate racial differences in reproductive conditions such as polycystic ovary syndrome and fibroids.
In a European multicentre trial, 119 schizophrenia patients showed significant improvements in positive and negative symptoms after transitioning to risperidone long-acting injection. The study found that over one-third of patients experienced an improvement of more than 20% in the PANSS total score.
Researchers found that seizure-alerting dogs exhibited distinctive behaviors to anticipate seizures, with licking and protective actions being common. The study also highlights the importance of education and research in improving patient care through organizations like the American Academy of Neurology.
A recent study published in Neurosurgery found that administering clot-dissolving medication directly to the site of blockages resulted in a 50% success rate in reducing neurological disability, compared to 39% with IV treatment. The intra-arterial therapy showed better results in re-opening blood vessels and improving stroke outcomes.
A meta-analysis of 33 trials found that continuous use of asthma drugs increases airway inflammation and decreases bronchodilator response, while also posing cardiac risks for patients with chronic obstructive lung disease. The studies suggested that pharmaceutical company sponsorship may be a factor in the conflicting results.
The VALUE trial found no difference in cardiac disease between valsartan and amlodipine, but patients on valsartan had lower rates of hospitalization for heart failure and type 2 diabetes. Early blood pressure control was associated with improved cardiovascular outcomes.
A new study from the University of Michigan Health System found that pulsed dye laser therapy was not effective in treating acne. Researchers compared the changes in acne severity on both sides of the face, with no significant difference between treated and untreated sides.
Researchers found tamoxifen stimulates tumor growth in HER2-overexpressing breast cancer cells due to estrogen agonist activity. Combining tamoxifen with growth factor pathway inhibitors like gefitinib may help overcome resistance, according to a new study.
A new study shows that VELCADE (bortezomib) can significantly extend survival and induce important responses in relapsed and refractory multiple myeloma patients. The median overall survival was 17.2 months, with a 14.1-month duration of response and 15.3-month time to disease progression.
Recent studies sponsored by GSK have shown mixed results for paroxetine's safety and efficacy in children. The company faces criticism for 'off-label' prescribing, despite a lack of published trials demonstrating its benefits. GSK is urged to disclose all relevant documents related to paroxetine use in minors.
Researchers at UIC are testing pioglitazone, a diabetes drug, to treat multiple sclerosis. The study found that the drug reduces inflammation of nervous tissue and prevents aberrant immune responses, potentially offering new hope for treating MS.
The combination of BAY 43-9006 and standard chemotherapy showed durable partial responses in 40% of patients with advanced metastatic melanoma. The study demonstrated anti-tumor activity that was not solely dependent on a BRAF gene mutation, offering new hope for treatment options.
A new clinical trial data shows Saforis reduces incidence of moderate to severe oral mucositis by 22% and demonstrates excellent safety profile. Saforis has been evaluated in pediatric and adult patients with various cancer types, showing promise for treatment of this debilitating side effect.
BAY 43-9006 demonstrates durable disease stabilization or tumor shrinkage in 89 participants with renal cell carcinoma. The study also shows an estimated median time to tumor progression of 48 weeks, with 88% of patients remaining progression-free at six months.
Two landmark studies show that Taxotere-based regimens improve patients' PSA responses by 43% and pain responses by 59%, leading to a 27% increase in disease-progression-free survival. The treatment also provides hope to thousands of men worldwide, offering an important new option for living longer.
In a Phase III trial, over 65% of early-stage HER-2 positive breast cancer patients achieved a complete response rate when treated with Herceptin and chemotherapy. The results were so striking that the trial was halted early after accruing 42 patients.
A new investigational drug has shown promise in treating kidney cancer, producing durable responses and stable disease in patients. The study found that nearly two-thirds of patients experienced stable disease after 12 weeks, and the median time to progression was nearly one year.
A novel therapeutic bortezomib combination will be tested in a phase II trial for advanced non-small cell lung cancer. The regimen, combining bortezomib with gemcitabine and carboplatin, shows promise in preclinical research, where giving bortezomib last may enhance its effectiveness.
A multicenter trial demonstrated that Taxotere in combination with cisplatin and 5-FU prolonged progression-free survival by 12.7 months compared to the standard treatment. Patients also showed significantly improved overall response rates, indicating a potential new paradigm for treating head and neck cancer.
A Phase III trial found Velcade to be more effective than dexamethasone in treating relapsed multiple myeloma, with a 58% increase in efficacy. The study showed improved survival and reduced time to disease progression for patients receiving Velcade.
A University of Pittsburgh study finds that throwing athletes' shoulders differ from non-throwers', suggesting adaptations for efficient performance. Additionally, stronger hip muscles in golfers correlate with better performances. Research also highlights the importance of unplanned reactive jumps in ACL injury prevention.
The study found that higher doses of Concerta were associated with significantly greater symptom response and remission rates in children with ADHD, compared to immediate-release methylphenidate. Overall, 70% of subjects showed a clinically meaningful treatment response to Concerta.
A study found a high level of agreement between brown bags and pharmacy records, with mismatches often caused by missing medications from the pharmacy records. The method is useful for monitoring medication adherence in low-income older adults, particularly those with worse health or certain medical conditions.
Researchers found that COX-2 inhibitors significantly reduced postoperative pain, nausea and vomiting, and allowed patients to return home sooner. The study showed a 21% reduction in opiate use and improved patient satisfaction with minimally invasive surgery.
This June 2004 Ophthalmology Journal issue presents various studies on retinal detachment, glaucoma valve implantation, and age-related maculopathy. The efficacy and safety of adjunctive Mitomycin C during Ahmed Glaucoma Valve Implantation are also examined.
Researchers found that genetic variations in XPD and XRCC1 genes are associated with decreased median survival in non-small cell lung cancer patients. Patients with more variations in these genes had shorter survival times, with those having no variations surviving the longest.
CZEN-002 demonstrated anti-infective and anti-inflammatory properties, with 88.2% of subjects showing efficacy in potassium hydroxide tests and mycological cultures. The treatment was well-tolerated with no significant changes from baseline vital signs.
A landmark study by Penn Medicine reveals significant improvements in quality of life and survival rates for heart failure patients treated with cardiac resynchronization therapy (CRT) and optimized pharmacologic therapy. The study shows a 36% reduction in all-cause mortality for patients implanted with CRT defibrillators.
A review of studies on holidays and death found contradictory results with only modest effects, and failed to explain mechanisms for delaying or advancing death. The authors conclude that future studies need to be better designed to find valid answers.
Researchers found that a weekly cycle of once-daily anti-HIV drugs can effectively treat HIV infection while reducing medication costs. The study involved eight patients who received a treatment regimen of 7 days on, followed by 7 days off, and maintained undetectable levels of HIV in their bloodstream for up to 84 weeks.
Researchers have found that natalizumab and adalimumab can help maintain clinical response and remission in patients with Crohn's disease. A trial also investigated the use of helminth ova as a potential treatment, showing significant improvements in clinical response and remission.
A study on tablet splitting found that the practice can lead to significant weight variability and uneven drug content, potentially putting patients at risk of experiencing side effects. Researchers recommend taking the prescribed dose as intended to ensure consistent medication amounts.
Two studies found that low-carbohydrate diets led to greater weight loss in obese adults than conventional diets. The low-carb group showed improvements in triglyceride levels and better control of blood sugar for those with diabetes.
The phase II clinical trial found that LEA29Y was as effective as cyclosporine in preventing acute kidney rejection, but had better kidney function and lower cholesterol levels. Patients treated with LEA29Y also showed improved cardiovascular risk profiles.
A new study found that the diabetes drug rosiglitazone improved insulin sensitivity in HIV patients with lipodystrophy by 20%, reversing fat loss and increasing total body fat. However, larger trials are needed to determine safety and optimal therapeutic approaches.
A worldwide increase in diabetes is forecasted to lead to a renal disease explosion. FOSRENOL, a new phosphate binding medication, has been shown to be effective in managing hyperphosphataemia, a condition associated with ESRD. The study highlights the need for new treatments to manage serious complications of dialysis.
Two randomized trials compared low-carbohydrate diets with low-fat diets, finding improved triglyceride levels and slightly improved HDL cholesterol levels on the low-carb diet. Participants on the low-carb diet also lost more weight in the short-term study, but both groups lost similar amounts of weight in the 12-month study.
A randomized study shows rifaximin to be highly effective in preventing all forms of diarrhea and intestinal symptoms in healthy adults traveling to high-risk areas. The medication was also found to prevent chronic diarrhea and irritable bowel syndrome in some individuals, making it a promising treatment for travelers.
Research shows that obesity-related surgeries can be completed as outpatient procedures, reducing associated costs. Adjustable gastric banding surgeries may also be suitable for certain obese patients, offering a safe and convenient alternative.
A recent study found that statins reduced brain lesions in people with MS by 44% after six months of treatment. Researchers suggest that statins may be beneficial for patients as monotherapy or as an add-on to existing therapies, but more data is needed to confirm their efficacy.
The Mectizan Donation Program has demonstrated significant success in combating river blindness through a public-private partnership between Merck and the World Health Organization. The program has resulted in nearly 50 million treatments approved since its inception, with minimal costs to participating organizations.
A study found that less educated individuals face higher daily stress levels, which have more significant negative impacts on their health. The researchers discovered that daily stressors vary by socio-economic status, with those in disadvantaged positions experiencing greater health downturns.
A study at the University of Pittsburgh Medical Center found that paroxetine significantly improved bowel movements and food avoidance in participants with irritable bowel syndrome. The drug relieved some symptoms of IBS and showed improvement in overall well-being, particularly in those without depression.
A recent study found that carotid endarterectomy (CEA) significantly reduces the risk of stroke among high-risk patients. The 5-year risk of stroke was around half for patients under 75 years old given CEA compared to those receiving no intervention. However, the benefits of immediate surgery may be short-lived, and ongoing follow-up i...
The KRONUS-MSP trial found that switching to sustained-release opioid Kadian improves pain relief and quality of life, while reducing the need for medication. Patients who previously exceeded recommended doses of OxyContin or MS Contin found relief with Kadian.
Researchers found that surgery to remove fatty deposits from narrowed vessels can significantly reduce stroke risk, with a 50% reduction in strokes among those who underwent the procedure. The study's results confirm previous findings and highlight the need for more adults to be screened for narrowed carotid arteries.
A phase III study presented at the American Psychiatric Association Meeting found that ADDERALL XR improves ADHD symptoms for up to 24 months. The medication reduced symptoms by an average of 45% in patients who received it consistently, with a significant reduction in inattention and impulsivity subscales.
A randomized trial of 542 patients with bipolar depression found Seroquel (quetiapine fumarate) to be effective in reducing symptoms, with a response rate of 50% compared to placebo. The study suggests that Seroquel may be a viable treatment option for bipolar disorder, particularly for patients who exhibit anxiety and agitation.
A large-scale national trial led by Duke University Medical Center researchers found that exercising reduced the risk of death and non-fatal heart attacks in heart attack patients who were depressed or socially isolated. The study followed 2,078 patients and compared their outcomes to those who did not exercise.
A new study shows that mixed amphetamine salts significantly improve behavior scores compared to atomoxetine, particularly in a 12-hour analog classroom setting. Additionally, mixed amphetamine salts also improve attention and academic productivity, allowing children to complete more math problems correctly.
A study found that adding a benefit box to pharmaceutical ads can increase public understanding and preference for such ads. However, the ads may still be overly optimistic about drug effectiveness, suggesting that more accurate information is needed.